Incidental Mutation 'R2036:Or5b95'
ID 224703
Institutional Source Beutler Lab
Gene Symbol Or5b95
Ensembl Gene ENSMUSG00000045030
Gene Name olfactory receptor family 5 subfamily B member 95
Synonyms MOR202-8, Olfr1443, GA_x6K02T2RE5P-3006492-3007430
MMRRC Submission 040043-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.052) question?
Stock # R2036 (G1)
Quality Score 225
Status Validated
Chromosome 19
Chromosomal Location 12655530-12661215 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to C at 12658165 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Alanine at position 231 (G231A)
Ref Sequence ENSEMBL: ENSMUSP00000150063 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049724] [ENSMUST00000207341] [ENSMUST00000208494] [ENSMUST00000208657] [ENSMUST00000213486] [ENSMUST00000215134]
AlphaFold Q8VFW8
Predicted Effect probably damaging
Transcript: ENSMUST00000049724
AA Change: G231A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000059886
Gene: ENSMUSG00000045030
AA Change: G231A

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 2.4e-50 PFAM
Pfam:7TM_GPCR_Srsx 33 303 1.5e-6 PFAM
Pfam:7tm_1 39 288 8.6e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000207341
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208407
Predicted Effect probably benign
Transcript: ENSMUST00000208494
Predicted Effect probably benign
Transcript: ENSMUST00000208657
Predicted Effect probably damaging
Transcript: ENSMUST00000213486
AA Change: G231A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000215134
AA Change: G231A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 93.8%
Validation Efficiency 100% (58/58)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930415H17Rik C T 11: 99,576,358 (GRCm39) C3Y unknown Het
Abr G T 11: 76,343,176 (GRCm39) T547K probably benign Het
Akr1c21 T C 13: 4,626,305 (GRCm39) Y110H probably damaging Het
Ankar T A 1: 72,705,689 (GRCm39) K556* probably null Het
Anks1b T C 10: 90,805,715 (GRCm39) V431A probably damaging Het
Ap5b1 T C 19: 5,618,897 (GRCm39) S106P possibly damaging Het
Arhgap17 T C 7: 122,917,717 (GRCm39) N156D possibly damaging Het
Arhgap35 T C 7: 16,297,058 (GRCm39) E669G probably damaging Het
Arhgap44 T C 11: 64,932,318 (GRCm39) M201V possibly damaging Het
Arsi G A 18: 61,049,723 (GRCm39) G202E probably benign Het
Atg4c C T 4: 99,106,376 (GRCm39) T112M possibly damaging Het
Bcl11a A T 11: 24,114,087 (GRCm39) N477Y possibly damaging Het
Brinp3 A T 1: 146,577,579 (GRCm39) I205F possibly damaging Het
Capza2 T C 6: 17,660,777 (GRCm39) F159S probably damaging Het
Cd40 T C 2: 164,904,221 (GRCm39) C61R probably benign Het
Cdc25c G C 18: 34,871,292 (GRCm39) L275V probably damaging Het
Cdh23 A G 10: 60,301,822 (GRCm39) I415T possibly damaging Het
Clnk A T 5: 38,910,143 (GRCm39) probably null Het
Ctcfl C T 2: 172,943,778 (GRCm39) R524Q possibly damaging Het
Cyb5r4 T G 9: 86,924,932 (GRCm39) probably benign Het
Ddb1 T A 19: 10,588,186 (GRCm39) probably benign Het
Ddx51 C A 5: 110,804,491 (GRCm39) Q526K probably benign Het
Dennd6a A T 14: 26,329,274 (GRCm39) Q56L probably damaging Het
Dhdds T C 4: 133,698,410 (GRCm39) E142G probably damaging Het
Dnai1 A G 4: 41,632,225 (GRCm39) H553R probably damaging Het
Fryl T C 5: 73,179,887 (GRCm39) N2908S probably benign Het
Fryl C A 5: 73,265,305 (GRCm39) probably null Het
Fut9 A G 4: 25,620,322 (GRCm39) I164T probably damaging Het
Gba2 G A 4: 43,568,118 (GRCm39) probably benign Het
