Incidental Mutation 'R2066:Tpp2'
| ID |
226638 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tpp2
|
| Ensembl Gene |
ENSMUSG00000041763 |
| Gene Name |
tripeptidyl peptidase II |
| Synonyms |
TppII |
| MMRRC Submission |
040071-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.398)
|
| Stock # |
R2066 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
43933647-44003000 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to G
at 43978438 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Serine
at position 734
(I734S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000139918
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000087933]
[ENSMUST00000188302]
[ENSMUST00000188313]
[ENSMUST00000189388]
[ENSMUST00000190207]
|
| AlphaFold |
Q64514 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000087933
AA Change: I734S
PolyPhen 2
Score 0.483 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000085244
Gene: ENSMUSG00000041763
AA Change: I734S
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Peptidase_S8
|
35 |
500 |
1.4e-96 |
PFAM |
|
low complexity region
|
674 |
685 |
N/A |
INTRINSIC |
|
Pfam:TPPII
|
777 |
964 |
2.4e-80 |
PFAM |
|
low complexity region
|
1017 |
1033 |
N/A |
INTRINSIC |
|
PDB:3LXU|X
|
1034 |
1262 |
1e-20 |
PDB |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000186441
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000188302
|
| SMART Domains |
Protein: ENSMUSP00000140474
Gene: ENSMUSG00000041763
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Peptidase_S8
|
39 |
509 |
4.3e-84 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000188313
AA Change: I734S
PolyPhen 2
Score 0.483 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000139918
Gene: ENSMUSG00000041763
AA Change: I734S
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Peptidase_S8
|
39 |
509 |
5.1e-83 |
PFAM |
|
low complexity region
|
674 |
685 |
N/A |
INTRINSIC |
|
Pfam:TPPII
|
773 |
966 |
2.7e-93 |
PFAM |
|
low complexity region
|
1004 |
1020 |
N/A |
INTRINSIC |
|
PDB:3LXU|X
|
1021 |
1249 |
1e-20 |
PDB |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000189388
AA Change: I734S
PolyPhen 2
Score 0.198 (Sensitivity: 0.92; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000140562
Gene: ENSMUSG00000041763
AA Change: I734S
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Peptidase_S8
|
39 |
509 |
2.3e-81 |
PFAM |
|
low complexity region
|
674 |
685 |
N/A |
INTRINSIC |
|
Pfam:TPPII
|
773 |
880 |
7.8e-49 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000190207
|
| SMART Domains |
Protein: ENSMUSP00000140313
Gene: ENSMUSG00000041763
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
70 |
86 |
N/A |
INTRINSIC |
|
PDB:3LXU|X
|
87 |
281 |
3e-19 |
PDB |
|
| Meta Mutation Damage Score |
0.8131 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.7%
- 10x: 97.4%
- 20x: 95.6%
|
| Validation Efficiency |
100% (79/79) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a mammalian peptidase that, at neutral pH, removes tripeptides from the N terminus of longer peptides. The protein has a specialized function that is essential for some MHC class I antigen presentation. The protein is a high molecular mass serine exopeptidase; the amino acid sequence surrounding the serine residue at the active site is similar to the peptidases of the subtilisin class rather than the trypsin class. [provided by RefSeq, Jul 2008]
PHENOTYPE: Engineered mutations of this gene result in decreased lifespan and symptoms of immunohematopoietic senescence. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 76 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4933436I01Rik |
