Incidental Mutation 'R0148:Fbxw21'
ID 22665
Institutional Source Beutler Lab
Gene Symbol Fbxw21
Ensembl Gene ENSMUSG00000047237
Gene Name F-box and WD-40 domain protein 21
Synonyms E330009P21Rik
MMRRC Submission 038432-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.059) question?
Stock # R0148 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 108968522-108991090 bp(-) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) A to G at 108977085 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000143095 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054925] [ENSMUST00000198076] [ENSMUST00000199540]
AlphaFold Q8BI38
Predicted Effect probably null
Transcript: ENSMUST00000054925
SMART Domains Protein: ENSMUSP00000056358
Gene: ENSMUSG00000047237

DomainStartEndE-ValueType
FBOX 5 45 1.46e-6 SMART
SCOP:d1tbga_ 119 249 1e-7 SMART
Blast:WD40 137 176 1e-6 BLAST
Predicted Effect noncoding transcript
Transcript: ENSMUST00000197401
Predicted Effect probably null
Transcript: ENSMUST00000198076
SMART Domains Protein: ENSMUSP00000143095
Gene: ENSMUSG00000047237

DomainStartEndE-ValueType
FBOX 5 45 1.46e-6 SMART
SCOP:d1tbga_ 119 249 9e-8 SMART
Blast:WD40 137 176 1e-6 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000199540
SMART Domains Protein: ENSMUSP00000143200
Gene: ENSMUSG00000047237

DomainStartEndE-ValueType
FBOX 5 45 9e-9 SMART
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 96.0%
  • 20x: 91.8%
Validation Efficiency 86% (30/35)
Allele List at MGI
Other mutations in this stock
Total: 76 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2m T C 6: 121,639,405 (GRCm39) probably null Het
Agtr1a T C 13: 30,565,927 (GRCm39) S331P probably benign Het
Ank1 T A 8: 23,613,993 (GRCm39) N1545K probably damaging Het
Bahcc1 A T 11: 120,159,230 (GRCm39) Q152H probably damaging Het
Bend3 T A 10: 43,387,946 (GRCm39) Y780N probably damaging Het
Bod1l G T 5: 41,976,040 (GRCm39) A1758E possibly damaging Het
Ctcfl T C 2: 172,960,340 (GRCm39) D81G possibly damaging Het
Ddx39a C T 8: 84,449,105 (GRCm39) R298C possibly damaging Het
Dock8 T C 19: 25,096,823 (GRCm39) L577P probably benign Het
Drc1 A T 5: 30,486,487 (GRCm39) N13I possibly damaging Het
Efl1 T C 7: 82,320,878 (GRCm39) S104P probably damaging Het
Eml4 T A 17: 83,729,081 (GRCm39) N85K probably damaging Het
Epb41l4a T C 18: 33,931,853 (GRCm39) T581A probably damaging Het
Epha3 T C 16: 63,433,307 (GRCm39) D446G possibly damaging Het
Fam209 G T 2: 172,315,900 (GRCm39) G92C probably damaging Het
Fbln1 G A 15: 85,115,027 (GRCm39) R193H probably damaging Het
Fgf17 C T 14: 70,876,313 (GRCm39) R49Q probably damaging Het
Flnb T C 14: 7,939,077 (GRCm38) S2307P probably benign Het
Galr1 A G 18: 82,423,695 (GRCm39) L194P probably benign Het
Gar1 T C 3: 129,623,122 (GRCm39) H89R probably damaging Het
Gbp4 T A 5: 105,267,362 (GRCm39) Y519F probably benign Het
Git1 A G 11: 77,396,554 (GRCm39) T601A probably benign Het
Gm10722 T "C,A" 9: 3,001,405 (GRCm39) probably null Het
Gm5142 C T 14: 59,416,119 (GRCm39) R13H possibly damaging Het
Gria2 A C 3: 80,615,038 (GRCm39) W481G probably damaging Het
Homer2 T C 7: 81,274,026 (GRCm39) T57A probably benign Het
Hpse2 A C 19: 42,920,099 (GRCm39) probably null Het
Hspb7 T C 4: 141,151,302 (GRCm39) I148T probably damaging Het
Htr1d C A 4: 136,170,788 (GRCm39) T339K probably damaging Het
