Incidental Mutation 'R2043:Or51ag1'
ID 225194
Institutional Source Beutler Lab
Gene Symbol Or51ag1
Ensembl Gene ENSMUSG00000045584
Gene Name olfactory receptor family 51 subfamily AG member 1
Synonyms GA_x6K02T2PBJ9-6221839-6220892, Olfr610, MOR9-2
MMRRC Submission 040050-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.068) question?
Stock # R2043 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 103155204-103156151 bp(-) (GRCm39)
Type of Mutation start codon destroyed
DNA Base Change (assembly) A to G at 103156150 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Threonine at position 1 (M1T)
Ref Sequence ENSEMBL: ENSMUSP00000150921 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000063109] [ENSMUST00000217627]
AlphaFold E9Q598
Predicted Effect probably null
Transcript: ENSMUST00000063109
AA Change: M1T

PolyPhen 2 Score 0.975 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000052577
Gene: ENSMUSG00000045584
AA Change: M1T

DomainStartEndE-ValueType
Pfam:7tm_4 33 313 3.5e-106 PFAM
Pfam:7TM_GPCR_Srsx 37 310 1.9e-10 PFAM
Pfam:7tm_1 43 295 1.4e-22 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213422
Predicted Effect probably null
Transcript: ENSMUST00000217627
AA Change: M1T

