|Institutional Source||Beutler Lab|
|Gene Name||monocyte to macrophage differentiation-associated 2|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R2034 (G1)|
|Chromosomal Location||142562358-142608800 bp(-) (GRCm38)|
|Type of Mutation||critical splice donor site (2 bp from exon)|
|DNA Base Change (assembly)||A to T at 142575184 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000039357 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000037048]|
|Predicted Effect||probably null
|Meta Mutation Damage Score||0.9489|
|Coding Region Coverage||
|Validation Efficiency||100% (71/71)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the PAQR (progestin and adipoQ receptor) family. Members of this family are evolutionarily conserved with significant sequence identity to bacterial hemolysin-like proteins and are defined by a set of seven transmembrane domains. The protein encoded by this gene localizes to the Golgi apparatus to modulate Ras signaling. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Mmd2||
(F):5'- AGTGCTCTACCATCCTAGGG -3'
(R):5'- TAAAGGCTGGCCGTGATCTG -3'
(F):5'- AAGCAGGTCACAGCCTCTG -3'
(R):5'- GCTGGCCGTGATCTGTCTTC -3'