Incidental Mutation 'R0656:Lpar3'
ID 226134
Institutional Source Beutler Lab
Gene Symbol Lpar3
Ensembl Gene ENSMUSG00000036832
Gene Name lysophosphatidic acid receptor 3
Synonyms Edg7, LPA3
MMRRC Submission 038841-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0656 (G1)
Quality Score 22
Status Validated
Chromosome 3
Chromosomal Location 145926718-145991941 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 145946426 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Serine at position 35 (C35S)
Ref Sequence ENSEMBL: ENSMUSP00000037712 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039164]
AlphaFold Q9EQ31
Predicted Effect possibly damaging
Transcript: ENSMUST00000039164
AA Change: C35S

PolyPhen 2 Score 0.539 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000037712
Gene: ENSMUSG00000036832
AA Change: C35S

DomainStartEndE-ValueType
Pfam:7tm_1 47 293 2.4e-37 PFAM
Meta Mutation Damage Score 0.0886 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.3%
  • 20x: 94.2%
Validation Efficiency 98% (92/94)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null females produce smaller litter sizes and exhibit delayed implantation and altered embryo spacing that leads to delayed development of embryos and hypertrophic placentas that were shared by multiple embryos. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930533K18Rik T A 10: 70,704,630 (GRCm39) noncoding transcript Het
Alox5 A G 6: 116,400,291 (GRCm39) probably benign Het
Anxa11 T A 14: 25,874,421 (GRCm39) D203E probably damaging Het
Atp12a A T 14: 56,611,938 (GRCm39) N371Y probably damaging Het
Bloc1s6 A G 2: 122,584,543 (GRCm39) I39M probably benign Het
Celsr3 A C 9: 108,711,854 (GRCm39) I1688L possibly damaging Het
Cgn T C 3: 94,682,204 (GRCm39) probably benign Het
Chd4 A T 6: 125,079,930 (GRCm39) I453F probably damaging Het
Dbnl A G 11: 5,747,321 (GRCm39) T247A probably benign Het
Dpysl3 T C 18: 43,571,136 (GRCm39) E46G possibly damaging Het
Dsg1a T C 18: 20,468,949 (GRCm39) probably benign Het
Fbp1 C T 13: 63,019,099 (GRCm39) E150K probably benign Het
Flnb T A 14: 7,927,352 (GRCm38) L1854Q probably damaging Het
Gcn1 C T 5: 115,727,362 (GRCm39) T714M probably benign Het
Gm12216 A T 11: 53,704,162 (GRCm39) probably benign Het
Gpr82 T C X: 13,531,829 (GRCm39) S126P probably benign Het
Hmbs T A 9: 44,248,657 (GRCm39) H256L probably benign Het
Ibsp A T 5: 104,457,886 (GRCm39) probably null Het
Ints13 A G 6: 146,453,959 (GRCm39) V240A probably benign Het
Iqca1l C T 5: 24,754,760 (GRCm39) V337M possibly damaging Het
Kalrn T C 16: 33,852,837 (GRCm39) D343G probably damaging Het
Kin T C 2: 10,090,531 (GRCm39) probably benign Het
Klhdc1 T C 12: 69,304,804 (GRCm39) V192A probably benign Het
Lrrtm4 A G 6: 79,998,953 (GRCm39) I122V possibly damaging Het
Mfsd13a C T 19: 46,354,943 (GRCm39) T40I probably benign Het
Mgat4c T C 10: 102,224,452 (GRCm39) M222T probably damaging Het
Muc4 C A 16: 32,570,488 (GRCm39) S516Y possibly damaging Het
Myo1e A T 9: 70,274,956 (GRCm39) Q703L probably damaging Het
Neb A G 2: 52,115,570 (GRCm39) probably benign Het
Necab3 T G 2: 154,388,223 (GRCm39) E239A probably null Het
Npr1 G T 3: 90,368,676 (GRCm39) N461K probably benign Het
Or4k44 T C 2: 111,367,972 (GRCm39) I221V probably damaging Het
Pcdhb2 A G 18: 37,428,543 (GRCm39) Y172C probably damaging Het
Pcdhb7 A G 18: 37,474,954 (GRCm39) D30G probably benign Het
Phf12 A C 11: 77,920,158 (GRCm39) Q898P probably benign Het
Plekhn1 T C 4: 156,309,821 (GRCm39) E132G possibly damaging Het
Ptpn3 A G 4: 57,270,075 (GRCm39) V29A probably benign Het
Rundc3b T A 5: 8,619,529 (GRCm39) I143F probably damaging Het
Ryr3 T G 2: 112,478,651 (GRCm39) probably benign Het
Sash1 A G 10: 8,626,901 (GRCm39) probably null Het
Slc4a2 A G 5: 24,636,257 (GRCm39) D201G probably benign Het
Tecpr1 T A 5: 144,150,871 (GRCm39) probably null Het
Timm21 T C 18: 84,967,326 (GRCm39) H150R probably damaging Het
Tmem79 T C 3: 88,240,241 (GRCm39) T236A probably damaging Het
Usp34 G T 11: 23,422,967 (GRCm39) V3095F probably damaging Het
Vmn1r8 A T 6: 57,013,573 (GRCm39) Q208L probably benign Het
Other mutations in Lpar3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02444:Lpar3 APN 3 145,946,949 (GRCm39) missense probably damaging 1.00
R0893:Lpar3 UTSW 3 145,946,348 (GRCm39) missense possibly damaging 0.82
R1809:Lpar3 UTSW 3 145,946,303 (GRCm39) splice site probably benign
R4937:Lpar3 UTSW 3 145,990,506 (GRCm39) missense probably damaging 0.98
R6116:Lpar3 UTSW 3 145,946,352 (GRCm39) missense possibly damaging 0.70
R6587:Lpar3 UTSW 3 145,946,918 (GRCm39) missense probably damaging 1.00
R7232:Lpar3 UTSW 3 145,947,061 (GRCm39) critical splice donor site probably null
R8029:Lpar3 UTSW 3 145,946,718 (GRCm39) missense probably benign 0.01
R8266:Lpar3 UTSW 3 145,946,385 (GRCm39) missense probably benign 0.02
R9676:Lpar3 UTSW 3 145,990,434 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TCCAGAGTGATGATGCCAGTCTCC -3'
(R):5'- CAAGTTGCTGTGGACTCTCATCCTC -3'

Sequencing Primer
(F):5'- GATGATGCCAGTCTCCCTGTG -3'
(R):5'- GACGGTCAACGTTTTCGACAC -3'
Posted On 2014-09-17