Incidental Mutation 'R1354:Trdv1'
ID226094
Institutional Source Beutler Lab
Gene Symbol Trdv1
Ensembl Gene ENSMUSG00000076864
Gene NameT cell receptor delta variable 1
Synonyms
MMRRC Submission 039419-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.040) question?
Stock #R1354 (G1)
Quality Score225
Status Not validated
Chromosome14
Chromosomal Location53881532-53882216 bp(+) (GRCm38)
Type of Mutationintron
DNA Base Change (assembly) T to A at 53881918 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000139783 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103676] [ENSMUST00000103676] [ENSMUST00000187163]
Predicted Effect probably benign
Transcript: ENSMUST00000103676
SMART Domains Protein: ENSMUSP00000100453
Gene: ENSMUSG00000076864

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Pfam:ig 26 112 6.7e-7 PFAM
Pfam:V-set 26 112 1.6e-14 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000103676
SMART Domains Protein: ENSMUSP00000100453
Gene: ENSMUSG00000076864

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Pfam:ig 26 112 6.7e-7 PFAM
Pfam:V-set 26 112 1.6e-14 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000187163
SMART Domains Protein: ENSMUSP00000139783
Gene: ENSMUSG00000076864

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
IG_like 37 110 6.4e-5 SMART
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 95.9%
  • 20x: 92.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 20 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atoh1 A G 6: 64,729,357 E12G possibly damaging Het
Ccdc183 T C 2: 25,612,139 N241S probably benign Het
Cmya5 G A 13: 93,092,058 T2174I possibly damaging Het
Edem1 A G 6: 108,854,316 I579M possibly damaging Het
Gimap9 A T 6: 48,678,048 M190L probably benign Het
Glod4 A T 11: 76,237,828 probably null Het
Ighv8-6 A T 12: 115,166,080 S19T probably damaging Het
Lef1 C T 3: 131,194,668 P267S probably damaging Het
Megf11 A G 9: 64,653,177 E335G probably benign Het
Muc5ac A G 7: 141,807,377 N1475S probably damaging Het
Ndst2 C A 14: 20,724,975 R749L possibly damaging Het
Oas3 C A 5: 120,770,000 V292L possibly damaging Het
Phactr1 A T 13: 43,057,331 I210F possibly damaging Het
Plppr5 G A 3: 117,575,847 R51H possibly damaging Het
Ppp1r12b G A 1: 134,835,983 T771M probably benign Het
Rasgrf2 G A 13: 92,028,666 P331S probably damaging Het
Rtl6 C T 15: 84,556,527 V223M probably damaging Het
Tbc1d9 A C 8: 83,268,981 probably null Het
Tgm3 T C 2: 130,041,898 I492T probably benign Het
Wdr45b A T 11: 121,335,430 I191N probably damaging Het
Other mutations in Trdv1
AlleleSourceChrCoordTypePredicted EffectPPH Score
R2091:Trdv1 UTSW 14 53882169 missense probably benign 0.11
R4903:Trdv1 UTSW 14 53881918 intron probably benign
R5519:Trdv1 UTSW 14 53881948 missense probably benign
R6077:Trdv1 UTSW 14 53882056 missense probably benign 0.04
Predicted Primers
Posted On2014-09-11