Incidental Mutation 'R2051:Cnot1'
| ID |
226436 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Cnot1
|
| Ensembl Gene |
ENSMUSG00000036550 |
| Gene Name |
CCR4-NOT transcription complex, subunit 1 |
| Synonyms |
6030411K04Rik |
| MMRRC Submission |
040058-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R2051 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
8 |
| Chromosomal Location |
96446079-96534092 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 96451221 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Leucine
at position 2171
(F2171L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000063565
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000068452]
[ENSMUST00000098473]
[ENSMUST00000211887]
[ENSMUST00000213006]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000068452
AA Change: F2171L
PolyPhen 2
Score 0.465 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000063565
Gene: ENSMUSG00000036550
AA Change: F2171L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
181 |
189 |
N/A |
INTRINSIC |
|
low complexity region
|
687 |
698 |
N/A |
INTRINSIC |
|
low complexity region
|
779 |
796 |
N/A |
INTRINSIC |
|
PDB:4J8S|A
|
798 |
999 |
1e-137 |
PDB |
|
low complexity region
|
1011 |
1028 |
N/A |
INTRINSIC |
|
low complexity region
|
1031 |
1055 |
N/A |
INTRINSIC |
|
PDB:4CT4|C
|
1056 |
1295 |
1e-148 |
PDB |
|
low complexity region
|
1296 |
1308 |
N/A |
INTRINSIC |
|
low complexity region
|
1328 |
1345 |
N/A |
INTRINSIC |
|
Pfam:DUF3819
|
1381 |
1530 |
2.5e-56 |
PFAM |
|
low complexity region
|
1634 |
1648 |
N/A |
INTRINSIC |
|
Pfam:Not1
|
1991 |
2305 |
2.4e-125 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000098473
AA Change: F2176L
PolyPhen 2
Score 0.320 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000096073
Gene: ENSMUSG00000036550
AA Change: F2176L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
181 |
189 |
N/A |
INTRINSIC |
|
Pfam:CNOT1_HEAT
|
500 |
656 |
2.4e-57 |
PFAM |
|
low complexity region
|
687 |
698 |
N/A |
INTRINSIC |
|
low complexity region
|
779 |
796 |
N/A |
INTRINSIC |
|
Pfam:CNOT1_TTP_bind
|
812 |
1004 |
1.4e-87 |
PFAM |
|
low complexity region
|
1016 |
1033 |
N/A |
INTRINSIC |
|
low complexity region
|
1036 |
1060 |
N/A |
INTRINSIC |
|
Pfam:CNOT1_CAF1_bind
|
1087 |
1313 |
5.7e-99 |
PFAM |
|
low complexity region
|
1333 |
1350 |
N/A |
INTRINSIC |
|
Pfam:DUF3819
|
1387 |
1534 |
2.3e-57 |
PFAM |
|
low complexity region
|
1639 |
1653 |
N/A |
INTRINSIC |
|
Pfam:Not1
|
1998 |
2357 |
5.7e-157 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000211887
AA Change: F2169L
PolyPhen 2
Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000212302
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000212369
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000213006
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 95.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice hmozygous for a conditional allele activated in cardiomyocytes exhibit postnatal lethality, decreased cardiac muscle contractility, prolonged QT interval and cardiac muscle cell death. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 99 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700123K08Rik |
G |
A |
5: 138,562,447 (GRCm39) |
T98M |
probably damaging |
Het |
| 4932414N04Rik |
G |
T |
2: 68,541,392 (GRCm39) |
K10N |
possibly damaging |
Het |
| Aadat |
T |
A |
8: 60,960,173 (GRCm39) |
S40T |
probably benign |
Het |
| Abca13 |
A |
G |
11: 9,278,098 (GRCm39) |
I3093V |
probably benign |
Het |
| Acacb |
A |
T |
5: 114,383,951 (GRCm39) |
Q2160L |
probably damaging |
Het |
