Incidental Mutation 'R0142:Brd10'
ID 22412
Institutional Source Beutler Lab
Gene Symbol Brd10
Ensembl Gene ENSMUSG00000046138
Gene Name bromodomain containing 10
Synonyms 9930021J03Rik, Gm9832
MMRRC Submission 038427-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.138) question?
Stock # R0142 (G1)
Quality Score 225
Status Validated (trace)
Chromosome 19
Chromosomal Location 29691802-29783389 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 29695654 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 1347 (S1347P)
Gene Model predicted gene model for transcript(s): [ENSMUST00000177155]
AlphaFold H3BKP8
Predicted Effect possibly damaging
Transcript: ENSMUST00000059484
AA Change: S1347P

PolyPhen 2 Score 0.933 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000054060
Gene: ENSMUSG00000046138
AA Change: S1347P

DomainStartEndE-ValueType
low complexity region 4 66 N/A INTRINSIC
BROMO 75 198 1.22e-3 SMART
low complexity region 225 235 N/A INTRINSIC
coiled coil region 248 289 N/A INTRINSIC
low complexity region 347 365 N/A INTRINSIC
low complexity region 495 508 N/A INTRINSIC
coiled coil region 673 705 N/A INTRINSIC
low complexity region 722 756 N/A INTRINSIC
coiled coil region 764 796 N/A INTRINSIC
low complexity region 1146 1160 N/A INTRINSIC
internal_repeat_1 1164 1293 9.57e-8 PROSPERO
low complexity region 1295 1304 N/A INTRINSIC
low complexity region 1386 1415 N/A INTRINSIC
low complexity region 1468 1483 N/A INTRINSIC
low complexity region 1602 1624 N/A INTRINSIC
low complexity region 1647 1663 N/A INTRINSIC
low complexity region 1732 1745 N/A INTRINSIC
internal_repeat_1 1766 1910 9.57e-8 PROSPERO
low complexity region 1987 1993 N/A INTRINSIC
low complexity region 2013 2027 N/A INTRINSIC
low complexity region 2053 2071 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000175726
AA Change: S1224P
Predicted Effect unknown
Transcript: ENSMUST00000175764
AA Change: S579P
SMART Domains Protein: ENSMUSP00000135031
Gene: ENSMUSG00000046138
AA Change: S579P

DomainStartEndE-ValueType
low complexity region 2 19 N/A INTRINSIC
low complexity region 379 393 N/A INTRINSIC
internal_repeat_1 397 526 2.65e-5 PROSPERO
low complexity region 528 537 N/A INTRINSIC
low complexity region 619 648 N/A INTRINSIC
low complexity region 701 716 N/A INTRINSIC
low complexity region 835 857 N/A INTRINSIC
low complexity region 880 896 N/A INTRINSIC
low complexity region 965 978 N/A INTRINSIC
internal_repeat_1 999 1143 2.65e-5 PROSPERO
low complexity region 1220 1226 N/A INTRINSIC
low complexity region 1246 1260 N/A INTRINSIC
low complexity region 1286 1304 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000176773
Predicted Effect probably benign
Transcript: ENSMUST00000177155
AA Change: S1280P

PolyPhen 2 Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000135473
Gene: ENSMUSG00000046138
AA Change: S1280P

DomainStartEndE-ValueType
low complexity region 4 66 N/A INTRINSIC
BROMO 75 198 1.22e-3 SMART
low complexity region 205 219 N/A INTRINSIC
low complexity region 280 298 N/A INTRINSIC
low complexity region 428 441 N/A INTRINSIC
coiled coil region 606 638 N/A INTRINSIC
low complexity region 655 689 N/A INTRINSIC
coiled coil region 697 729 N/A INTRINSIC
low complexity region 1079 1093 N/A INTRINSIC
internal_repeat_1 1097 1226 1.32e-7 PROSPERO
low complexity region 1228 1237 N/A INTRINSIC
low complexity region 1319 1348 N/A INTRINSIC
low complexity region 1401 1416 N/A INTRINSIC