Il4ra T A 7: 125,174,709 (GRCm39) C306S probably damaging Het
Kansl3 A T 1: 36,392,897 (GRCm39) C225S probably damaging Het
Lama3 G A 18: 12,581,329 (GRCm39) C596Y probably damaging Het
Lama5 T C 2: 179,832,199 (GRCm39) H1714R probably benign Het
Marchf6 C T 15: 31,490,758 (GRCm39) V293M probably damaging Het
Med12l A G 3: 58,945,075 (GRCm39) D100G probably damaging Het
Mettl14 G A 3: 123,165,043 (GRCm39) T316I probably damaging Het
Mmp15 A T 8: 96,098,945 (GRCm39) N591Y probably benign Het
Mrpl53 T C 6: 83,086,518 (GRCm39) L74P probably damaging Het
Mvp C T 7: 126,589,037 (GRCm39) V577M probably damaging Het
Neb T C 2: 52,139,388 (GRCm39) K140E probably damaging Het
Nfya A G 17: 48,706,026 (GRCm39) V48A possibly damaging Het
Ngf G T 3: 102,417,119 (GRCm39) probably benign Het
Nipsnap3b C T 4: 53,017,088 (GRCm39) A104V possibly damaging Het
Nlrp14 A G 7: 106,781,928 (GRCm39) Y375C probably benign Het
Nod1 A G 6: 54,915,202 (GRCm39) Y764H probably damaging Het
Or13d1 A T 4: 52,971,232 (GRCm39) I204F probably benign Het
Or2w25 G A 11: 59,504,320 (GRCm39) V177M probably damaging Het
Or7e177 T G 9: 20,212,387 (GRCm39) M297R probably damaging Het
Pcdhb19 A T 18: 37,630,235 (GRCm39) Q10L probably benign Het
Pdcl T C 2: 37,242,142 (GRCm39) I203V probably benign Het
Peg10 C A 6: 4,755,711 (GRCm39) R96S possibly damaging Het
Pknox1 T A 17: 31,823,764 (GRCm39) N379K probably benign Het
Prodh T G 16: 17,895,677 (GRCm39) Q360P probably damaging Het
Raf1 C T 6: 115,609,934 (GRCm39) G202S probably benign Het
Rgs11 T A 17: 26,426,433 (GRCm39) probably null Het
Rilp A T 11: 75,401,059 (GRCm39) H29L probably damaging Het
Rtel1 T C 2: 180,962,839 (GRCm39) C31R probably damaging Het
Rubcnl T A 14: 75,279,898 (GRCm39) I427K probably damaging Het
Ryr1 C A 7: 28,751,460 (GRCm39) R3706L probably damaging Het
Ryr2 T C 13: 11,729,434 (GRCm39) D2396G probably damaging Het
Slc45a2 T C 15: 11,025,954 (GRCm39) S435P probably damaging Het
Spata17 A G 1: 186,844,798 (GRCm39) V111A probably damaging Het
Svep1 C T 4: 58,116,608 (GRCm39) D881N possibly damaging Het
Sypl2 T A 3: 108,126,411 (GRCm39) N67I possibly damaging Het
Tenm3 T C 8: 48,689,755 (GRCm39) Y1944C probably damaging Het
Tep1 A T 14: 51,062,246 (GRCm39) D2535E possibly damaging Het
Tkt T A 14: 30,294,177 (GRCm39) I529N probably damaging Het
Trp53i11 T G 2: 93,028,080 (GRCm39) V39G probably damaging Het
Trpm2 C T 10: 77,761,659 (GRCm39) G997D probably damaging Het
Usp3 A G 9: 66,447,449 (GRCm39) V219A possibly damaging Het
Usp4 T A 9: 108,268,870 (GRCm39) probably null Het
Wdfy3 A G 5: 102,065,277 (GRCm39) V1297A probably benign Het
Wdr46 T A 17: 34,159,997 (GRCm39) F70I probably benign Het
Xkr6 T C 14: 64,056,998 (GRCm39) V303A unknown Het
Zdbf2 C T 1: 63,343,165 (GRCm39) Q515* probably null Het
Zfhx2 A G 14: 55,310,354 (GRCm39) Y731H possibly damaging Het
Other mutations in Fbxw21
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00679:Fbxw21 APN 9 108,991,032 (GRCm39) missense probably damaging 1.00
IGL00901:Fbxw21 APN 9 108,985,467 (GRCm39) missense probably benign 0.00
IGL01377:Fbxw21 APN 9 108,975,713 (GRCm39) nonsense probably null
IGL01941:Fbxw21 APN 9 108,977,224 (GRCm39) missense probably benign 0.07
IGL02491:Fbxw21 APN 9 108,972,887 (GRCm39) missense probably benign
IGL03163:Fbxw21 APN 9 108,974,552 (GRCm39) missense probably benign 0.01
