Incidental Mutation 'R2037:Fcmr'
ID 224715
Institutional Source Beutler Lab
Gene Symbol Fcmr
Ensembl Gene ENSMUSG00000042474
Gene Name Fc fragment of IgM receptor
Synonyms 1810037B05Rik, FcmuR, Faim3
MMRRC Submission 040044-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R2037 (G1)
Quality Score 225
Status Not validated
Chromosome 1
Chromosomal Location 130793514-130808528 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 130806070 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 342 (D342G)
Ref Sequence ENSEMBL: ENSMUSP00000048303 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038829] [ENSMUST00000121040] [ENSMUST00000187650] [ENSMUST00000191279]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000038829
AA Change: D342G

PolyPhen 2 Score 0.613 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000048303
Gene: ENSMUSG00000042474
AA Change: D342G

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
Pfam:V-set 21 122 1.3e-10 PFAM
low complexity region 212 223 N/A INTRINSIC
transmembrane domain 264 283 N/A INTRINSIC
low complexity region 285 311 N/A INTRINSIC
low complexity region 344 363 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000121040
SMART Domains Protein: ENSMUSP00000113064
Gene: ENSMUSG00000026420

DomainStartEndE-ValueType
low complexity region 44 56 N/A INTRINSIC
IL10 76 219 1.14e-1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126821
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145446
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149355
Predicted Effect probably benign
Transcript: ENSMUST00000187650
SMART Domains Protein: ENSMUSP00000140149
Gene: ENSMUSG00000026420

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
IL10 37 180 5.4e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000191279
SMART Domains Protein: ENSMUSP00000140821
Gene: ENSMUSG00000026420

