Mutagenetix > Incidental Mutation

Incidental Mutation 'R1997:Vmn2r19'

224332

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r19

Ensembl Gene

ENSMUSG00000091260

Gene Name

vomeronasal 2, receptor 19

Synonyms

EG232358

MMRRC Submission

040007-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.074) question?

Stock #

R1997 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

123308333-123336537 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 123315921 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glutamic Acid at position 307 (D307E)

Ref Sequence

ENSEMBL: ENSMUSP00000073604 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000073948]

AlphaFold

G5E8G4

Predicted Effect

probably damaging
Transcript: ENSMUST00000073948
AA Change: D307E

PolyPhen 2 Score 0.978 (Sensitivity: 0.76; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000073604
Gene: ENSMUSG00000091260
AA Change: D307E

Domain	Start	End	E-Value	Type
signal peptide	1	17	N/A	INTRINSIC
Pfam:ANF_receptor	81	476	2.9e-35	PFAM
Pfam:NCD3G	518	571	8.3e-23	PFAM
Pfam:7tm_3	603	839	7.2e-52	PFAM

Coding Region Coverage

1x: 99.1%
3x: 98.4%
10x: 96.4%
20x: 92.2%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 100 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1600015I10Rik	A	T	6: 48,932,429 (GRCm38)	Q536L	probably damaging	Het
3425401B19Rik	A	G	14: 32,660,048 (GRCm38)	F1320S	possibly damaging	Het
Aaas	C	T	15: 102,340,059 (GRCm38)	V241I	probably benign	Het
Abca17	A	G	17: 24,285,726 (GRCm38)	I1233T	probably benign	Het
Acin1	T	C	14: 54,646,699 (GRCm38)		probably null	Het
Acly	A	T	11: 100,519,151 (GRCm38)	I185N	probably damaging	Het
Adamts16	T	C	13: 70,753,267 (GRCm38)	D897G	probably benign	Het
Allc	A	C	12: 28,563,483 (GRCm38)	D153E	probably benign	Het
Ankrd12	A	G	17: 65,984,884 (GRCm38)	S1185P	probably damaging	Het
Ap1g2	T	C	14: 55,102,378 (GRCm38)	E448G	probably benign	Het
Atg9a	A	T	1: 75,189,626 (GRCm38)	V50D	probably benign	Het
Bace2	A	T	16: 97,415,089 (GRCm38)	D294V	possibly damaging	Het
Camsap2	T	C	1: 136,271,545 (GRCm38)	K708E	probably damaging	Het
Card10	G	A	15: 78,793,975 (GRCm38)	R358C	probably damaging	Het
Ccdc81	A	T	7: 89,898,063 (GRCm38)	V39E	probably damaging	Het
Cdh7	A	T	1: 110,048,938 (GRCm38)	D111V	probably damaging	Het
Cercam	C	A	2: 29,872,923 (GRCm38)	T223K	probably benign	Het
Cog5	A	G	12: 31,660,849 (GRCm38)	H76R	possibly damaging	Het
Col28a1	A	T	6: 7,999,644 (GRCm38)	N1024K	probably benign	Het
