Incidental Mutation 'R2049:Jmjd1c'
| ID |
226241 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Jmjd1c
|
| Ensembl Gene |
ENSMUSG00000037876 |
| Gene Name |
jumonji domain containing 1C |
| Synonyms |
D630035I23Rik, TRIP8, 5430433L24Rik |
| MMRRC Submission |
040056-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.655)
|
| Stock # |
R2049 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
10 |
| Chromosomal Location |
66932189-67092105 bp(+) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
T to A
at 66993777 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Stop codon
at position 86
(L86*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000134551
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000051446]
[ENSMUST00000174317]
[ENSMUST00000174408]
|
| AlphaFold |
Q69ZK6 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000051446
AA Change: L86*
|
| SMART Domains |
Protein: ENSMUSP00000056227
Gene: ENSMUSG00000037876
AA Change: L86*
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:JmjC
|
143 |
2236 |
N/A |
BLAST |
|
JmjC
|
2264 |
2488 |
3.29e-53 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000173295
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000174062
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000174317
|
| SMART Domains |
Protein: ENSMUSP00000134246
Gene: ENSMUSG00000037876
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:JmjC
|
1 |
744 |
N/A |
BLAST |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000174408
AA Change: L86*
|
| SMART Domains |
Protein: ENSMUSP00000134551
Gene: ENSMUSG00000037876
AA Change: L86*
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:JmjC
|
143 |
2237 |
N/A |
BLAST |
|
JmjC
|
2265 |
2489 |
3.29e-53 |
SMART |
|
| Meta Mutation Damage Score |
0.9755 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 95.3%
|
| Validation Efficiency |
97% (118/122) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene interacts with thyroid hormone receptors and contains a jumonji domain. It is a candidate histone demethylase and is thought to be a coactivator for key transcription factors. It plays a role in the DNA-damage response pathway by demethylating the mediator of DNA damage checkpoint 1 (MDC1) protein, and is required for the survival of acute myeloid leukemia. Mutations in this gene are associated with Rett syndrome and intellectual disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
PHENOTYPE: Mice homozygous for a null allele exhibit an age-dependent male infertility phenotype, characterized by early loss of undifferentiated spermatogonia, and a progressive reduction in testis size/weight and male germ cells, partly due to increased male germ cell apoptosis. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 118 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4931414P19Rik |
G |
A |
14: 54,822,444 (GRCm39) |
R8* |
probably null |
Het |
| Abhd17a |
A |
G |
10: 80,421,440 (GRCm39) |
|
probably null |
Het |
| Acsm1 |
A |
G |
7: 119,255,262 (GRCm39) |
R415G |
probably damaging |
Het |
| Acta1 |
G |
T |
8: 124,618,803 (GRCm39) |
T360N |
