Incidental Mutation 'R2054:Zfp64'
ID 226496
Institutional Source Beutler Lab
Gene Symbol Zfp64
Ensembl Gene ENSMUSG00000027551
Gene Name zinc finger protein 64
Synonyms
MMRRC Submission 040059-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.828) question?
Stock # R2054 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 168735251-168797507 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 168767728 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 628 (V628A)
Ref Sequence ENSEMBL: ENSMUSP00000085285 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087971] [ENSMUST00000109162]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000087971
AA Change: V628A

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000085285
Gene: ENSMUSG00000027551
AA Change: V628A

DomainStartEndE-ValueType
ZnF_C2H2 31 51 5.54e1 SMART
low complexity region 71 93 N/A INTRINSIC
ZnF_C2H2 142 167 1.68e1 SMART
ZnF_C2H2 173 195 2.24e-3 SMART
ZnF_C2H2 201 223 1.58e-3 SMART
ZnF_C2H2 229 251 2.24e-3 SMART
ZnF_C2H2 257 279 3.89e-3 SMART
ZnF_C2H2 285 308 6.32e-3 SMART
ZnF_C2H2 313 335 2.05e-2 SMART
ZnF_C2H2 341 363 1.95e-3 SMART
ZnF_C2H2 369 392 1.36e-2 SMART
ZnF_C2H2 423 445 1.47e-3 SMART
low complexity region 503 522 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000109162
SMART Domains Protein: ENSMUSP00000104790
Gene: ENSMUSG00000027551

DomainStartEndE-ValueType
ZnF_C2H2 31 51 5.54e1 SMART
low complexity region 71 93 N/A INTRINSIC
ZnF_C2H2 142 167 1.68e1 SMART
ZnF_C2H2 173 195 2.24e-3 SMART
ZnF_C2H2 201 223 1.58e-3 SMART
ZnF_C2H2 229 251 2.24e-3 SMART
ZnF_C2H2 297 322 5.2e0 SMART
ZnF_C2H2 328 350 4.17e-3 SMART
ZnF_C2H2 356 378 6.78e-3 SMART
ZnF_C2H2 384 406 2.24e-3 SMART
ZnF_C2H2 412 434 1.79e-2 SMART
ZnF_C2H2 440 463 9.58e-3 SMART
ZnF_C2H2 465 487 3.78e-1 SMART
ZnF_C2H2 493 515 3.89e-3 SMART
ZnF_C2H2 521 544 1.92e-2 SMART
ZnF_C2H2 578 600 5.34e-1 SMART
Meta Mutation Damage Score 0.4963 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.2%
Validation Efficiency 99% (67/68)
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2300003K06Rik A T 11: 99,728,562 (GRCm39) C94S possibly damaging Het
A930011G23Rik T C 5: 99,375,914 (GRCm39) Y432C probably benign Het
Abtb2 A G 2: 103,535,462 (GRCm39) D543G probably benign Het
Adam9 A T 8: 25,481,310 (GRCm39) V318E probably damaging Het
Aim2 T C 1: 173,291,548 (GRCm39) F318L probably damaging Het
Apob A T 12: 8,063,134 (GRCm39) D3872V probably damaging Het
Atat1 T A 17: 36,212,261 (GRCm39) R323W probably null Het
Atp2b4 T C 1: 133,642,907 (GRCm39) D1066G probably benign Het
Bltp1 A G 3: 37,002,002 (GRCm39) T1316A probably benign Het
Caskin2 T C 11: 115,697,127 (GRCm39) probably benign Het
Cblif G A 19: 11,736,370 (GRCm39) V314I probably benign Het
Ccdc54 T A 16: 50,410,987 (GRCm39) N93I probably damaging Het
Ccnd1 A C 7: 144,491,128 (GRCm39) D159E possibly damaging Het
Cnot1 A C 8: 96,466,469 (GRCm39) S1589R possibly damaging Het
Copa T A 1: 171,946,524 (GRCm39) Y980* probably null Het
Defb19 A G 2: 152,418,090 (GRCm39) I82T possibly damaging Het
Elapor2 C A 5: 9,513,030 (GRCm39) T1008K possibly damaging Het
Fiz1 G A 7: 5,011,235 (GRCm39) R428C probably damaging Het
Fnip2 A T 3: 79,479,772 (GRCm39) probably benign Het
