Incidental Mutation 'R2036:Vmn2r58'
| ID |
224641 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r58
|
| Ensembl Gene |
ENSMUSG00000090383 |
| Gene Name |
vomeronasal 2, receptor 58 |
| Synonyms |
EG628422 |
| MMRRC Submission |
040043-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.280)
|
| Stock # |
R2036 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
41486305-41522094 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 41513417 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Histidine
at position 409
(Y409H)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126966
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000171671]
|
| AlphaFold |
K7N6V2 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000171671
AA Change: Y409H
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000126966
Gene: ENSMUSG00000090383
AA Change: Y409H
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
471 |
8e-43 |
PFAM |
|
Pfam:NCD3G
|
514 |
567 |
1.8e-23 |
PFAM |
|
Pfam:7tm_3
|
597 |
835 |
2.9e-52 |
PFAM |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.8%
- 20x: 93.8%
|
| Validation Efficiency |
100% (58/58) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 57 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930415H17Rik |
C |
T |
11: 99,576,358 (GRCm39) |
C3Y |
unknown |
Het |
| Abr |
G |
T |
11: 76,343,176 (GRCm39) |
T547K |
probably benign |
Het |
| Akr1c21 |
T |
C |
13: 4,626,305 (GRCm39) |
Y110H |
probably damaging |
Het |
| Ankar |
T |
A |
1: 72,705,689 (GRCm39) |
K556* |
probably null |
Het |
| Anks1b |
T |
C |
10: 90,805,715 (GRCm39) |
V431A |
probably damaging |
Het |
| Ap5b1 |
T |
C |
19: 5,618,897 (GRCm39) |
S106P |
possibly damaging |
Het |
| Arhgap17 |
T |
C |
7: 122,917,717 (GRCm39) |
N156D |
possibly damaging |
Het |
| Arhgap35 |
T |
C |
7: 16,297,058 (GRCm39) |
E669G |
probably damaging |
Het |
| Arhgap44 |
T |
C |
11: 64,932,318 (GRCm39) |
M201V |
possibly damaging |
Het |
| Arsi |
G |
A |
18: 61,049,723 (GRCm39) |
G202E |
probably benign |
Het |
| Atg4c |
C |
T |
4: 99,106,376 (GRCm39) |
T112M |
possibly damaging |
Het |
| Bcl11a |
A |
T |
11: 24,114,087 (GRCm39) |
N477Y |
possibly damaging |
Het |
| Brinp3 |
A |
T |
1: 146,577,579 (GRCm39) |
I205F |
possibly damaging |
Het |
| Capza2 |
T |
C |
6: 17,660,777 (GRCm39) |
F159S |
probably damaging |
Het |
| Cd40 |
T |
C |
2: 164,904,221 (GRCm39) |
C61R |
probably benign |
Het |
| Cdc25c |
G |
C |
18: 34,871,292 (GRCm39) |
L275V |
probably damaging |
Het |
| Cdh23 |
A |
G |
10: 60,301,822 (GRCm39) |
I415T |
possibly damaging |
Het |
| Clnk |
A |
T |
5: 38,910,143 (GRCm39) |
|
probably null |
Het |
| Ctcfl |
C |
T |
2: 172,943,778 (GRCm39) |
R524Q |
possibly damaging |
Het |
| Cyb5r4 |
T |
G |
9: 86,924,932 (GRCm39) |
|
probably benign |
Het |
| Ddb1 |
T |
A |
19: 10,588,186 (GRCm39) |
|
probably benign |
Het |
| Ddx51 |
C |
A |
5: 110,804,491 (GRCm39) |
Q526K |
probably benign |
Het |
| Dennd6a |
A |
T |
14: 26,329,274 (GRCm39) |
Q56L |
probably damaging |
Het |
| Dhdds |
T |
C |
4: 133,698,410 (GRCm39) |
E142G |
probably damaging |
Het |
| Dnai1 |
A |
G |
4: 41,632,225 (GRCm39) |
H553R |
probably damaging |
Het |
| Fryl |
T |
C |
5: 73,179,887 (GRCm39) |
N2908S |
probably benign |
Het |
| Fryl |
C |
A |
5: 73,265,305 (GRCm39) |
|
probably null |
Het |
| Fut9 |
A |
G |
4: 25,620,322 (GRCm39) |
I164T |
probably damaging |
Het |
| Gba2 |
G |
A |
4: 43,568,118 (GRCm39) |
|
probably benign |
Het |
| Gm11627 |
C |
T |
11: 102,467,580 (GRCm39) |
V33I |
unknown |
Het |
| Helz2 |
T |
A |
2: 180,879,272 (GRCm39) |
H782L |
probably benign |
Het |
| Kcnmb3 |
A |
G |
3: 32,526,531 (GRCm39) |
V220A |
probably damaging |
Het |
| Kif20a |
T |
C |
18: 34,761,515 (GRCm39) |
S303P |
possibly damaging |
Het |
| Kif22 |
A |
T |
7: 126,630,126 (GRCm39) |
V470E |
possibly damaging |
Het |
| Majin |
C |
T |
19: 6,263,342 (GRCm39) |
T132M |
probably benign |
Het |
| Mboat7 |
A |
G |
7: 3,688,671 (GRCm39) |
|
probably null |
Het |
| Mkrn2 |
C |
A |
6: 115,588,875 (GRCm39) |
P206Q |
probably benign |
Het |
| Mphosph9 |
G |
A |
5: 124,442,274 (GRCm39) |
T358M |
probably damaging |
Het |