DomainStartEndE-ValueType
low complexity region 44 56 N/A INTRINSIC
Blast:IL10 76 118 2e-21 BLAST
SCOP:d2ilk__ 80 119 2e-9 SMART
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010 [PubMed 20042454]).[supplied by OMIM, Jul 2010]
PHENOTYPE: Mice homozygous for knock-out alleles exhibit a slight decrease in B cell numbers reduced sensitivity to Gal-induced liver damage, increased granulocyte production of ROS and increased sensitivity to infection by Listeria monocytogenes. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8a A T 11: 109,980,810 (GRCm39) probably null Het
AI987944 T C 7: 41,023,815 (GRCm39) Y391C probably benign Het
Ankfn1 A T 11: 89,346,946 (GRCm39) S296T probably benign Het
Apob A G 12: 8,057,488 (GRCm39) D1957G probably benign Het
Baz1a G T 12: 54,976,431 (GRCm39) P415Q probably damaging Het
Brca2 T A 5: 150,464,134 (GRCm39) H1299Q probably benign Het
C7 G T 15: 5,063,720 (GRCm39) S227* probably null Het
Catsperb A T 12: 101,474,221 (GRCm39) R306S probably damaging Het
Cbx3 T A 6: 51,448,793 (GRCm39) probably null Het
Ccnt2 A G 1: 127,731,136 (GRCm39) Y671C probably damaging Het
Crocc A G 4: 140,774,253 (GRCm39) probably null Het
Ctr9 G A 7: 110,646,014 (GRCm39) V669I probably benign Het
Dck T G 5: 88,920,576 (GRCm39) Y99D probably damaging Het
Ddx52 T A 11: 83,835,432 (GRCm39) D119E probably benign Het
Dnah10 A T 5: 124,823,768 (GRCm39) K596N probably benign Het
Dnah7a A T 1: 53,621,741 (GRCm39) V1128E probably benign Het
Dph1 A T 11: 75,076,679 (GRCm39) probably null Het
Enah G A 1: 181,749,537 (GRCm39) P415L probably damaging Het
Enthd1 A G 15: 80,444,550 (GRCm39) S2P possibly damaging Het
Erc1 A C 6: 119,699,216 (GRCm39) V802G possibly damaging Het
F8 ATCTCTCTC ATCTCTC X: 74,366,604 (GRCm39) probably null Het
Fam169a C A 13: 97,243,600 (GRCm39) A210E probably benign Het
Fgfr4 T G 13: 55,315,702 (GRCm39) V743G possibly damaging Het
Fsip2 A G 2: 82,808,856 (GRCm39) D1725G probably damaging Het
Heatr5b A T 17: 79,136,934 (GRCm39) C195* probably null Het
Herc2 G A 7: 55,855,709 (GRCm39) A3882T probably damaging Het
Il20 T A 1: 130,836,115 (GRCm39) N143Y probably damaging Het
Inpp5b A G 4: 124,692,092 (GRCm39) S892G probably damaging Het
Ipo13 A T 4: 117,761,858 (GRCm39) Y447* probably null Het
Itprid1 A G 6: 55,874,860 (GRCm39) N270S probably benign Het
Kbtbd12 A T 6: 88,594,779 (GRCm39) N350K probably benign Het
Kiz T C 2: 146,811,880 (GRCm39) F663S probably damaging Het
Matn2 A G 15: 34,433,263 (GRCm39) D870G probably benign Het
Methig1 C T 15: 100,251,467 (GRCm39) A126V probably benign Het
Mme A G 3: 63,235,681 (GRCm39) D209G probably null Het
Mroh4 A G 15: 74,481,610 (GRCm39) F811L possibly damaging Het
Myo9b G T 8: 71,743,510 (GRCm39) K190N probably damaging Het
Ncf1 T C 5: 134,258,406 (GRCm39) I6V probably damaging Het
Nmt2 T C 2: 3,310,618 (GRCm39) F121L probably damaging Het
Nol10 A G 12: 17,411,152 (GRCm39) D183G probably benign Het
Nsun7 T C 5: 66,418,429 (GRCm39) V53A probably benign Het
Or10u4 T C 10: 129,802,009 (GRCm39) I187V probably benign Het
Or8j3 T C 2: 86,028,176 (GRCm39) S307G probably benign Het
Or8k22 T C 2: 86,162,774 (GRCm39) N309D probably benign Het
Pappa2 A T 1: 158,784,214 (GRCm39) Y265* probably null Het
Pigg G A 5: 108,486,518 (GRCm39) A724T probably damaging Het
Pik3r4 C T 9: 105,527,534 (GRCm39) R296C probably benign Het
Pkhd1l1 A G 15: 44,431,617 (GRCm39) probably null Het
Pld4 A G 12: 112,734,992 (GRCm39) D483G probably damaging Het
Ppip5k1 C T 2: 121,173,674 (GRCm39) R399H probably damaging Het
Qrfpr A T 3: 36,236,806 (GRCm39) H198Q probably damaging Het