probably benign |
Het |
| Adam6a |
T |
A |
12: 113,508,049 (GRCm39) |
S141T |
probably benign |
Het |
| Adgrd1 |
G |
T |
5: 129,192,159 (GRCm39) |
K76N |
probably benign |
Het |
| Afdn |
A |
G |
17: 14,030,695 (GRCm39) |
E202G |
probably damaging |
Het |
| Agps |
T |
A |
2: 75,689,270 (GRCm39) |
M156K |
probably benign |
Het |
| Agxt |
A |
G |
1: 93,065,037 (GRCm39) |
I149V |
probably benign |
Het |
| Aoc1l1 |
T |
A |
6: 48,954,689 (GRCm39) |
L609* |
probably null |
Het |
| Aqp2 |
A |
G |
15: 99,477,247 (GRCm39) |
T72A |
probably damaging |
Het |
| Arhgap18 |
T |
A |
10: 26,725,938 (GRCm39) |
D54E |
probably benign |
Het |
| Asb8 |
C |
A |
15: 98,033,950 (GRCm39) |
E202* |
probably null |
Het |
| Bmp5 |
A |
G |
9: 75,801,072 (GRCm39) |
I401V |
probably damaging |
Het |
| Bscl2 |
T |
C |
19: 8,822,684 (GRCm39) |
|
probably null |
Het |
| Capn9 |
G |
A |
8: 125,332,450 (GRCm39) |
G430R |
possibly damaging |
Het |
| Cd55 |
C |
T |
1: 130,377,160 (GRCm39) |
V333I |
probably benign |
Het |
| Cep112 |
A |
G |
11: 108,497,151 (GRCm39) |
E697G |
probably damaging |
Het |
| Cerk |
G |
A |
15: 86,027,009 (GRCm39) |
S167L |
probably benign |
Het |
| Chrm3 |
T |
A |
13: 9,928,371 (GRCm39) |
I222F |
probably damaging |
Het |
| Clcn6 |
A |
G |
4: 148,108,594 (GRCm39) |
F145S |
possibly damaging |
Het |
| Cnksr1 |
A |
G |
4: 133,956,939 (GRCm39) |
Y488H |
probably damaging |
Het |
| Cntrl |
CAGAG |
CAG |
2: 35,012,818 (GRCm39) |
|
probably null |
Het |
| Commd10 |
A |
T |
18: 47,096,814 (GRCm39) |
T74S |
probably benign |
Het |
| Cyp4f39 |
T |
C |
17: 32,701,112 (GRCm39) |
F201L |
probably benign |
Het |
| Dennd4a |
A |
G |
9: 64,796,887 (GRCm39) |
T860A |
possibly damaging |
Het |
| Dlg5 |
A |
T |
14: 24,204,715 (GRCm39) |
I1253N |
probably damaging |
Het |
| Dnah7b |
T |
A |
1: 46,307,830 (GRCm39) |
M3048K |
probably damaging |
Het |
| Dnah9 |
A |
G |
11: 65,935,509 (GRCm39) |
M1970T |
probably damaging |
Het |
| Dsc3 |
A |
T |
18: 20,122,737 (GRCm39) |
D62E |
possibly damaging |
Het |
| Dsel |
T |
C |
1: 111,787,187 (GRCm39) |
N1116S |
probably benign |
Het |
| Dusp7 |
C |
T |
9: 106,251,096 (GRCm39) |
T407M |
probably damaging |
Het |
| Efnb1 |
A |
G |
X: 98,191,123 (GRCm39) |
Y343C |
probably damaging |
Het |
| Eif1ad8 |
A |
G |
12: 87,564,046 (GRCm39) |
D127G |
unknown |
Het |
| Entpd5 |
A |
G |
12: 84,443,632 (GRCm39) |
I12T |
probably benign |
Het |
| Espn |
T |
C |
4: 152,205,714 (GRCm39) |
E408G |
probably damaging |
Het |
| Fhip1b |
A |
T |
7: 105,039,046 (GRCm39) |
D64E |
probably damaging |
Het |
| Gdpd3 |
A |
G |
7: 126,367,766 (GRCm39) |
T200A |
probably damaging |
Het |
| Gli1 |
A |
G |
10: 127,172,596 (GRCm39) |
L182P |
probably damaging |
Het |
| Gm5134 |
G |
A |
10: 75,840,718 (GRCm39) |
A521T |
possibly damaging |
Het |
| Gprasp1 |
G |
A |
X: 134,702,791 (GRCm39) |
E995K |
possibly damaging |
Het |
| H2-M10.1 |
T |
C |
17: 36,636,108 (GRCm39) |
D153G |
possibly damaging |
Het |
| Helb |
A |
T |
10: 119,941,926 (GRCm39) |
M254K |
possibly damaging |
Het |
| I0C0044D17Rik |
A |
G |
4: 98,708,533 (GRCm39) |
|
probably benign |
Het |
| Igfn1 |
AGGG |