IGL03377:Fbxw21 APN 9 108,968,597 (GRCm39) missense probably benign 0.01
R0328:Fbxw21 UTSW 9 108,975,653 (GRCm39) missense possibly damaging 0.52
R0909:Fbxw21 UTSW 9 108,985,476 (GRCm39) missense possibly damaging 0.84
R1506:Fbxw21 UTSW 9 108,977,257 (GRCm39) missense probably damaging 1.00
R1575:Fbxw21 UTSW 9 108,990,984 (GRCm39) missense probably benign 0.00
R1615:Fbxw21 UTSW 9 108,972,794 (GRCm39) missense probably damaging 1.00
R1719:Fbxw21 UTSW 9 108,977,242 (GRCm39) missense possibly damaging 0.85
R2415:Fbxw21 UTSW 9 108,985,469 (GRCm39) missense possibly damaging 0.71
R2424:Fbxw21 UTSW 9 108,986,587 (GRCm39) nonsense probably null
R2508:Fbxw21 UTSW 9 108,974,553 (GRCm39) missense probably benign 0.31
R2898:Fbxw21 UTSW 9 108,985,404 (GRCm39) missense possibly damaging 0.52
R2964:Fbxw21 UTSW 9 108,974,578 (GRCm39) missense probably benign 0.10
R2965:Fbxw21 UTSW 9 108,974,578 (GRCm39) missense probably benign 0.10
R2966:Fbxw21 UTSW 9 108,974,578 (GRCm39) missense probably benign 0.10
R4809:Fbxw21 UTSW 9 108,972,458 (GRCm39) missense probably damaging 1.00
R4911:Fbxw21 UTSW 9 108,974,731 (GRCm39) missense probably damaging 1.00
R5669:Fbxw21 UTSW 9 108,974,578 (GRCm39) missense probably benign 0.12
R5928:Fbxw21 UTSW 9 108,972,893 (GRCm39) missense possibly damaging 0.55
R6043:Fbxw21 UTSW 9 108,974,607 (GRCm39) missense possibly damaging 0.69
R6277:Fbxw21 UTSW 9 108,974,623 (GRCm39) missense possibly damaging 0.95
R6805:Fbxw21 UTSW 9 108,986,633 (GRCm39) missense probably damaging 1.00
R6944:Fbxw21 UTSW 9 108,986,603 (GRCm39) missense probably damaging 1.00
R7079:Fbxw21 UTSW 9 108,974,578 (GRCm39) missense probably benign 0.10
R7081:Fbxw21 UTSW 9 108,990,990 (GRCm39) missense probably damaging 1.00
R7744:Fbxw21 UTSW 9 108,986,720 (GRCm39) missense possibly damaging 0.81
R7774:Fbxw21 UTSW 9 108,972,908 (GRCm39) missense probably benign 0.00
R7980:Fbxw21 UTSW 9 108,985,639 (GRCm39) splice site probably null
R8043:Fbxw21 UTSW 9 108,975,694 (GRCm39) missense probably benign 0.01
R8260:Fbxw21 UTSW 9 108,975,614 (GRCm39) critical splice donor site probably null
R9142:Fbxw21 UTSW 9 108,985,413 (GRCm39) missense probably damaging 1.00
R9172:Fbxw21 UTSW 9 108,975,764 (GRCm39) missense probably benign 0.00
R9250:Fbxw21 UTSW 9 108,972,846 (GRCm39) missense probably benign 0.31
R9251:Fbxw21 UTSW 9 108,974,687 (GRCm39) missense probably damaging 1.00
R9294:Fbxw21 UTSW 9 108,972,830 (GRCm39) missense probably damaging 0.99
R9303:Fbxw21 UTSW 9 108,986,727 (GRCm39) missense probably benign
R9479:Fbxw21 UTSW 9 108,968,612 (GRCm39) missense probably benign 0.00
R9509:Fbxw21 UTSW 9 108,977,217 (GRCm39) missense possibly damaging 0.90
R9765:Fbxw21 UTSW 9 108,975,625 (GRCm39) missense possibly damaging 0.71
R9773:Fbxw21 UTSW 9 108,977,128 (GRCm39) missense possibly damaging 0.89
R9774:Fbxw21 UTSW 9 108,991,057 (GRCm39) start codon destroyed probably null 0.98
Z1088:Fbxw21 UTSW 9 108,974,605 (GRCm39) missense probably benign
Z1176:Fbxw21 UTSW 9 108,974,605 (GRCm39) missense probably benign
Z1177:Fbxw21 UTSW 9 108,974,605 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- acctctccctagatccCAGGAAAGAAT -3'
(R):5'- AGTATCAAGCTGTTGACTACCCTCCC -3'

Sequencing Primer
(F):5'- aaatgggaatgggtgggtag -3'
(R):5'- GTTGACTACCCTCCCTGAGATG -3'
Posted On 2013-04-16