T |
A |
X: 67,920,702 (GRCm38) |
I184L |
probably benign |
Het |
| 9530002B09Rik |
T |
A |
4: 122,689,322 (GRCm38) |
|
probably benign |
Het |
| Acadl |
C |
T |
1: 66,841,746 (GRCm38) |
|
probably null |
Het |
| Acss1 |
G |
A |
2: 150,668,131 (GRCm38) |
Q23* |
probably null |
Het |
| Afap1l1 |
A |
T |
18: 61,739,122 (GRCm38) |
|
probably null |
Het |
| Akt3 |
A |
G |
1: 177,102,985 (GRCm38) |
S136P |
possibly damaging |
Het |
| Amy2a1 |
T |
C |
3: 113,530,568 (GRCm38) |
I108V |
probably benign |
Het |
| Ano5 |
T |
G |
7: 51,585,386 (GRCm38) |
L639R |
probably damaging |
Het |
| Arhgap26 |
T |
C |
18: 39,306,728 (GRCm38) |
S71P |
probably damaging |
Het |
| B3gnt2 |
A |
G |
11: 22,836,735 (GRCm38) |
L151P |
probably damaging |
Het |
| Bach1 |
A |
T |
16: 87,729,625 (GRCm38) |
K658N |
probably damaging |
Het |
| Bdnf |
C |
A |
2: 109,723,902 (GRCm38) |
T207K |
probably damaging |
Het |
| Bod1l |
G |
T |
5: 41,805,156 (GRCm38) |
T2746K |
probably damaging |
Het |
| Brwd1 |
A |
G |
16: 96,046,465 (GRCm38) |
S652P |
probably benign |
Het |
| Ccnt1 |
A |
T |
15: 98,551,942 (GRCm38) |
H156Q |
probably benign |
Het |
| Clasp2 |
T |
A |
9: 113,906,157 (GRCm38) |
I1021N |
possibly damaging |
Het |
| Cnep1r1 |
G |
T |
8: 88,118,817 (GRCm38) |
|
probably benign |
Het |
| Cntn6 |
C |
T |
6: 104,861,822 (GRCm38) |
R946* |
probably null |
Het |
| Dnaaf3 |
T |
C |
7: 4,523,799 (GRCm38) |
I426M |
possibly damaging |
Het |
| Dnajc13 |
A |
T |
9: 104,221,441 (GRCm38) |
I471N |
probably benign |
Het |
| Ehd1 |
T |
C |
19: 6,298,078 (GRCm38) |
L362P |
probably benign |
Het |
| Emx2 |
A |
G |
19: 59,461,698 (GRCm38) |
N149S |
probably benign |
Het |
| Fbln7 |
G |
T |
2: 128,877,466 (GRCm38) |
R61L |
probably damaging |
Het |
| Fgb |
C |
A |
3: 83,049,689 (GRCm38) |
D25Y |
probably benign |
Het |
| Filip1 |
A |
G |
9: 79,820,216 (GRCm38) |
S374P |
probably damaging |
Het |
| Fry |
T |
A |
5: 150,370,119 (GRCm38) |
|
probably benign |
Het |
| Gm12695 |
T |
C |
4: 96,769,726 (GRCm38) |
T69A |
probably benign |
Het |
| Gm2959 |
A |
G |
14: 42,413,701 (GRCm38) |
|
noncoding transcript |
Het |
| Gm9912 |
T |
C |
3: 149,185,159 (GRCm38) |
T113A |
unknown |
Het |
| Hdlbp |
A |
G |
1: 93,421,880 (GRCm38) |
|
probably benign |
Het |
| Hunk |
G |
A |
16: 90,481,245 (GRCm38) |
|
probably null |
Het |
| Ifnb1 |
T |
A |
4: 88,522,759 (GRCm38) |
I6F |
possibly damaging |
Het |
| Il2rg |
A |
G |
X: 101,267,810 (GRCm38) |
L57P |
possibly damaging |
Het |
| Ints1 |
A |
G |
5: 139,767,496 (GRCm38) |
V720A |
probably benign |
Het |
| Invs |
T |
A |
4: 48,396,287 (GRCm38) |
L320Q |
probably damaging |
Het |
| Jpt2 |
G |
A |
17: 24,948,739 (GRCm38) |
Q79* |
probably null |
Het |
| Lingo2 |
A |
G |
4: 35,709,179 (GRCm38) |
L267P |
probably benign |
Het |
| Lonp2 |
A |
G |
8: 86,665,775 (GRCm38) |
T490A |
probably damaging |
Het |
| Meiob |
G |
T |
17: 24,818,316 (GRCm38) |
R56L |
probably damaging |
Het |
| Mindy3 |
A |
T |
2: 12,419,249 (GRCm38) |
S2T |
probably damaging |
Het |
| Mrm3 |
A |
T |
11: 76,250,321 (GRCm38) |
D385V |
probably damaging |
Het |
| Mrto4 |
T |
C |
4: 139,349,023 (GRCm38) |
K86E |
probably benign |
Het |
| Naf1 |
A |
G |
8: 66,887,780 (GRCm38) |
D414G |
probably damaging |
Het |
| Nav1 |
C |
T |
1: 135,449,004 (GRCm38) |
R1694Q |
probably damaging |
Het |
| Nbea |
A |
G |
3: 55,968,146 (GRCm38) |
V1701A |
probably damaging |
Het |
| Nipal4 |
T |
G |
11: 46,156,795 (GRCm38) |
D104A |