Gm11627 C T 11: 102,467,580 (GRCm39) V33I unknown Het
Helz2 T A 2: 180,879,272 (GRCm39) H782L probably benign Het
Kcnmb3 A G 3: 32,526,531 (GRCm39) V220A probably damaging Het
Kif20a T C 18: 34,761,515 (GRCm39) S303P possibly damaging Het
Kif22 A T 7: 126,630,126 (GRCm39) V470E possibly damaging Het
Majin C T 19: 6,263,342 (GRCm39) T132M probably benign Het
Mboat7 A G 7: 3,688,671 (GRCm39) probably null Het
Mkrn2 C A 6: 115,588,875 (GRCm39) P206Q probably benign Het
Mphosph9 G A 5: 124,442,274 (GRCm39) T358M probably damaging Het
Nkd1 A G 8: 89,318,305 (GRCm39) D210G probably damaging Het
Or4c110 C T 2: 88,831,976 (GRCm39) V219I probably damaging Het
Or4k41 T A 2: 111,279,971 (GRCm39) L162Q possibly damaging Het
Or5ae2 G T 7: 84,505,566 (GRCm39) probably benign Het
Or5p69 T A 7: 107,966,947 (GRCm39) N83K probably benign Het
Or6c35 G A 10: 129,169,541 (GRCm39) D264N probably benign Het
Or9s15 A T 1: 92,524,328 (GRCm39) E29V probably benign Het
Pi4ka A G 16: 17,120,976 (GRCm39) Y63H probably damaging Het
Plekha1 A G 7: 130,503,922 (GRCm39) R210G probably damaging Het
Ppp2r2c C T 5: 37,109,748 (GRCm39) T369I possibly damaging Het
Relch A G 1: 105,670,979 (GRCm39) D1029G probably damaging Het
Rmnd1 T C 10: 4,357,884 (GRCm39) D12G probably damaging Het
Rtn2 A G 7: 19,027,664 (GRCm39) K120E probably damaging Het
Sh3tc1 A G 5: 35,873,508 (GRCm39) S30P probably benign Het
Tln2 T C 9: 67,179,986 (GRCm39) E795G possibly damaging Het
Tmprss11d T A 5: 86,457,128 (GRCm39) Y177F probably damaging Het
Trrap C A 5: 144,765,372 (GRCm39) D2529E probably benign Het
Vmn2r58 A G 7: 41,513,417 (GRCm39) Y409H probably benign Het
Wdr72 T A 9: 74,058,876 (GRCm39) V323D probably damaging Het
Other mutations in Or5b95
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01322:Or5b95 APN 19 12,658,113 (GRCm39) missense probably benign 0.02
IGL01392:Or5b95 APN 19 12,658,167 (GRCm39) missense probably benign 0.42
IGL01470:Or5b95 APN 19 12,658,035 (GRCm39) missense possibly damaging 0.91
IGL03106:Or5b95 APN 19 12,658,287 (GRCm39) missense possibly damaging 0.61
R3942:Or5b95 UTSW 19 12,657,768 (GRCm39) missense probably benign 0.03
R5459:Or5b95 UTSW 19 12,657,799 (GRCm39) missense probably damaging 1.00
R5643:Or5b95 UTSW 19 12,658,336 (GRCm39) missense probably damaging 1.00
R5644:Or5b95 UTSW 19 12,658,336 (GRCm39) missense probably damaging 1.00
R6879:Or5b95 UTSW 19 12,658,135 (GRCm39) missense probably benign 0.18
R6991:Or5b95 UTSW 19 12,658,112 (GRCm39) missense probably benign 0.14
R7084:Or5b95 UTSW 19 12,658,198 (GRCm39) missense probably damaging 0.98
R7352:Or5b95 UTSW 19 12,658,115 (GRCm39) missense possibly damaging 0.78
R7749:Or5b95 UTSW 19 12,657,576 (GRCm39) missense probably benign 0.10
R8133:Or5b95 UTSW 19 12,657,844 (GRCm39) missense probably damaging 1.00
R8163:Or5b95 UTSW 19 12,657,552 (GRCm39) missense probably benign 0.01
R8941:Or5b95 UTSW 19 12,657,471 (GRCm39) start gained probably benign
R9109:Or5b95 UTSW 19 12,658,190 (GRCm39) nonsense probably null
R9176:Or5b95 UTSW 19 12,657,600 (GRCm39) missense probably benign 0.14
R9298:Or5b95 UTSW 19 12,658,190 (GRCm39) nonsense probably null
R9414:Or5b95 UTSW 19 12,657,712 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- CTGGGGACACATTCAGACTC -3'
(R):5'- TCCTTAAGCTATAGACCACAGGG -3'

Sequencing Primer
(F):5'- GCAAGTCCAATGTGGTCCATC -3'
(R):5'- GGTTCAGCATGGGAATGACC -3'
Posted On 2014-08-25