Csrnp3	A	T	2: 65,949,102 (GRCm38)	N41Y	probably damaging	Het
Cyp2t4	G	A	7: 27,157,613 (GRCm38)		probably null	Het
Dbn1	T	C	13: 55,482,441 (GRCm38)	H38R	probably damaging	Het
Dclre1b	A	G	3: 103,803,356 (GRCm38)	V287A	probably benign	Het
Dennd4c	A	G	4: 86,837,397 (GRCm38)	T1609A	probably benign	Het
Depdc5	T	A	5: 32,901,906 (GRCm38)		probably null	Het
Dhcr7	T	G	7: 143,847,430 (GRCm38)	D446E	probably damaging	Het
Dlx5	A	T	6: 6,879,680 (GRCm38)	M129K	possibly damaging	Het
Dnah11	C	G	12: 118,082,468 (GRCm38)	G1745A	possibly damaging	Het
Dnm3	T	C	1: 162,353,712 (GRCm38)	T133A	possibly damaging	Het
Eif3e	A	G	15: 43,265,609 (GRCm38)	L205P	probably damaging	Het
Fam166a	T	G	2: 25,220,205 (GRCm38)	L43R	probably damaging	Het
Fam91a1	A	G	15: 58,424,195 (GRCm38)		probably null	Het
Fank1	C	T	7: 133,862,225 (GRCm38)	T50I	probably damaging	Het
Fhod3	A	G	18: 25,090,416 (GRCm38)	T940A	possibly damaging	Het
Fkbp10	T	C	11: 100,416,015 (GRCm38)	F78L	probably damaging	Het
Gabbr2	A	C	4: 46,787,502 (GRCm38)	F387C	probably damaging	Het
Ggnbp2	A	T	11: 84,860,561 (GRCm38)	L138I	probably damaging	Het
Gm2832	T	A	14: 41,280,986 (GRCm38)		probably null	Het
Gm38394	A	G	1: 133,656,713 (GRCm38)	L962P	probably damaging	Het
Gm5084	T	A	13: 60,212,530 (GRCm38)		noncoding transcript	Het
Gm9979	T	C	13: 40,705,752 (GRCm38)		noncoding transcript	Het
Hepacam2	A	G	6: 3,487,241 (GRCm38)	S39P	probably damaging	Het
Hesx1	A	T	14: 27,001,383 (GRCm38)	N57Y	probably damaging	Het
Kcnh1	G	A	1: 192,276,935 (GRCm38)	V266I	probably damaging	Het
Kif24	T	C	4: 41,392,904 (GRCm38)	T1168A	possibly damaging	Het
Kng2	A	T	16: 23,024,876 (GRCm38)	F118I	possibly damaging	Het
Lig3	C	T	11: 82,787,666 (GRCm38)	P245S	probably benign	Het
Loxhd1	G	T	18: 77,295,769 (GRCm38)	W121C	probably damaging	Het
Ltn1	A	G	16: 87,381,637 (GRCm38)	V1568A	probably damaging	Het
Map3k4	A	T	17: 12,254,995 (GRCm38)		probably null	Het
Mcm10	C	T	2: 4,993,760 (GRCm38)	V790M	probably damaging	Het
Mia3	A	T	1: 183,344,286 (GRCm38)	F1223I	possibly damaging	Het
Mlec	C	A	5: 115,150,346 (GRCm38)	K150N	probably damaging	Het
Morn4	T	C	19: 42,076,538 (GRCm38)	K70R	possibly damaging	Het
Mphosph10	A	C	7: 64,387,447 (GRCm38)		probably null	Het
Myocd	G	A	11: 65,204,321 (GRCm38)	Q47*	probably null	Het
Nav2	T	A	7: 49,548,471 (GRCm38)	S1283T	probably benign	Het
Nbeal2	T	C	9: 110,632,198 (GRCm38)	H1599R	probably damaging	Het
Nek10	G	T	14: 14,827,003 (GRCm38)	G67V	probably benign	Het
Nlgn2	A	C	11: 69,828,050 (GRCm38)	V271G	probably damaging	Het