probably damaging |
Het |
| Npas4 |
A |
G |
19: 4,987,414 (GRCm38) |
V284A |
probably damaging |
Het |
| Nup133 |
C |
A |
8: 123,914,575 (GRCm38) |
D869Y |
probably damaging |
Het |
| Obscn |
G |
A |
11: 59,135,732 (GRCm38) |
A215V |
possibly damaging |
Het |
| Olfr1218 |
A |
G |
2: 89,054,899 (GRCm38) |
Y176H |
probably damaging |
Het |
| Olfr870 |
G |
T |
9: 20,171,554 (GRCm38) |
Q6K |
probably benign |
Het |
| Olfr938 |
T |
C |
9: 39,078,214 (GRCm38) |
Y177C |
probably damaging |
Het |
| Pgs1 |
G |
A |
11: 118,014,570 (GRCm38) |
|
probably benign |
Het |
| Phc2 |
T |
C |
4: 128,747,136 (GRCm38) |
F672S |
probably damaging |
Het |
| Phldb2 |
A |
T |
16: 45,770,758 (GRCm38) |
L970Q |
probably damaging |
Het |
| Plxnb3 |
T |
A |
X: 73,771,751 (GRCm38) |
Y1845* |
probably null |
Het |
| Ppip5k1 |
A |
G |
2: 121,342,871 (GRCm38) |
|
probably benign |
Het |
| Prune2 |
A |
G |
19: 17,120,678 (GRCm38) |
D1182G |
possibly damaging |
Het |
| Psg25 |
G |
A |
7: 18,529,562 (GRCm38) |
T112I |
probably damaging |
Het |
| Sec61g |
T |
C |
11: 16,508,124 (GRCm38) |
T24A |
probably benign |
Het |
| Skint1 |
T |
A |
4: 112,025,533 (GRCm38) |
V258D |
probably benign |
Het |
| Sorbs1 |
T |
C |
19: 40,365,028 (GRCm38) |
|
probably null |
Het |
| Sox2 |
C |
A |
3: 34,651,307 (GRCm38) |
Q298K |
possibly damaging |
Het |
| Spatc1 |
T |
A |
15: 76,283,537 (GRCm38) |
|
probably null |
Het |
| Szt2 |
T |
C |
4: 118,373,980 (GRCm38) |
M2529V |
unknown |
Het |
| Thrap3 |
T |
C |
4: 126,175,396 (GRCm38) |
Y654C |
possibly damaging |
Het |
| Troap |
T |
C |
15: 99,082,463 (GRCm38) |
L508P |
probably benign |
Het |
| Ttc28 |
C |
A |
5: 111,225,933 (GRCm38) |
F1078L |
probably benign |
Het |
| Ttn |
T |
C |
2: 76,714,373 (GRCm38) |
N32795S |
probably damaging |
Het |
| Ubap2 |
C |
T |
4: 41,199,872 (GRCm38) |
A752T |
probably benign |
Het |
| Ugt2b36 |
T |
C |
5: 87,092,241 (GRCm38) |
E95G |
probably benign |
Het |
| Vmn1r55 |
A |
G |
7: 5,147,049 (GRCm38) |
V125A |
possibly damaging |
Het |
| Vstm2a |
A |
T |
11: 16,261,483 (GRCm38) |
I98F |
probably benign |
Het |
| Zdhhc13 |
T |
A |
7: 48,816,427 (GRCm38) |
V284D |
probably benign |
Het |
| Zfp668 |
C |
A |
7: 127,867,031 (GRCm38) |
R327L |
probably damaging |
Het |
| Zgrf1 |
T |
C |
3: 127,613,350 (GRCm38) |
C1589R |
probably damaging |
Het |
|
| Other mutations in Tpp2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00977:Tpp2
|
APN |
1 |
43,983,291 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
IGL01021:Tpp2
|
APN |
1 |
43,934,187 (GRCm38) |
nonsense |
probably null |
|
|
IGL01096:Tpp2
|
APN |
1 |
43,960,888 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01344:Tpp2
|
APN |
1 |
43,983,262 (GRCm38) |
missense |
probably benign |
0.04 |
|
IGL01642:Tpp2
|
APN |
1 |
43,954,653 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02719:Tpp2
|
APN |
1 |
43,940,231 (GRCm38) |
missense |
probably benign |
0.09 |
|
IGL02890:Tpp2
|
APN |
1 |
43,999,690 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03102:Tpp2
|
APN |
1 |
43,956,489 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03175:Tpp2
|
APN |
1 |
43,973,511 (GRCm38) |
missense |
probably benign |
0.35 |
|
beaver
|
UTSW |
1 |
43,971,715 (GRCm38) |
missense |
probably benign |
0.08 |
|
billingsly
|
UTSW |
1 |
43,983,552 (GRCm38) |
missense |
probably damaging |
1.00 |
|
cleaver
|
UTSW |
1 |
43,978,508 (GRCm38) |
nonsense |
probably null |
|
|
dow
|
UTSW |
1 |
43,970,392 (GRCm38) |
splice site |
probably benign |
|
|
Eddie
|
UTSW |
1 |
43,968,988 (GRCm38) |
missense |
probably damaging |
