|Institutional Source||Beutler Lab|
|Gene Name||interleukin 13|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R0144 (G1)|
|Chromosomal Location||53631324-53634702 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to C at 53633176 bp|
|Amino Acid Change||Aspartic acid to Glycine at position 60 (D60G)|
|Ref Sequence||ENSEMBL: ENSMUSP00000020650 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000020650]|
|Predicted Effect||possibly damaging
AA Change: D60G
PolyPhen 2 Score 0.782 (Sensitivity: 0.85; Specificity: 0.93)
AA Change: D60G
|Meta Mutation Damage Score||0.1795|
|Coding Region Coverage||
|Validation Efficiency||100% (90/90)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for knock-out alleles exhibit defects in immune system morphology and physiology. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Il13||
(F):5'- ACACAGGAAGGCCGTTGAACTG -3'
(R):5'- GTTGTCAAGCCAGGCTCTATGCTAC -3'
(F):5'- cccaggaaagcagcaaaag -3'
(R):5'- TCTATGCTACCCGAGGGATG -3'