Incidental Mutation 'R2000:Zfp101'
ID 225866
Institutional Source Beutler Lab
Gene Symbol Zfp101
Ensembl Gene ENSMUSG00000055240
Gene Name zinc finger protein 101
Synonyms
MMRRC Submission 040010-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.056) question?
Stock # R2000 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 33599148-33613593 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 33600491 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Threonine at position 422 (A422T)
Ref Sequence ENSEMBL: ENSMUSP00000132508 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000167107] [ENSMUST00000174417] [ENSMUST00000174512]
AlphaFold Q8BP18
Predicted Effect possibly damaging
Transcript: ENSMUST00000167107
AA Change: A422T

PolyPhen 2 Score 0.922 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000132508
Gene: ENSMUSG00000055240
AA Change: A422T

DomainStartEndE-ValueType
KRAB 10 62 9.34e-15 SMART
ZnF_C2H2 219 241 2.57e-3 SMART
ZnF_C2H2 247 269 6.32e-3 SMART
ZnF_C2H2 275 297 3.16e-3 SMART
ZnF_C2H2 302 322 1.65e2 SMART
ZnF_C2H2 330 352 6.75e0 SMART
ZnF_C2H2 358 380 2.75e-3 SMART
ZnF_C2H2 386 408 4.47e-3 SMART
ZnF_C2H2 414 436 2.09e-3 SMART
ZnF_C2H2 442 464 4.79e-3 SMART
ZnF_C2H2 470 492 2.2e-2 SMART
ZnF_C2H2 498 520 4.47e-3 SMART
ZnF_C2H2 526 548 4.72e-2 SMART
ZnF_C2H2 554 576 1.28e-3 SMART
ZnF_C2H2 583 605 5.06e-2 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000173151
Predicted Effect probably benign
Transcript: ENSMUST00000174417
SMART Domains Protein: ENSMUSP00000134459
Gene: ENSMUSG00000055240

DomainStartEndE-ValueType
Blast:KRAB 1 38 5e-16 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000174512
SMART Domains Protein: ENSMUSP00000133873
Gene: ENSMUSG00000055240

