Incidental Mutation 'R2038:Ninl'
ID 225273
Institutional Source Beutler Lab
Gene Symbol Ninl
Ensembl Gene ENSMUSG00000068115
Gene Name ninein-like
Synonyms LOC381388, 4930519N13Rik, LOC381387
MMRRC Submission 040045-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R2038 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 150776439-150851330 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 150817763 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Stop codon at position 134 (K134*)
Ref Sequence ENSEMBL: ENSMUSP00000121872 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000109896] [ENSMUST00000128627] [ENSMUST00000150595]
AlphaFold Q6ZQ12
Predicted Effect probably null
Transcript: ENSMUST00000109896
AA Change: K134*
SMART Domains Protein: ENSMUSP00000105522
Gene: ENSMUSG00000068115
AA Change: K134*

DomainStartEndE-ValueType
EFh 12 40 6.56e0 SMART
low complexity region 76 93 N/A INTRINSIC
EFh 201 229 4.45e1 SMART
EFh 238 266 8.98e-4 SMART
low complexity region 295 306 N/A INTRINSIC
coiled coil region 381 423 N/A INTRINSIC
coiled coil region 461 517 N/A INTRINSIC
coiled coil region 541 584 N/A INTRINSIC
coiled coil region 620 699 N/A INTRINSIC
coiled coil region 728 751 N/A INTRINSIC
coiled coil region 835 863 N/A INTRINSIC
coiled coil region 1058 1334 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000128564
Predicted Effect probably null
Transcript: ENSMUST00000128627
AA Change: K134*
SMART Domains Protein: ENSMUSP00000121872
Gene: ENSMUSG00000068115
AA Change: K134*

DomainStartEndE-ValueType
SCOP:d1c07a_ 3 76 3e-7 SMART
PDB:2PMY|B 10 75 1e-6 PDB
Blast:EFh 12 40 4e-12 BLAST
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149268
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149979
Predicted Effect probably benign
Transcript: ENSMUST00000150595
SMART Domains Protein: ENSMUSP00000117001
Gene: ENSMUSG00000068115

DomainStartEndE-ValueType
low complexity region 33 45 N/A INTRINSIC
coiled coil region 85 122 N/A INTRINSIC
coiled coil region 160 216 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.7%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit bone-marrow myeloid hyperplasia. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310022B05Rik T C 8: 125,389,762 (GRCm39) Y54C probably damaging Het
Adgrf4 A T 17: 42,978,754 (GRCm39) H196Q probably damaging Het
Astn1 T G 1: 158,484,690 (GRCm39) S918A probably benign Het
Cd79a A T 7: 24,598,782 (GRCm39) K110N probably benign Het
Cdc34b C T 11: 94,633,114 (GRCm39) Q105* probably null Het
Cdh23 T C 10: 60,148,366 (GRCm39) D2667G probably damaging Het
Clpx G A 9: 65,224,775 (GRCm39) G168R probably damaging Het
Col8a2 T C 4: 126,205,108 (GRCm39) probably benign Het
Ddx27 G A 2: 166,875,675 (GRCm39) E669K probably damaging Het
Dnah8 A T 17: 30,977,255 (GRCm39) I2898F probably damaging Het
Dus2 T C 8: 106,775,294 (GRCm39) Y274H probably damaging Het
Dync2h1 A G 9: 6,967,226 (GRCm39) S4073P probably damaging Het
