Incidental Mutation 'R1993:Tiam2'
| ID |
224004 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tiam2
|
| Ensembl Gene |
ENSMUSG00000023800 |
| Gene Name |
T cell lymphoma invasion and metastasis 2 |
| Synonyms |
3000002F19Rik, STEF |
| MMRRC Submission |
040004-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R1993 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
3326573-3531344 bp(+) (GRCm38) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
A to T
at 3415126 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Stop codon
at position 377
(R377*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000125842
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000072156]
[ENSMUST00000169838]
|
| AlphaFold |
Q6ZPF3 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000072156
AA Change: R377*
|
| SMART Domains |
Protein: ENSMUSP00000072020
Gene: ENSMUSG00000023800
AA Change: R377*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
230 |
245 |
N/A |
INTRINSIC |
|
low complexity region
|
267 |
281 |
N/A |
INTRINSIC |
|
low complexity region
|
471 |
492 |
N/A |
INTRINSIC |
|
PH
|
505 |
620 |
7.82e-16 |
SMART |
|
RBD
|
831 |
902 |
1.32e-26 |
SMART |
|
PDZ
|
921 |
995 |
2.38e-7 |
SMART |
|
RhoGEF
|
1124 |
1313 |
2.23e-61 |
SMART |
|
PH
|
1347 |
1478 |
2.86e0 |
SMART |
|
low complexity region
|
1522 |
1532 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000169838
AA Change: R377*
|
| SMART Domains |
Protein: ENSMUSP00000125842
Gene: ENSMUSG00000023800
AA Change: R377*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
230 |
245 |
N/A |
INTRINSIC |
|
low complexity region
|
267 |
281 |
N/A |
INTRINSIC |
|
low complexity region
|
471 |
492 |
N/A |
INTRINSIC |
|
PH
|
505 |
620 |
7.82e-16 |
SMART |
|
RBD
|
831 |
902 |
1.32e-26 |
SMART |
|
PDZ
|
921 |
995 |
2.38e-7 |
SMART |
|
RhoGEF
|
1124 |
1313 |
2.23e-61 |
SMART |
|
PH
|
1347 |
1478 |
2.86e0 |
SMART |
|
low complexity region
|
1522 |
1532 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000226905
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 97.0%
- 20x: 94.3%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 104 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcb1b |
T |
G |
5: 8,821,322 (GRCm38) |
I292S |
possibly damaging |
Het |
| Abcc4 |
T |
C |
14: 118,526,282 (GRCm38) |
N1047S |
probably benign |
Het |
| Abcc8 |
G |
T |
7: 46,117,423 (GRCm38) |
|
probably null |
Het |
| Akap9 |
T |
A |
5: 4,038,520 (GRCm38) |
|
probably null |
Het |
| Alox5 |
T |
A |
6: 116,415,463 (GRCm38) |
I366F |
probably damaging |
Het |
| Amn |
A |
G |
12: 111,276,092 (GRCm38) |
N447S |
probably damaging |
Het |
| Ankrd22 |
A |
T |
19: 34,165,774 (GRCm38) |
M1K |
probably null |
Het |
| Asic1 |
G |
T |
15: 99,671,884 (GRCm38) |
G29C |
probably damaging |
Het |
| Atxn7l1 |
A |
G |
12: 33,345,977 (GRCm38) |
N235S |
probably benign |
Het |
| AY358078 |
T |
A |
14: 51,826,062 (GRCm38) |
D388E |
probably damaging |
Het |
| Bod1l |
A |
G |
5: 41,817,336 (GRCm38) |
