Incidental Mutation 'R1999:Or3a1b'
ID 224752
Institutional Source Beutler Lab
Gene Symbol Or3a1b
Ensembl Gene ENSMUSG00000070380
Gene Name olfactory receptor family 3 subfamily A member 1B
Synonyms GA_x6K02T2P1NL-4278037-4278984, Olfr401, MOR255-6
MMRRC Submission 040009-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # R1999 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 74012117-74013064 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 74012406 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 97 (Y97C)
Ref Sequence ENSEMBL: ENSMUSP00000149542 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079827] [ENSMUST00000213754]
AlphaFold Q8VFX6
Predicted Effect probably benign
Transcript: ENSMUST00000079827
AA Change: Y97C

PolyPhen 2 Score 0.279 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000078756
Gene: ENSMUSG00000070380
AA Change: Y97C

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 9.4e-51 PFAM
Pfam:7tm_1 44 293 2.2e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213754
AA Change: Y97C

PolyPhen 2 Score 0.279 (Sensitivity: 0.91; Specificity: 0.88)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.0%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acot1 T A 12: 84,056,527 (GRCm39) W82R probably damaging Het
Adprm A G 11: 66,929,055 (GRCm39) V312A probably benign Het
Ambp C T 4: 63,067,666 (GRCm39) M181I possibly damaging Het
Anln A G 9: 22,244,348 (GRCm39) *1122Q probably null Het
Apc2 C T 10: 80,144,994 (GRCm39) T635I probably damaging Het
Arhgap32 A G 9: 32,027,436 (GRCm39) E2G possibly damaging Het
Bltp1 C T 3: 36,962,360 (GRCm39) T487I probably damaging Het
Ccdc63 C G 5: 122,265,628 (GRCm39) A71P possibly damaging Het
Ceacam5 A T 7: 17,481,172 (GRCm39) K306N possibly damaging Het
Cep295nl T C 11: 118,223,915 (GRCm39) R310G probably damaging Het
Ces2h A G 8: 105,746,977 (GRCm39) T538A probably benign Het
Dab2 T C 15: 6,446,398 (GRCm39) V5A probably benign Het
Diaph3 T A 14: 87,222,302 (GRCm39) D405V possibly damaging Het
Dync1h1 T C 12: 110,632,857 (GRCm39) probably null Het
Epha7 C T 4: 28,938,686 (GRCm39) Q514* probably null Het
Etfb C T 7: 43,103,987 (GRCm39) L141F probably benign Het
Fat1 T C 8: 45,405,430 (GRCm39) V727A probably damaging Het
Flt4 T C 11: 49,536,824 (GRCm39) Y1265H probably benign Het
Fndc3c1 C T X: 105,464,311 (GRCm39) E1276K probably benign Het
Ghdc T C 11: 100,660,018 (GRCm39) E243G probably benign Het
Gpld1 T C 13: 25,146,630 (GRCm39) V225A probably benign Het
Herc1 A G 9: 66,393,360 (GRCm39) T4080A probably benign Het
Hoxa3 A C 6: 52,147,382 (GRCm39) Y290* probably null Het
Htr5a G A 5: 28,055,887 (GRCm39) V293M possibly damaging Het
Itgb7 C T 15: 102,130,553 (GRCm39) V378M probably damaging Het
Kcnq5 T C 1: 21,472,428 (GRCm39) S811G probably null Het
Kcnt1 T A 2: 25,782,372 (GRCm39) H156Q probably benign Het
Kif1a T C 1: 92,988,517 (GRCm39) N507S probably damaging Het
Krt84 T C 15: 101,438,019 (GRCm39) E312G possibly damaging Het
Manea A G 4: 26,327,871 (GRCm39) L390P probably damaging Het
Mboat2 A G 12: 24,996,672 (GRCm39) D225G possibly damaging Het
Medag T A 5: 149,350,717 (GRCm39) F64Y probably damaging Het
Mtmr6 T A 14: 60,530,856 (GRCm39) S331R probably damaging Het
Myh1 A C 11: 67,113,234 (GRCm39) D1873A probably benign Het
Nek9 A G 12: 85,376,677 (GRCm39) W235R probably damaging Het
Nomo1 T C 7: 45,706,151 (GRCm39) S502P possibly damaging Het
Or10g6 A G 9: 39,933,985 (GRCm39) I99V probably benign Het
Or8k30 T A 2: 86,339,089 (GRCm39) Y95* probably null Het
Otof T A 5: 30,546,116 (GRCm39) E427D probably benign Het
Pclo T C 5: 14,727,094 (GRCm39) probably benign Het
Pkhd1l1 T G 15: 44,363,378 (GRCm39) probably null Het
Prl2c2 G C 13: 13,176,786 (GRCm39) T47R probably damaging Het
Pwwp4a G T X: 72,171,261 (GRCm39) G218C probably damaging Het
Rad21l T C 2: 151,496,621 (GRCm39) probably null Het
Rbbp6 T C 7: 122,589,575 (GRCm39) V459A probably damaging Het