Gabrb3 G A 7: 57,474,241 (GRCm39) G408S probably benign Het
Hao1 C T 2: 134,340,178 (GRCm39) silent Het
Hecw1 T A 13: 14,471,998 (GRCm39) M557L probably damaging Het
Itch A T 2: 155,052,496 (GRCm39) I699F probably damaging Het
Kmt2a T C 9: 44,734,671 (GRCm39) probably benign Het
Leng8 T G 7: 4,147,289 (GRCm39) Y562* probably null Het
Lonrf2 G A 1: 38,852,357 (GRCm39) P165S probably benign Het
Lrp1b A T 2: 40,587,494 (GRCm39) N151K unknown Het
Lrrc71 T C 3: 87,649,980 (GRCm39) E316G probably damaging Het
Mgat5 A G 1: 127,325,344 (GRCm39) N404D probably damaging Het
Mrps26 C A 2: 130,406,087 (GRCm39) T100K probably benign Het
Mtor A G 4: 148,547,309 (GRCm39) T431A probably benign Het
Mtor T A 4: 148,550,482 (GRCm39) C713S probably benign Het
Mug2 A G 6: 122,054,451 (GRCm39) K1077E probably damaging Het
Nbas A G 12: 13,524,207 (GRCm39) T1688A probably benign Het
Nek2 T C 1: 191,553,764 (GRCm39) S3P possibly damaging Het
Nell2 T C 15: 95,332,990 (GRCm39) T190A probably benign Het
Npr2 A T 4: 43,646,560 (GRCm39) N636I probably damaging Het
Orc3 A T 4: 34,584,846 (GRCm39) I453K probably damaging Het
Pcnx1 A G 12: 81,980,448 (GRCm39) H865R probably benign Het
Pex1 T C 5: 3,653,341 (GRCm39) V80A possibly damaging Het
Phka2 T A X: 159,337,323 (GRCm39) D424E probably damaging Het
Pkd1 C T 17: 24,793,770 (GRCm39) T1819I probably benign Het
Poglut1 T C 16: 38,355,169 (GRCm39) D219G probably damaging Het
Ppargc1a T C 5: 51,631,130 (GRCm39) I500V possibly damaging Het
Pwwp4a G T X: 72,171,261 (GRCm39) G218C probably damaging Het
Pygm C G 19: 6,438,185 (GRCm39) N163K probably benign Het
Qrich1 T A 9: 108,436,469 (GRCm39) N722K possibly damaging Het
Reep6 T A 10: 80,166,156 (GRCm39) C104* probably null Het
Rfx8 A G 1: 39,724,719 (GRCm39) V214A possibly damaging Het
Sis G A 3: 72,820,570 (GRCm39) T1398I probably benign Het
Skint5 A G 4: 113,676,360 (GRCm39) probably null Het
Slc7a14 A G 3: 31,291,511 (GRCm39) probably benign Het
Smc2 T A 4: 52,462,948 (GRCm39) M646K probably benign Het
Snx29 A G 16: 11,449,356 (GRCm39) N165S probably damaging Het
Supt6 T A 11: 78,115,187 (GRCm39) probably benign Het
Tead4 G T 6: 128,247,925 (GRCm39) S37R probably damaging Het
Tedc2 T A 17: 24,435,291 (GRCm39) E366V probably damaging Het
Tedc2 C A 17: 24,435,292 (GRCm39) E366* probably null Het
Tex56 T A 13: 35,108,574 (GRCm39) Y19N probably damaging Het
Tff2 T C 17: 31,362,199 (GRCm39) K40E probably benign Het
Traip C T 9: 107,840,118 (GRCm39) T265M probably benign Het
Trim47 T C 11: 115,999,109 (GRCm39) T256A probably benign Het
Trpm1 A G 7: 63,890,303 (GRCm39) M853V possibly damaging Het
Tti1 G T 2: 157,849,365 (GRCm39) Q625K possibly damaging Het
Ube2n A G 10: 95,377,128 (GRCm39) N31S probably damaging Het
Vmn2r17 T C 5: 109,600,352 (GRCm39) M550T probably damaging Het
Zfp512 T A 5: 31,622,793 (GRCm39) N31K probably benign Het
Other mutations in Zfp64
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00155:Zfp64 APN 2 168,768,601 (GRCm39) missense probably benign 0.06
IGL01479:Zfp64 APN 2 168,793,599 (GRCm39) missense probably damaging 1.00
IGL02320:Zfp64 APN 2 168,768,118 (GRCm39) missense probably damaging 0.98