S2212P |
probably damaging |
Het |
| Cacna1e |
T |
A |
1: 154,477,817 (GRCm38) |
Q423L |
probably damaging |
Het |
| Calu |
T |
C |
6: 29,366,975 (GRCm38) |
I62T |
possibly damaging |
Het |
| Cars2 |
A |
G |
8: 11,514,515 (GRCm38) |
V75A |
probably benign |
Het |
| Catsperb |
T |
A |
12: 101,602,767 (GRCm38) |
N899K |
possibly damaging |
Het |
| Ccdc50 |
T |
A |
16: 27,409,339 (GRCm38) |
C86* |
probably null |
Het |
| Cdh5 |
G |
T |
8: 104,137,815 (GRCm38) |
L469F |
probably damaging |
Het |
| Clrn3 |
A |
T |
7: 135,514,119 (GRCm38) |
D167E |
probably benign |
Het |
| Csmd1 |
A |
T |
8: 16,346,684 (GRCm38) |
C411S |
probably damaging |
Het |
| Dchs1 |
A |
T |
7: 105,762,548 (GRCm38) |
S1454T |
probably benign |
Het |
| Ddx20 |
G |
A |
3: 105,679,344 (GRCm38) |
Q562* |
probably null |
Het |
| Dgkg |
T |
G |
16: 22,600,594 (GRCm38) |
Y52S |
probably damaging |
Het |
| Dhx58 |
T |
C |
11: 100,703,490 (GRCm38) |
|
probably null |
Het |
| Dpp6 |
A |
T |
5: 27,399,006 (GRCm38) |
I145L |
probably benign |
Het |
| Efna2 |
A |
T |
10: 80,186,877 (GRCm38) |
Y85F |
possibly damaging |
Het |
| Eif3a |
C |
T |
19: 60,781,516 (GRCm38) |
V127I |
probably benign |
Het |
| Exph5 |
A |
T |
9: 53,373,635 (GRCm38) |
H672L |
possibly damaging |
Het |
| Fam131b |
T |
C |
6: 42,320,884 (GRCm38) |
T112A |
possibly damaging |
Het |
| Fcgr1 |
A |
T |
3: 96,285,868 (GRCm38) |
V271E |
probably damaging |
Het |
| Fgfr4 |
A |
G |
13: 55,165,902 (GRCm38) |
D508G |
probably damaging |
Het |
| Fndc3b |
A |
G |
3: 27,419,400 (GRCm38) |
M1172T |
probably benign |
Het |
| Fryl |
G |
T |
5: 73,108,493 (GRCm38) |
T495K |
probably damaging |
Het |
| Garin5b |
A |
T |
7: 4,758,018 (GRCm38) |
V565E |
probably damaging |
Het |
| Gm5134 |
A |
T |
10: 75,966,393 (GRCm38) |
I93F |
probably damaging |
Het |
| Gpbar1 |
G |
A |
1: 74,279,444 (GRCm38) |
G282D |
possibly damaging |
Het |
| Gria2 |
G |
A |
3: 80,802,357 (GRCm38) |
L10F |
probably benign |
Het |
| Grm7 |
T |
C |
6: 111,207,808 (GRCm38) |
Y367H |
probably benign |
Het |
| H1f9 |
T |
A |
11: 94,968,032 (GRCm38) |
V51E |
probably damaging |
Het |
| Hivep1 |
G |
A |
13: 42,157,493 (GRCm38) |
A1070T |
probably benign |
Het |
| Il33 |
A |
G |
19: 29,956,904 (GRCm38) |
D155G |
possibly damaging |
Het |
| Kdm6b |
T |
C |
11: 69,406,303 (GRCm38) |
S408G |
probably null |
Het |
| Kntc1 |
A |
G |
5: 123,810,811 (GRCm38) |
|
probably null |
Het |
| Kntc1 |
G |
A |
5: 123,759,099 (GRCm38) |
|
probably null |
Het |
| Ltbp2 |
T |
G |
12: 84,808,446 (GRCm38) |
|
probably null |
Het |
| Mapk8ip3 |
G |
T |
17: 24,914,588 (GRCm38) |
L83I |
probably damaging |
Het |
| Meltf |
C |
A |
16: 31,892,622 (GRCm38) |
Y554* |
probably null |
Het |
| Mov10 |
A |
C |
3: 104,799,419 (GRCm38) |
F725C |
probably damaging |
Het |
| Ms4a6d |
A |
C |
19: 11,590,159 (GRCm38) |
L18R |
probably damaging |
Het |
| Naip2 |
T |
C |
13: 100,162,007 (GRCm38) |
N507S |
probably benign |
Het |
| Nodal |
A |
G |
10: 61,418,334 (GRCm38) |