Rsbn1l G A 5: 21,107,368 (GRCm39) H549Y probably damaging Het
Rsf1 CG CGACGGCGGTG 7: 97,229,115 (GRCm39) probably benign Het
Senp1 C T 15: 97,956,196 (GRCm39) V408I possibly damaging Het
Slc44a5 T C 3: 153,964,130 (GRCm39) F499L possibly damaging Het
Slitrk3 C T 3: 72,957,297 (GRCm39) V492I probably benign Het
Spef2 T A 15: 9,668,989 (GRCm39) probably null Het
Ssc5d A T 7: 4,945,713 (GRCm39) D915V possibly damaging Het
Stard9 A G 2: 120,523,349 (GRCm39) D668G probably damaging Het
Sycp2l A G 13: 41,271,780 (GRCm39) D73G probably benign Het
Tectb C G 19: 55,169,431 (GRCm39) probably benign Het
Tmem8b G A 4: 43,681,300 (GRCm39) C439Y probably damaging Het
Vmn1r195 C G 13: 22,462,934 (GRCm39) L135V possibly damaging Het
Vmn1r74 G T 7: 11,581,302 (GRCm39) V201F probably damaging Het
Vmn2r-ps158 A T 7: 42,696,883 (GRCm39) I647F probably damaging Het
Zfp956 G A 6: 47,940,805 (GRCm39) R388H probably damaging Het
Other mutations in Or3a1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00087:Or3a1b APN 11 74,012,705 (GRCm39) missense probably benign 0.00
IGL01303:Or3a1b APN 11 74,012,160 (GRCm39) missense probably damaging 1.00
IGL01397:Or3a1b APN 11 74,012,590 (GRCm39) missense probably damaging 0.97
IGL02101:Or3a1b APN 11 74,012,571 (GRCm39) nonsense probably null
IGL02121:Or3a1b APN 11 74,012,113 (GRCm39) splice site probably benign
IGL02347:Or3a1b APN 11 74,012,397 (GRCm39) missense probably benign 0.03
IGL03113:Or3a1b APN 11 74,012,529 (GRCm39) missense probably benign 0.13
IGL03126:Or3a1b APN 11 74,012,610 (GRCm39) missense probably benign 0.01
IGL03302:Or3a1b APN 11 74,012,459 (GRCm39) missense possibly damaging 0.60
R0549:Or3a1b UTSW 11 74,012,301 (GRCm39) missense probably damaging 1.00
R1180:Or3a1b UTSW 11 74,012,406 (GRCm39) missense probably benign 0.28
R1350:Or3a1b UTSW 11 74,013,039 (GRCm39) missense possibly damaging 0.96
R1800:Or3a1b UTSW 11 74,012,234 (GRCm39) missense probably benign 0.00
R1808:Or3a1b UTSW 11 74,012,257 (GRCm39) missense probably damaging 0.96
R1962:Or3a1b UTSW 11 74,012,650 (GRCm39) missense probably benign 0.02
R1998:Or3a1b UTSW 11 74,012,406 (GRCm39) missense probably benign 0.28
R2000:Or3a1b UTSW 11 74,012,406 (GRCm39) missense probably benign 0.28
R2859:Or3a1b UTSW 11 74,012,808 (GRCm39) missense probably damaging 1.00
R4914:Or3a1b UTSW 11 74,012,705 (GRCm39) missense probably benign 0.00
R4915:Or3a1b UTSW 11 74,012,705 (GRCm39) missense probably benign 0.00
R4916:Or3a1b UTSW 11 74,012,705 (GRCm39) missense probably benign 0.00
R4918:Or3a1b UTSW 11 74,012,705 (GRCm39) missense probably benign 0.00
R5292:Or3a1b UTSW 11 74,012,877 (GRCm39) missense probably damaging 0.99
R5522:Or3a1b UTSW 11 74,012,484 (GRCm39) missense probably damaging 1.00
R5761:Or3a1b UTSW 11 74,012,335 (GRCm39) missense probably damaging 0.97
R6318:Or3a1b UTSW 11 74,012,547 (GRCm39) missense possibly damaging 0.82
R6608:Or3a1b UTSW 11 74,012,454 (GRCm39) missense probably benign 0.00
R6737:Or3a1b UTSW 11 74,012,732 (GRCm39) missense probably benign
R6790:Or3a1b UTSW 11 74,012,427 (GRCm39) missense probably damaging 1.00
R7243:Or3a1b UTSW 11 74,012,559 (GRCm39) missense probably damaging 0.97
R7423:Or3a1b UTSW 11 74,012,811 (GRCm39) missense probably benign 0.01
R7517:Or3a1b UTSW 11 74,012,335 (GRCm39) missense probably damaging 0.97
R7833:Or3a1b UTSW 11 74,012,663 (GRCm39) missense probably damaging 1.00
R8241:Or3a1b UTSW 11 74,013,035 (GRCm39) missense probably benign 0.03
R8423:Or3a1b UTSW 11 74,012,492 (GRCm39) missense probably benign 0.06
R8937:Or3a1b UTSW 11 74,012,874 (GRCm39) missense probably benign 0.03
R9145:Or3a1b UTSW 11 74,012,526 (GRCm39) missense probably benign 0.01
R9725:Or3a1b UTSW 11 74,012,612 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- AGCTGTGGCCACTTGTCTTC -3'
(R):5'- CATTGCTGAAGGAACAAGCCC -3'

Sequencing Primer
(F):5'- TGGCTTACATGACCACAGTTG -3'
(R):5'- CAGGATGAGGCCACCAAAATTCTC -3'
Posted On 2014-08-25