1.00 |
|
jerry
|
UTSW |
1 |
43,978,737 (GRCm38) |
missense |
probably benign |
0.04 |
|
June
|
UTSW |
1 |
43,954,710 (GRCm38) |
missense |
probably damaging |
1.00 |
|
landers
|
UTSW |
1 |
43,977,255 (GRCm38) |
missense |
probably damaging |
1.00 |
|
mathers
|
UTSW |
1 |
43,992,268 (GRCm38) |
missense |
probably damaging |
1.00 |
|
recurrentis
|
UTSW |
1 |
43,992,393 (GRCm38) |
missense |
probably null |
0.29 |
|
state
|
UTSW |
1 |
43,978,438 (GRCm38) |
missense |
possibly damaging |
0.48 |
|
wally
|
UTSW |
1 |
43,992,396 (GRCm38) |
critical splice donor site |
probably null |
|
|
Ward
|
UTSW |
1 |
43,954,736 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
wilson
|
UTSW |
1 |
43,972,689 (GRCm38) |
critical splice donor site |
probably null |
|
|
BB010:Tpp2
|
UTSW |
1 |
43,960,961 (GRCm38) |
missense |
probably damaging |
1.00 |
|
BB020:Tpp2
|
UTSW |
1 |
43,960,961 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0001:Tpp2
|
UTSW |
1 |
43,971,726 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0003:Tpp2
|
UTSW |
1 |
43,960,139 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R0066:Tpp2
|
UTSW |
1 |
43,981,748 (GRCm38) |
missense |
possibly damaging |
0.56 |
|
R0110:Tpp2
|
UTSW |
1 |
43,978,504 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0110:Tpp2
|
UTSW |
1 |
43,999,693 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0167:Tpp2
|
UTSW |
1 |
43,970,488 (GRCm38) |
missense |
probably benign |
0.01 |
|
R0441:Tpp2
|
UTSW |
1 |
43,990,562 (GRCm38) |
missense |
possibly damaging |
0.85 |
|
R0520:Tpp2
|
UTSW |
1 |
43,990,530 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0639:Tpp2
|
UTSW |
1 |
43,975,447 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1118:Tpp2
|
UTSW |
1 |
43,992,396 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1119:Tpp2
|
UTSW |
1 |
43,992,396 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1593:Tpp2
|
UTSW |
1 |
43,975,433 (GRCm38) |
missense |
probably benign |
0.01 |
|
R1702:Tpp2
|
UTSW |
1 |
43,990,548 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1756:Tpp2
|
UTSW |
1 |
43,978,725 (GRCm38) |
splice site |
probably null |
|
|
R2171:Tpp2
|
UTSW |
1 |
43,957,446 (GRCm38) |
missense |
probably benign |
0.00 |
|
R2378:Tpp2
|
UTSW |
1 |
43,999,765 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R2394:Tpp2
|
UTSW |
1 |
43,983,186 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R2507:Tpp2
|
UTSW |
1 |
44,001,449 (GRCm38) |
missense |
probably benign |
0.31 |
|
R2879:Tpp2
|
UTSW |
1 |
43,971,623 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3436:Tpp2
|
UTSW |
1 |
43,940,144 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4106:Tpp2
|
UTSW |
1 |
44,001,457 (GRCm38) |
missense |
possibly damaging |
0.71 |
|
R4658:Tpp2
|
UTSW |
1 |
43,954,710 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4760:Tpp2
|
UTSW |
1 |
43,971,715 (GRCm38) |
missense |
probably benign |
0.08 |
|
R4963:Tpp2
|
UTSW |
1 |
43,992,268 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5049:Tpp2
|
UTSW |
1 |
44,001,473 (GRCm38) |
missense |
possibly damaging |
0.46 |
|
R5073:Tpp2
|
UTSW |
1 |
43,954,736 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R6010:Tpp2
|
UTSW |
1 |
43,951,213 (GRCm38) |
critical splice donor site |
probably null |
|
|
R6118:Tpp2
|
UTSW |
1 |
43,940,146 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6155:Tpp2
|
UTSW |
1 |
43,956,489 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6169:Tpp2
|
UTSW |
1 |
43,983,579 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6236:Tpp2
|