Q12R |
probably benign |
Het |
| Npy6r |
T |
C |
18: 44,276,508 (GRCm38) |
L332P |
probably damaging |
Het |
| Nrxn3 |
A |
G |
12: 89,260,411 (GRCm38) |
K272R |
possibly damaging |
Het |
| Obox2 |
G |
T |
7: 15,397,249 (GRCm38) |
K93N |
probably benign |
Het |
| Or10j27 |
C |
T |
1: 173,130,851 (GRCm38) |
R122H |
possibly damaging |
Het |
| Or51a6 |
G |
T |
7: 102,954,746 (GRCm38) |
P285Q |
probably damaging |
Het |
| Or5b112 |
A |
G |
19: 13,341,814 (GRCm38) |
T19A |
possibly damaging |
Het |
| Or5w13 |
C |
T |
2: 87,693,433 (GRCm38) |
V150M |
probably benign |
Het |
| Pcdh12 |
T |
A |
18: 38,282,143 (GRCm38) |
D643V |
possibly damaging |
Het |
| Pcsk2 |
A |
G |
2: 143,687,619 (GRCm38) |
D112G |
probably benign |
Het |
| Pms1 |
A |
G |
1: 53,195,015 (GRCm38) |
S781P |
probably benign |
Het |
| Prtg |
A |
G |
9: 72,844,896 (GRCm38) |
D188G |
probably benign |
Het |
| Psg21 |
A |
T |
7: 18,654,770 (GRCm38) |
N132K |
probably benign |
Het |
| Psip1 |
A |
G |
4: 83,482,532 (GRCm38) |
V25A |
probably damaging |
Het |
| Psmd13 |
T |
A |
7: 140,898,194 (GRCm38) |
I319N |
probably damaging |
Het |
| Ptges2 |
A |
G |
2: 32,400,092 (GRCm38) |
T173A |
probably benign |
Het |
| Ptprm |
G |
A |
17: 66,747,160 (GRCm38) |
R975W |
probably damaging |
Het |
| Rdh1 |
A |
G |
10: 127,765,345 (GRCm38) |
D254G |
probably benign |
Het |
| Rnf138 |
T |
G |
18: 21,024,483 (GRCm38) |
N212K |
probably damaging |
Het |
| Serpine2 |
A |
G |
1: 79,821,442 (GRCm38) |
S32P |
probably damaging |
Het |
| Serpini1 |
G |
T |
3: 75,614,664 (GRCm38) |
W154L |
probably damaging |
Het |
| Sf3a1 |
C |
A |
11: 4,179,177 (GRCm38) |
Q713K |
possibly damaging |
Het |
| Sgo2b |
A |
T |
8: 63,926,833 (GRCm38) |
H988Q |
probably benign |
Het |
| Sin3a |
T |
C |
9: 57,101,199 (GRCm38) |
F468L |
probably damaging |
Het |
| Slamf6 |
A |
T |
1: 171,934,209 (GRCm38) |
I66F |
possibly damaging |
Het |
| Slc22a28 |
A |
T |
19: 8,117,124 (GRCm38) |
C178S |
possibly damaging |
Het |
| Slc35a1 |
A |
C |
4: 34,675,181 (GRCm38) |
V119G |
probably damaging |
Het |
| Slc39a12 |
A |
T |
2: 14,434,219 (GRCm38) |
H428L |
probably damaging |
Het |
| Speer2 |
A |
G |
16: 69,858,077 (GRCm38) |
S167P |
probably benign |
Het |
| Sphkap |
G |
A |
1: 83,277,515 (GRCm38) |
R838* |
probably null |
Het |
| Spsb2 |
T |
C |
6: 124,809,366 (GRCm38) |
|
probably null |
Het |
| Stam2 |
A |
T |
2: 52,703,156 (GRCm38) |
Y341* |
probably null |
Het |
| Sv2b |
G |
A |
7: 75,206,341 (GRCm38) |
A67V |
probably benign |
Het |
| Svep1 |
A |
G |
4: 58,064,170 (GRCm38) |
|
probably null |
Het |
| Syt15 |
A |
T |
14: 34,223,012 (GRCm38) |
Q172L |
probably benign |
Het |
| T |
G |
A |
17: 8,441,802 (GRCm38) |
S415N |
probably benign |
Het |
| Tep1 |
A |
G |
14: 50,824,184 (GRCm38) |
F2625S |
possibly damaging |
Het |
| Tex14 |
T |
C |
11: 87,536,755 (GRCm38) |
V11A |
possibly damaging |
Het |
| Tirap |
A |
G |
9: 35,191,016 (GRCm38) |
|
probably null |
Het |
| Tm4sf20 |
T |
C |
1: 82,760,217 (GRCm38) |
