Incidental Mutation 'IGL00226:Fbxw18'
| ID |
2267 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Fbxw18
|
| Ensembl Gene |
ENSMUSG00000074059 |
| Gene Name |
F-box and WD-40 domain protein 18 |
| Synonyms |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.061)
|
| Stock # |
IGL00226
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
9 |
| Chromosomal Location |
109505802-109531768 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 109522411 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Serine
at position 153
(T153S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000095962
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000098359]
|
| AlphaFold |
Q3TSA9 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000098359
AA Change: T153S
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000095962
Gene: ENSMUSG00000074059
AA Change: T153S
| Domain | Start | End | E-Value | Type |
|---|
|
FBOX
|
8 |
48 |
4.13e-6 |
SMART |
|
Blast:WD40
|
140 |
179 |
2e-7 |
BLAST |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 31 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1810062G17Rik |
C |
A |
3: 36,533,690 (GRCm39) |
|
probably benign |
Het |
| Ankib1 |
G |
A |
5: 3,777,573 (GRCm39) |
S439L |
probably benign |
Het |
| Cdcp3 |
T |
A |
7: 130,839,823 (GRCm39) |
|
probably null |
Het |
| Cpd |
G |
T |
11: 76,688,615 (GRCm39) |
H886N |
probably benign |
Het |
| Dhrs7 |
A |
G |
12: 72,706,124 (GRCm39) |
C94R |
probably damaging |
Het |
| Dmxl2 |
T |
A |
9: 54,323,277 (GRCm39) |
H1369L |
probably damaging |
Het |
| Dnah5 |
A |
G |
15: 28,272,488 (GRCm39) |
N1068S |
probably benign |
Het |
| Dop1a |
T |
A |
9: 86,433,732 (GRCm39) |
D2329E |
possibly damaging |
Het |
| Eif1ad |
A |
G |
19: 5,418,212 (GRCm39) |
|
probably benign |
Het |
| Fam149a |
T |
C |
8: 45,792,380 (GRCm39) |
R693G |
probably damaging |
Het |
| Glg1 |
A |
T |
8: 111,886,481 (GRCm39) |
C1104S |
probably damaging |
Het |
| Jak3 |
T |
C |
8: 72,134,341 (GRCm39) |
|
probably benign |
Het |
| Kctd6 |
C |
T |
14: 8,222,856 (GRCm38) |
R233C |
possibly damaging |
Het |
| Kpna3 |
A |
G |
14: 61,611,737 (GRCm39) |
V300A |
possibly damaging |
Het |
| Msh5 |
A |
T |
17: 35,248,857 (GRCm39) |
Y725* |
probably null |
Het |
| Myh2 |
T |
C |
11: 67,076,059 (GRCm39) |
S749P |
possibly damaging |
Het |
| Or2ag15 |
T |
A |
7: 106,340,908 (GRCm39) |
T78S |
probably benign |
Het |
| Or4c110 |
A |
G |
2: 88,831,683 (GRCm39) |
|
probably benign |
Het |
| Or5ac17 |
A |
T |
16: 59,036,859 (GRCm39) |
M39K |
probably damaging |
Het |
| Or8g19 |
T |
A |
9: 39,056,053 (GRCm39) |
I219N |
possibly damaging |
Het |
| Pdcd1 |
A |
G |
1: 93,967,860 (GRCm39) |
|
probably benign |
Het |
| Pde5a |
T |
A |
3: 122,588,006 (GRCm39) |
F391I |
probably damaging |
Het |
| Ptpn12 |
A |
C |
5: 21,203,666 (GRCm39) |
S371A |
probably damaging |
Het |
| Sec16b |
A |
G |
1: 157,365,900 (GRCm39) |
Y254C |
probably damaging |
Het |
| Slc2a10 |
G |
A |
2: 165,356,700 (GRCm39) |
C120Y |
probably damaging |
Het |
| Spink5 |
G |
A |
18: 44,120,938 (GRCm39) |
|
probably benign |
Het |
| Svil |
A |
G |
18: 5,099,045 (GRCm39) |
Q1250R |
probably benign |
Het |
| Tph1 |
G |
T |
7: 46,306,294 (GRCm39) |
N222K |
probably benign |
Het |
| Vmn2r83 |
A |
T |
10: 79,314,805 (GRCm39) |
D351V |
probably damaging |
Het |
| Zfp54 |
A |
G |
17: 21,653,821 (GRCm39) |
D105G |
possibly damaging |
Het |
| Zfp623 |
T |
C |
15: 75,820,052 (GRCm39) |
I336T |
probably damaging |
Het |
|
| Other mutations in Fbxw18 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00820:Fbxw18
|
APN |
9 |
109,522,437 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01447:Fbxw18
|
APN |
9 |
109,530,675 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01511:Fbxw18
|
APN |
9 |
109,517,889 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
IGL01956:Fbxw18
|
APN |
9 |
109,522,425 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02089:Fbxw18
|
APN |
9 |
109,530,390 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4810001:Fbxw18
|
UTSW |
9 |
109,505,958 (GRCm39) |
nonsense |
probably null |
|
|
R0004:Fbxw18
|
UTSW |
9 |
109,530,381 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0124:Fbxw18
|
UTSW |
9 |
109,520,583 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0375:Fbxw18
|
UTSW |
9 |
109,517,907 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R1652:Fbxw18
|
UTSW |
9 |
109,519,695 (GRCm39) |
missense |
probably benign |
0.35 |
|
R2153:Fbxw18
|
UTSW |
9 |
109,522,438 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2294:Fbxw18
|
UTSW |
9 |
109,505,865 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3738:Fbxw18
|
UTSW |
9 |
109,517,981 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R4706:Fbxw18
|
UTSW |
9 |
109,519,585 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4982:Fbxw18
|
UTSW |
9 |
109,531,719 (GRCm39) |
start gained |
probably benign |
|
|
R4990:Fbxw18
|
UTSW |
9 |
109,517,461 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5314:Fbxw18
|
UTSW |
9 |
109,522,246 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R5520:Fbxw18
|
UTSW |
9 |
109,520,589 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5634:Fbxw18
|
UTSW |
9 |
109,505,871 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R5718:Fbxw18
|
UTSW |
9 |
109,520,636 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5894:Fbxw18
|
UTSW |
9 |
109,529,235 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R5928:Fbxw18
|
UTSW |
9 |
109,529,149 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6175:Fbxw18
|
UTSW |
9 |
109,505,947 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6696:Fbxw18
|
UTSW |
9 |
109,517,832 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6944:Fbxw18
|
UTSW |
9 |
109,531,655 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7396:Fbxw18
|
UTSW |
9 |
109,517,954 (GRCm39) |
missense |
probably benign |
0.19 |
|
R7737:Fbxw18
|
UTSW |
9 |
109,530,331 (GRCm39) |
nonsense |
probably null |
|
|
R7883:Fbxw18
|
UTSW |
9 |
109,517,474 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9002:Fbxw18
|
UTSW |
9 |
109,519,660 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9053:Fbxw18
|
UTSW |
9 |
109,517,491 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9782:Fbxw18
|
UTSW |
9 |
109,522,376 (GRCm39) |
missense |
probably benign |
0.07 |
|
| Posted On |
2011-12-09 |
Incidental Mutation