Incidental Mutation 'R2041:Or4p18'
ID 224882
Institutional Source Beutler Lab
Gene Symbol Or4p18
Ensembl Gene ENSMUSG00000075127
Gene Name olfactory receptor family 4 subfamily P member 18
Synonyms MOR225-2, GA_x6K02T2Q125-49890854-49889931, Olfr1179
MMRRC Submission 040048-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.067) question?
Stock # R2041 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 88232353-88233276 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 88232568 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 237 (T237A)
Ref Sequence ENSEMBL: ENSMUSP00000151174 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099825] [ENSMUST00000213157] [ENSMUST00000214040]
AlphaFold A2AUS6
Predicted Effect probably damaging
Transcript: ENSMUST00000099825
AA Change: T237A

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000097413
Gene: ENSMUSG00000075127
AA Change: T237A

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 1.1e-47 PFAM
Pfam:7tm_1 39 285 3e-18 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213157
AA Change: T237A

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably benign
Transcript: ENSMUST00000214040
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217346
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219086
Meta Mutation Damage Score 0.3360 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.1%
Validation Efficiency 100% (61/61)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700018F24Rik T A 5: 144,982,211 (GRCm39) D265E probably damaging Het
2610021A01Rik A G 7: 41,275,403 (GRCm39) R369G possibly damaging Het
Actr3b T C 5: 25,965,128 (GRCm39) probably null Het
Adamts12 A T 15: 11,215,821 (GRCm39) M281L probably damaging Het
Aipl1 T A 11: 71,922,332 (GRCm39) M126L possibly damaging Het
Akap12 C T 10: 4,306,489 (GRCm39) P1100S probably benign Het
Alox8 T A 11: 69,088,517 (GRCm39) H40L possibly damaging Het
Anks1 T A 17: 28,227,388 (GRCm39) F659L probably damaging Het
Asxl3 G T 18: 22,656,508 (GRCm39) R1506L probably benign Het
Bicd2 A G 13: 49,495,252 (GRCm39) T36A probably benign Het
Ccar1 A T 10: 62,601,827 (GRCm39) L448Q probably damaging Het
Ccdc17 T G 4: 116,456,789 (GRCm39) N497K probably damaging Het
Chek2 T C 5: 110,996,530 (GRCm39) I164T probably damaging Het
Cntnap5c T C 17: 58,411,765 (GRCm39) probably null Het
Cntnap5c T A 17: 58,505,984 (GRCm39) D669E probably benign Het
Cpsf6 A G 10: 117,195,033 (GRCm39) I482T probably damaging Het
Csf3 C T 11: 98,592,483 (GRCm39) S65L possibly damaging Het
Dlc1 A G 8: 37,049,922 (GRCm39) Y1049H probably damaging Het
Dnah6 T C 6: 73,050,422 (GRCm39) D3048G probably damaging Het
Eif4g3 T A 4: 137,832,617 (GRCm39) probably benign Het
Epb41l4b T C 4: 57,084,070 (GRCm39) K195R probably damaging Het
Epn1 T C 7: 5,086,874 (GRCm39) S41P probably damaging Het
Fam120a C A 13: 49,051,243 (GRCm39) V721L probably benign Het
Fchsd1 T A 18: 38,100,729 (GRCm39) probably null Het
Fer1l6 G A 15: 58,430,155 (GRCm39) G194D probably damaging Het
Fpr-rs4 CAGGAA CA 17: 18,242,596 (GRCm39) probably null Het
Fyb1 A C 15: 6,674,268 (GRCm39) T635P possibly damaging Het
Gpr153 A G 4: 152,367,810 (GRCm39) S554G probably benign Het
Grm1 A G 10: 10,622,347 (GRCm39) F459L probably damaging Het
H60c C T 10: 3,209,972 (GRCm39) G105D probably damaging Het
Ifnlr1 T A 4: 135,433,148 (GRCm39) M528K possibly damaging Het