T118A |
probably benign |
Het |
| Trank1 |
A |
T |
9: 111,378,832 (GRCm38) |
Q1715L |
probably benign |
Het |
| Trpm2 |
C |
T |
10: 77,947,989 (GRCm38) |
V217M |
probably damaging |
Het |
| Ubap1l |
G |
A |
9: 65,371,796 (GRCm38) |
E126K |
possibly damaging |
Het |
| Urgcp |
G |
T |
11: 5,716,526 (GRCm38) |
P604Q |
probably damaging |
Het |
| Vmn1r63 |
A |
G |
7: 5,803,255 (GRCm38) |
V126A |
probably benign |
Het |
| Vmn2r90 |
T |
C |
17: 17,713,263 (GRCm38) |
C362R |
probably damaging |
Het |
| Vmn2r96 |
A |
G |
17: 18,583,876 (GRCm38) |
I271V |
probably damaging |
Het |
| Vps13a |
A |
T |
19: 16,722,458 (GRCm38) |
I740K |
probably benign |
Het |
| Vps13c |
A |
G |
9: 67,975,856 (GRCm38) |
T3562A |
probably damaging |
Het |
| Wdr91 |
T |
A |
6: 34,892,362 (GRCm38) |
H409L |
probably damaging |
Het |
| Wnt7a |
T |
A |
6: 91,365,956 (GRCm38) |
T315S |
possibly damaging |
Het |
| Zfp616 |
A |
G |
11: 74,084,969 (GRCm38) |
H688R |
probably benign |
Het |
| Zfp763 |
A |
T |
17: 33,018,439 (GRCm38) |
H577Q |
probably damaging |
Het |
| Zfp808 |
G |
A |
13: 62,172,907 (GRCm38) |
S650N |
probably benign |
Het |
| Zfp977 |
A |
T |
7: 42,579,985 (GRCm38) |
M372K |
probably benign |
Het |
|
| Other mutations in Tiam2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01011:Tiam2
|
APN |
17 |
3,415,028 (GRCm38) |
missense |
probably benign |
0.21 |
|
IGL01320:Tiam2
|
APN |
17 |
3,505,745 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01384:Tiam2
|
APN |
17 |
3,427,202 (GRCm38) |
missense |
probably benign |
0.08 |
|
IGL01575:Tiam2
|
APN |
17 |
3,454,316 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01769:Tiam2
|
APN |
17 |
3,427,290 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02395:Tiam2
|
APN |
17 |
3,421,481 (GRCm38) |
missense |
possibly damaging |
0.49 |
|
IGL02652:Tiam2
|
APN |
17 |
3,439,696 (GRCm38) |
splice site |
probably benign |
|
|
IGL03102:Tiam2
|
APN |
17 |
3,509,548 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03222:Tiam2
|
APN |
17 |
3,438,708 (GRCm38) |
missense |
probably damaging |
0.97 |
|
Feste_burg
|
UTSW |
17 |
3,414,622 (GRCm38) |
frame shift |
probably null |
|
|
R0257:Tiam2
|
UTSW |
17 |
3,450,813 (GRCm38) |
missense |
possibly damaging |
0.49 |
|
R0420:Tiam2
|
UTSW |
17 |
3,502,918 (GRCm38) |
missense |
probably benign |
0.01 |
|
R0528:Tiam2
|
UTSW |
17 |
3,511,071 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0532:Tiam2
|
UTSW |
17 |
3,421,646 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0551:Tiam2
|
UTSW |
17 |
3,428,954 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0554:Tiam2
|
UTSW |
17 |
3,438,681 (GRCm38) |
nonsense |
probably null |
|
|
R0645:Tiam2
|
UTSW |
17 |
3,514,698 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R0726:Tiam2
|
UTSW |
17 |
3,512,833 (GRCm38) |
unclassified |
probably benign |
|
|
R1139:Tiam2
|
UTSW |
17 |
3,477,267 (GRCm38) |
missense |
possibly damaging |
0.55 |
|
R1392:Tiam2
|
UTSW |
17 |
3,414,197 (GRCm38) |
