Mutagenetix > Incidental Mutation

Incidental Mutation 'R0691:Dera'

226037

Institutional Source

Beutler Lab

Gene Symbol

Dera

Ensembl Gene

ENSMUSG00000030225

Gene Name

deoxyribose-phosphate aldolase

Synonyms

2500002K03Rik, 2010002D22Rik

MMRRC Submission

038876-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R0691 (G1)

Quality Score

Status

Validated

Chromosome

Chromosomal Location

137731093-137814894 bp(+) (GRCm39)

Type of Mutation

intron

DNA Base Change (assembly)

T to C at 137773745 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s): [ENSMUST00000087675] [ENSMUST00000203216] [ENSMUST00000203693]

AlphaFold

Q91YP3

Predicted Effect

probably benign
Transcript: ENSMUST00000087675

SMART Domains

Protein: ENSMUSP00000084959
Gene: ENSMUSG00000030225

Domain	Start	End	E-Value	Type
DeoC	49	299	1.16e-79	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000203216

SMART Domains

Protein: ENSMUSP00000145264
Gene: ENSMUSG00000030225

Domain	Start	End	E-Value	Type
Pfam:DeoC	2	97	1e-6	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000203693

SMART Domains

Protein: ENSMUSP00000144935
Gene: ENSMUSG00000030225

Domain	Start	End	E-Value	Type
DeoC	49	271	4.4e-50	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000204356

Predicted Effect

probably benign
Transcript: ENSMUST00000204779

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000204976

Coding Region Coverage

1x: 99.3%
3x: 98.8%
10x: 97.5%
20x: 95.4%

Validation Efficiency

97% (58/60)

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc9	T	C	6: 142,584,979 (GRCm39)	D865G	possibly damaging	Het
Acy1	A	T	9: 106,313,070 (GRCm39)		probably null	Het
Adcy4	A	T	14: 56,010,104 (GRCm39)		probably benign	Het
Anpep	T	G	7: 79,489,047 (GRCm39)	D347A	probably damaging	Het
Arhgap28	C	T	17: 68,203,159 (GRCm39)		probably null	Het
Ccdc32	A	G	2: 118,857,610 (GRCm39)		probably benign	Het
Cdc42bpa	A	G	1: 179,972,400 (GRCm39)	T1401A	possibly damaging	Het
Celsr2	A	G	3: 108,319,939 (GRCm39)	Y958H	probably damaging	Het
Cenpe	A	G	3: 134,923,066 (GRCm39)	E137G	probably damaging	Het
Chd8	T	C	14: 52,450,890 (GRCm39)	D1399G	probably damaging	Het
Cntn3	T	C	6: 102,145,908 (GRCm39)	T978A	possibly damaging	Het
Col10a1	A	G	10: 34,271,692 (GRCm39)	T555A	possibly damaging	Het
Crybg3	A	C	16: 59,385,574 (GRCm39)		probably null	Het
Cts7	A	G	13: 61,503,548 (GRCm39)	F139L	probably damaging	Het
Dgka	A	G	10: 128,559,129 (GRCm39)		probably benign	Het
Dhrs7	T	A	12: 72,699,125 (GRCm39)	I286F	probably damaging	Het
Dtwd2	A	G	18: 49,861,424 (GRCm39)		probably benign	Het
Fermt1	A	G	2: 132,748,653 (GRCm39)	S657P	probably damaging	Het
Fhip2b	T	C	14: 70,825,727 (GRCm39)	D351G	probably damaging	Het
Flnb	T	C	14: 7,890,810 (GRCm38)	V564A	probably benign	Het
Garnl3	A	G	2: 32,975,919 (GRCm39)	F16L	probably damaging	Het
Gck	T	C	11: 5,856,691 (GRCm39)	R191G	probably damaging	Het
Gucy1b1	A	T	3: 81,952,941 (GRCm39)		probably benign	Het
Ifna2	A	C	4: 88,601,895 (GRCm39)	L41R	probably damaging	Het
Krt33a	T	G	11: 99,903,541 (GRCm39)	E197A	probably damaging	Het
Lce1e	G	A	3: 92,615,063 (GRCm39)	R95C	unknown	Het
Lct	G	T	1: 128,235,971 (GRCm39)	S345R	probably benign	Het
Lrp2	A	T	2: 69,281,724 (GRCm39)	N3882K	probably benign	Het
Mcc	G	T	18: 44,578,927 (GRCm39)	T652K	possibly damaging	Het
Mier1	A	G	4: 102,996,699 (GRCm39)	S109G	probably benign	Het
Nfat5	A	G	8: 108,082,237 (GRCm39)	N469S	probably damaging	Het
Or1e23	C	A	11: 73,407,670 (GRCm39)	M118I	possibly damaging	Het
Or6c214	G	A	10: 129,591,271 (GRCm39)	T16I	probably damaging	Het
Piwil1	G	T	5: 128,820,371 (GRCm39)	R256M	probably null	Het
Rgma	T	C	7: 73,059,160 (GRCm39)	V88A	probably damaging	Het
Sdk2	T	C	11: 113,685,746 (GRCm39)		probably null	Het
Sec22b	A	G	3: 97,819,990 (GRCm39)	E94G	probably damaging	Het
Snrnp70	T	C	7: 45,036,669 (GRCm39)	R131G	possibly damaging	Het
Spata31d1a	A	G	13: 59,848,199 (GRCm39)	S1310P	possibly damaging	Het
Spint1	A	G	2: 119,076,948 (GRCm39)	E344G	probably damaging	Het
Srrm1	G	A	4: 135,052,302 (GRCm39)	Q141*	probably null	Het
Tecta	A	T	9: 42,295,637 (GRCm39)	L286Q	probably damaging	Het
Tep1	T	A	14: 51,104,301 (GRCm39)	K198*	probably null	Het
Tk2	A	G	8: 104,957,824 (GRCm39)	V174A	probably benign	Het
Txndc5	T	C	13: 38,691,872 (GRCm39)	K165E	probably damaging	Het
Ubr4	G	A	4: 139,151,217 (GRCm39)	R1884Q	probably damaging	Het
Vmn2r61	T	C	7: 41,949,844 (GRCm39)	Y755H	probably damaging	Het
Xrn1	T	A	9: 95,855,592 (GRCm39)	H296Q	probably damaging	Het
Zar1l	A	T	5: 150,436,407 (GRCm39)	V223D	probably damaging	Het