low complexity region 1535 1557 N/A INTRINSIC
low complexity region 1580 1596 N/A INTRINSIC
low complexity region 1665 1678 N/A INTRINSIC
internal_repeat_1 1699 1843 1.32e-7 PROSPERO
low complexity region 1920 1926 N/A INTRINSIC
low complexity region 1946 1960 N/A INTRINSIC
low complexity region 1986 2004 N/A INTRINSIC
Meta Mutation Damage Score 0.0843 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 97.9%
  • 10x: 95.0%
  • 20x: 87.6%
Validation Efficiency 92% (61/66)
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca6 T G 11: 110,079,467 (GRCm39) D1229A probably damaging Het
Abhd8 A C 8: 71,914,506 (GRCm39) F41V probably damaging Het
Ago4 T G 4: 126,410,725 (GRCm39) E222A probably benign Het
Ap3b2 T C 7: 81,122,828 (GRCm39) I470V probably damaging Het
Bcl9l C T 9: 44,418,409 (GRCm39) T749M probably benign Het
Bicc1 T C 10: 70,761,200 (GRCm39) K937E probably damaging Het
Bmi1 G A 2: 18,688,095 (GRCm39) probably null Het
Boc A C 16: 44,310,604 (GRCm39) I772S probably damaging Het
C2 T A 17: 35,092,504 (GRCm39) I178F possibly damaging Het
Cacna1c G T 6: 118,580,843 (GRCm39) A1416E probably damaging Het
Chst10 A G 1: 38,910,810 (GRCm39) L118P probably damaging Het
Crybg1 G A 10: 43,875,059 (GRCm39) T683I possibly damaging Het
Cul5 C T 9: 53,546,350 (GRCm39) V314I probably damaging Het
Dnajc17 C A 2: 119,010,415 (GRCm39) R211I probably benign Het
Emilin1 A G 5: 31,071,264 (GRCm39) T16A probably benign Het
Ercc6l2 A C 13: 64,020,320 (GRCm39) probably benign Het
Fsd2 T A 7: 81,209,683 (GRCm39) D53V probably damaging Het
Galnt13 A G 2: 54,988,615 (GRCm39) D479G probably damaging Het
Grk3 A T 5: 113,062,919 (GRCm39) W643R probably damaging Het
Hdgf G A 3: 87,820,416 (GRCm39) A4T possibly damaging Het
Hnrnpr T A 4: 136,054,593 (GRCm39) V182E probably damaging Het
Ipo13 A C 4: 117,762,766 (GRCm39) L279R probably damaging Het
Itga9 C A 9: 118,465,654 (GRCm39) N169K probably damaging Het
Jph3 A G 8: 122,480,110 (GRCm39) T263A possibly damaging Het
Jph4 G T 14: 55,345,783 (GRCm39) Q625K probably benign Het
Kctd3 A C 1: 188,728,595 (GRCm39) probably null Het
Kif26b A T 1: 178,742,954 (GRCm39) S570C probably damaging Het
Klhl5 G A 5: 65,300,693 (GRCm39) W164* probably null Het
Lacc1 A T 14: 77,268,239 (GRCm39) H357Q probably benign Het
Lama2 A G 10: 27,063,841 (GRCm39) I1316T probably benign Het
Lcp2 C T 11: 34,032,418 (GRCm39) P332L probably damaging Het
Map3k6 A T 4: 132,978,257 (GRCm39) H1033L probably benign Het
Mfsd2b A G 12: 4,916,234 (GRCm39) V252A probably benign Het
Myo16 T A 8: 10,619,790 (GRCm39) I1447N probably benign Het
Myo19 G A 11: 84,785,429 (GRCm39) R224H probably damaging Het
Myo5a C T 9: 75,067,856 (GRCm39) H637Y probably benign Het
Nek10 C T 14: 14,861,560 (GRCm38) R539C possibly damaging Het
Nfix A T 8: 85,448,315 (GRCm39) V404E probably damaging Het
Nr1i2 T C 16: 38,073,368 (GRCm39) R203G probably benign Het
Nup210l G A 3: 90,079,420 (GRCm39) G968D probably damaging Het
Or10q1 A T 19: 13,726,619 (GRCm39) I50F probably benign Het
Or2ag15 G T 7: 106,340,972 (GRCm39) H56Q probably benign Het
Or8b37 A T 9: 37,959,406 (GRCm39) H296L probably benign Het
Phlpp2 C T 8: 110,634,145 (GRCm39) R242W probably damaging Het
Plcz1 A G 6: 139,953,423 (GRCm39) F398S probably damaging Het
Ppfibp2 C A 7: 107,343,384 (GRCm39) P808T probably damaging Het
Srpk2 T C 5: 23,732,928 (GRCm39) K239E probably damaging Het
Svep1 A G 4: 58,118,232 (GRCm39) V830A probably benign Het
Tesc A T 5: 118,194,635 (GRCm39) I149F possibly damaging Het