missense |
possibly damaging |
0.71 |
|
R1392:Tiam2
|
UTSW |
17 |
3,414,197 (GRCm38) |
missense |
possibly damaging |
0.71 |
|
R1529:Tiam2
|
UTSW |
17 |
3,516,703 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1671:Tiam2
|
UTSW |
17 |
3,506,834 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1731:Tiam2
|
UTSW |
17 |
3,518,423 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R1759:Tiam2
|
UTSW |
17 |
3,516,003 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R1850:Tiam2
|
UTSW |
17 |
3,437,235 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1853:Tiam2
|
UTSW |
17 |
3,415,135 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1855:Tiam2
|
UTSW |
17 |
3,415,135 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1931:Tiam2
|
UTSW |
17 |
3,514,725 (GRCm38) |
missense |
possibly damaging |
0.68 |
|
R1932:Tiam2
|
UTSW |
17 |
3,514,725 (GRCm38) |
missense |
possibly damaging |
0.68 |
|
R2211:Tiam2
|
UTSW |
17 |
3,414,918 (GRCm38) |
nonsense |
probably null |
|
|
R2217:Tiam2
|
UTSW |
17 |
3,415,114 (GRCm38) |
missense |
probably benign |
0.34 |
|
R2278:Tiam2
|
UTSW |
17 |
3,427,220 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R2407:Tiam2
|
UTSW |
17 |
3,477,261 (GRCm38) |
missense |
probably benign |
0.14 |
|
R2516:Tiam2
|
UTSW |
17 |
3,453,382 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2991:Tiam2
|
UTSW |
17 |
3,518,250 (GRCm38) |
missense |
probably benign |
|
|
R3086:Tiam2
|
UTSW |
17 |
3,421,582 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3121:Tiam2
|
UTSW |
17 |
3,439,702 (GRCm38) |
missense |
probably benign |
0.01 |
|
R3686:Tiam2
|
UTSW |
17 |
3,421,684 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R3740:Tiam2
|
UTSW |
17 |
3,414,113 (GRCm38) |
missense |
possibly damaging |
0.54 |
|
R3742:Tiam2
|
UTSW |
17 |
3,414,113 (GRCm38) |
missense |
possibly damaging |
0.54 |
|
R3826:Tiam2
|
UTSW |
17 |
3,507,701 (GRCm38) |
splice site |
probably benign |
|
|
R3829:Tiam2
|
UTSW |
17 |
3,507,701 (GRCm38) |
splice site |
probably benign |
|
|
R3844:Tiam2
|
UTSW |
17 |
3,421,651 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R3970:Tiam2
|
UTSW |
17 |
3,428,831 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4060:Tiam2
|
UTSW |
17 |
3,428,980 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4296:Tiam2
|
UTSW |
17 |
3,450,845 (GRCm38) |
missense |
probably benign |
|
|
R4357:Tiam2
|
UTSW |
17 |
3,450,853 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4368:Tiam2
|
UTSW |
17 |
3,414,683 (GRCm38) |
missense |
probably benign |
0.01 |
|
R4369:Tiam2
|
UTSW |
17 |
3,413,967 (GRCm38) |
start gained |
probably benign |
|
|
R4524:Tiam2
|
UTSW |
17 |
3,514,711 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4619:Tiam2
|
UTSW |
17 |
3,518,342 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4715:Tiam2
|
UTSW |
17 |
3,454,168 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4723:Tiam2
|
UTSW |
17 |
3,450,317 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4979:Tiam2