Olfr167	A	C	16: 19,515,042 (GRCm38)	V198G	probably damaging	Het
Olfr97	A	G	17: 37,231,632 (GRCm38)	V246A	probably damaging	Het
Pcolce2	A	T	9: 95,694,740 (GRCm38)	M355L	probably benign	Het
Per2	T	C	1: 91,440,859 (GRCm38)	E264G	probably damaging	Het
Phf2	A	G	13: 48,828,908 (GRCm38)	L113P	unknown	Het
Piwil2	A	G	14: 70,426,658 (GRCm38)	V14A	possibly damaging	Het
Plekha6	G	A	1: 133,263,818 (GRCm38)	A146T	probably benign	Het
Plxnb2	C	T	15: 89,158,768 (GRCm38)	V1473I	probably benign	Het
Pms2	T	C	5: 143,913,700 (GRCm38)	L111P	probably damaging	Het
Polg	A	G	7: 79,459,231 (GRCm38)	L533P	probably damaging	Het
Ppp1r12b	A	G	1: 134,846,355 (GRCm38)		probably benign	Het
Ppp2r1b	T	A	9: 50,867,371 (GRCm38)	M208K	possibly damaging	Het
Prdm5	A	G	6: 65,936,088 (GRCm38)	Y207C	probably damaging	Het
Prkar2b	A	G	12: 31,963,935 (GRCm38)	V314A	probably damaging	Het
Proser1	T	A	3: 53,478,871 (GRCm38)	S725T	probably benign	Het
Psg20	A	G	7: 18,682,610 (GRCm38)	F194L	probably benign	Het
Ptprz1	A	G	6: 23,050,497 (GRCm38)	I2255V	probably damaging	Het
Sardh	T	G	2: 27,244,397 (GRCm38)	T36P	probably damaging	Het
Sec23a	T	A	12: 59,002,007 (GRCm38)	I110L	probably benign	Het
Slc22a29	T	A	19: 8,217,798 (GRCm38)	I158L	probably benign	Het
Slc35c1	T	C	2: 92,454,639 (GRCm38)	D210G	probably benign	Het
Syde2	A	G	3: 145,998,991 (GRCm38)	N566S	probably benign	Het
Tcf20	G	A	15: 82,857,230 (GRCm38)	Q7*	probably null	Het
Terb2	T	A	2: 122,204,857 (GRCm38)	H186Q	possibly damaging	Het
Tet2	G	A	3: 133,486,589 (GRCm38)	Q695*	probably null	Het
Tnfaip1	T	C	11: 78,530,147 (GRCm38)	Y29C	probably damaging	Het
Traf3	A	G	12: 111,260,661 (GRCm38)	K328E	probably benign	Het
Uaca	A	G	9: 60,870,341 (GRCm38)	E668G	probably damaging	Het
Ube2o	T	A	11: 116,545,337 (GRCm38)	E326V	probably damaging	Het
Ubr1	C	T	2: 120,946,273 (GRCm38)		probably null	Het
Vmn1r19	T	A	6: 57,405,048 (GRCm38)	S195R	probably damaging	Het
Vmn1r213	T	G	13: 23,012,303 (GRCm38)	V352G	probably benign	Het
Wdfy3	T	C	5: 101,968,946 (GRCm38)	D76G	probably damaging	Het
Zan	A	T	5: 137,403,114 (GRCm38)	C4114*	probably null	Het
Zdhhc23	A	T	16: 43,978,942 (GRCm38)	C37S	probably damaging	Het
Zfp628	G	T	7: 4,918,832 (GRCm38)	G18W	probably damaging	Het
Zfp712	T	A	13: 67,042,050 (GRCm38)	K138*	probably null	Het
Zfp867	A	T	11: 59,463,591 (GRCm38)	V304D	probably damaging	Het
Zfp870	T	C	17: 32,884,053 (GRCm38)	T102A	possibly damaging	Het
Zmym5	G	A	14: 56,797,753 (GRCm38)	S286L	possibly damaging	Het

