Mutagenetix > Incidental Mutation

Incidental Mutation 'R2036:Olfr291'

224644

Institutional Source

Beutler Lab

Gene Symbol

Olfr291

Ensembl Gene

ENSMUSG00000070460

Gene Name

olfactory receptor 291

Synonyms

GA_x6K02T2NHDJ-11231385-11230438, MOR254-2

MMRRC Submission

040043-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.054) question?

Stock #

R2036 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

84853553-84859612 bp(+) (GRCm38)

Type of Mutation

start gained

DNA Base Change (assembly)

G to T at 84856358 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000150934 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000211582] [ENSMUST00000217039]

AlphaFold

no structure available at present

Predicted Effect

SMART Domains

Protein: ENSMUSP00000077303
Gene: ENSMUSG00000070460

Domain	Start	End	E-Value	Type
Pfam:7tm_4	33	311	3e-54	PFAM
Pfam:7TM_GPCR_Srsx	37	270	1.5e-10	PFAM
Pfam:7tm_1	43	293	1.9e-30	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000211582

Predicted Effect

probably benign
Transcript: ENSMUST00000217039

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.8%
20x: 93.8%

Validation Efficiency

100% (58/58)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 57 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2310035C23Rik	A	G	1: 105,743,254	D1029G	probably damaging	Het
4930415H17Rik	C	T	11: 99,685,532	C3Y	unknown	Het
Abr	G	T	11: 76,452,350	T547K	probably benign	Het
Akr1c21	T	C	13: 4,576,306	Y110H	probably damaging	Het
Ankar	T	A	1: 72,666,530	K556*	probably null	Het
Anks1b	T	C	10: 90,969,853	V431A	probably damaging	Het
Ap5b1	T	C	19: 5,568,869	S106P	possibly damaging	Het
Arhgap17	T	C	7: 123,318,494	N156D	possibly damaging	Het
Arhgap35	T	C	7: 16,563,133	E669G	probably damaging	Het
Arhgap44	T	C	11: 65,041,492	M201V	possibly damaging	Het
Arsi	G	A	18: 60,916,651	G202E	probably benign	Het
Atg4c	C	T	4: 99,218,139	T112M	possibly damaging	Het
Bcl11a	A	T	11: 24,164,087	N477Y	possibly damaging	Het
Brinp3	A	T	1: 146,701,841	I205F	possibly damaging	Het
Capza2	T	C	6: 17,660,778	F159S	probably damaging	Het
Cd40	T	C	2: 165,062,301	C61R	probably benign	Het
Cdc25c	G	C	18: 34,738,239	L275V	probably damaging	Het
Cdh23	A	G	10: 60,466,043	I415T	possibly damaging	Het
Clnk	A	T	5: 38,752,800		probably null	Het
Ctcfl	C	T	2: 173,101,985	R524Q	possibly damaging	Het
Cyb5r4	T	G	9: 87,042,879		probably benign	Het
Ddb1	T	A	19: 10,610,822		probably benign	Het
Ddx51	C	A	5: 110,656,625	Q526K	probably benign	Het
Dennd6a	A	T	14: 26,608,119	Q56L	probably damaging	Het
Dhdds	T	C	4: 133,971,099	E142G	probably damaging	Het
Dnaic1	A	G	4: 41,632,225	H553R	probably damaging	Het
Fryl	T	C	5: 73,022,544	N2908S	probably benign	Het
Fryl	C	A	5: 73,107,962		probably null	Het
Fut9	A	G	4: 25,620,322	I164T	probably damaging	Het
Gba2	G	A	4: 43,568,118		probably benign	Het
Gm11627	C	T	11: 102,576,754	V33I	unknown	Het
Helz2	T	A	2: 181,237,479	H782L	probably benign	Het
Kcnmb3	A	G	3: 32,472,382	V220A	probably damaging	Het
Kif20a	T	C	18: 34,628,462	S303P	possibly damaging	Het
Kif22	A	T	7: 127,030,954	V470E	possibly damaging	Het
Majin	C	T	19: 6,213,312	T132M	probably benign	Het
Mboat7	A	G	7: 3,685,672		probably null	Het
Mkrn2	C	A	6: 115,611,914	P206Q	probably benign	Het
Mphosph9	G	A	5: 124,304,211	T358M	probably damaging	Het
Nkd1	A	G	8: 88,591,677	D210G	probably damaging	Het
Olfr1215	C	T	2: 89,001,632	V219I	probably damaging	Het
Olfr1287	T	A	2: 111,449,626	L162Q	possibly damaging	Het
Olfr1411	A	T	1: 92,596,606	E29V	probably benign	Het
Olfr1443	G	C	19: 12,680,801	G231A	probably damaging	Het
Olfr494	T	A	7: 108,367,740	N83K	probably benign	Het
Olfr781	G	A	10: 129,333,672	D264N	probably benign	Het
Pi4ka	A	G	16: 17,303,112	Y63H	probably damaging	Het
Plekha1	A	G	7: 130,902,192	R210G	probably damaging	Het
Ppp2r2c	C	T	5: 36,952,404	T369I	possibly damaging	Het
Rmnd1	T	C	10: 4,407,884	D12G	probably damaging	Het
Rtn2	A	G	7: 19,293,739	K120E	probably damaging	Het
Sh3tc1	A	G	5: 35,716,164	S30P	probably benign	Het
Tln2	T	C	9: 67,272,704	E795G	possibly damaging	Het
Tmprss11d	T	A	5: 86,309,269	Y177F	probably damaging	Het
Trrap	C	A	5: 144,828,562	D2529E	probably benign	Het
Vmn2r58	A	G	7: 41,863,993	Y409H	probably benign	Het
Wdr72	T	A	9: 74,151,594	V323D	probably damaging	Het

