Mutagenetix > Incidental Mutation

Incidental Mutation 'R2041:Fpr-rs4'

224989

Institutional Source

Beutler Lab

Gene Symbol

Fpr-rs4

Ensembl Gene

ENSMUSG00000048062

Gene Name

formyl peptide receptor, related sequence 4

Synonyms

MMRRC Submission

040048-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.094) question?

Stock #

R2041 (G1)

Quality Score

217

Status

Validated

Chromosome

Chromosomal Location

18021733-18022704 bp(+) (GRCm38)

Type of Mutation

frame shift

DNA Base Change (assembly)

CAGGAA to CA at 18022334 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000093311 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000095651]

AlphaFold

A4FUQ5

Predicted Effect

probably null
Transcript: ENSMUST00000095651

SMART Domains

Protein: ENSMUSP00000093311
Gene: ENSMUSG00000048062

Domain	Start	End	E-Value	Type
Pfam:7tm_1	43	297	4.9e-35	PFAM

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.2%
20x: 95.1%

Validation Efficiency

100% (61/61)

Allele List at MGI

Other mutations in this stock

Total: 58 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700018F24Rik	T	A	5: 145,045,401	D265E	probably damaging	Het
2610021A01Rik	A	G	7: 41,625,979	R369G	possibly damaging	Het
Actr3b	T	C	5: 25,760,130		probably null	Het
Adamts12	A	T	15: 11,215,735	M281L	probably damaging	Het
Aipl1	T	A	11: 72,031,506	M126L	possibly damaging	Het
Akap12	C	T	10: 4,356,489	P1100S	probably benign	Het
Alox8	T	A	11: 69,197,691	H40L	possibly damaging	Het
Anks1	T	A	17: 28,008,414	F659L	probably damaging	Het
Asxl3	G	T	18: 22,523,451	R1506L	probably benign	Het
Bicd2	A	G	13: 49,341,776	T36A	probably benign	Het
Ccar1	A	T	10: 62,766,048	L448Q	probably damaging	Het
Ccdc17	T	G	4: 116,599,592	N497K	probably damaging	Het
Chek2	T	C	5: 110,848,664	I164T	probably damaging	Het
Cntnap5c	T	C	17: 58,104,770		probably null	Het
Cntnap5c	T	A	17: 58,198,989	D669E	probably benign	Het
Cpsf6	A	G	10: 117,359,128	I482T	probably damaging	Het
Csf3	C	T	11: 98,701,657	S65L	possibly damaging	Het
Dlc1	A	G	8: 36,582,768	Y1049H	probably damaging	Het
Dnah6	T	C	6: 73,073,439	D3048G	probably damaging	Het
Eif4g3	T	A	4: 138,105,306		probably benign	Het
Epb41l4b	T	C	4: 57,084,070	K195R	probably damaging	Het
Epn1	T	C	7: 5,083,875	S41P	probably damaging	Het
Fam120a	C	A	13: 48,897,767	V721L	probably benign	Het
Fchsd1	T	A	18: 37,967,676		probably null	Het
Fer1l6	G	A	15: 58,558,306	G194D	probably damaging	Het
Fyb	A	C	15: 6,644,787	T635P	possibly damaging	Het
Gpr153	A	G	4: 152,283,353	S554G	probably benign	Het
Grm1	A	G	10: 10,746,603	F459L	probably damaging	Het
H60c	C	T	10: 3,259,972	G105D	probably damaging	Het
Ifnlr1	T	A	4: 135,705,837	M528K	possibly damaging	Het
Lama4	A	T	10: 39,069,991	D790V	probably damaging	Het
Mfsd13b	T	C	7: 120,991,916		probably benign	Het
Mis12	T	A	11: 71,025,306	I55N	probably damaging	Het
Morn1	T	C	4: 155,090,942	Y103H	probably damaging	Het
Mrgpra2b	C	T	7: 47,464,160	V249I	probably benign	Het
Ndst3	C	A	3: 123,672,215	G36V	probably benign	Het
Nlrp4a	T	A	7: 26,450,186	M406K	probably damaging	Het
Olfr1154	T	C	2: 87,902,797	N293S	probably damaging	Het
Olfr1179	T	C	2: 88,402,224	T237A	probably damaging	Het
Olfr1459	A	T	19: 13,146,677		probably benign	Het
Olfr574	T	A	7: 102,948,963	V156E	probably damaging	Het
Olfr851	A	T	9: 19,496,835	D29V	probably benign	Het
Pars2	A	G	4: 106,653,617	T199A	probably damaging	Het
Plcb4	C	T	2: 135,938,271	T172I	probably damaging	Het
Pomgnt2	A	T	9: 121,982,288	W476R	probably benign	Het
Psg23	T	A	7: 18,614,778	S35C	possibly damaging	Het
Pycrl	T	A	15: 75,919,295		probably null	Het
Rab3gap1	T	C	1: 127,937,990	V764A	possibly damaging	Het
Rgs2	A	G	1: 144,002,222	F80S	probably damaging	Het
Sall1	A	G	8: 89,032,801	L225P	probably benign	Het
Setd3	A	G	12: 108,113,392	I284T	possibly damaging	Het
Slc4a9	C	T	18: 36,530,793	T290I	possibly damaging	Het
Tmem87b	T	C	2: 128,831,589	V251A	probably damaging	Het
Ube3b	T	C	5: 114,387,233	L39P	probably damaging	Het
Ubr2	C	A	17: 46,986,047	R269L	probably damaging	Het
Vrk2	A	T	11: 26,547,914	I90K	probably benign	Het
Zer1	G	A	2: 30,108,274	L342F	probably damaging	Het
Zfp984	A	T	4: 147,755,339	C352S	probably damaging	Het