| Nkd1 |
A |
G |
8: 89,318,305 (GRCm39) |
D210G |
probably damaging |
Het |
| Or4c110 |
C |
T |
2: 88,831,976 (GRCm39) |
V219I |
probably damaging |
Het |
| Or4k41 |
T |
A |
2: 111,279,971 (GRCm39) |
L162Q |
possibly damaging |
Het |
| Or5ae2 |
G |
T |
7: 84,505,566 (GRCm39) |
|
probably benign |
Het |
| Or5b95 |
G |
C |
19: 12,658,165 (GRCm39) |
G231A |
probably damaging |
Het |
| Or5p69 |
T |
A |
7: 107,966,947 (GRCm39) |
N83K |
probably benign |
Het |
| Or6c35 |
G |
A |
10: 129,169,541 (GRCm39) |
D264N |
probably benign |
Het |
| Or9s15 |
A |
T |
1: 92,524,328 (GRCm39) |
E29V |
probably benign |
Het |
| Pi4ka |
A |
G |
16: 17,120,976 (GRCm39) |
Y63H |
probably damaging |
Het |
| Plekha1 |
A |
G |
7: 130,503,922 (GRCm39) |
R210G |
probably damaging |
Het |
| Ppp2r2c |
C |
T |
5: 37,109,748 (GRCm39) |
T369I |
possibly damaging |
Het |
| Relch |
A |
G |
1: 105,670,979 (GRCm39) |
D1029G |
probably damaging |
Het |
| Rmnd1 |
T |
C |
10: 4,357,884 (GRCm39) |
D12G |
probably damaging |
Het |
| Rtn2 |
A |
G |
7: 19,027,664 (GRCm39) |
K120E |
probably damaging |
Het |
| Sh3tc1 |
A |
G |
5: 35,873,508 (GRCm39) |
S30P |
probably benign |
Het |
| Tln2 |
T |
C |
9: 67,179,986 (GRCm39) |
E795G |
possibly damaging |
Het |
| Tmprss11d |
T |
A |
5: 86,457,128 (GRCm39) |
Y177F |
probably damaging |
Het |
| Trrap |
C |
A |
5: 144,765,372 (GRCm39) |
D2529E |
probably benign |
Het |
| Wdr72 |
T |
A |
9: 74,058,876 (GRCm39) |
V323D |
probably damaging |
Het |
|
| Other mutations in Vmn2r58 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00089:Vmn2r58
|
APN |
7 |
41,513,854 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
IGL00924:Vmn2r58
|
APN |
7 |
41,486,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01291:Vmn2r58
|
APN |
7 |
41,513,935 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01480:Vmn2r58
|
APN |
7 |
41,514,116 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01551:Vmn2r58
|
APN |
7 |
41,514,703 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL01591:Vmn2r58
|
APN |
7 |
41,514,753 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01940:Vmn2r58
|
APN |
7 |
41,487,071 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01994:Vmn2r58
|
APN |
7 |
41,486,394 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02041:Vmn2r58
|
APN |
7 |
41,514,703 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02222:Vmn2r58
|
APN |
7 |
41,513,449 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL02317:Vmn2r58
|
APN |
7 |
41,486,765 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL02614:Vmn2r58
|
APN |
7 |
41,486,553 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02673:Vmn2r58
|
APN |
7 |
41,514,082 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL03323:Vmn2r58
|
APN |
7 |
41,511,295 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL03337:Vmn2r58
|
APN |
7 |
41,513,810 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL03380:Vmn2r58
|
APN |
7 |
41,513,874 (GRCm39) |
missense |
probably benign |
0.00 |
|
ANU05:Vmn2r58
|
UTSW |
7 |
41,513,935 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0138:Vmn2r58
|
UTSW |
7 |
41,487,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0141:Vmn2r58
|
UTSW |
7 |
41,511,309 (GRCm39) |
missense |
probably benign |
0.11 |
|
R0421:Vmn2r58
|
UTSW |
7 |
41,514,628 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0604:Vmn2r58
|
UTSW |
7 |
41,510,000 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R0854:Vmn2r58
|
UTSW |
7 |
41,486,562 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1413:Vmn2r58
|
UTSW |
7 |
41,513,387 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1441:Vmn2r58
|
UTSW |
7 |
41,486,864 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1678:Vmn2r58
|
UTSW |
7 |
41,513,480 (GRCm39) |
missense |
probably benign |
0.40 |
|
R1691:Vmn2r58
|
UTSW |
7 |
41,486,913 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1699:Vmn2r58
|
UTSW |
7 |
41,509,951 (GRCm39) |
missense |
probably benign |
|
|
R1865:Vmn2r58
|
UTSW |
7 |
41,486,682 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R2008:Vmn2r58
|
UTSW |
7 |
41,509,924 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2202:Vmn2r58