| Acp6 |
G |
T |
3: 97,075,333 (GRCm39) |
S189I |
probably benign |
Het |
| Actr5 |
A |
T |
2: 158,474,213 (GRCm39) |
M339L |
probably benign |
Het |
| Adcy1 |
A |
T |
11: 7,111,885 (GRCm39) |
K917* |
probably null |
Het |
| Adgrg5 |
C |
T |
8: 95,668,695 (GRCm39) |
R504C |
probably benign |
Het |
| Ago1 |
T |
C |
4: 126,354,246 (GRCm39) |
H188R |
probably benign |
Het |
| Akap9 |
T |
A |
5: 4,025,685 (GRCm39) |
C23* |
probably null |
Het |
| Ank3 |
T |
C |
10: 69,733,920 (GRCm39) |
I728T |
probably damaging |
Het |
| Ankrd50 |
A |
G |
3: 38,508,642 (GRCm39) |
S1242P |
probably benign |
Het |
| Arhgap29 |
G |
A |
3: 121,775,509 (GRCm39) |
R84H |
probably benign |
Het |
| Arhgef10 |
A |
G |
8: 14,995,320 (GRCm39) |
D7G |
probably null |
Het |
| Arid4b |
A |
G |
13: 14,362,230 (GRCm39) |
E898G |
probably damaging |
Het |
| Atrnl1 |
A |
G |
19: 57,680,281 (GRCm39) |
N727S |
probably benign |
Het |
| Baalc |
G |
T |
15: 38,796,629 (GRCm39) |
|
probably benign |
Het |
| Cdc25c |
G |
C |
18: 34,871,292 (GRCm39) |
L275V |
probably damaging |
Het |
| Chpf2 |
G |
T |
5: 24,796,274 (GRCm39) |
V407L |
probably benign |
Het |
| Chrnb3 |
C |
A |
8: 27,876,839 (GRCm39) |
N84K |
probably damaging |
Het |
| Csmd3 |
C |
T |
15: 48,485,389 (GRCm39) |
|
probably null |
Het |
| Cux1 |
T |
A |
5: 136,361,512 (GRCm39) |
Q138L |
probably damaging |
Het |
| Cyp2c65 |
A |
G |
19: 39,070,675 (GRCm39) |
N286S |
probably benign |
Het |
| Dclre1b |
T |
C |
3: 103,716,356 (GRCm39) |
S17G |
possibly damaging |
Het |
| Dlgap5 |
A |
G |
14: 47,648,941 (GRCm39) |
S221P |
probably benign |
Het |
| Dnah1 |
T |
G |
14: 31,001,080 (GRCm39) |
T2422P |
probably damaging |
Het |
| Enpp1 |
A |
G |
10: 24,587,702 (GRCm39) |
|
probably null |
Het |
| Erbb2 |
T |
C |
11: 98,310,998 (GRCm39) |
C53R |
probably damaging |
Het |
| Exoc8 |
A |
G |
8: 125,622,219 (GRCm39) |
V716A |
probably benign |
Het |
| Fam193a |
T |
A |
5: 34,619,494 (GRCm39) |
D766E |
probably benign |
Het |
| Fbxo43 |
C |
A |
15: 36,162,278 (GRCm39) |
G310W |
probably damaging |
Het |
| Fcgbp |
C |
T |
7: 27,819,785 (GRCm39) |
T2504I |
probably damaging |
Het |
| Fnbp4 |
C |
T |
2: 90,587,876 (GRCm39) |
P418L |
probably benign |
Het |
| Gjd2 |
T |
C |
2: 113,841,539 (GRCm39) |
T313A |
probably damaging |
Het |
| Gm12695 |
T |
A |
4: 96,658,008 (GRCm39) |
R54W |
probably damaging |
Het |
| Gm128 |
T |
C |
3: 95,148,051 (GRCm39) |
D81G |
possibly damaging |
Het |
| Gm21834 |
A |
G |
17: 58,048,763 (GRCm39) |
V151A |
possibly damaging |
Het |
| Grhl1 |
T |
A |
12: 24,636,151 (GRCm39) |
|
probably null |
Het |
| Hcn1 |
C |
T |
13: 118,112,619 (GRCm39) |
T861I |
probably damaging |
Het |
| Herc6 |
C |
A |
6: 57,602,961 (GRCm39) |
Q547K |
probably benign |
Het |
| Iqgap3 |
T |
C |
3: 88,027,474 (GRCm39) |
L699P |
probably damaging |
Het |
| Kank4 |
T |
C |
4: 98,668,339 (GRCm39) |
D36G |
probably damaging |
Het |
| Kcnk5 |
A |
T |
14: 20,192,277 (GRCm39) |
S295T |
probably damaging |
Het |
| Krt18 |
T |
C |
15: 101,937,935 (GRCm39) |
V144A |
probably benign |
Het |
| Krtap9-5 |
A |
G |
11: 99,840,030 (GRCm39) |
I244V |
unknown |
Het |
| Leng1 |
T |
G |
7: 3,668,400 (GRCm39) |
N16T |
probably damaging |
Het |
| Lss |
A |
G |
10: 76,367,712 (GRCm39) |
K15E |
possibly damaging |
Het |
| Mastl |
G |
T |
2: 23,022,836 (GRCm39) |
A629E |
possibly damaging |
Het |
| Mavs |
G |
C |
2: 131,082,370 (GRCm39) |
A85P |
possibly damaging |
Het |
| Nav3 |
T |
C |
10: 109,660,536 (GRCm39) |
D678G |
probably damaging |
Het |
| Nsd3 |
T |
G |
8: 26,181,116 (GRCm39) |
S906A |
probably damaging |
Het |
| Nsfl1c |
A |
G |