Other mutations in Fpr-rs4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00539:Fpr-rs4	APN	17	18021926	missense	probably damaging	1.00
IGL01064:Fpr-rs4	APN	17	18022517	missense	probably damaging	1.00
IGL01626:Fpr-rs4	APN	17	18022231	missense	probably damaging	0.97
IGL02544:Fpr-rs4	APN	17	18022211	missense	probably benign
IGL02837:Fpr-rs4	UTSW	17	18022251	missense	probably benign	0.00
R0179:Fpr-rs4	UTSW	17	18022027	nonsense	probably null
R0383:Fpr-rs4	UTSW	17	18022097	missense	probably damaging	1.00
R0686:Fpr-rs4	UTSW	17	18022351	missense	probably benign	0.05
R1551:Fpr-rs4	UTSW	17	18022327	missense	possibly damaging	0.89
R1956:Fpr-rs4	UTSW	17	18022256	missense	probably damaging	0.97
R2040:Fpr-rs4	UTSW	17	18022334	frame shift	probably null
R2043:Fpr-rs4	UTSW	17	18022334	frame shift	probably null
R2045:Fpr-rs4	UTSW	17	18022334	frame shift	probably null
R2048:Fpr-rs4	UTSW	17	18022334	frame shift	probably null
R2092:Fpr-rs4	UTSW	17	18022334	frame shift	probably null
R2093:Fpr-rs4	UTSW	17	18022334	frame shift	probably null
R2136:Fpr-rs4	UTSW	17	18022334	frame shift	probably null
R3624:Fpr-rs4	UTSW	17	18022334	frame shift	probably null
R4684:Fpr-rs4	UTSW	17	18022184	missense	probably damaging	1.00
R6076:Fpr-rs4	UTSW	17	18022055	missense	probably damaging	1.00
R6247:Fpr-rs4	UTSW	17	18022486	missense	probably benign	0.00
R6639:Fpr-rs4	UTSW	17	18022132	nonsense	probably null
R6757:Fpr-rs4	UTSW	17	18022132	nonsense	probably null
R8703:Fpr-rs4	UTSW	17	18022070	missense	probably damaging	0.99
R9007:Fpr-rs4	UTSW	17	18022154	missense	probably damaging	1.00
R9318:Fpr-rs4	UTSW	17	18021955	missense	probably benign
R9357:Fpr-rs4	UTSW	17	18021949	missense	probably damaging	0.97
R9435:Fpr-rs4	UTSW	17	18022129	missense	probably benign	0.00
Z1088:Fpr-rs4	UTSW	17	18021919	missense	possibly damaging	0.85
Z1088:Fpr-rs4	UTSW	17	18022694	missense	probably benign	0.16

Predicted Primers

PCR Primer
(F):5'- GGCCAGAAAAGTGGTTCTTG -3'
(R):5'- AAGCCAAGGTATTTGCTGGG -3'

Sequencing Primer
(F):5'- CCAGAAAAGTGGTTCTTGGAGCTTG -3'
(R):5'- CCAAGGTATTTGCTGGGTTAACCAAC -3'

Posted On

2014-08-25