Lama4 A T 10: 38,945,987 (GRCm39) D790V probably damaging Het
Mfsd13b T C 7: 120,591,139 (GRCm39) probably benign Het
Mis12 T A 11: 70,916,132 (GRCm39) I55N probably damaging Het
Morn1 T C 4: 155,175,399 (GRCm39) Y103H probably damaging Het
Mrgpra2b C T 7: 47,113,908 (GRCm39) V249I probably benign Het
Ndst3 C A 3: 123,465,864 (GRCm39) G36V probably benign Het
Nlrp4a T A 7: 26,149,611 (GRCm39) M406K probably damaging Het
Or51t4 T A 7: 102,598,170 (GRCm39) V156E probably damaging Het
Or5b106 A T 19: 13,124,041 (GRCm39) probably benign Het
Or7g32 A T 9: 19,408,131 (GRCm39) D29V probably benign Het
Or9m1 T C 2: 87,733,141 (GRCm39) N293S probably damaging Het
Pars2 A G 4: 106,510,814 (GRCm39) T199A probably damaging Het
Plcb4 C T 2: 135,780,191 (GRCm39) T172I probably damaging Het
Pomgnt2 A T 9: 121,811,354 (GRCm39) W476R probably benign Het
Psg23 T A 7: 18,348,703 (GRCm39) S35C possibly damaging Het
Pycr3 T A 15: 75,791,144 (GRCm39) probably null Het
Rab3gap1 T C 1: 127,865,727 (GRCm39) V764A possibly damaging Het
Rgs2 A G 1: 143,877,960 (GRCm39) F80S probably damaging Het
Sall1 A G 8: 89,759,429 (GRCm39) L225P probably benign Het
Setd3 A G 12: 108,079,651 (GRCm39) I284T possibly damaging Het
Slc4a9 C T 18: 36,663,846 (GRCm39) T290I possibly damaging Het
Tmem87b T C 2: 128,673,509 (GRCm39) V251A probably damaging Het
Ube3b T C 5: 114,525,294 (GRCm39) L39P probably damaging Het
Ubr2 C A 17: 47,296,973 (GRCm39) R269L probably damaging Het
Vrk2 A T 11: 26,497,914 (GRCm39) I90K probably benign Het
Zer1 G A 2: 29,998,286 (GRCm39) L342F probably damaging Het
Zfp984 A T 4: 147,839,796 (GRCm39) C352S probably damaging Het
Other mutations in Or4p18
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02008:Or4p18 APN 2 88,232,421 (GRCm39) missense possibly damaging 0.95
IGL02445:Or4p18 APN 2 88,232,456 (GRCm39) missense possibly damaging 0.60
R0127:Or4p18 UTSW 2 88,232,699 (GRCm39) missense probably benign 0.05
R0604:Or4p18 UTSW 2 88,232,727 (GRCm39) missense probably benign 0.03
R1526:Or4p18 UTSW 2 88,232,777 (GRCm39) missense probably damaging 1.00
R1816:Or4p18 UTSW 2 88,232,943 (GRCm39) missense possibly damaging 0.65
R3694:Or4p18 UTSW 2 88,232,540 (GRCm39) missense possibly damaging 0.80
R4229:Or4p18 UTSW 2 88,233,227 (GRCm39) missense possibly damaging 0.67
R4735:Or4p18 UTSW 2 88,233,267 (GRCm39) missense probably benign 0.02
R4974:Or4p18 UTSW 2 88,232,756 (GRCm39) missense probably damaging 1.00
R5173:Or4p18 UTSW 2 88,233,266 (GRCm39) missense probably benign 0.00
R5909:Or4p18 UTSW 2 88,232,535 (GRCm39) missense probably damaging 0.98
R6931:Or4p18 UTSW 2 88,232,408 (GRCm39) missense probably benign 0.01
R6990:Or4p18 UTSW 2 88,232,639 (GRCm39) missense probably benign 0.13
R7167:Or4p18 UTSW 2 88,232,552 (GRCm39) missense possibly damaging 0.46
R8121:Or4p18 UTSW 2 88,233,040 (GRCm39) missense probably benign
R8140:Or4p18 UTSW 2 88,232,457 (GRCm39) missense possibly damaging 0.74
R8269:Or4p18 UTSW 2 88,232,381 (GRCm39) missense probably damaging 0.98
R8832:Or4p18 UTSW 2 88,233,137 (GRCm39) missense probably damaging 0.98
R9269:Or4p18 UTSW 2 88,232,586 (GRCm39) missense probably benign 0.06
Z1176:Or4p18 UTSW 2 88,232,466 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCACCAAACTTTTCTCAAGGC -3'
(R):5'- GCCACAATGAGATGGATCACTATTTC -3'

Sequencing Primer
(F):5'- CAAGGCATTCTTCATCTCTGTG -3'
(R):5'- TTCAGGCATGATGGGACT -3'
Posted On 2014-08-25