2: 151,345,002 (GRCm39) |
N118S |
probably damaging |
Het |
| Nup205 |
T |
A |
6: 35,207,451 (GRCm39) |
M1501K |
probably benign |
Het |
| Or4p7 |
C |
T |
2: 88,221,882 (GRCm39) |
T97M |
possibly damaging |
Het |
| Or6n1 |
T |
A |
1: 173,916,785 (GRCm39) |
Y60N |
possibly damaging |
Het |
| Pax8 |
A |
G |
2: 24,326,520 (GRCm39) |
S281P |
probably benign |
Het |
| Pds5b |
T |
G |
5: 150,671,655 (GRCm39) |
I433R |
probably damaging |
Het |
| Peg3 |
T |
C |
7: 6,715,720 (GRCm39) |
N117D |
probably damaging |
Het |
| Pfkm |
A |
T |
15: 98,029,573 (GRCm39) |
D728V |
probably benign |
Het |
| Phkb |
T |
C |
8: 86,776,450 (GRCm39) |
|
probably null |
Het |
| Pkp4 |
T |
C |
2: 59,165,248 (GRCm39) |
V704A |
probably benign |
Het |
| Ppfia2 |
T |
A |
10: 106,673,160 (GRCm39) |
S501T |
probably damaging |
Het |
| Ptpru |
T |
C |
4: 131,546,398 (GRCm39) |
E284G |
possibly damaging |
Het |
| Ror1 |
C |
T |
4: 100,265,065 (GRCm39) |
R180* |
probably null |
Het |
| Ryr3 |
T |
A |
2: 112,586,986 (GRCm39) |
Y2666F |
probably damaging |
Het |
| Sec23a |
C |
A |
12: 59,037,754 (GRCm39) |
|
probably null |
Het |
| Sertad3 |
C |
T |
7: 27,175,694 (GRCm39) |
Q43* |
probably null |
Het |
| Setd2 |
C |
T |
9: 110,379,958 (GRCm39) |
H1258Y |
probably benign |
Het |
| Sharpin |
A |
G |
15: 76,232,407 (GRCm39) |
S177P |
probably benign |
Het |
| Skap1 |
T |
C |
11: 96,432,289 (GRCm39) |
F86S |
possibly damaging |
Het |
| Slc8a2 |
T |
C |
7: 15,874,940 (GRCm39) |
I396T |
probably damaging |
Het |
| Slc9a2 |
T |
C |
1: 40,765,597 (GRCm39) |
F329S |
probably damaging |
Het |
| Slx4ip |
C |
T |
2: 136,908,125 (GRCm39) |
L161F |
possibly damaging |
Het |
| Sox4 |
A |
G |
13: 29,136,764 (GRCm39) |
S81P |
probably damaging |
Het |
| Ssc4d |
G |
T |
5: 135,999,118 (GRCm39) |
S28R |
probably benign |
Het |
| St8sia2 |
C |
T |
7: 73,592,950 (GRCm39) |
G369S |
possibly damaging |
Het |
| Swt1 |
T |
C |
1: 151,248,081 (GRCm39) |
Y836C |
probably damaging |
Het |
| Taar7d |
A |
G |
10: 23,903,904 (GRCm39) |
D262G |
probably benign |
Het |
| Taar8b |
T |
A |
10: 23,967,212 (GRCm39) |
L327F |
probably benign |
Het |
| Tars1 |
A |
T |
15: 11,393,280 (GRCm39) |
L138* |
probably null |
Het |
| Tbcd |
A |
T |
11: 121,344,496 (GRCm39) |
D75V |
probably damaging |
Het |
| Tesc |
A |
G |
5: 118,184,394 (GRCm39) |
I25V |
probably damaging |
Het |
| Tmem132e |
G |
T |
11: 82,331,264 (GRCm39) |
S407I |
probably damaging |
Het |
| Tmem50b |
C |
A |
16: 91,377,180 (GRCm39) |
A95S |
possibly damaging |
Het |
| Tnr |
T |
C |
1: 159,719,603 (GRCm39) |
I960T |
probably benign |
Het |
| Tns2 |
C |
T |
15: 102,017,369 (GRCm39) |
R281C |
probably damaging |
Het |
| Tpcn1 |
G |
C |
5: 120,681,453 (GRCm39) |
P532A |
probably damaging |
Het |
| Tpsb2 |
T |
C |
17: 25,585,539 (GRCm39) |
|
probably benign |
Het |
| Triobp |
C |
A |
15: 78,888,740 (GRCm39) |
H1948Q |
probably damaging |
Het |
| Tshb |
T |
C |
3: 102,684,857 (GRCm39) |
I116V |
probably benign |
Het |
| Ttc13 |
A |
T |
8: 125,398,950 (GRCm39) |
|
probably null |
Het |
| Usp34 |
A |
T |
11: 23,414,468 (GRCm39) |
T2804S |
probably damaging |
Het |
| Vmn2r18 |
A |
T |
5: 151,486,016 (GRCm39) |
C493S |
possibly damaging |
Het |
| Vmn2r2 |
T |
C |
3: 64,024,766 (GRCm39) |
K605R |
possibly damaging |
Het |
| Vmn2r37 |
T |
C |
7: 9,220,792 (GRCm39) |
Y357C |
probably damaging |
Het |
| Zc3h6 |
T |
G |
2: 128,857,538 (GRCm39) |
S686A |
possibly damaging |
Het |
| Zfp608 |
G |
A |
18: 55,121,386 (GRCm39) |
P67L |
probably benign |
Het |
| Zyg11a |
T |
C |
4: 108,049,244 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Cnot1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00516:Cnot1
