Incidental Mutation 'R2051:Triobp'
| ID |
226470 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Triobp
|
| Ensembl Gene |
ENSMUSG00000033088 |
| Gene Name |
TRIO and F-actin binding protein |
| Synonyms |
EST478828, Mus EST 478828, Tara |
| MMRRC Submission |
040058-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R2051 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
15 |
| Chromosomal Location |
78831924-78890069 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to A
at 78888740 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Glutamine
at position 1948
(H1948Q)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000105311
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000109687]
[ENSMUST00000109688]
[ENSMUST00000109689]
[ENSMUST00000109690]
|
| AlphaFold |
Q99KW3 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000109687
AA Change: H607Q
PolyPhen 2
Score 0.637 (Sensitivity: 0.87; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000105309
Gene: ENSMUSG00000033088
AA Change: H607Q
| Domain | Start | End | E-Value | Type |
|---|
|
PH
|
7 |
104 |
6.2e-19 |
SMART |
|
coiled coil region
|
277 |
304 |
N/A |
INTRINSIC |
|
coiled coil region
|
339 |
377 |
N/A |
INTRINSIC |
|
coiled coil region
|
401 |
463 |
N/A |
INTRINSIC |
|
coiled coil region
|
497 |
576 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000109688
|
| SMART Domains |
Protein: ENSMUSP00000105310
Gene: ENSMUSG00000033088
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
6 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
30 |
47 |
N/A |
INTRINSIC |
|
PH
|
54 |
151 |
6.2e-19 |
SMART |
|
coiled coil region
|
324 |
351 |
N/A |
INTRINSIC |
|
coiled coil region
|
386 |
424 |
N/A |
INTRINSIC |
|
coiled coil region
|
448 |
510 |
N/A |
INTRINSIC |
|
coiled coil region
|
544 |
623 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000109689
AA Change: H1948Q
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000105311
Gene: ENSMUSG00000033088
AA Change: H1948Q
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
130 |
154 |
N/A |
INTRINSIC |
|
low complexity region
|
291 |
311 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
312 |
394 |
7.43e-13 |
PROSPERO |
|
internal_repeat_1
|
390 |
540 |
7.43e-13 |
PROSPERO |
|
low complexity region
|
585 |
600 |
N/A |
INTRINSIC |
|
low complexity region
|
638 |
657 |
N/A |
INTRINSIC |
|
low complexity region
|
697 |
729 |
N/A |
INTRINSIC |
|
low complexity region
|
767 |
777 |
N/A |
INTRINSIC |
|
low complexity region
|
885 |
901 |
N/A |
INTRINSIC |
|
low complexity region
|
903 |
923 |
N/A |
INTRINSIC |
|
low complexity region
|
995 |
1017 |
N/A |
INTRINSIC |
|
low complexity region
|
1054 |
1068 |
N/A |
INTRINSIC |
|
low complexity region
|
1221 |
1235 |
N/A |
INTRINSIC |
|
PH
|
1395 |
1492 |
6.2e-19 |
SMART |
|
coiled coil region
|
1665 |
1692 |
N/A |
INTRINSIC |
|
coiled coil region
|
1727 |
1765 |
N/A |
INTRINSIC |
|
coiled coil region
|
1789 |
1851 |
N/A |
INTRINSIC |
|
coiled coil region
|
1885 |
1964 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000109690
AA Change: H1994Q
PolyPhen 2
Score 0.982 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000105312
Gene: ENSMUSG00000033088
AA Change: H1994Q
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
130 |
154 |
N/A |
INTRINSIC |
|
low complexity region
|
291 |
311 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
312 |
394 |
9.24e-13 |
PROSPERO |
|
internal_repeat_1
|
390 |
540 |
9.24e-13 |
PROSPERO |
|
low complexity region
|
585 |
600 |
N/A |
INTRINSIC |
|
low complexity region
|
638 |
657 |
N/A |
INTRINSIC |
|
low complexity region
|
697 |
729 |
N/A |
INTRINSIC |
|
low complexity region