IGL03411:Zfp64 APN 2 168,793,462 (GRCm39) splice site probably null
PIT4362001:Zfp64 UTSW 2 168,767,735 (GRCm39) missense probably benign 0.23
R0033:Zfp64 UTSW 2 168,767,635 (GRCm39) missense possibly damaging 0.94
R0033:Zfp64 UTSW 2 168,767,635 (GRCm39) missense possibly damaging 0.94
R0230:Zfp64 UTSW 2 168,754,150 (GRCm39) splice site probably benign
R0325:Zfp64 UTSW 2 168,767,960 (GRCm39) missense probably benign 0.00
R0689:Zfp64 UTSW 2 168,777,121 (GRCm39) splice site probably benign
R1741:Zfp64 UTSW 2 168,768,238 (GRCm39) missense probably benign 0.05
R2133:Zfp64 UTSW 2 168,782,663 (GRCm39) missense probably damaging 1.00
R2254:Zfp64 UTSW 2 168,768,662 (GRCm39) missense probably damaging 0.96
R4093:Zfp64 UTSW 2 168,767,855 (GRCm39) missense probably benign 0.00
R4094:Zfp64 UTSW 2 168,767,855 (GRCm39) missense probably benign 0.00
R4257:Zfp64 UTSW 2 168,768,298 (GRCm39) missense probably damaging 1.00
R4630:Zfp64 UTSW 2 168,768,463 (GRCm39) missense possibly damaging 0.94
R4642:Zfp64 UTSW 2 168,776,851 (GRCm39) missense probably benign 0.22
R4817:Zfp64 UTSW 2 168,768,032 (GRCm39) missense probably benign
R4880:Zfp64 UTSW 2 168,736,297 (GRCm39) missense probably damaging 1.00
R5051:Zfp64 UTSW 2 168,768,304 (GRCm39) missense probably damaging 0.98
R5155:Zfp64 UTSW 2 168,748,885 (GRCm39) missense probably benign 0.17
R5562:Zfp64 UTSW 2 168,767,642 (GRCm39) missense probably benign 0.00
R5619:Zfp64 UTSW 2 168,741,734 (GRCm39) missense probably damaging 0.99
R5619:Zfp64 UTSW 2 168,741,735 (GRCm39) missense probably damaging 0.97
R5620:Zfp64 UTSW 2 168,741,888 (GRCm39) missense possibly damaging 0.70
R5919:Zfp64 UTSW 2 168,768,419 (GRCm39) missense probably benign 0.05
R6156:Zfp64 UTSW 2 168,768,088 (GRCm39) missense probably benign 0.34
R6364:Zfp64 UTSW 2 168,754,186 (GRCm39) missense probably damaging 1.00
R6488:Zfp64 UTSW 2 168,777,129 (GRCm39) critical splice donor site probably null
R6512:Zfp64 UTSW 2 168,735,997 (GRCm39) missense probably benign 0.00
R6588:Zfp64 UTSW 2 168,768,827 (GRCm39) missense probably damaging 1.00
R7103:Zfp64 UTSW 2 168,768,357 (GRCm39) missense probably benign 0.00
R7313:Zfp64 UTSW 2 168,741,810 (GRCm39) missense probably damaging 1.00
R7470:Zfp64 UTSW 2 168,767,731 (GRCm39) missense probably damaging 1.00
R7529:Zfp64 UTSW 2 168,735,992 (GRCm39) missense probably benign
R7560:Zfp64 UTSW 2 168,767,585 (GRCm39) missense probably damaging 1.00
R7963:Zfp64 UTSW 2 168,793,538 (GRCm39) missense probably benign 0.32
R8037:Zfp64 UTSW 2 168,741,932 (GRCm39) missense probably damaging 1.00
R8038:Zfp64 UTSW 2 168,741,932 (GRCm39) missense probably damaging 1.00
R8825:Zfp64 UTSW 2 168,793,552 (GRCm39) missense probably benign
R8840:Zfp64 UTSW 2 168,768,635 (GRCm39) missense probably benign
R8891:Zfp64 UTSW 2 168,797,083 (GRCm39) start codon destroyed probably null 0.37
R9062:Zfp64 UTSW 2 168,767,747 (GRCm39) missense probably benign
R9592:Zfp64 UTSW 2 168,768,118 (GRCm39) missense probably damaging 1.00
R9681:Zfp64 UTSW 2 168,793,680 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCACAGTACTCCTCTCGCAG -3'
(R):5'- TGAGTCAGCCAACTGTCCTG -3'

Sequencing Primer
(F):5'- GCAGTTTGTCTTGTCTGTCAC -3'
(R):5'- AGCCAACTGTCCTGCTGAC -3'
Posted On 2014-09-17