Incidental Mutation 'R1557:Kremen1'
ID 226108
Institutional Source Beutler Lab
Gene Symbol Kremen1
Ensembl Gene ENSMUSG00000020393
Gene Name kringle containing transmembrane protein 1
Synonyms Krm1
MMRRC Submission 039596-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.124) question?
Stock # R1557 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 5141552-5211558 bp(-) (GRCm39)
Type of Mutation splice site (34 bp from exon)
DNA Base Change (assembly) T to C at 5165373 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000020662]
AlphaFold Q99N43
Predicted Effect probably null
Transcript: ENSMUST00000020662
SMART Domains Protein: ENSMUSP00000020662
Gene: ENSMUSG00000020393

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
KR 30 116 9.81e-23 SMART
Pfam:WSC 119 200 3.7e-21 PFAM
CUB 214 321 4.27e-19 SMART
transmembrane domain 391 413 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000151978
SMART Domains Protein: ENSMUSP00000121252
Gene: ENSMUSG00000020393

DomainStartEndE-ValueType
Pfam:WSC 17 98 2.3e-22 PFAM
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.2%
  • 10x: 95.9%
  • 20x: 91.1%
Validation Efficiency 96% (75/78)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null allele exhibit no abnormal phenotype. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700019A02Rik A C 1: 53,221,025 (GRCm39) D68E possibly damaging Het
Abca3 T C 17: 24,618,954 (GRCm39) V870A possibly damaging Het
Aldh3a2 A T 11: 61,139,885 (GRCm39) F416I probably damaging Het
Armc6 A T 8: 70,678,098 (GRCm39) L77Q possibly damaging Het
Asb17 A G 3: 153,556,570 (GRCm39) I226V probably benign Het
Aspm A G 1: 139,396,406 (GRCm39) I862V probably benign Het
Atr T A 9: 95,753,502 (GRCm39) D701E probably damaging Het
Baz1b C T 5: 135,247,097 (GRCm39) L849F possibly damaging Het
Cbr1 T C 16: 93,405,677 (GRCm39) V97A probably benign Het
Cep295 G A 9: 15,243,306 (GRCm39) Q1669* probably null Het
Cfap54 T C 10: 92,820,089 (GRCm39) T1242A possibly damaging Het
Chrm3 T A 13: 9,928,350 (GRCm39) T229S possibly damaging Het
Cimip4 C A 15: 78,270,474 (GRCm39) R98M probably damaging Het
Cnga3 A G 1: 37,300,066 (GRCm39) Y300C probably damaging Het
Col14a1 A C 15: 55,251,975 (GRCm39) I544L unknown Het
Crocc T C 4: 140,752,776 (GRCm39) E1208G probably damaging Het
Cyp2j8 A T 4: 96,358,713 (GRCm39) probably benign Het
Dcbld2 T C 16: 58,285,713 (GRCm39) I624T possibly damaging Het
Ddah1 A C 3: 145,597,227 (GRCm39) I258L probably benign Het
Dnah6 G A 6: 73,026,114 (GRCm39) Q3460* probably null Het
Dync2h1 T A 9: 7,140,911 (GRCm39) D1372V probably damaging Het
Egln1 G A 8: 125,674,980 (GRCm39) R272* probably null Het
Elf1 A G 14: 79,804,620 (GRCm39) D95G possibly damaging Het
Fkbp5 A G 17: 28,621,729 (GRCm39) F374L probably damaging Het
Fli1 T C 9: 32,372,540 (GRCm39) probably benign Het
Gabbr2 T C 4: 46,846,436 (GRCm39) T158A probably damaging Het
Gp2 A C 7: 119,049,302 (GRCm39) Y412D probably damaging Het
Hmcn1 A G 1: 150,610,283 (GRCm39) V1462A possibly damaging Het
Ide T C 19: 37,258,160 (GRCm39) probably null Het
Kalrn T C 16: 34,134,648 (GRCm39) K372R possibly damaging Het
Kcnj16 A G 11: 110,916,067 (GRCm39) D243G possibly damaging Het
Kif7 A G 7: 79,363,905 (GRCm39) M1T probably null Het
Klri2 A T 6: 129,709,174 (GRCm39) L226Q probably damaging Het
Lama3 T C 18: 12,646,788 (GRCm39) probably benign Het
Lmln C A 16: 32,908,581 (GRCm39) R336S probably benign Het
Lrch4 T A 5: 137,635,818 (GRCm39) D266E probably benign Het
Lrrc28 C T 7: 67,209,677 (GRCm39) R174H probably damaging Het
Mib1 T A 18: 10,798,474 (GRCm39) D778E probably damaging Het
Msra T C 14: 64,360,775 (GRCm39) I125V possibly damaging Het
Or10c1 A G 17: 37,522,244 (GRCm39) F167L probably damaging Het
Or4k37 T A 2: 111,158,964 (GRCm39) S67T probably damaging Het
Or4p19 A T 2: 88,242,555 (GRCm39) V149E possibly damaging Het
Or52e18 A G 7: 104,609,747 (GRCm39) F64S probably damaging Het