|
767 |
777 |
N/A |
INTRINSIC |
|
low complexity region
|
885 |
901 |
N/A |
INTRINSIC |
|
low complexity region
|
903 |
923 |
N/A |
INTRINSIC |
|
low complexity region
|
995 |
1017 |
N/A |
INTRINSIC |
|
low complexity region
|
1054 |
1068 |
N/A |
INTRINSIC |
|
low complexity region
|
1221 |
1235 |
N/A |
INTRINSIC |
|
PH
|
1441 |
1538 |
6.2e-19 |
SMART |
|
coiled coil region
|
1711 |
1738 |
N/A |
INTRINSIC |
|
coiled coil region
|
1773 |
1811 |
N/A |
INTRINSIC |
|
coiled coil region
|
1835 |
1897 |
N/A |
INTRINSIC |
|
coiled coil region
|
1931 |
2010 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000129922
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000183598
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000229535
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000230425
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 95.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: This gene encodes a protein that interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility, and cell growth. The encoded protein also associates with F-actin and stabilizes F-actin structures. Domains contained in this encoded protein are an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. Mutations in the human gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants have been described [provided by RefSeq, Sep 2012]
PHENOTYPE: Mice homozygous for gene trapped alleles exhibit embryonic lethality. Mice homozygous for a targeted allele eliminating isoforms 4 and 5 exhibit profound deafness associated with stereocilia fragility and degeneration. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 99 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700123K08Rik |
G |
A |
5: 138,562,447 (GRCm39) |
T98M |
probably damaging |
Het |
| 4932414N04Rik |
G |
T |
2: 68,541,392 (GRCm39) |
K10N |
possibly damaging |
Het |
| Aadat |
T |
A |
8: 60,960,173 (GRCm39) |
S40T |
probably benign |
Het |
| Abca13 |
A |
G |
11: 9,278,098 (GRCm39) |
I3093V |
probably benign |
Het |
| Acacb |
A |
T |
5: 114,383,951 (GRCm39) |
Q2160L |
probably damaging |
Het |
| Acp6 |
G |
T |
3: 97,075,333 (GRCm39) |
S189I |
probably benign |
Het |
| Actr5 |
A |
T |
2: 158,474,213 (GRCm39) |
M339L |
probably benign |
Het |
| Adcy1 |
A |
T |
11: 7,111,885 (GRCm39) |
K917* |
probably null |
Het |
| Adgrg5 |
C |
T |
8: 95,668,695 (GRCm39) |
R504C |
probably benign |
Het |
| Ago1 |
T |
C |
4: 126,354,246 (GRCm39) |
H188R |
probably benign |
Het |
| Akap9 |
T |
A |
5: 4,025,685 (GRCm39) |
C23* |
probably null |
Het |
| Ank3 |
T |
C |
10: 69,733,920 (GRCm39) |
I728T |
probably damaging |
Het |
| Ankrd50 |
A |
G |
3: 38,508,642 (GRCm39) |
S1242P |
probably benign |
Het |
| Arhgap29 |
G |
A |
3: 121,775,509 (GRCm39) |
R84H |
probably benign |
Het |
| Arhgef10 |
A |
G |
8: 14,995,320 (GRCm39) |
D7G |
probably null |
Het |
| Arid4b |
A |
G |
13: 14,362,230 (GRCm39) |
E898G |
probably damaging |
Het |
| Atrnl1 |
A |
G |
19: 57,680,281 (GRCm39) |
N727S |
probably benign |
Het |
| Baalc |
G |
T |
15: 38,796,629 (GRCm39) |
|
probably benign |
Het |
| Cdc25c |
G |
C |
18: 34,871,292 (GRCm39) |
L275V |
probably damaging |
Het |
| Chpf2 |
G |
T |
5: 24,796,274 (GRCm39) |
V407L |
probably benign |
Het |
| Chrnb3 |
C |
A |
8: 27,876,839 (GRCm39) |
N84K |
probably damaging |
Het |
| Cnot1 |
A |
G |
8: 96,451,221 (GRCm39) |
F2171L |
possibly damaging |
Het |
| Csmd3 |
C |
T |
15: 48,485,389 (GRCm39) |
|
probably null |
Het |
| Cux1 |
T |
A |
5: 136,361,512 (GRCm39) |
Q138L |
probably damaging |
Het |
| Cyp2c65 |
A |
G |
19: 39,070,675 (GRCm39) |
N286S |
probably benign |
Het |
| Dclre1b |
T |
C |
3: 103,716,356 (GRCm39) |
S17G |