|
APN |
8 |
96,452,707 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01340:Cnot1
|
APN |
8 |
96,487,165 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01457:Cnot1
|
APN |
8 |
96,467,637 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01505:Cnot1
|
APN |
8 |
96,455,346 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02401:Cnot1
|
APN |
8 |
96,482,761 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02693:Cnot1
|
APN |
8 |
96,500,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02696:Cnot1
|
APN |
8 |
96,471,645 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02754:Cnot1
|
APN |
8 |
96,481,706 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL03092:Cnot1
|
APN |
8 |
96,496,243 (GRCm39) |
intron |
probably benign |
|
|
IGL03174:Cnot1
|
APN |
8 |
96,487,983 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03310:Cnot1
|
APN |
8 |
96,462,308 (GRCm39) |
splice site |
probably benign |
|
|
IGL03371:Cnot1
|
APN |
8 |
96,501,344 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
Affiliate
|
UTSW |
8 |
96,491,753 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Barge
|
UTSW |
8 |
96,460,757 (GRCm39) |
missense |
probably benign |
0.13 |
|
Byproduct
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
|
Chairman
|
UTSW |
8 |
96,491,655 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
cohort
|
UTSW |
8 |
96,462,377 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Director
|
UTSW |
8 |
96,491,690 (GRCm39) |
missense |
probably benign |
0.15 |
|
kowloon
|
UTSW |
8 |
96,515,286 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Quorum
|
UTSW |
8 |
96,452,746 (GRCm39) |
missense |
probably damaging |
1.00 |
|
tugboat
|
UTSW |
8 |
96,500,246 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Xiao
|
UTSW |
8 |
96,457,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB001:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
|
BB003:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
|
BB011:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
|
BB013:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
|
R0008:Cnot1
|
UTSW |
8 |
96,487,969 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0008:Cnot1
|
UTSW |
8 |
96,487,969 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0091:Cnot1
|
UTSW |
8 |
96,489,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0335:Cnot1
|
UTSW |
8 |
96,498,628 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0409:Cnot1
|
UTSW |
8 |
96,475,483 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0445:Cnot1
|
UTSW |
8 |
96,486,836 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1505:Cnot1
|
UTSW |
8 |
96,455,295 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1517:Cnot1
|
UTSW |
8 |
96,469,841 (GRCm39) |
missense |
probably benign |
0.38 |
|
R1640:Cnot1
|
UTSW |
8 |
96,496,460 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1737:Cnot1
|
UTSW |
8 |
96,474,904 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1755:Cnot1
|
UTSW |
8 |
96,451,205 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1901:Cnot1
|
UTSW |
8 |
96,469,749 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R1902:Cnot1
|
UTSW |
8 |
96,469,749 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R1903:Cnot1
|
UTSW |
8 |
96,469,749 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R1988:Cnot1
|
UTSW |
8 |
96,468,572 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R2054:Cnot1
|
UTSW |
8 |
96,466,469 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R2072:Cnot1
|
UTSW |
8 |