Dynlrb2 G A 8: 117,241,549 (GRCm39) R31Q possibly damaging Het
Esyt1 C T 10: 128,347,820 (GRCm39) V957I probably benign Het
Fhdc1 A T 3: 84,351,868 (GRCm39) L1119Q probably benign Het
H2-T10 T C 17: 36,430,317 (GRCm39) K212E probably benign Het
H60b A T 10: 22,162,114 (GRCm39) N113I probably benign Het
Hace1 A C 10: 45,576,721 (GRCm39) K798Q probably benign Het
Hdac7 C T 15: 97,696,151 (GRCm39) R631H probably damaging Het
Kat7 T A 11: 95,190,928 (GRCm39) I153F probably benign Het
Lman1 T C 18: 66,131,681 (GRCm39) T101A probably benign Het
Mapk8 A T 14: 33,110,893 (GRCm39) C245* probably null Het
Mfhas1 T A 8: 36,058,431 (GRCm39) W969R probably damaging Het
Mlxipl A T 5: 135,135,853 (GRCm39) D26V probably damaging Het
Msh5 A G 17: 35,265,016 (GRCm39) V53A probably benign Het
Msl2 C A 9: 100,979,183 (GRCm39) A519D probably damaging Het
Nbeal1 A G 1: 60,245,503 (GRCm39) S176G probably benign Het
Or10d1 A G 9: 39,484,283 (GRCm39) S91P probably damaging Het
Or1e25 T A 11: 73,494,239 (GRCm39) Y278N probably damaging Het
Or4a68 C A 2: 89,269,689 (GRCm39) M311I probably benign Het
Pabpn1 T G 14: 55,134,609 (GRCm39) I250S probably damaging Het
Ppp4r4 G A 12: 103,542,539 (GRCm39) probably null Het
Rad51ap2 T C 12: 11,507,025 (GRCm39) S316P possibly damaging Het
Scn7a C A 2: 66,567,780 (GRCm39) W271C probably damaging Het
Set T C 2: 29,960,212 (GRCm39) S182P probably benign Het
Sez6l T C 5: 112,620,618 (GRCm39) T321A possibly damaging Het
Sfpq A T 4: 126,915,295 (GRCm39) H29L unknown Het
Slc33a1 A G 3: 63,855,577 (GRCm39) L356P probably damaging Het
Sptbn1 C G 11: 30,109,293 (GRCm39) probably null Het
Srrd C T 5: 112,486,316 (GRCm39) G179D probably benign Het
Taf4b T C 18: 14,940,456 (GRCm39) S312P probably damaging Het
Tgfbrap1 A T 1: 43,093,794 (GRCm39) L566* probably null Het
Tln2 T A 9: 67,304,935 (GRCm39) M1L probably benign Het
Ttc27 T C 17: 75,163,497 (GRCm39) F702L probably benign Het
Vmn2r54 C T 7: 12,363,637 (GRCm39) G419R possibly damaging Het
Vps13b A G 15: 35,884,887 (GRCm39) S3187G probably damaging Het
Vps13d C A 4: 144,907,685 (GRCm39) probably null Het
Vps35l T C 7: 118,411,097 (GRCm39) F677L probably damaging Het
Zfp568 A T 7: 29,688,507 (GRCm39) E23V probably null Het
Other mutations in Ninl
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00230:Ninl APN 2 150,808,161 (GRCm39) missense probably damaging 0.98
IGL01697:Ninl APN 2 150,781,867 (GRCm39) missense probably damaging 1.00
IGL01756:Ninl APN 2 150,821,436 (GRCm39) missense probably damaging 1.00
IGL01925:Ninl APN 2 150,812,979 (GRCm39) missense probably damaging 1.00
IGL02341:Ninl APN 2 150,786,525 (GRCm39) nonsense probably null
IGL02838:Ninl APN 2 150,797,631 (GRCm39) splice site probably null
IGL02868:Ninl APN 2 150,778,974 (GRCm39) missense probably benign
IGL03116:Ninl APN 2 150,806,139 (GRCm39) missense probably damaging 1.00
IGL03396:Ninl APN 2 150,808,132 (GRCm39) missense possibly damaging 0.88
R0117:Ninl UTSW 2 150,779,593 (GRCm39) missense probably damaging 0.98