possibly damaging |
Het |
| Dlgap5 |
A |
G |
14: 47,648,941 (GRCm39) |
S221P |
probably benign |
Het |
| Dnah1 |
T |
G |
14: 31,001,080 (GRCm39) |
T2422P |
probably damaging |
Het |
| Enpp1 |
A |
G |
10: 24,587,702 (GRCm39) |
|
probably null |
Het |
| Erbb2 |
T |
C |
11: 98,310,998 (GRCm39) |
C53R |
probably damaging |
Het |
| Exoc8 |
A |
G |
8: 125,622,219 (GRCm39) |
V716A |
probably benign |
Het |
| Fam193a |
T |
A |
5: 34,619,494 (GRCm39) |
D766E |
probably benign |
Het |
| Fbxo43 |
C |
A |
15: 36,162,278 (GRCm39) |
G310W |
probably damaging |
Het |
| Fcgbp |
C |
T |
7: 27,819,785 (GRCm39) |
T2504I |
probably damaging |
Het |
| Fnbp4 |
C |
T |
2: 90,587,876 (GRCm39) |
P418L |
probably benign |
Het |
| Gjd2 |
T |
C |
2: 113,841,539 (GRCm39) |
T313A |
probably damaging |
Het |
| Gm12695 |
T |
A |
4: 96,658,008 (GRCm39) |
R54W |
probably damaging |
Het |
| Gm128 |
T |
C |
3: 95,148,051 (GRCm39) |
D81G |
possibly damaging |
Het |
| Gm21834 |
A |
G |
17: 58,048,763 (GRCm39) |
V151A |
possibly damaging |
Het |
| Grhl1 |
T |
A |
12: 24,636,151 (GRCm39) |
|
probably null |
Het |
| Hcn1 |
C |
T |
13: 118,112,619 (GRCm39) |
T861I |
probably damaging |
Het |
| Herc6 |
C |
A |
6: 57,602,961 (GRCm39) |
Q547K |
probably benign |
Het |
| Iqgap3 |
T |
C |
3: 88,027,474 (GRCm39) |
L699P |
probably damaging |
Het |
| Kank4 |
T |
C |
4: 98,668,339 (GRCm39) |
D36G |
probably damaging |
Het |
| Kcnk5 |
A |
T |
14: 20,192,277 (GRCm39) |
S295T |
probably damaging |
Het |
| Krt18 |
T |
C |
15: 101,937,935 (GRCm39) |
V144A |
probably benign |
Het |
| Krtap9-5 |
A |
G |
11: 99,840,030 (GRCm39) |
I244V |
unknown |
Het |
| Leng1 |
T |
G |
7: 3,668,400 (GRCm39) |
N16T |
probably damaging |
Het |
| Lss |
A |
G |
10: 76,367,712 (GRCm39) |
K15E |
possibly damaging |
Het |
| Mastl |
G |
T |
2: 23,022,836 (GRCm39) |
A629E |
possibly damaging |
Het |
| Mavs |
G |
C |
2: 131,082,370 (GRCm39) |
A85P |
possibly damaging |
Het |
| Nav3 |
T |
C |
10: 109,660,536 (GRCm39) |
D678G |
probably damaging |
Het |
| Nsd3 |
T |
G |
8: 26,181,116 (GRCm39) |
S906A |
probably damaging |
Het |
| Nsfl1c |
A |
G |
2: 151,345,002 (GRCm39) |
N118S |
probably damaging |
Het |
| Nup205 |
T |
A |
6: 35,207,451 (GRCm39) |
M1501K |
probably benign |
Het |
| Or4p7 |
C |
T |
2: 88,221,882 (GRCm39) |
T97M |
possibly damaging |
Het |
| Or6n1 |
T |
A |
1: 173,916,785 (GRCm39) |
Y60N |
possibly damaging |
Het |
| Pax8 |
A |
G |
2: 24,326,520 (GRCm39) |
S281P |
probably benign |
Het |
| Pds5b |
T |
G |
5: 150,671,655 (GRCm39) |
I433R |
probably damaging |
Het |
| Peg3 |
T |
C |
7: 6,715,720 (GRCm39) |
N117D |
probably damaging |
Het |
| Pfkm |
A |
T |
15: 98,029,573 (GRCm39) |
D728V |
probably benign |
Het |
| Phkb |
T |
C |
8: 86,776,450 (GRCm39) |
|
probably null |
Het |
| Pkp4 |
T |
C |
2: 59,165,248 (GRCm39) |
V704A |
probably benign |
Het |
| Ppfia2 |
T |
A |
10: 106,673,160 (GRCm39) |
S501T |
probably damaging |
Het |
| Ptpru |
T |
C |
4: 131,546,398 (GRCm39) |
E284G |
possibly damaging |
Het |
| Ror1 |
C |
T |
4: 100,265,065 (GRCm39) |
R180* |
probably null |
Het |
| Ryr3 |
T |
A |
2: 112,586,986 (GRCm39) |
Y2666F |
probably damaging |
Het |
| Sec23a |
C |
A |
12: 59,037,754 (GRCm39) |
|
probably null |
Het |
| Sertad3 |
C |
T |
7: 27,175,694 (GRCm39) |
Q43* |
probably null |
Het |
| Setd2 |
C |
T |
9: 110,379,958 (GRCm39) |
H1258Y |
probably benign |
Het |
| Sharpin |
A |
G |
15: 76,232,407 (GRCm39) |
S177P |
probably benign |
Het |
| Skap1 |
T |
C |
11: 96,432,289 (GRCm39) |
F86S |
possibly damaging |
Het |
| Slc8a2 |
T |
C |
7: 15,874,940 (GRCm39) |
I396T |
probably damaging |
Het |
| Slc9a2 |
T |
C |
1: 40,765,597 (GRCm39) |
F329S |
probably damaging |