96,466,461 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R2074:Cnot1
|
UTSW |
8 |
96,466,461 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R2075:Cnot1
|
UTSW |
8 |
96,466,461 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R2093:Cnot1
|
UTSW |
8 |
96,501,986 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2116:Cnot1
|
UTSW |
8 |
96,452,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2191:Cnot1
|
UTSW |
8 |
96,488,054 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2238:Cnot1
|
UTSW |
8 |
96,496,149 (GRCm39) |
missense |
probably benign |
0.04 |
|
R2239:Cnot1
|
UTSW |
8 |
96,496,149 (GRCm39) |
missense |
probably benign |
0.04 |
|
R2251:Cnot1
|
UTSW |
8 |
96,489,814 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2252:Cnot1
|
UTSW |
8 |
96,489,814 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2253:Cnot1
|
UTSW |
8 |
96,489,814 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2315:Cnot1
|
UTSW |
8 |
96,475,690 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2431:Cnot1
|
UTSW |
8 |
96,501,280 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2988:Cnot1
|
UTSW |
8 |
96,470,906 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R2989:Cnot1
|
UTSW |
8 |
96,470,906 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R3108:Cnot1
|
UTSW |
8 |
96,462,377 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3109:Cnot1
|
UTSW |
8 |
96,462,377 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3114:Cnot1
|
UTSW |
8 |
96,470,906 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R3115:Cnot1
|
UTSW |
8 |
96,470,906 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R3153:Cnot1
|
UTSW |
8 |
96,470,906 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R3154:Cnot1
|
UTSW |
8 |
96,470,906 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R4112:Cnot1
|
UTSW |
8 |
96,500,246 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4359:Cnot1
|
UTSW |
8 |
96,466,476 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4382:Cnot1
|
UTSW |
8 |
96,496,407 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4747:Cnot1
|
UTSW |
8 |
96,501,310 (GRCm39) |
missense |
probably benign |
0.27 |
|
R4910:Cnot1
|
UTSW |
8 |
96,459,859 (GRCm39) |
missense |
probably benign |
0.43 |
|
R4913:Cnot1
|
UTSW |
8 |
96,489,695 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R4971:Cnot1
|
UTSW |
8 |
96,448,254 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5056:Cnot1
|
UTSW |
8 |
96,467,636 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5092:Cnot1
|
UTSW |
8 |
96,479,396 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R5101:Cnot1
|
UTSW |
8 |
96,486,815 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R5498:Cnot1
|
UTSW |
8 |
96,483,983 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5719:Cnot1
|
UTSW |
8 |
96,470,924 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5850:Cnot1
|
UTSW |
8 |
96,460,775 (GRCm39) |
nonsense |
probably null |
|
|
R5956:Cnot1
|
UTSW |
8 |
96,481,606 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5981:Cnot1
|
UTSW |
8 |
96,515,293 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6093:Cnot1
|
UTSW |
8 |
96,475,522 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6108:Cnot1
|
UTSW |
8 |
96,457,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6261:Cnot1
|
UTSW |
8 |
96,468,549 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6632:Cnot1
|
UTSW |
8 |
96,499,895 (GRCm39) |
intron |
probably benign |
|
|
R6882:Cnot1
|
UTSW |
8 |
96,447,054 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R6966:Cnot1
|
UTSW |
8 |