AGG |
1: 135,902,590 (GRCm39) |
|
probably benign |
Het |
| Igfn1 |
T |
A |
1: 135,898,376 (GRCm39) |
Q730L |
probably benign |
Het |
| Ipo9 |
ATCCTCCTCCTCCTCCTC |
ATCCTCCTCCTCCTCCTCCTC |
1: 135,314,006 (GRCm39) |
|
probably benign |
Het |
| Ipo9 |
A |
G |
1: 135,329,988 (GRCm39) |
V484A |
probably benign |
Het |
| Kat5 |
T |
A |
19: 5,655,713 (GRCm39) |
|
probably null |
Het |
| Kif14 |
A |
G |
1: 136,414,818 (GRCm39) |
N768S |
probably benign |
Het |
| Kif14 |
A |
G |
1: 136,437,905 (GRCm39) |
E1199G |
possibly damaging |
Het |
| Klhl29 |
A |
G |
12: 5,187,876 (GRCm39) |
S163P |
probably damaging |
Het |
| Kmt2c |
C |
A |
5: 25,490,077 (GRCm39) |
Q4287H |
probably damaging |
Het |
| Krt82 |
T |
A |
15: 101,453,591 (GRCm39) |
Q265L |
probably damaging |
Het |
| Macf1 |
C |
T |
4: 123,248,895 (GRCm39) |
C7210Y |
probably damaging |
Het |
| Mx2 |
G |
A |
16: 97,339,903 (GRCm39) |
E20K |
probably benign |
Het |
| Myom2 |
T |
G |
8: 15,156,379 (GRCm39) |
I742S |
probably damaging |
Het |
| Narf |
A |
T |
11: 121,141,195 (GRCm39) |
R310* |
probably null |
Het |
| Nktr |
T |
A |
9: 121,570,760 (GRCm39) |
D167E |
probably damaging |
Het |
| Nle1 |
A |
G |
11: 82,796,192 (GRCm39) |
W183R |
probably damaging |
Het |
| Npas3 |
A |
G |
12: 54,108,871 (GRCm39) |
N425S |
probably damaging |
Het |
| Obsl1 |
G |
A |
1: 75,486,756 (GRCm38) |
T1764M |
probably benign |
Het |
| Optc |
A |
T |
1: 133,831,534 (GRCm39) |
|
probably null |
Het |
| Or4a27 |
A |
T |
2: 88,559,089 (GRCm39) |
Y285N |
probably damaging |
Het |
| Or4a68 |
C |
T |
2: 89,269,927 (GRCm39) |
R232H |
probably benign |
Het |
| Or4d5 |
T |
A |
9: 40,012,415 (GRCm39) |
I124L |
probably benign |
Het |
| Or6c69 |
A |
G |
10: 129,748,036 (GRCm39) |
V37A |
probably benign |
Het |
| Or8g52 |
A |
T |
9: 39,631,411 (GRCm39) |
D296V |
probably damaging |
Het |
| Or8s2 |
G |
A |
15: 98,276,277 (GRCm39) |
T238I |
possibly damaging |
Het |
| Otol1 |
T |
A |
3: 69,926,169 (GRCm39) |
F115I |
probably benign |
Het |
| Parp8 |
T |
A |
13: 117,031,422 (GRCm39) |
D430V |
probably benign |
Het |
| Pex7 |
T |
A |
10: 19,770,061 (GRCm39) |
H123L |
probably damaging |
Het |
| Pkhd1l1 |
T |
A |
15: 44,410,909 (GRCm39) |
|
probably benign |
Het |
| Pkhd1l1 |
G |
A |
15: 44,445,137 (GRCm39) |
D3670N |
probably damaging |
Het |
| Plec |
T |
C |
15: 76,067,374 (GRCm39) |
T1331A |
probably benign |
Het |
| Plekha4 |
A |
G |
7: 45,203,222 (GRCm39) |
D704G |
probably benign |
Het |
| Plxnb2 |
T |
A |
15: 89,043,205 (GRCm39) |
N1453I |
probably damaging |
Het |
| Pms1 |
T |
A |
1: 53,321,147 (GRCm39) |
I29F |
probably damaging |
Het |
| Ppp1r1a |
G |
A |
15: 103,439,833 (GRCm39) |
T153I |
probably damaging |
Het |
| Pramel12 |
T |
A |
4: 143,143,441 (GRCm39) |
L69Q |
probably damaging |
Het |
| Prelp |
C |
T |
1: 133,842,869 (GRCm39) |
R92K |
probably benign |
Het |
| Ptpre |
A |
G |
7: 135,272,424 (GRCm39) |
|
probably benign |
Het |
| Ptprt |
A |
T |
2: 161,376,465 (GRCm39) |
I1312N |
probably damaging |
Het |
| Ren1 |
C |
G |
1: 133,278,516 (GRCm39) |
|
probably null |
Het |
| Rims1 |
C |
T |
1: 22,635,516 (GRCm39) |