Het |
| Slx4ip |
C |
T |
2: 136,908,125 (GRCm39) |
L161F |
possibly damaging |
Het |
| Sox4 |
A |
G |
13: 29,136,764 (GRCm39) |
S81P |
probably damaging |
Het |
| Ssc4d |
G |
T |
5: 135,999,118 (GRCm39) |
S28R |
probably benign |
Het |
| St8sia2 |
C |
T |
7: 73,592,950 (GRCm39) |
G369S |
possibly damaging |
Het |
| Swt1 |
T |
C |
1: 151,248,081 (GRCm39) |
Y836C |
probably damaging |
Het |
| Taar7d |
A |
G |
10: 23,903,904 (GRCm39) |
D262G |
probably benign |
Het |
| Taar8b |
T |
A |
10: 23,967,212 (GRCm39) |
L327F |
probably benign |
Het |
| Tars1 |
A |
T |
15: 11,393,280 (GRCm39) |
L138* |
probably null |
Het |
| Tbcd |
A |
T |
11: 121,344,496 (GRCm39) |
D75V |
probably damaging |
Het |
| Tesc |
A |
G |
5: 118,184,394 (GRCm39) |
I25V |
probably damaging |
Het |
| Tmem132e |
G |
T |
11: 82,331,264 (GRCm39) |
S407I |
probably damaging |
Het |
| Tmem50b |
C |
A |
16: 91,377,180 (GRCm39) |
A95S |
possibly damaging |
Het |
| Tnr |
T |
C |
1: 159,719,603 (GRCm39) |
I960T |
probably benign |
Het |
| Tns2 |
C |
T |
15: 102,017,369 (GRCm39) |
R281C |
probably damaging |
Het |
| Tpcn1 |
G |
C |
5: 120,681,453 (GRCm39) |
P532A |
probably damaging |
Het |
| Tpsb2 |
T |
C |
17: 25,585,539 (GRCm39) |
|
probably benign |
Het |
| Tshb |
T |
C |
3: 102,684,857 (GRCm39) |
I116V |
probably benign |
Het |
| Ttc13 |
A |
T |
8: 125,398,950 (GRCm39) |
|
probably null |
Het |
| Usp34 |
A |
T |
11: 23,414,468 (GRCm39) |
T2804S |
probably damaging |
Het |
| Vmn2r18 |
A |
T |
5: 151,486,016 (GRCm39) |
C493S |
possibly damaging |
Het |
| Vmn2r2 |
T |
C |
3: 64,024,766 (GRCm39) |
K605R |
possibly damaging |
Het |
| Vmn2r37 |
T |
C |
7: 9,220,792 (GRCm39) |
Y357C |
probably damaging |
Het |
| Zc3h6 |
T |
G |
2: 128,857,538 (GRCm39) |
S686A |
possibly damaging |
Het |
| Zfp608 |
G |
A |
18: 55,121,386 (GRCm39) |
P67L |
probably benign |
Het |
| Zyg11a |
T |
C |
4: 108,049,244 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Triobp |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01634:Triobp
|
APN |
15 |
78,877,568 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01904:Triobp
|
APN |
15 |
78,851,564 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
IGL01957:Triobp
|
APN |
15 |
78,856,847 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02085:Triobp
|
APN |
15 |
78,858,497 (GRCm39) |
splice site |
probably benign |
|
|
IGL02260:Triobp
|
APN |
15 |
78,850,562 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02498:Triobp
|
APN |
15 |
78,845,243 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02551:Triobp
|
APN |
15 |
78,857,689 (GRCm39) |
missense |
probably benign |
|
|
IGL02740:Triobp
|
APN |
15 |
78,850,889 (GRCm39) |
missense |
probably benign |
0.21 |
|
IGL02810:Triobp
|
APN |
15 |
78,886,403 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL03063:Triobp
|
APN |
15 |
78,875,084 (GRCm39) |
missense |
probably damaging |
1.00 |
|
FR4304:Triobp
|
UTSW |
15 |
78,877,587 (GRCm39) |
unclassified |
probably benign |
|
|
FR4340:Triobp
|
UTSW |
15 |
78,877,590 (GRCm39) |
unclassified |
probably benign |
|
|
FR4342:Triobp
|
UTSW |
15 |
78,877,592 (GRCm39) |
unclassified |
probably benign |
|
|
FR4449:Triobp
|
UTSW |
15 |
78,877,589 (GRCm39) |
unclassified |
probably benign |
|
|
FR4548:Triobp
|
UTSW |
15 |
78,877,590 (GRCm39) |
unclassified |
probably benign |
|
|
FR4548:Triobp
|
UTSW |
15 |
78,877,587 (GRCm39) |
unclassified |
probably benign |
|
|
R0276:Triobp
|
UTSW |
15 |
78,857,876 (GRCm39) |
missense |
probably benign |
0.09 |
|
R0309:Triobp
|
UTSW |
15 |
78,860,740 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0433:Triobp
|
UTSW |
15 |
78,852,401 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R0464:Triobp