Other mutations in Dera

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02134:Dera	APN	6	137,807,269 (GRCm39)	missense	probably damaging	1.00
IGL02220:Dera	APN	6	137,757,815 (GRCm39)	splice site	probably null
IGL02449:Dera	APN	6	137,757,815 (GRCm39)	splice site	probably null
IGL03256:Dera	APN	6	137,756,643 (GRCm39)	missense	probably benign	0.00
R0644:Dera	UTSW	6	137,760,046 (GRCm39)	missense	probably benign	0.10
R0733:Dera	UTSW	6	137,773,846 (GRCm39)	missense	probably damaging	1.00
R1478:Dera	UTSW	6	137,807,193 (GRCm39)	missense	possibly damaging	0.91
R3950:Dera	UTSW	6	137,814,118 (GRCm39)	missense	probably damaging	0.99
R3951:Dera	UTSW	6	137,814,118 (GRCm39)	missense	probably damaging	0.99
R3952:Dera	UTSW	6	137,814,118 (GRCm39)	missense	probably damaging	0.99
R4561:Dera	UTSW	6	137,757,736 (GRCm39)	missense	possibly damaging	0.83
R7687:Dera	UTSW	6	137,813,878 (GRCm39)	missense
R7956:Dera	UTSW	6	137,813,826 (GRCm39)	missense	probably benign	0.02
R8676:Dera	UTSW	6	137,807,202 (GRCm39)	missense	probably damaging	1.00
R9600:Dera	UTSW	6	137,814,135 (GRCm39)	missense	probably benign	0.04
R9607:Dera	UTSW	6	137,833,732 (GRCm39)	missense	unknown
R9608:Dera	UTSW	6	137,813,876 (GRCm39)	missense	possibly damaging	0.81
Z1088:Dera	UTSW	6	137,814,116 (GRCm39)	missense	possibly damaging	0.87

Predicted Primers

PCR Primer
(F):5'- GTCAAACCAGGCACTGAATGTGAAC -3'
(R):5'- TGACGGTAGCACTTGCAATACCATC -3'

Sequencing Primer
(F):5'- GCACTGAATGTGAACTGTAGC -3'
(R):5'- TGCAATACCATCCAAATGCTTGTC -3'

Posted On

2014-09-10