C155Y |
probably damaging |
Het |
| Ro60 |
T |
C |
1: 143,635,772 (GRCm39) |
D458G |
probably benign |
Het |
| Slitrk6 |
T |
G |
14: 110,988,226 (GRCm39) |
T494P |
probably benign |
Het |
| Sltm |
G |
A |
9: 70,488,583 (GRCm39) |
G578S |
probably benign |
Het |
| Smyd5 |
A |
G |
6: 85,421,300 (GRCm39) |
E338G |
probably benign |
Het |
| Snx2 |
G |
A |
18: 53,327,516 (GRCm39) |
V81M |
probably damaging |
Het |
| Sp2 |
G |
T |
11: 96,852,191 (GRCm39) |
N244K |
probably benign |
Het |
| Sspo |
C |
A |
6: 48,437,697 (GRCm39) |
|
probably benign |
Het |
| Sspo |
A |
C |
6: 48,440,465 (GRCm39) |
D1568A |
probably benign |
Het |
| Ssrp1 |
T |
C |
2: 84,871,771 (GRCm39) |
|
probably benign |
Het |
| Syt2 |
ACTCTCTCT |
ACTCTCTCTCT |
1: 134,674,479 (GRCm39) |
|
probably benign |
Het |
| Syt7 |
G |
A |
19: 10,416,577 (GRCm39) |
R138Q |
probably benign |
Het |
| Taar7f |
T |
C |
10: 23,926,323 (GRCm39) |
Y306H |
possibly damaging |
Het |
| Tbccd1 |
T |
C |
16: 22,637,291 (GRCm39) |
|
probably null |
Het |
| Tesl1 |
T |
A |
X: 23,773,549 (GRCm39) |
V350E |
probably benign |
Het |
| Tex261 |
A |
G |
6: 83,749,241 (GRCm39) |
Y119H |
probably damaging |
Het |
| Tmem131l |
T |
G |
3: 83,850,095 (GRCm39) |
E234D |
probably damaging |
Het |
| Tnnt2 |
TG |
TGG |
1: 135,774,499 (GRCm39) |
|
probably benign |
Het |
| Top6bl |
A |
G |
19: 4,748,633 (GRCm39) |
|
probably benign |
Het |
| Ttn |
C |
T |
2: 76,643,683 (GRCm39) |
G11436R |
probably damaging |
Het |
| Ubap1 |
C |
T |
4: 41,379,257 (GRCm39) |
A157V |
probably damaging |
Het |
| Ubr4 |
C |
T |
4: 139,204,518 (GRCm39) |
T4810M |
probably damaging |
Het |
| Uso1 |
G |
A |
5: 92,329,795 (GRCm39) |
G427R |
probably damaging |
Het |
| Usp15 |
A |
T |
10: 122,955,042 (GRCm39) |
V912D |
probably damaging |
Het |
| Vmn1r20 |
T |
C |
6: 57,408,943 (GRCm39) |
S90P |
probably damaging |
Het |
| Vmn1r32 |
T |
C |
6: 66,530,545 (GRCm39) |
K77R |
probably damaging |
Het |
| Vmn2r100 |
A |
G |
17: 19,742,312 (GRCm39) |
K229E |
probably benign |
Het |
| Vmn2r106 |
A |
G |
17: 20,488,566 (GRCm39) |
V611A |
possibly damaging |
Het |
| Xrcc6 |
T |
A |
15: 81,907,178 (GRCm39) |
F167I |
probably damaging |
Het |
| Zbtb21 |
G |
T |
16: 97,751,355 (GRCm39) |
P804H |
probably damaging |
Het |
| Zdhhc3 |
T |
C |
9: 122,929,602 (GRCm39) |
D11G |
probably damaging |
Het |
| Zfhx3 |
A |
G |
8: 109,671,809 (GRCm39) |
T1324A |
probably benign |
Het |
| Zfp281 |
GCGGCAGCTCCGGCAGC |
GCGGCAGCTCCGGCAGCTCCGGCAGC |
1: 136,553,091 (GRCm39) |
|
probably benign |
Het |
| Zfp608 |
G |
T |
18: 55,028,637 (GRCm39) |
L1259I |
probably damaging |
Het |
|
| Other mutations in Jmjd1c |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01062:Jmjd1c
|
APN |
10 |
67,062,494 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01604:Jmjd1c
|
APN |
10 |
67,085,541 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01753:Jmjd1c
|
APN |
10 |
67,067,794 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02081:Jmjd1c
|
APN |
10 |
67,055,305 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02128:Jmjd1c
|
APN |
10 |
67,079,648 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02134:Jmjd1c