|
UTSW |
15 |
78,851,186 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R0525:Triobp
|
UTSW |
15 |
78,858,098 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R0665:Triobp
|
UTSW |
15 |
78,858,098 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R0689:Triobp
|
UTSW |
15 |
78,844,188 (GRCm39) |
nonsense |
probably null |
|
|
R1149:Triobp
|
UTSW |
15 |
78,850,679 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1149:Triobp
|
UTSW |
15 |
78,850,679 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1151:Triobp
|
UTSW |
15 |
78,850,679 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1152:Triobp
|
UTSW |
15 |
78,850,679 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1510:Triobp
|
UTSW |
15 |
78,887,967 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1519:Triobp
|
UTSW |
15 |
78,857,938 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1642:Triobp
|
UTSW |
15 |
78,886,348 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1732:Triobp
|
UTSW |
15 |
78,851,428 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R1755:Triobp
|
UTSW |
15 |
78,850,679 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1975:Triobp
|
UTSW |
15 |
78,850,908 (GRCm39) |
missense |
probably benign |
|
|
R2073:Triobp
|
UTSW |
15 |
78,858,095 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2260:Triobp
|
UTSW |
15 |
78,875,640 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2351:Triobp
|
UTSW |
15 |
78,888,780 (GRCm39) |
missense |
probably benign |
0.09 |
|
R2902:Triobp
|
UTSW |
15 |
78,857,618 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R3801:Triobp
|
UTSW |
15 |
78,857,900 (GRCm39) |
missense |
probably benign |
0.04 |
|
R3959:Triobp
|
UTSW |
15 |
78,886,589 (GRCm39) |
nonsense |
probably null |
|
|
R4003:Triobp
|
UTSW |
15 |
78,844,177 (GRCm39) |
unclassified |
probably benign |
|
|
R4084:Triobp
|
UTSW |
15 |
78,857,871 (GRCm39) |
missense |
probably benign |
0.19 |
|
R4482:Triobp
|
UTSW |
15 |
78,850,763 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R4592:Triobp
|
UTSW |
15 |
78,851,295 (GRCm39) |
missense |
probably benign |
|
|
R4662:Triobp
|
UTSW |
15 |
78,877,469 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4732:Triobp
|
UTSW |
15 |
78,851,313 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4733:Triobp
|
UTSW |
15 |
78,851,313 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4789:Triobp
|
UTSW |
15 |
78,875,228 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4968:Triobp
|
UTSW |
15 |
78,850,816 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4990:Triobp
|
UTSW |
15 |
78,851,205 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5129:Triobp
|
UTSW |
15 |
78,845,296 (GRCm39) |
missense |
probably benign |
0.15 |
|
R5181:Triobp
|
UTSW |
15 |
78,851,954 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5279:Triobp
|
UTSW |
15 |
78,878,591 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R5584:Triobp
|
UTSW |
15 |
78,852,332 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R5601:Triobp
|
UTSW |
15 |
78,857,833 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5810:Triobp
|
UTSW |
15 |
78,852,467 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5969:Triobp
|
UTSW |
15 |
78,851,740 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6722:Triobp
|
UTSW |
15 |
78,885,765 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6739:Triobp
|
UTSW |
15 |
78,850,566 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R6810:Triobp
|
UTSW |
15 |
78,850,815 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R7011:Triobp
|
UTSW |
15 |
78,862,923 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7015:Triobp