Thsd7a A G 6: 12,418,334 (GRCm39) W632R probably damaging Het
Tmprss9 A G 10: 80,730,212 (GRCm39) D704G possibly damaging Het
Tob1 T C 11: 94,105,423 (GRCm39) Y320H probably damaging Het
Trpm3 G T 19: 22,965,280 (GRCm39) D1582Y probably damaging Het
Ttc28 A G 5: 111,425,323 (GRCm39) K1716R probably benign Het
Uqcrfs1 A G 13: 30,724,925 (GRCm39) V205A probably benign Het
Usp29 G A 7: 6,965,334 (GRCm39) M392I probably benign Het
Uspl1 A T 5: 149,125,159 (GRCm39) Y22F possibly damaging Het
Virma C A 4: 11,548,783 (GRCm39) N1780K probably benign Het
Vmn1r56 C T 7: 5,199,372 (GRCm39) A82T probably benign Het
Vmn2r5 A T 3: 64,400,009 (GRCm39) C553S probably damaging Het
Vwce A T 19: 10,641,976 (GRCm39) R901W probably damaging Het
Wdpcp C A 11: 21,807,444 (GRCm39) probably null Het
Zfp423 A T 8: 88,506,968 (GRCm39) C1000* probably null Het
Zscan20 A G 4: 128,479,630 (GRCm39) F954L probably benign Het
Other mutations in Brd10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01311:Brd10 APN 19 29,731,420 (GRCm39) missense probably benign 0.33
IGL01535:Brd10 APN 19 29,731,212 (GRCm39) missense possibly damaging 0.53
IGL02019:Brd10 APN 19 29,694,463 (GRCm39) missense probably benign 0.28
IGL02034:Brd10 APN 19 29,694,259 (GRCm39) missense possibly damaging 0.73
IGL03114:Brd10 APN 19 29,694,532 (GRCm39) missense probably benign 0.18
IGL03382:Brd10 APN 19 29,694,676 (GRCm39) missense probably damaging 1.00
R0020:Brd10 UTSW 19 29,693,597 (GRCm39) missense probably damaging 0.98
R0020:Brd10 UTSW 19 29,693,597 (GRCm39) missense probably damaging 0.98
R0178:Brd10 UTSW 19 29,732,188 (GRCm39) missense probably damaging 1.00
R0453:Brd10 UTSW 19 29,731,068 (GRCm39) missense probably damaging 1.00
R0730:Brd10 UTSW 19 29,695,381 (GRCm39) missense probably benign 0.00
R0735:Brd10 UTSW 19 29,695,038 (GRCm39) missense possibly damaging 0.92
R0891:Brd10 UTSW 19 29,695,053 (GRCm39) missense probably damaging 1.00
R0894:Brd10 UTSW 19 29,697,974 (GRCm39) splice site probably benign
R1289:Brd10 UTSW 19 29,700,852 (GRCm39) missense probably benign 0.07
R1368:Brd10 UTSW 19 29,693,796 (GRCm39) missense probably damaging 0.97
R1387:Brd10 UTSW 19 29,700,853 (GRCm39) missense probably benign 0.15
R1483:Brd10 UTSW 19 29,696,745 (GRCm39) missense possibly damaging 0.93
R1526:Brd10 UTSW 19 29,712,545 (GRCm39) missense probably damaging 1.00
R1612:Brd10 UTSW 19 29,695,245 (GRCm39) missense possibly damaging 0.86
R1721:Brd10 UTSW 19 29,720,998 (GRCm39) missense probably damaging 0.99
R1764:Brd10 UTSW 19 29,696,560 (GRCm39) missense possibly damaging 0.53
R1822:Brd10 UTSW 19 29,693,814 (GRCm39) missense probably damaging 0.99
R1824:Brd10 UTSW 19 29,693,814 (GRCm39) missense probably damaging 0.99
R1859:Brd10 UTSW 19 29,732,323 (GRCm39) missense possibly damaging 0.53
R1868:Brd10 UTSW 19 29,720,998 (GRCm39) missense probably damaging 0.99
R1880:Brd10 UTSW 19 29,695,523 (GRCm39) missense probably benign 0.06
R1898:Brd10 UTSW 19 29,712,532 (GRCm39) missense possibly damaging 0.74
R1936:Brd10 UTSW 19 29,731,077 (GRCm39) missense possibly damaging 0.87
R1939:Brd10 UTSW 19 29,731,077 (GRCm39) missense possibly damaging 0.87
R1969:Brd10 UTSW 19 29,694,075 (GRCm39) missense possibly damaging 0.95
R2153:Brd10 UTSW 19 29,694,229 (GRCm39) missense probably benign 0.01
R2366:Brd10 UTSW 19 29,731,035 (GRCm39) missense probably damaging 0.99
R2379:Brd10 UTSW 19 29,696,275 (GRCm39) missense probably benign 0.01