|
APN |
10 |
67,056,171 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL02215:Jmjd1c
|
APN |
10 |
67,056,101 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02408:Jmjd1c
|
APN |
10 |
67,062,161 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02502:Jmjd1c
|
APN |
10 |
67,061,640 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL02546:Jmjd1c
|
APN |
10 |
67,061,115 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02943:Jmjd1c
|
APN |
10 |
67,055,433 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03171:Jmjd1c
|
APN |
10 |
67,061,277 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL03261:Jmjd1c
|
APN |
10 |
67,067,849 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Accordion
|
UTSW |
10 |
67,069,193 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4378001:Jmjd1c
|
UTSW |
10 |
67,065,692 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0126:Jmjd1c
|
UTSW |
10 |
67,055,105 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0133:Jmjd1c
|
UTSW |
10 |
67,076,587 (GRCm39) |
missense |
probably benign |
0.22 |
|
R0201:Jmjd1c
|
UTSW |
10 |
67,054,888 (GRCm39) |
missense |
unknown |
|
|
R0396:Jmjd1c
|
UTSW |
10 |
67,055,302 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R0401:Jmjd1c
|
UTSW |
10 |
67,056,161 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0452:Jmjd1c
|
UTSW |
10 |
67,091,261 (GRCm39) |
missense |
probably benign |
0.28 |
|
R0488:Jmjd1c
|
UTSW |
10 |
67,076,506 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0504:Jmjd1c
|
UTSW |
10 |
67,061,534 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0555:Jmjd1c
|
UTSW |
10 |
67,061,568 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0673:Jmjd1c
|
UTSW |
10 |
67,062,588 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0718:Jmjd1c
|
UTSW |
10 |
67,054,725 (GRCm39) |
splice site |
probably null |
|
|
R0755:Jmjd1c
|
UTSW |
10 |
66,932,378 (GRCm39) |
intron |
probably benign |
|
|
R1142:Jmjd1c
|
UTSW |
10 |
67,061,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1196:Jmjd1c
|
UTSW |
10 |
67,075,015 (GRCm39) |
splice site |
probably benign |
|
|
R1413:Jmjd1c
|
UTSW |
10 |
67,085,529 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1619:Jmjd1c
|
UTSW |
10 |
67,055,654 (GRCm39) |
missense |
probably benign |
0.25 |
|
R1676:Jmjd1c
|
UTSW |
10 |
67,060,588 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1751:Jmjd1c
|
UTSW |
10 |
67,061,469 (GRCm39) |
missense |
probably benign |
|
|
R1950:Jmjd1c
|
UTSW |
10 |
67,075,701 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1968:Jmjd1c
|
UTSW |
10 |
67,061,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2061:Jmjd1c
|
UTSW |
10 |
67,054,205 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2202:Jmjd1c
|
UTSW |
10 |
67,075,242 (GRCm39) |
splice site |
probably null |
|
|
R2203:Jmjd1c
|
UTSW |
10 |
67,075,242 (GRCm39) |
splice site |
probably null |
|
|
R2256:Jmjd1c
|
UTSW |
10 |
67,061,073 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2312:Jmjd1c
|
UTSW |
10 |
67,074,629 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2349:Jmjd1c