Rasgrf2 A T 13: 92,050,748 (GRCm39) D883E probably damaging Het
Retnlg T C 16: 48,694,615 (GRCm39) C88R probably damaging Het
Sin3a C T 9: 57,004,109 (GRCm39) T287I probably benign Het
Slc44a1 GCC GCCCCC 4: 53,563,243 (GRCm39) probably benign Het
Sppl2c G C 11: 104,077,307 (GRCm39) V36L probably benign Het
Srp72 T A 5: 77,124,338 (GRCm39) I68N probably damaging Het
Srrm3 T A 5: 135,883,231 (GRCm39) S195R probably damaging Het
Srrm4 T A 5: 116,605,887 (GRCm39) probably benign Het
Ssb A G 2: 69,699,163 (GRCm39) S199G probably benign Het
Sult2a6 T A 7: 13,988,634 (GRCm39) Y42F probably damaging Het
Syne2 A G 12: 76,072,343 (GRCm39) T120A probably benign Het
Tas1r1 A G 4: 152,112,627 (GRCm39) F809L probably damaging Het
Tead3 A G 17: 28,555,544 (GRCm39) S117P probably damaging Het
Tefm C T 11: 80,031,056 (GRCm39) R60H probably damaging Het
Tmem104 G A 11: 115,092,221 (GRCm39) R110H possibly damaging Het
Tnxb G A 17: 34,918,179 (GRCm39) G2364D probably damaging Het
Vmn1r211 T A 13: 23,036,134 (GRCm39) I178F probably damaging Het
Vmn1r6 A T 6: 56,980,109 (GRCm39) Y235F probably damaging Het
Xrcc5 C A 1: 72,385,529 (GRCm39) T540K probably benign Het
Other mutations in Fcmr
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01638:Fcmr APN 1 130,802,859 (GRCm39) missense probably benign 0.06
IGL01652:Fcmr APN 1 130,806,244 (GRCm39) missense probably benign 0.25
IGL02106:Fcmr APN 1 130,802,872 (GRCm39) missense probably benign
IGL03270:Fcmr APN 1 130,803,779 (GRCm39) missense possibly damaging 0.63
R1635:Fcmr UTSW 1 130,803,922 (GRCm39) splice site probably null
R1651:Fcmr UTSW 1 130,805,988 (GRCm39) missense probably benign
R1728:Fcmr UTSW 1 130,806,006 (GRCm39) missense probably benign 0.00
R1728:Fcmr UTSW 1 130,803,711 (GRCm39) missense probably benign
R1729:Fcmr UTSW 1 130,806,006 (GRCm39) missense probably benign 0.00
R1729:Fcmr UTSW 1 130,803,711 (GRCm39) missense probably benign
R1730:Fcmr UTSW 1 130,806,006 (GRCm39) missense probably benign 0.00
R1730:Fcmr UTSW 1 130,803,711 (GRCm39) missense probably benign
R1739:Fcmr UTSW 1 130,806,006 (GRCm39) missense probably benign 0.00
R1739:Fcmr UTSW 1 130,803,711 (GRCm39) missense probably benign
R1762:Fcmr UTSW 1 130,806,006 (GRCm39) missense probably benign 0.00
R1762:Fcmr UTSW 1 130,803,711 (GRCm39) missense probably benign
R1783:Fcmr UTSW 1 130,806,006 (GRCm39) missense probably benign 0.00
R1783:Fcmr UTSW 1 130,803,711 (GRCm39) missense probably benign
R1784:Fcmr UTSW 1 130,806,006 (GRCm39) missense probably benign 0.00
R1784:Fcmr UTSW 1 130,803,711 (GRCm39) missense probably benign
R1785:Fcmr UTSW 1 130,806,006 (GRCm39) missense probably benign 0.00
R1785:Fcmr UTSW 1 130,803,711 (GRCm39) missense probably benign
R6111:Fcmr UTSW 1 130,805,566 (GRCm39) missense probably damaging 0.96
R6217:Fcmr UTSW 1 130,806,060 (GRCm39) missense probably damaging 0.96
R6538:Fcmr UTSW 1 130,802,762 (GRCm39) missense possibly damaging 0.72
R6712:Fcmr UTSW 1 130,805,588 (GRCm39) missense probably damaging 0.99
R6965:Fcmr UTSW 1 130,803,724 (GRCm39) missense possibly damaging 0.65
R7765:Fcmr UTSW 1 130,802,025 (GRCm39) missense probably damaging 1.00
R8770:Fcmr UTSW 1 130,803,799 (GRCm39) missense probably benign
R9343:Fcmr UTSW 1 130,802,072 (GRCm39) missense
R9468:Fcmr UTSW 1 130,801,951 (GRCm39) missense possibly damaging 0.65
X0025:Fcmr UTSW 1 130,802,004 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTTCTTGGTGACCTCCTGAAGC -3'
(R):5'- AGGGCTTCAATTTAGGGACTGG -3'

Sequencing Primer
(F):5'- TGAAGCCTCCTCCAGACGTG -3'
(R):5'- AGCTTACCTGCGGAGAAGC -3'
Posted On 2014-08-25