|
UTSW |
17 |
3,505,710 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5182:Tiam2
|
UTSW |
17 |
3,438,721 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5451:Tiam2
|
UTSW |
17 |
3,428,996 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5728:Tiam2
|
UTSW |
17 |
3,414,956 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5827:Tiam2
|
UTSW |
17 |
3,448,489 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5879:Tiam2
|
UTSW |
17 |
3,437,265 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5960:Tiam2
|
UTSW |
17 |
3,438,640 (GRCm38) |
missense |
probably benign |
0.24 |
|
R5974:Tiam2
|
UTSW |
17 |
3,414,809 (GRCm38) |
missense |
possibly damaging |
0.51 |
|
R6198:Tiam2
|
UTSW |
17 |
3,414,121 (GRCm38) |
missense |
probably benign |
0.06 |
|
R6222:Tiam2
|
UTSW |
17 |
3,453,338 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R6295:Tiam2
|
UTSW |
17 |
3,509,556 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6355:Tiam2
|
UTSW |
17 |
3,414,622 (GRCm38) |
frame shift |
probably null |
|
|
R6356:Tiam2
|
UTSW |
17 |
3,414,622 (GRCm38) |
frame shift |
probably null |
|
|
R6454:Tiam2
|
UTSW |
17 |
3,438,663 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6497:Tiam2
|
UTSW |
17 |
3,506,827 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6579:Tiam2
|
UTSW |
17 |
3,414,622 (GRCm38) |
frame shift |
probably null |
|
|
R6580:Tiam2
|
UTSW |
17 |
3,414,622 (GRCm38) |
frame shift |
probably null |
|
|
R6581:Tiam2
|
UTSW |
17 |
3,414,622 (GRCm38) |
frame shift |
probably null |
|
|
R6582:Tiam2
|
UTSW |
17 |
3,414,622 (GRCm38) |
frame shift |
probably null |
|
|
R6648:Tiam2
|
UTSW |
17 |
3,506,873 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6705:Tiam2
|
UTSW |
17 |
3,518,243 (GRCm38) |
missense |
probably benign |
0.01 |
|
R6758:Tiam2
|
UTSW |
17 |
3,518,403 (GRCm38) |
missense |
probably benign |
0.01 |
|
R6836:Tiam2
|
UTSW |
17 |
3,414,380 (GRCm38) |
missense |
probably benign |
0.17 |
|
R6924:Tiam2
|
UTSW |
17 |
3,507,795 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6977:Tiam2
|
UTSW |
17 |
3,518,659 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7051:Tiam2
|
UTSW |
17 |
3,448,483 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R7151:Tiam2
|
UTSW |
17 |
3,448,385 (GRCm38) |
missense |
probably benign |
0.36 |
|
R7214:Tiam2
|
UTSW |
17 |
3,518,412 (GRCm38) |
missense |
possibly damaging |
0.85 |
|
R7332:Tiam2
|
UTSW |
17 |
3,453,369 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7334:Tiam2
|
UTSW |
17 |
3,503,008 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R7414:Tiam2
|
UTSW |
17 |
3,414,113 (GRCm38) |
missense |
possibly damaging |
0.54 |
|
R7660:Tiam2
|
UTSW |
17 |
3,482,605 (GRCm38) |
start codon destroyed |
probably null |
0.66 |
|
R7743:Tiam2
|
UTSW |
17 |
3,518,156 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
R7755:Tiam2
|
UTSW |
17 |
3,421,316 (GRCm38) |
missense |
probably benign |
0.01 |
|
R7805:Tiam2
|