|
UTSW |
10 |
67,091,279 (GRCm39) |
missense |
probably benign |
|
|
R2392:Jmjd1c
|
UTSW |
10 |
67,065,683 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3015:Jmjd1c
|
UTSW |
10 |
66,993,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3110:Jmjd1c
|
UTSW |
10 |
67,075,863 (GRCm39) |
splice site |
probably benign |
|
|
R4043:Jmjd1c
|
UTSW |
10 |
67,055,245 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R4097:Jmjd1c
|
UTSW |
10 |
67,054,787 (GRCm39) |
missense |
probably benign |
0.09 |
|
R4118:Jmjd1c
|
UTSW |
10 |
67,055,532 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4193:Jmjd1c
|
UTSW |
10 |
66,932,460 (GRCm39) |
intron |
probably benign |
|
|
R4352:Jmjd1c
|
UTSW |
10 |
67,080,588 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4577:Jmjd1c
|
UTSW |
10 |
67,085,529 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4630:Jmjd1c
|
UTSW |
10 |
66,993,753 (GRCm39) |
nonsense |
probably null |
|
|
R4717:Jmjd1c
|
UTSW |
10 |
66,993,830 (GRCm39) |
nonsense |
probably null |
|
|
R4741:Jmjd1c
|
UTSW |
10 |
67,060,718 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R4774:Jmjd1c
|
UTSW |
10 |
67,060,571 (GRCm39) |
missense |
possibly damaging |
0.45 |
|
R4836:Jmjd1c
|
UTSW |
10 |
67,069,225 (GRCm39) |
missense |
probably benign |
0.21 |
|
R4914:Jmjd1c
|
UTSW |
10 |
67,054,750 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4939:Jmjd1c
|
UTSW |
10 |
67,081,916 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5211:Jmjd1c
|
UTSW |
10 |
67,067,795 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5215:Jmjd1c
|
UTSW |
10 |
67,076,480 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5514:Jmjd1c
|
UTSW |
10 |
67,053,928 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5530:Jmjd1c
|
UTSW |
10 |
67,085,541 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5624:Jmjd1c
|
UTSW |
10 |
67,069,193 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5640:Jmjd1c
|
UTSW |
10 |
67,061,857 (GRCm39) |
missense |
probably benign |
0.10 |
|
R5654:Jmjd1c
|
UTSW |
10 |
67,065,785 (GRCm39) |
missense |
probably benign |
0.10 |
|
R5742:Jmjd1c
|
UTSW |
10 |
67,056,112 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5764:Jmjd1c
|
UTSW |
10 |
67,062,291 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6118:Jmjd1c
|
UTSW |
10 |
67,075,791 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6163:Jmjd1c
|
UTSW |
10 |
67,083,827 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6256:Jmjd1c
|
UTSW |
10 |
67,056,187 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6266:Jmjd1c
|
UTSW |
10 |
67,085,439 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6358:Jmjd1c
|
UTSW |
10 |
67,061,718 (GRCm39) |
missense |
probably benign |
|
|
R6430:Jmjd1c
|
UTSW |
10 |
67,059,939 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R6455:Jmjd1c
|
UTSW |
10 |
67,061,795 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6887:Jmjd1c
|
UTSW |
10 |
67,025,599 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R6895:Jmjd1c
|
UTSW |
10 |
67,052,869 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7041:Jmjd1c
|
UTSW |