R3107:Brd10 UTSW 19 29,700,847 (GRCm39) missense probably damaging 1.00
R4012:Brd10 UTSW 19 29,720,990 (GRCm39) missense probably damaging 1.00
R4222:Brd10 UTSW 19 29,696,149 (GRCm39) missense probably benign 0.18
R4328:Brd10 UTSW 19 29,720,961 (GRCm39) missense probably benign 0.00
R4329:Brd10 UTSW 19 29,720,961 (GRCm39) missense probably benign 0.00
R4387:Brd10 UTSW 19 29,782,715 (GRCm39) unclassified probably benign
R4688:Brd10 UTSW 19 29,694,501 (GRCm39) missense probably benign 0.33
R4796:Brd10 UTSW 19 29,731,018 (GRCm39) missense probably benign 0.33
R4820:Brd10 UTSW 19 29,695,809 (GRCm39) missense possibly damaging 0.53
R4832:Brd10 UTSW 19 29,694,616 (GRCm39) missense possibly damaging 0.53
R5056:Brd10 UTSW 19 29,694,759 (GRCm39) missense probably benign
R5150:Brd10 UTSW 19 29,782,950 (GRCm39) missense probably damaging 0.96
R5224:Brd10 UTSW 19 29,696,450 (GRCm39) missense possibly damaging 0.73
R5306:Brd10 UTSW 19 29,707,230 (GRCm39) intron probably benign
R5460:Brd10 UTSW 19 29,732,250 (GRCm39) missense probably damaging 0.98
R5477:Brd10 UTSW 19 29,731,518 (GRCm39) missense probably benign 0.33
R5531:Brd10 UTSW 19 29,731,072 (GRCm39) missense possibly damaging 0.73
R5559:Brd10 UTSW 19 29,694,363 (GRCm39) missense possibly damaging 0.91
R5647:Brd10 UTSW 19 29,731,210 (GRCm39) missense possibly damaging 0.73
R5886:Brd10 UTSW 19 29,696,677 (GRCm39) missense probably benign 0.03
R6029:Brd10 UTSW 19 29,732,367 (GRCm39) unclassified probably benign
R6240:Brd10 UTSW 19 29,694,640 (GRCm39) missense probably benign 0.18
R6331:Brd10 UTSW 19 29,695,147 (GRCm39) missense probably benign 0.33
R6456:Brd10 UTSW 19 29,693,914 (GRCm39) missense possibly damaging 0.93
R6584:Brd10 UTSW 19 29,696,128 (GRCm39) missense possibly damaging 0.53
R6661:Brd10 UTSW 19 29,700,864 (GRCm39) missense possibly damaging 0.53
R6991:Brd10 UTSW 19 29,696,508 (GRCm39) missense possibly damaging 0.86
R7059:Brd10 UTSW 19 29,696,945 (GRCm39) missense probably benign 0.33
R7128:Brd10 UTSW 19 29,693,881 (GRCm39) missense possibly damaging 0.53
R7211:Brd10 UTSW 19 29,763,712 (GRCm39) missense
R7471:Brd10 UTSW 19 29,707,139 (GRCm39) splice site probably null
R7686:Brd10 UTSW 19 29,694,870 (GRCm39) missense probably benign 0.34
R8012:Brd10 UTSW 19 29,695,534 (GRCm39) missense possibly damaging 0.73
R8203:Brd10 UTSW 19 29,693,443 (GRCm39) missense probably benign 0.18
R8353:Brd10 UTSW 19 29,731,242 (GRCm39) missense possibly damaging 0.53
R8672:Brd10 UTSW 19 29,731,564 (GRCm39) missense probably benign
R8755:Brd10 UTSW 19 29,693,890 (GRCm39) missense probably benign 0.03
R8918:Brd10 UTSW 19 29,696,841 (GRCm39) missense possibly damaging 0.53
R8954:Brd10 UTSW 19 29,696,126 (GRCm39) missense possibly damaging 0.72
R9038:Brd10 UTSW 19 29,731,900 (GRCm39) missense possibly damaging 0.86
R9195:Brd10 UTSW 19 29,763,703 (GRCm39) missense
R9204:Brd10 UTSW 19 29,696,938 (GRCm39) missense possibly damaging 0.73
R9518:Brd10 UTSW 19 29,731,541 (GRCm39) missense possibly damaging 0.53
R9743:Brd10 UTSW 19 29,694,261 (GRCm39) missense probably benign
R9747:Brd10 UTSW 19 29,731,911 (GRCm39) missense possibly damaging 0.73
RF011:Brd10 UTSW 19 29,721,009 (GRCm39) missense possibly damaging 0.53
X0027:Brd10 UTSW 19 29,712,599 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TGACACCAGCATCAGTTTCTGACC -3'
(R):5'- TACAGATCCTGGCAGTTCCATCCC -3'

Sequencing Primer
(F):5'- AGCATCAGTTTCTGACCTGGAG -3'
(R):5'- CACAGTCAATTCTTGTTAGGACTCG -3'
Posted On 2013-04-16