|
UTSW |
15 |
78,878,260 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7200:Triobp
|
UTSW |
15 |
78,851,042 (GRCm39) |
small deletion |
probably benign |
|
|
R7294:Triobp
|
UTSW |
15 |
78,858,176 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7688:Triobp
|
UTSW |
15 |
78,845,311 (GRCm39) |
splice site |
probably null |
|
|
R7805:Triobp
|
UTSW |
15 |
78,858,204 (GRCm39) |
missense |
probably benign |
0.37 |
|
R7972:Triobp
|
UTSW |
15 |
78,852,186 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7977:Triobp
|
UTSW |
15 |
78,885,744 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7987:Triobp
|
UTSW |
15 |
78,885,744 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7999:Triobp
|
UTSW |
15 |
78,844,144 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8344:Triobp
|
UTSW |
15 |
78,842,475 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R8348:Triobp
|
UTSW |
15 |
78,878,326 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8446:Triobp
|
UTSW |
15 |
78,878,326 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8448:Triobp
|
UTSW |
15 |
78,878,326 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8469:Triobp
|
UTSW |
15 |
78,851,219 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8491:Triobp
|
UTSW |
15 |
78,878,326 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8492:Triobp
|
UTSW |
15 |
78,878,326 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8493:Triobp
|
UTSW |
15 |
78,878,326 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R9424:Triobp
|
UTSW |
15 |
78,844,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9495:Triobp
|
UTSW |
15 |
78,877,378 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9514:Triobp
|
UTSW |
15 |
78,877,378 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9530:Triobp
|
UTSW |
15 |
78,886,321 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9550:Triobp
|
UTSW |
15 |
78,858,077 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9576:Triobp
|
UTSW |
15 |
78,844,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9646:Triobp
|
UTSW |
15 |
78,887,934 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF001:Triobp
|
UTSW |
15 |
78,851,227 (GRCm39) |
small insertion |
probably benign |
|
|
RF005:Triobp
|
UTSW |
15 |
78,851,261 (GRCm39) |
small insertion |
probably benign |
|
|
RF007:Triobp
|
UTSW |
15 |
78,851,244 (GRCm39) |
small insertion |
probably benign |
|
|
RF022:Triobp
|
UTSW |
15 |
78,858,482 (GRCm39) |
missense |
probably benign |
0.05 |
|
RF028:Triobp
|
UTSW |
15 |
78,851,239 (GRCm39) |
small insertion |
probably benign |
|
|
RF032:Triobp
|
UTSW |
15 |
78,851,236 (GRCm39) |
small insertion |
probably benign |
|
|
RF035:Triobp
|
UTSW |
15 |
78,851,239 (GRCm39) |
small insertion |
probably benign |
|
|
RF039:Triobp
|
UTSW |
15 |
78,851,239 (GRCm39) |
small insertion |
probably benign |
|
|
RF039:Triobp
|
UTSW |
15 |
78,851,236 (GRCm39) |
small insertion |
probably benign |
|
|
RF040:Triobp
|
UTSW |
15 |
78,851,263 (GRCm39) |
small insertion |
probably benign |
|
|
RF049:Triobp
|
UTSW |
15 |
78,851,261 (GRCm39) |
small insertion |
probably benign |
|
|
RF051:Triobp
|
UTSW |
15 |
78,851,234 (GRCm39) |
small insertion |
probably benign |
|
|
RF058:Triobp
|
UTSW |
15 |
78,851,244 (GRCm39) |
small insertion |
probably benign |
|
|
X0026:Triobp
|
UTSW |
15 |
78,844,223 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
Z1177:Triobp
|
UTSW |
15 |
78,886,381 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACAATGAAATCTCCATCACTGGG -3'
(R):5'- CAGACTTGGACTGTCCTATGG -3'
Sequencing Primer
(F):5'- GCTACCAGCAGGGGCAAAG -3'
(R):5'- GGACTGTCCTATGGCCATAAC -3'
|
| Posted On |
2014-09-17 |
Incidental Mutation