PolyPhen 2 Score 0.975 (Sensitivity: 0.76; Specificity: 0.96)
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.9%
Validation Efficiency 96% (47/49)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam9 A G 8: 25,486,669 (GRCm39) probably null Het
Adnp2 A C 18: 80,171,541 (GRCm39) M956R probably damaging Het
Aldh1l1 T A 6: 90,534,314 (GRCm39) D36E probably benign Het
Ankmy1 T C 1: 92,804,249 (GRCm39) probably benign Het
Apaf1 T C 10: 90,872,890 (GRCm39) D718G probably damaging Het
Ascc3 C T 10: 50,576,616 (GRCm39) P857L probably damaging Het
Atp8b1 T C 18: 64,738,271 (GRCm39) K60R possibly damaging Het
Bub1 A T 2: 127,646,140 (GRCm39) C947S probably damaging Het
Cacna1c C T 6: 118,573,049 (GRCm39) G2017D probably benign Het
Capn3 A G 2: 120,322,382 (GRCm39) N414S possibly damaging Het
Ccdc110 T C 8: 46,395,864 (GRCm39) M585T probably benign Het
Cep85l A T 10: 53,234,224 (GRCm39) N51K possibly damaging Het
Cftr T C 6: 18,320,934 (GRCm39) F1415L probably benign Het
Cln5 T C 14: 103,313,380 (GRCm39) S211P probably damaging Het
Dcaf5 A T 12: 80,386,991 (GRCm39) D378E probably benign Het
Dhx57 A G 17: 80,560,509 (GRCm39) probably benign Het
Dsn1 G A 2: 156,847,273 (GRCm39) S55L possibly damaging Het
Eif5b T C 1: 38,080,900 (GRCm39) F747S probably damaging Het
Entrep3 A G 3: 89,092,874 (GRCm39) Y251C probably damaging Het
Fbxo25 A G 8: 13,971,905 (GRCm39) I86V probably damaging Het
Fpr-rs4 CAGGAA CA 17: 18,242,596 (GRCm39) probably null Het
Glcci1 T A 6: 8,582,590 (GRCm39) I130K probably damaging Het
Gm5424 A G 10: 61,906,990 (GRCm39) noncoding transcript Het
Gsdma G A 11: 98,557,046 (GRCm39) V54M possibly damaging Het
H3c3 A G 13: 23,929,278 (GRCm39) F68S probably damaging Het
Heatr3 T A 8: 88,874,322 (GRCm39) probably benign Het
Hspa13 A G 16: 75,555,156 (GRCm39) L310S probably benign Het
Il6st A C 13: 112,616,753 (GRCm39) Q100P probably benign Het
Ly6g6e G A 17: 35,296,840 (GRCm39) R27Q possibly damaging Het
Mis18bp1 A T 12: 65,196,192 (GRCm39) I524K probably damaging Het
Myo18a T C 11: 77,714,189 (GRCm39) I761T probably damaging Het
Mypop T C 7: 18,734,944 (GRCm39) probably benign Het
Pcdh20 G A 14: 88,704,591 (GRCm39) T903I probably benign Het
Pdk4 A T 6: 5,485,502 (GRCm39) C396S probably benign Het
Piwil2 A G 14: 70,628,919 (GRCm39) V699A probably benign Het
Plekha5 T C 6: 140,498,530 (GRCm39) probably benign Het
Ralgapa1 T A 12: 55,723,811 (GRCm39) I1572L probably damaging Het
Rasgrf2 T A 13: 92,167,351 (GRCm39) M241L possibly damaging Het
Ryr1 C T 7: 28,759,056 (GRCm39) R3374H probably damaging Het
Slc24a2 A T 4: 86,914,882 (GRCm39) M519K probably damaging Het
Smg9 T A 7: 24,105,001 (GRCm39) I67N possibly damaging Het
Spart G A 3: 55,034,969 (GRCm39) A452T probably damaging Het
Ush2a T A 1: 188,648,453 (GRCm39) F4686Y probably benign Het
Zfp146 T C 7: 29,861,664 (GRCm39) K126R possibly damaging Het
Zfp386 T A 12: 116,022,781 (GRCm39) D131E probably benign Het
Zfp423 T C 8: 88,509,246 (GRCm39) D366G probably damaging Het
Zfp729a T C 13: 67,769,291 (GRCm39) K313E probably damaging Het
Zfp955a G A 17: 33,461,527 (GRCm39) H202Y possibly damaging Het
Other mutations in Or51ag1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01924:Or51ag1 APN 7 103,156,003 (GRCm39) missense possibly damaging 0.67
IGL02179:Or51ag1 APN 7 103,155,934 (GRCm39) missense probably damaging 1.00
IGL02303:Or51ag1 APN 7 103,155,295 (GRCm39) missense probably benign 0.05
IGL02507:Or51ag1 APN 7 103,155,925 (GRCm39) nonsense probably null
IGL02562:Or51ag1 APN 7 103,155,423 (GRCm39) nonsense probably null
IGL02806:Or51ag1 APN 7 103,155,210 (GRCm39) missense probably benign 0.10
R0743:Or51ag1 UTSW 7 103,156,069 (GRCm39) nonsense probably null
R0884:Or51ag1 UTSW 7 103,156,069 (GRCm39) nonsense probably null
R1673:Or51ag1 UTSW 7 103,155,896 (GRCm39) missense probably damaging 0.99
R1752:Or51ag1 UTSW 7 103,155,765 (GRCm39) missense probably benign 0.02
R1800:Or51ag1 UTSW 7 103,155,248 (GRCm39) missense possibly damaging 0.89
R2254:Or51ag1 UTSW 7 103,155,271 (GRCm39) missense probably damaging 1.00
R2566:Or51ag1 UTSW 7 103,155,367 (GRCm39) missense probably benign 0.08
R4433:Or51ag1 UTSW 7 103,155,346 (GRCm39) missense probably benign 0.04
R5206:Or51ag1 UTSW 7 103,155,309 (GRCm39) nonsense probably null
R5470:Or51ag1 UTSW 7 103,155,716 (GRCm39) missense probably benign 0.00
R6020:Or51ag1 UTSW 7 103,156,006 (GRCm39) missense probably benign
R6848:Or51ag1 UTSW 7 103,155,664 (GRCm39) missense possibly damaging 0.50
R7222:Or51ag1 UTSW 7 103,155,664 (GRCm39) missense possibly damaging 0.50
R7832:Or51ag1 UTSW 7 103,155,586 (GRCm39) missense probably damaging 1.00
R7837:Or51ag1 UTSW 7 103,156,052 (GRCm39) missense possibly damaging 0.80
R7893:Or51ag1 UTSW 7 103,155,817 (GRCm39) missense possibly damaging 0.86
R9293:Or51ag1 UTSW 7 103,155,727 (GRCm39) missense probably benign 0.00
R9335:Or51ag1 UTSW 7 103,155,727 (GRCm39) missense probably benign 0.00
R9567:Or51ag1 UTSW 7 103,155,727 (GRCm39) missense probably benign 0.00
R9615:Or51ag1 UTSW 7 103,155,727 (GRCm39) missense probably benign 0.00
R9653:Or51ag1 UTSW 7 103,155,727 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- ATGTAGAAGCTGAGAGGCCC -3'
(R):5'- GTCTGCATTGTTTTAGAGTAGAAGC -3'

Sequencing Primer
(F):5'- AGGTCAGCCATCGACAGCATG -3'
(R):5'- TTTAGAGTAGAAGCTTCTGAGAGG -3'
Posted On 2014-08-25