Or6c75 C A 10: 129,337,491 (GRCm39) T246N probably damaging Het
Or8d23 A G 9: 38,841,955 (GRCm39) M163V possibly damaging Het
Pes1 T A 11: 3,926,824 (GRCm39) Y369N probably damaging Het
Pgam2 T C 11: 5,751,773 (GRCm39) D221G possibly damaging Het
Prl2c5 T C 13: 13,365,265 (GRCm39) V137A possibly damaging Het
Rasal1 T A 5: 120,814,914 (GRCm39) D721E possibly damaging Het
Sass6 G T 3: 116,412,381 (GRCm39) E385D possibly damaging Het
Sema5a A G 15: 32,460,418 (GRCm39) R60G probably benign Het
Sesn1 T C 10: 41,779,762 (GRCm39) S399P probably damaging Het
Skic2 G A 17: 35,067,398 (GRCm39) L47F probably damaging Het
Slc10a2 C T 8: 5,141,755 (GRCm39) V210M probably damaging Het
Slc8a3 C T 12: 81,362,331 (GRCm39) G163S probably damaging Het
Sorbs2 T C 8: 46,212,234 (GRCm39) probably benign Het
Speer4f1 T C 5: 17,684,490 (GRCm39) W173R probably damaging Het
Spon2 C A 5: 33,374,108 (GRCm39) G92W probably damaging Het
Sycp2 A T 2: 178,037,009 (GRCm39) probably benign Het
Tfb1m A G 17: 3,605,241 (GRCm39) V84A probably damaging Het
Tmem18 G T 12: 30,637,198 (GRCm39) probably null Het
Tom1l1 A G 11: 90,547,210 (GRCm39) L290S possibly damaging Het
Tube1 T G 10: 39,021,711 (GRCm39) probably null Het
Ugt2b35 T A 5: 87,155,156 (GRCm39) probably null Het
Unc93b1 T A 19: 3,992,403 (GRCm39) Y269N probably benign Het
Usp16 T C 16: 87,259,030 (GRCm39) probably null Het
Vmn1r38 A T 6: 66,753,370 (GRCm39) S249T probably benign Het
Vmn1r42 T A 6: 89,821,733 (GRCm39) M279L possibly damaging Het
Zdhhc23 T A 16: 43,791,829 (GRCm39) T315S possibly damaging Het
Zfp472 T C 17: 33,194,900 (GRCm39) F12L probably benign Het
Zfr2 T C 10: 81,083,225 (GRCm39) S634P probably benign Het
Other mutations in Kremen1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01813:Kremen1 APN 11 5,149,667 (GRCm39) missense probably benign 0.00
R0038:Kremen1 UTSW 11 5,157,703 (GRCm39) splice site probably benign
R0511:Kremen1 UTSW 11 5,165,447 (GRCm39) missense probably damaging 1.00
R1579:Kremen1 UTSW 11 5,151,791 (GRCm39) unclassified probably benign
R1729:Kremen1 UTSW 11 5,151,791 (GRCm39) unclassified probably benign
R1784:Kremen1 UTSW 11 5,151,792 (GRCm39) unclassified probably benign
R1800:Kremen1 UTSW 11 5,151,791 (GRCm39) unclassified probably benign
R2079:Kremen1 UTSW 11 5,151,794 (GRCm39) frame shift probably null
R2100:Kremen1 UTSW 11 5,151,788 (GRCm39) unclassified probably benign
R2286:Kremen1 UTSW 11 5,151,791 (GRCm39) unclassified probably benign
R2298:Kremen1 UTSW 11 5,151,788 (GRCm39) unclassified probably benign
R2352:Kremen1 UTSW 11 5,151,791 (GRCm39) unclassified probably benign
R2512:Kremen1 UTSW 11 5,151,791 (GRCm39) unclassified probably benign
R2761:Kremen1 UTSW 11 5,151,792 (GRCm39) unclassified probably benign
R2846:Kremen1 UTSW 11 5,151,793 (GRCm39) unclassified probably benign
R2882:Kremen1 UTSW 11 5,151,791 (GRCm39) unclassified probably benign
R2944:Kremen1 UTSW 11 5,151,791 (GRCm39) unclassified probably benign
R2980:Kremen1 UTSW 11 5,151,794 (GRCm39) unclassified probably benign
R3151:Kremen1 UTSW 11 5,145,012 (GRCm39) missense probably damaging 0.99
R3610:Kremen1 UTSW 11 5,151,791 (GRCm39) unclassified probably benign
R3831:Kremen1 UTSW 11 5,151,794 (GRCm39) unclassified probably benign
R3957:Kremen1 UTSW 11 5,151,791 (GRCm39) unclassified probably benign
R4231:Kremen1 UTSW 11 5,193,881 (GRCm39) nonsense probably null
R4397:Kremen1 UTSW 11 5,149,610 (GRCm39) missense probably benign 0.36
R5627:Kremen1 UTSW 11 5,149,709 (GRCm39) missense probably benign 0.01
R6818:Kremen1 UTSW 11 5,145,051 (GRCm39) missense probably benign 0.02
R7584:Kremen1 UTSW 11 5,144,964 (GRCm39) missense possibly damaging 0.95
R8803:Kremen1 UTSW 11 5,144,981 (GRCm39) missense probably benign 0.01
T0975:Kremen1 UTSW 11 5,145,105 (GRCm39) missense probably benign 0.02
Y4339:Kremen1 UTSW 11 5,151,791 (GRCm39) unclassified probably benign
Predicted Primers
Posted On 2014-09-12