|
UTSW |
7 |
41,513,594 (GRCm39) |
missense |
probably benign |
0.07 |
|
R3787:Vmn2r58
|
UTSW |
7 |
41,513,498 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3883:Vmn2r58
|
UTSW |
7 |
41,513,914 (GRCm39) |
nonsense |
probably null |
|
|
R3944:Vmn2r58
|
UTSW |
7 |
41,513,885 (GRCm39) |
missense |
probably benign |
0.03 |
|
R3949:Vmn2r58
|
UTSW |
7 |
41,513,348 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4232:Vmn2r58
|
UTSW |
7 |
41,487,011 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4409:Vmn2r58
|
UTSW |
7 |
41,522,051 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R4411:Vmn2r58
|
UTSW |
7 |
41,511,360 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4413:Vmn2r58
|
UTSW |
7 |
41,511,360 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4600:Vmn2r58
|
UTSW |
7 |
41,522,046 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4610:Vmn2r58
|
UTSW |
7 |
41,487,117 (GRCm39) |
missense |
probably benign |
|
|
R4646:Vmn2r58
|
UTSW |
7 |
41,509,935 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4793:Vmn2r58
|
UTSW |
7 |
41,514,495 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4870:Vmn2r58
|
UTSW |
7 |
41,486,639 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R4981:Vmn2r58
|
UTSW |
7 |
41,486,885 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4993:Vmn2r58
|
UTSW |
7 |
41,487,176 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5024:Vmn2r58
|
UTSW |
7 |
41,513,746 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5064:Vmn2r58
|
UTSW |
7 |
41,486,534 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5330:Vmn2r58
|
UTSW |
7 |
41,513,384 (GRCm39) |
nonsense |
probably null |
|
|
R5526:Vmn2r58
|
UTSW |
7 |
41,522,069 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5980:Vmn2r58
|
UTSW |
7 |
41,514,480 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R6163:Vmn2r58
|
UTSW |
7 |
41,486,825 (GRCm39) |
missense |
probably benign |
0.31 |
|
R6365:Vmn2r58
|
UTSW |
7 |
41,513,607 (GRCm39) |
missense |
probably benign |
0.42 |
|
R6567:Vmn2r58
|
UTSW |
7 |
41,514,673 (GRCm39) |
missense |
probably benign |
0.34 |
|
R6594:Vmn2r58
|
UTSW |
7 |
41,486,535 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6980:Vmn2r58
|
UTSW |
7 |
41,513,662 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R7373:Vmn2r58
|
UTSW |
7 |
41,487,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7458:Vmn2r58
|
UTSW |
7 |
41,487,123 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7630:Vmn2r58
|
UTSW |
7 |
41,513,611 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7807:Vmn2r58
|
UTSW |
7 |
41,521,910 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8114:Vmn2r58
|
UTSW |
7 |
41,511,392 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8232:Vmn2r58
|
UTSW |
7 |
41,514,076 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8313:Vmn2r58
|
UTSW |
7 |
41,521,952 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8412:Vmn2r58
|
UTSW |
7 |
41,513,722 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8530:Vmn2r58
|
UTSW |
7 |
41,513,576 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8851:Vmn2r58
|
UTSW |
7 |
41,487,219 (GRCm39) |
missense |
probably benign |
|
|
R8881:Vmn2r58
|
UTSW |
7 |
41,486,609 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8936:Vmn2r58
|
UTSW |
7 |
41,513,981 (GRCm39) |
missense |
|
|
|
R9045:Vmn2r58
|
UTSW |
7 |
41,487,087 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9166:Vmn2r58
|
UTSW |
7 |
41,513,431 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9706:Vmn2r58
|
UTSW |
7 |
41,510,000 (GRCm39) |
missense |
probably damaging |
0.99 |
|
RF006:Vmn2r58
|
UTSW |
7 |
41,486,383 (GRCm39) |
frame shift |
probably null |
|
|
RF027:Vmn2r58
|
UTSW |
7 |
41,486,383 (GRCm39) |
frame shift |
probably null |
|
|
Z1176:Vmn2r58
|
UTSW |
7 |
41,513,789 (GRCm39) |
missense |
probably benign |
0.01 |
|
| Predicted Primers |
PCR Primer
(F):5'- CTCCATTGCTTATTGACAGCTTAG -3'
(R):5'- GTTAATCCCTACAAATACCCAGAGG -3'
Sequencing Primer
(F):5'- ACAGCTTAGTGTAAAATATGTGATGC -3'
(R):5'- GGACAACTATCTTCCTAAGTTTTGGC -3'
|
| Posted On |
2014-08-25 |
Incidental Mutation