UTSW |
1 |
43,977,317 (GRCm38) |
missense |
probably benign |
0.01 |
|
R6695:Tpp2
|
UTSW |
1 |
43,983,276 (GRCm38) |
missense |
probably benign |
|
|
R6845:Tpp2
|
UTSW |
1 |
43,978,508 (GRCm38) |
nonsense |
probably null |
|
|
R7054:Tpp2
|
UTSW |
1 |
43,983,158 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7094:Tpp2
|
UTSW |
1 |
43,968,988 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7223:Tpp2
|
UTSW |
1 |
43,968,888 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7316:Tpp2
|
UTSW |
1 |
43,970,431 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7324:Tpp2
|
UTSW |
1 |
43,978,778 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7363:Tpp2
|
UTSW |
1 |
43,985,422 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7454:Tpp2
|
UTSW |
1 |
43,954,659 (GRCm38) |
missense |
probably benign |
0.01 |
|
R7496:Tpp2
|
UTSW |
1 |
43,983,517 (GRCm38) |
missense |
probably benign |
0.09 |
|
R7699:Tpp2
|
UTSW |
1 |
43,970,466 (GRCm38) |
missense |
probably benign |
|
|
R7700:Tpp2
|
UTSW |
1 |
43,970,466 (GRCm38) |
missense |
probably benign |
|
|
R7804:Tpp2
|
UTSW |
1 |
43,983,281 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7933:Tpp2
|
UTSW |
1 |
43,960,961 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7979:Tpp2
|
UTSW |
1 |
43,940,137 (GRCm38) |
missense |
probably benign |
0.35 |
|
R8032:Tpp2
|
UTSW |
1 |
43,975,468 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R8101:Tpp2
|
UTSW |
1 |
43,970,440 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8245:Tpp2
|
UTSW |
1 |
43,983,552 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8314:Tpp2
|
UTSW |
1 |
43,934,227 (GRCm38) |
missense |
probably benign |
0.10 |
|
R8518:Tpp2
|
UTSW |
1 |
43,980,385 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8519:Tpp2
|
UTSW |
1 |
43,977,205 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
R8529:Tpp2
|
UTSW |
1 |
43,983,140 (GRCm38) |
missense |
probably benign |
|
|
R8756:Tpp2
|
UTSW |
1 |
43,960,135 (GRCm38) |
nonsense |
probably null |
|
|
R8765:Tpp2
|
UTSW |
1 |
43,972,689 (GRCm38) |
critical splice donor site |
probably null |
|
|
R8773:Tpp2
|
UTSW |
1 |
43,970,392 (GRCm38) |
splice site |
probably benign |
|
|
R8915:Tpp2
|
UTSW |
1 |
43,977,255 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9049:Tpp2
|
UTSW |
1 |
43,953,342 (GRCm38) |
missense |
possibly damaging |
0.66 |
|
R9090:Tpp2
|
UTSW |
1 |
43,954,651 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9176:Tpp2
|
UTSW |
1 |
43,992,393 (GRCm38) |
missense |
probably null |
0.29 |
|
R9214:Tpp2
|
UTSW |
1 |
43,992,354 (GRCm38) |
missense |
probably benign |
|
|
R9271:Tpp2
|
UTSW |
1 |
43,954,651 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9316:Tpp2
|
UTSW |
1 |
43,978,444 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R9371:Tpp2
|
UTSW |
1 |
43,960,209 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9422:Tpp2
|
UTSW |
1 |
43,978,737 (GRCm38) |
missense |
probably benign |
0.04 |
|
R9488:Tpp2
|
UTSW |
1 |
44,002,112 (GRCm38) |
missense |
probably benign |
0.03 |
|
R9513:Tpp2
|
UTSW |
1 |
43,978,488 (GRCm38) |
missense |
probably benign |
0.01 |
|
R9514:Tpp2
|
UTSW |
1 |
43,978,488 (GRCm38) |
missense |
probably benign |
0.01 |
|
R9516:Tpp2
|
UTSW |
1 |
43,978,488 (GRCm38) |
missense |
probably benign |
0.01 |
|
| Predicted Primers |
PCR Primer
(F):5'- CTGGTACAACAGAGCTTAGGATAC -3'
(R):5'- TCCTTCAGATGCATGCTACAAAAC -3'
Sequencing Primer
(F):5'- AATTATGTTTAAATTGGGTCCTAGGG -3'
(R):5'- ATGCAAGTTTTCAATATCCATGAATG -3'
|
| Posted On |
2014-09-17 |
Incidental Mutation