DomainStartEndE-ValueType
KRAB 10 62 9.34e-15 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000183047
Meta Mutation Damage Score 0.0849 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.0%
Validation Efficiency 98% (62/63)
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atf2 T C 2: 73,693,584 (GRCm39) probably null Het
Atrn T C 2: 130,777,508 (GRCm39) Y186H probably damaging Het
Birc6 T C 17: 74,911,614 (GRCm39) V1528A possibly damaging Het
Brpf3 A C 17: 29,040,531 (GRCm39) E984A probably benign Het
Btnl9 T C 11: 49,059,948 (GRCm39) N600S probably benign Het
Camk1d A T 2: 5,366,836 (GRCm39) Y126* probably null Het
Casp8ap2 T A 4: 32,634,874 (GRCm39) L136H probably damaging Het
Cd46 A G 1: 194,760,012 (GRCm39) I280T probably benign Het
Cip2a A T 16: 48,835,332 (GRCm39) Q699L probably damaging Het
Crebbp A T 16: 3,902,116 (GRCm39) H2374Q probably damaging Het
Dock3 A G 9: 106,870,160 (GRCm39) probably benign Het
Dph7 T A 2: 24,861,653 (GRCm39) D355E probably benign Het
Dync1li1 C A 9: 114,542,631 (GRCm39) F264L probably benign Het
Fer1l6 G A 15: 58,474,160 (GRCm39) probably benign Het
Flt3 T C 5: 147,278,048 (GRCm39) D842G probably damaging Het
Fosl1 A G 19: 5,500,383 (GRCm39) probably benign Het
Gabrr2 T A 4: 33,084,400 (GRCm39) I162N probably damaging Het
Gata6 T C 18: 11,054,113 (GRCm39) F14S probably benign Het
Gm15446 T C 5: 110,090,677 (GRCm39) S310P possibly damaging Het
Gmppa A C 1: 75,418,172 (GRCm39) D190A probably damaging Het
Gpr108 C T 17: 57,543,712 (GRCm39) G455S probably benign Het
Gstm1 A G 3: 107,922,127 (GRCm39) F170S probably damaging Het
Gvin-ps6 G A 7: 106,022,438 (GRCm39) S188L probably benign Het
Gzf1 T C 2: 148,526,531 (GRCm39) I334T probably benign Het
Hadh A T 3: 131,038,888 (GRCm39) I156K probably benign Het
Htr5a G A 5: 28,055,887 (GRCm39) V293M possibly damaging Het
Ice1 C T 13: 70,750,546 (GRCm39) V47M possibly damaging Het
Ifnl3 G T 7: 28,222,354 (GRCm39) A32S possibly damaging Het
Itsn2 T A 12: 4,716,176 (GRCm39) Y978* probably null Het
Kif1a G T 1: 92,982,051 (GRCm39) T792N probably damaging Het
Lgals9 T C 11: 78,863,996 (GRCm39) N50D probably benign Het
Lrp2 A G 2: 69,297,434 (GRCm39) Y3176H probably damaging Het
Lvrn A T 18: 47,038,374 (GRCm39) N976I probably benign Het
Magea10 A T X: 71,426,379 (GRCm39) I205K probably benign Het
Myo1c A T 11: 75,561,405 (GRCm39) M820L probably damaging Het
Neb A T 2: 52,102,982 (GRCm39) C4222* probably null Het
Nkain2 T A 10: 32,766,281 (GRCm39) probably benign Het
Or10g6 A G 9: 39,933,985 (GRCm39) I99V probably benign Het
Or3a1b A G 11: 74,012,406 (GRCm39) Y97C probably benign Het
Or5d16 G A 2: 87,773,490 (GRCm39) L161F probably benign Het
Parp4 C T 14: 56,851,181 (GRCm39) T728M probably damaging Het
Pnma8a T A 7: 16,694,964 (GRCm39) V273D probably benign Het
Ppp1r9b A G 11: 94,887,446 (GRCm39) E486G probably damaging Het
Pth2 C A 7: 44,831,146 (GRCm39) R98S possibly damaging Het
Ramacl A T 13: 67,056,214 (GRCm39) N69I possibly damaging Het
Rif1 T A 2: 51,971,310 (GRCm39) F263I probably damaging Het
Rnf213 A T 11: 119,326,848 (GRCm39) I1613F probably damaging Het
Rsbn1l G A 5: 21,107,368 (GRCm39) H549Y probably damaging Het
Rtl1 C A 12: 109,560,321 (GRCm39) W506L probably damaging Het
Slc4a4 C T 5: 89,176,206 (GRCm39) P59L probably damaging Het
Smarcad1 A G 6: 65,050,200 (GRCm39) E273G probably damaging Het
Tectb C G 19: 55,169,431 (GRCm39) probably benign Het
Ttf1 T A 2: 28,955,197 (GRCm39) L187Q possibly damaging Het
Ttn A T 2: 76,800,047 (GRCm39) I387N probably damaging Het
Ufsp1 T C 5: 137,293,166 (GRCm39) probably null Het
Uox A C 3: 146,316,154 (GRCm39) K30Q possibly damaging Het
Ush1c A G 7: 45,870,857 (GRCm39) S327P probably damaging Het
Wwc1 A T 11: 35,767,374 (GRCm39) L419Q probably damaging Het
Xrn1 C T 9: 95,927,616 (GRCm39) Q1463* probably null Het
Yeats2 G A 16: 20,005,141 (GRCm39) A393T probably benign Het
Other mutations in Zfp101
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0189:Zfp101 UTSW 17 33,601,213 (GRCm39) missense possibly damaging 0.53
R0254:Zfp101 UTSW 17 33,599,952 (GRCm39) missense possibly damaging 0.71
R0448:Zfp101 UTSW 17 33,601,295 (GRCm39) missense possibly damaging 0.73
R0696:Zfp101 UTSW 17 33,600,401 (GRCm39) missense possibly damaging 0.86
R0834:Zfp101 UTSW 17 33,601,418 (GRCm39) missense probably benign 0.33
R2366:Zfp101 UTSW 17 33,599,972 (GRCm39) missense probably benign 0.06
R2471:Zfp101 UTSW 17 33,599,950 (GRCm39) missense possibly damaging 0.85
R3713:Zfp101 UTSW 17 33,600,880 (GRCm39) missense probably benign 0.05
R3857:Zfp101 UTSW 17 33,601,405 (GRCm39) nonsense probably null
R4537:Zfp101 UTSW 17 33,601,466 (GRCm39) missense possibly damaging 0.87
R4712:Zfp101 UTSW 17 33,613,457 (GRCm39) splice site probably null
R5049:Zfp101 UTSW 17 33,600,872 (GRCm39) missense possibly damaging 0.71
R5241:Zfp101 UTSW 17 33,601,210 (GRCm39) missense probably benign
R5499:Zfp101 UTSW 17 33,601,318 (GRCm39) missense probably benign 0.20
R5587:Zfp101 UTSW 17 33,600,295 (GRCm39) missense possibly damaging 0.71
R5694:Zfp101 UTSW 17 33,599,919 (GRCm39) missense probably benign
R5994:Zfp101 UTSW 17 33,599,936 (GRCm39) missense probably benign
R6193:Zfp101 UTSW 17 33,600,720 (GRCm39) nonsense probably null
R7331:Zfp101 UTSW 17 33,601,559 (GRCm39) missense possibly damaging 0.53
R7393:Zfp101 UTSW 17 33,605,674 (GRCm39) missense possibly damaging 0.71
R7434:Zfp101 UTSW 17 33,600,564 (GRCm39) missense possibly damaging 0.86
R7922:Zfp101 UTSW 17 33,600,511 (GRCm39) missense possibly damaging 0.93
R8087:Zfp101 UTSW 17 33,599,977 (GRCm39) missense probably benign
R8684:Zfp101 UTSW 17 33,600,977 (GRCm39) missense possibly damaging 0.86
R9443:Zfp101 UTSW 17 33,601,418 (GRCm39) missense probably benign 0.33
R9581:Zfp101 UTSW 17 33,605,730 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- CATGCTTAAGGAAATTACCACAGTAAG -3'
(R):5'- CCCAGTGACTATAATAGTTGTGAAAG -3'

Sequencing Primer
(F):5'- GGTTTTCCCACAAAGGTTACACG -3'
(R):5'- TATGTAAGAAATGTGGGAAAGCCTTC -3'
Posted On 2014-08-25