96,451,160 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6985:Cnot1
|
UTSW |
8 |
96,460,757 (GRCm39) |
missense |
probably benign |
0.13 |
|
R7210:Cnot1
|
UTSW |
8 |
96,515,286 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7410:Cnot1
|
UTSW |
8 |
96,459,787 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R7623:Cnot1
|
UTSW |
8 |
96,454,276 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7624:Cnot1
|
UTSW |
8 |
96,478,447 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7695:Cnot1
|
UTSW |
8 |
96,497,260 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7703:Cnot1
|
UTSW |
8 |
96,486,726 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7771:Cnot1
|
UTSW |
8 |
96,491,753 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7800:Cnot1
|
UTSW |
8 |
96,491,690 (GRCm39) |
missense |
probably benign |
0.15 |
|
R7809:Cnot1
|
UTSW |
8 |
96,478,406 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7857:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
|
R7914:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
|
R7924:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
|
R7926:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
|
R7981:Cnot1
|
UTSW |
8 |
96,489,797 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8004:Cnot1
|
UTSW |
8 |
96,479,380 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8061:Cnot1
|
UTSW |
8 |
96,491,655 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8185:Cnot1
|
UTSW |
8 |
96,487,979 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8269:Cnot1
|
UTSW |
8 |
96,478,389 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8306:Cnot1
|
UTSW |
8 |
96,473,649 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8322:Cnot1
|
UTSW |
8 |
96,496,472 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8427:Cnot1
|
UTSW |
8 |
96,460,952 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8723:Cnot1
|
UTSW |
8 |
96,462,907 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8934:Cnot1
|
UTSW |
8 |
96,491,695 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9025:Cnot1
|
UTSW |
8 |
96,475,660 (GRCm39) |
missense |
probably benign |
|
|
R9179:Cnot1
|
UTSW |
8 |
96,500,054 (GRCm39) |
missense |
probably benign |
0.16 |
|
R9280:Cnot1
|
UTSW |
8 |
96,497,227 (GRCm39) |
missense |
probably benign |
0.15 |
|
R9285:Cnot1
|
UTSW |
8 |
96,452,746 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9299:Cnot1
|
UTSW |
8 |
96,468,448 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9337:Cnot1
|
UTSW |
8 |
96,468,448 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9480:Cnot1
|
UTSW |
8 |
96,497,338 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9548:Cnot1
|
UTSW |
8 |
96,482,854 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9601:Cnot1
|
UTSW |
8 |
96,482,835 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9629:Cnot1
|
UTSW |
8 |
96,455,874 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9752:Cnot1
|
UTSW |
8 |
96,488,019 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9764:Cnot1
|
UTSW |
8 |
96,496,209 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9789:Cnot1
|
UTSW |
8 |
96,455,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0050:Cnot1
|
UTSW |
8 |
96,469,726 (GRCm39) |
splice site |
probably null |
|
|
Z1176:Cnot1
|
UTSW |
8 |
96,474,905 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
| Predicted Primers |
PCR Primer
(F):5'- CTTAAATCTGGGGATGGATGTCC -3'
(R):5'- GGTGGATTTGTAGTAATCACAGTC -3'
Sequencing Primer
(F):5'- GGTGGCTCACAACCATCTGTAATG -3'
(R):5'- TAACACGTCTGTGAAGGG -3'
|
| Posted On |
2014-09-17 |
Incidental Mutation