R0685:Ninl UTSW 2 150,781,775 (GRCm39) missense possibly damaging 0.73
R0928:Ninl UTSW 2 150,805,395 (GRCm39) missense probably damaging 0.99
R1051:Ninl UTSW 2 150,812,046 (GRCm39) missense probably damaging 1.00
R1441:Ninl UTSW 2 150,813,044 (GRCm39) missense probably benign 0.10
R1493:Ninl UTSW 2 150,822,015 (GRCm39) missense probably damaging 1.00
R1499:Ninl UTSW 2 150,822,096 (GRCm39) missense possibly damaging 0.70
R1539:Ninl UTSW 2 150,817,867 (GRCm39) missense probably damaging 1.00
R1658:Ninl UTSW 2 150,806,079 (GRCm39) missense probably damaging 1.00
R2156:Ninl UTSW 2 150,786,503 (GRCm39) missense probably damaging 1.00
R2232:Ninl UTSW 2 150,791,970 (GRCm39) missense probably benign 0.00
R2373:Ninl UTSW 2 150,822,037 (GRCm39) missense probably damaging 1.00
R3743:Ninl UTSW 2 150,792,168 (GRCm39) missense probably benign 0.01
R3906:Ninl UTSW 2 150,822,039 (GRCm39) missense probably damaging 1.00
R3950:Ninl UTSW 2 150,794,408 (GRCm39) missense possibly damaging 0.90
R4283:Ninl UTSW 2 150,795,336 (GRCm39) unclassified probably benign
R4798:Ninl UTSW 2 150,801,801 (GRCm39) nonsense probably null
R4963:Ninl UTSW 2 150,781,829 (GRCm39) missense probably benign 0.04
R4998:Ninl UTSW 2 150,795,284 (GRCm39) missense probably damaging 1.00
R5343:Ninl UTSW 2 150,813,110 (GRCm39) missense probably benign 0.01
R5810:Ninl UTSW 2 150,792,088 (GRCm39) missense probably benign 0.31
R5825:Ninl UTSW 2 150,782,644 (GRCm39) missense probably damaging 1.00
R6436:Ninl UTSW 2 150,808,098 (GRCm39) missense probably damaging 1.00
R6728:Ninl UTSW 2 150,817,777 (GRCm39) nonsense probably null
R6734:Ninl UTSW 2 150,787,003 (GRCm39) critical splice donor site probably null
R6997:Ninl UTSW 2 150,808,145 (GRCm39) missense probably benign 0.08
R7135:Ninl UTSW 2 150,797,524 (GRCm39) missense probably benign 0.00
R7157:Ninl UTSW 2 150,791,263 (GRCm39) missense possibly damaging 0.63
R7315:Ninl UTSW 2 150,791,970 (GRCm39) missense probably benign 0.00
R7840:Ninl UTSW 2 150,808,016 (GRCm39) missense probably benign 0.00
R8134:Ninl UTSW 2 150,792,234 (GRCm39) missense probably benign 0.01
R8319:Ninl UTSW 2 150,801,827 (GRCm39) missense probably damaging 1.00
R8802:Ninl UTSW 2 150,777,172 (GRCm39) missense probably damaging 1.00
R8997:Ninl UTSW 2 150,801,816 (GRCm39) missense probably damaging 0.98
R9231:Ninl UTSW 2 150,792,129 (GRCm39) missense probably benign
R9465:Ninl UTSW 2 150,782,726 (GRCm39) missense possibly damaging 0.83
R9474:Ninl UTSW 2 150,782,726 (GRCm39) missense probably benign 0.27
R9571:Ninl UTSW 2 150,791,803 (GRCm39) missense probably benign
R9789:Ninl UTSW 2 150,791,701 (GRCm39) missense probably benign 0.05
X0062:Ninl UTSW 2 150,811,966 (GRCm39) missense probably damaging 1.00
Z1177:Ninl UTSW 2 150,795,318 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AACAATGCAAGTCGCCCAGG -3'
(R):5'- AATCGTCCAGCCTCTAAGGGAG -3'

Sequencing Primer
(F):5'- AAGTCGCCCAGGAACTTG -3'
(R):5'- GCCTGCATCTAGCCCTACAG -3'
Posted On 2014-08-25