UTSW |
17 |
3,509,410 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7813:Tiam2
|
UTSW |
17 |
3,437,247 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7842:Tiam2
|
UTSW |
17 |
3,518,124 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R7989:Tiam2
|
UTSW |
17 |
3,518,249 (GRCm38) |
nonsense |
probably null |
|
|
R8011:Tiam2
|
UTSW |
17 |
3,448,396 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R8221:Tiam2
|
UTSW |
17 |
3,518,585 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8260:Tiam2
|
UTSW |
17 |
3,518,319 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R8292:Tiam2
|
UTSW |
17 |
3,506,867 (GRCm38) |
missense |
probably benign |
0.01 |
|
R8406:Tiam2
|
UTSW |
17 |
3,507,790 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R8424:Tiam2
|
UTSW |
17 |
3,516,042 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8424:Tiam2
|
UTSW |
17 |
3,516,041 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8430:Tiam2
|
UTSW |
17 |
3,518,262 (GRCm38) |
missense |
probably benign |
0.05 |
|
R8530:Tiam2
|
UTSW |
17 |
3,450,812 (GRCm38) |
missense |
probably benign |
0.03 |
|
R8692:Tiam2
|
UTSW |
17 |
3,428,807 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8902:Tiam2
|
UTSW |
17 |
3,477,196 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9067:Tiam2
|
UTSW |
17 |
3,511,132 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9080:Tiam2
|
UTSW |
17 |
3,414,244 (GRCm38) |
missense |
probably benign |
|
|
R9090:Tiam2
|
UTSW |
17 |
3,414,736 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9211:Tiam2
|
UTSW |
17 |
3,448,454 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R9271:Tiam2
|
UTSW |
17 |
3,414,736 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9347:Tiam2
|
UTSW |
17 |
3,421,648 (GRCm38) |
missense |
probably benign |
0.37 |
|
R9353:Tiam2
|
UTSW |
17 |
3,507,799 (GRCm38) |
nonsense |
probably null |
|
|
R9407:Tiam2
|
UTSW |
17 |
3,503,023 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9460:Tiam2
|
UTSW |
17 |
3,437,310 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9550:Tiam2
|
UTSW |
17 |
3,509,431 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9748:Tiam2
|
UTSW |
17 |
3,511,165 (GRCm38) |
missense |
probably benign |
0.20 |
|
X0027:Tiam2
|
UTSW |
17 |
3,414,000 (GRCm38) |
start codon destroyed |
probably null |
1.00 |
|
X0060:Tiam2
|
UTSW |
17 |
3,450,354 (GRCm38) |
splice site |
probably null |
|
|
X0065:Tiam2
|
UTSW |
17 |
3,505,708 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1088:Tiam2
|
UTSW |
17 |
3,415,019 (GRCm38) |
missense |
probably benign |
0.01 |
|
Z1176:Tiam2
|
UTSW |
17 |
3,505,776 (GRCm38) |
missense |
probably null |
1.00 |
|
Z1177:Tiam2
|
UTSW |
17 |
3,427,263 (GRCm38) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- ATCAGCTCTCAAGTCAGCCTG -3'
(R):5'- AGACTCAGAGTGGATTACTGAAGC -3'
Sequencing Primer
(F):5'- GAACAACCGAGTCTCCTTTGCG -3'
(R):5'- CAGAAATAAGCTGTGCTGGGTCTTC -3'
|
| Posted On |
2014-08-25 |
Incidental Mutation