Other mutations in Vmn2r19

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01407:Vmn2r19	APN	6	123,329,867 (GRCm38)	missense	possibly damaging	0.92
IGL02294:Vmn2r19	APN	6	123,329,978 (GRCm38)	missense	probably benign	0.19
IGL02442:Vmn2r19	APN	6	123,309,662 (GRCm38)	missense	possibly damaging	0.94
IGL02871:Vmn2r19	APN	6	123,336,083 (GRCm38)	missense	probably damaging	1.00
H8562:Vmn2r19	UTSW	6	123,315,902 (GRCm38)	missense	possibly damaging	0.82
R0025:Vmn2r19	UTSW	6	123,331,547 (GRCm38)	missense	probably benign	0.01
R0389:Vmn2r19	UTSW	6	123,335,986 (GRCm38)	missense	possibly damaging	0.53
R0402:Vmn2r19	UTSW	6	123,336,182 (GRCm38)	missense	probably damaging	1.00
R0411:Vmn2r19	UTSW	6	123,309,744 (GRCm38)	missense	probably damaging	0.98
R0554:Vmn2r19	UTSW	6	123,336,143 (GRCm38)	missense	probably damaging	0.99
R0578:Vmn2r19	UTSW	6	123,335,972 (GRCm38)	missense	probably damaging	1.00
R1102:Vmn2r19	UTSW	6	123,336,173 (GRCm38)	missense	probably benign	0.28
R1652:Vmn2r19	UTSW	6	123,315,697 (GRCm38)	missense	possibly damaging	0.68
R1663:Vmn2r19	UTSW	6	123,336,452 (GRCm38)	missense	probably benign	0.11
R1817:Vmn2r19	UTSW	6	123,330,052 (GRCm38)	missense	possibly damaging	0.80
R1866:Vmn2r19	UTSW	6	123,331,638 (GRCm38)	critical splice donor site	probably null
R1928:Vmn2r19	UTSW	6	123,331,630 (GRCm38)	missense	probably damaging	1.00
R2013:Vmn2r19	UTSW	6	123,315,995 (GRCm38)	missense	probably benign	0.01
R2015:Vmn2r19	UTSW	6	123,315,995 (GRCm38)	missense	probably benign	0.01
R2088:Vmn2r19	UTSW	6	123,335,836 (GRCm38)	missense	probably damaging	1.00
R2126:Vmn2r19	UTSW	6	123,316,074 (GRCm38)	missense	possibly damaging	0.82
R2128:Vmn2r19	UTSW	6	123,308,330 (GRCm38)	splice site	probably null
R2256:Vmn2r19	UTSW	6	123,329,886 (GRCm38)	missense	probably benign	0.20
R2517:Vmn2r19	UTSW	6	123,329,978 (GRCm38)	missense	probably benign	0.19
R3753:Vmn2r19	UTSW	6	123,315,589 (GRCm38)	missense	possibly damaging	0.80
R3817:Vmn2r19	UTSW	6	123,309,642 (GRCm38)	missense	probably damaging	1.00
R3929:Vmn2r19	UTSW	6	123,315,628 (GRCm38)	missense	probably benign	0.01
R3934:Vmn2r19	UTSW	6	123,315,669 (GRCm38)	missense	probably damaging	1.00
R4232:Vmn2r19	UTSW	6	123,329,912 (GRCm38)	missense	probably benign
R4574:Vmn2r19	UTSW	6	123,315,980 (GRCm38)	missense	probably benign	0.01
R4886:Vmn2r19	UTSW	6	123,309,841 (GRCm38)	missense	probably benign	0.05
R4995:Vmn2r19	UTSW	6	123,329,910 (GRCm38)	missense	probably benign	0.00
R5107:Vmn2r19	UTSW	6	123,309,643 (GRCm38)	nonsense	probably null
R5232:Vmn2r19	UTSW	6	123,335,957 (GRCm38)	missense	probably benign
R6102:Vmn2r19	UTSW	6	123,329,948 (GRCm38)	missense	probably damaging	1.00
R6105:Vmn2r19	UTSW	6	123,316,095 (GRCm38)	missense	possibly damaging	0.70
R6280:Vmn2r19	UTSW	6	123,336,253 (GRCm38)	missense	probably benign
R6393:Vmn2r19	UTSW	6	123,316,153 (GRCm38)	missense	possibly damaging	0.80
R6502:Vmn2r19	UTSW	6	123,316,108 (GRCm38)	missense	possibly damaging	0.68
R6617:Vmn2r19	UTSW	6	123,336,535 (GRCm38)	makesense	probably null
R6742:Vmn2r19	UTSW	6	123,329,958 (GRCm38)	missense	possibly damaging	0.90
R7662:Vmn2r19	UTSW	6	123,331,562 (GRCm38)	missense	probably benign	0.33
R8041:Vmn2r19	UTSW	6	123,335,791 (GRCm38)	missense	possibly damaging	0.94
R8054:Vmn2r19	UTSW	6	123,316,039 (GRCm38)	missense	probably damaging	1.00
R8074:Vmn2r19	UTSW	6	123,335,945 (GRCm38)	missense	probably damaging	0.96
R8267:Vmn2r19	UTSW	6	123,336,262 (GRCm38)	missense	possibly damaging	0.50
R8287:Vmn2r19	UTSW	6	123,331,629 (GRCm38)	missense	probably damaging	1.00
R8937:Vmn2r19	UTSW	6	123,316,324 (GRCm38)	critical splice donor site	probably null
R9058:Vmn2r19	UTSW	6	123,336,062 (GRCm38)	missense	possibly damaging	0.53
R9119:Vmn2r19	UTSW	6	123,315,568 (GRCm38)	missense	possibly damaging	0.68
R9384:Vmn2r19	UTSW	6	123,315,964 (GRCm38)	missense	probably benign	0.00
X0058:Vmn2r19	UTSW	6	123,308,349 (GRCm38)	missense	probably benign	0.00
Z1088:Vmn2r19	UTSW	6	123,308,339 (GRCm38)	missense	probably benign	0.02
Z1177:Vmn2r19	UTSW	6	123,336,077 (GRCm38)	missense	possibly damaging	0.89

Predicted Primers

PCR Primer
(F):5'- TTCCTTAGGGACATCACAGAGGAG -3'
(R):5'- AAGATGGACCACACATCCTGG -3'

Sequencing Primer
(F):5'- ACCAAGGAATTTGCGTTGC -3'
(R):5'- GATGGACCACACATCCTGGATAAAG -3'

Posted On

2014-08-25