Other mutations in Olfr291

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01863:Olfr291	APN	7	84856411	missense	probably damaging	1.00
IGL02643:Olfr291	APN	7	84857031	missense	probably damaging	1.00
IGL02928:Olfr291	APN	7	84857065	missense	probably benign	0.08
IGL03124:Olfr291	APN	7	84856723	missense	probably damaging	0.99
R0129:Olfr291	UTSW	7	84856988	missense	probably benign
R0605:Olfr291	UTSW	7	84857137	missense	probably damaging	1.00
R1085:Olfr291	UTSW	7	84856779	missense	probably benign	0.05
R1477:Olfr291	UTSW	7	84857017	missense	probably damaging	1.00
R1834:Olfr291	UTSW	7	84856482	missense	probably damaging	0.99
R1839:Olfr291	UTSW	7	84856548	missense	probably damaging	1.00
R4214:Olfr291	UTSW	7	84857289	missense	probably benign
R4386:Olfr291	UTSW	7	84856548	missense	probably damaging	1.00
R4679:Olfr291	UTSW	7	84856904	nonsense	probably null
R4789:Olfr291	UTSW	7	84857301	missense	probably benign	0.09
R4841:Olfr291	UTSW	7	84857120	missense	probably damaging	1.00
R5011:Olfr291	UTSW	7	84856438	missense	probably damaging	1.00
R5013:Olfr291	UTSW	7	84856438	missense	probably damaging	1.00
R6127:Olfr291	UTSW	7	84857202	missense	probably damaging	1.00
R7164:Olfr291	UTSW	7	84857043	missense	possibly damaging	0.73
R7328:Olfr291	UTSW	7	84857299	missense	probably benign	0.01
R8347:Olfr291	UTSW	7	84856755	missense	probably damaging	0.99
R8434:Olfr291	UTSW	7	84857289	missense	probably benign
R8882:Olfr291	UTSW	7	84856473	missense	probably damaging	1.00
R9242:Olfr291	UTSW	7	84856878	nonsense	probably null
R9640:Olfr291	UTSW	7	84856906	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- CCAGAGATGGAATGGGGATTTT -3'
(R):5'- TTTCTCAGTCACAATGGCCAA -3'

Sequencing Primer
(F):5'- TGCCTAGCGCCAGAAGATTTTAG -3'
(R):5'- GCCAAGAGGATGAGCCCATTTC -3'

Posted On

2014-08-25