10 |
67,056,388 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R7095:Jmjd1c
|
UTSW |
10 |
67,055,411 (GRCm39) |
missense |
probably benign |
0.39 |
|
R7113:Jmjd1c
|
UTSW |
10 |
66,993,780 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7225:Jmjd1c
|
UTSW |
10 |
67,061,844 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7249:Jmjd1c
|
UTSW |
10 |
67,025,596 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7361:Jmjd1c
|
UTSW |
10 |
67,054,143 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7383:Jmjd1c
|
UTSW |
10 |
67,025,537 (GRCm39) |
missense |
probably benign |
0.14 |
|
R7460:Jmjd1c
|
UTSW |
10 |
67,052,815 (GRCm39) |
missense |
probably benign |
0.24 |
|
R7475:Jmjd1c
|
UTSW |
10 |
67,061,092 (GRCm39) |
missense |
probably benign |
0.22 |
|
R7502:Jmjd1c
|
UTSW |
10 |
67,067,794 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7699:Jmjd1c
|
UTSW |
10 |
67,054,195 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7745:Jmjd1c
|
UTSW |
10 |
67,052,824 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7897:Jmjd1c
|
UTSW |
10 |
67,075,644 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7908:Jmjd1c
|
UTSW |
10 |
67,061,621 (GRCm39) |
missense |
probably benign |
|
|
R7911:Jmjd1c
|
UTSW |
10 |
67,067,774 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7967:Jmjd1c
|
UTSW |
10 |
67,085,461 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8058:Jmjd1c
|
UTSW |
10 |
67,090,274 (GRCm39) |
missense |
not run |
|
|
R8224:Jmjd1c
|
UTSW |
10 |
67,080,628 (GRCm39) |
missense |
noncoding transcript |
|
|
R8251:Jmjd1c
|
UTSW |
10 |
67,075,068 (GRCm39) |
missense |
noncoding transcript |
|
|
R8797:Jmjd1c
|
UTSW |
10 |
67,060,616 (GRCm39) |
missense |
probably benign |
|
|
R8833:Jmjd1c
|
UTSW |
10 |
67,054,162 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9262:Jmjd1c
|
UTSW |
10 |
67,083,793 (GRCm39) |
missense |
probably benign |
0.39 |
|
R9354:Jmjd1c
|
UTSW |
10 |
67,059,875 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9373:Jmjd1c
|
UTSW |
10 |
66,932,495 (GRCm39) |
intron |
probably benign |
|
|
R9477:Jmjd1c
|
UTSW |
10 |
66,993,734 (GRCm39) |
nonsense |
probably null |
|
|
R9519:Jmjd1c
|
UTSW |
10 |
66,993,798 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R9701:Jmjd1c
|
UTSW |
10 |
67,060,745 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9802:Jmjd1c
|
UTSW |
10 |
67,060,745 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
RF011:Jmjd1c
|
UTSW |
10 |
67,055,978 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
Z1088:Jmjd1c
|
UTSW |
10 |
67,073,953 (GRCm39) |
missense |
probably benign |
|
|
Z1176:Jmjd1c
|
UTSW |
10 |
67,073,953 (GRCm39) |
missense |
probably benign |
|
|
Z1177:Jmjd1c
|
UTSW |
10 |
67,081,904 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Z1177:Jmjd1c
|
UTSW |
10 |
67,073,953 (GRCm39) |
missense |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GAGTAAGGTTCTTGTTCTACAACG -3'
(R):5'- AACAGTGCTTTGAAAGTTCTGCTAG -3'
Sequencing Primer
(F):5'- AAGGTTCTTGTTCTACAACGTTCCAG -3'
(R):5'- GCTTTGAAAGTTCTGCTAGATTTTTC -3'
|
| Posted On |
2014-09-17 |
Incidental Mutation