Incidental Mutation 'R2069:Duox1'
| ID |
226913 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Duox1
|
| Ensembl Gene |
ENSMUSG00000033268 |
| Gene Name |
dual oxidase 1 |
| Synonyms |
NOXEF1, LNOX1, 9930101G15Rik, THOX1 |
| MMRRC Submission |
040074-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R2069 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
2 |
| Chromosomal Location |
122146153-122178453 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 122163543 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Serine
at position 792
(T792S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000097060
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000099461]
|
| AlphaFold |
A2AQ92 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000099461
AA Change: T792S
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000097060
Gene: ENSMUSG00000033268
AA Change: T792S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Pfam:An_peroxidase
|
29 |
557 |
2.1e-134 |
PFAM |
|
transmembrane domain
|
594 |
616 |
N/A |
INTRINSIC |
|
EFh
|
819 |
847 |
1.82e-4 |
SMART |
|
EFh
|
855 |
883 |
3.45e-5 |
SMART |
|
transmembrane domain
|
1044 |
1066 |
N/A |
INTRINSIC |
|
Pfam:Ferric_reduct
|
1087 |
1236 |
5.3e-21 |
PFAM |
|
Pfam:FAD_binding_8
|
1272 |
1374 |
8.5e-21 |
PFAM |
|
Pfam:NAD_binding_6
|
1380 |
1534 |
3.5e-33 |
PFAM |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.4%
- 20x: 95.4%
|
| Validation Efficiency |
100% (104/104) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2012]
|
| Allele List at MGI |
All alleles(6) : Targeted, other(3) Gene trapped(3)
|
| Other mutations in this stock |
Total: 104 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930519G04Rik |
T |
C |
5: 115,012,341 (GRCm39) |
V86A |
probably benign |
Het |
| Abcc3 |
A |
T |
11: 94,255,243 (GRCm39) |
I601N |
probably damaging |
Het |
| Abl2 |
T |
A |
1: 156,448,397 (GRCm39) |
|
probably null |
Het |
| Adgrf4 |
C |
T |
17: 42,977,789 (GRCm39) |
R518Q |
possibly damaging |
Het |
| Ahi1 |
C |
T |
10: 20,835,895 (GRCm39) |
T76I |
probably damaging |
Het |
| Arhgap42 |
C |
T |
9: 9,035,601 (GRCm39) |
G247D |
probably damaging |
Het |
| Arid2 |
C |
T |
15: 96,260,471 (GRCm39) |
L407F |
probably damaging |
Het |
| Atp13a1 |
T |
C |
8: 70,252,423 (GRCm39) |
F606L |
probably benign |
Het |
| Avl9 |
T |
A |
6: 56,713,420 (GRCm39) |
|
probably benign |
Het |
| B3glct |
C |
T |
5: 149,632,845 (GRCm39) |
A65V |
probably damaging |
Het |
| Bcorl1 |
T |
C |
X: 47,490,794 (GRCm39) |
|
probably benign |
Het |
| Bdp1 |
T |
C |
13: 100,187,496 (GRCm39) |
T1624A |
probably benign |
Het |
| Bmp15 |
A |
G |
X: 6,228,075 (GRCm39) |
M263T |
probably benign |
Het |
| Brd8 |
T |
C |
18: 34,747,532 (GRCm39) |
K110E |
probably damaging |
Het |
| Cachd1 |
A |
G |
4: 100,848,041 (GRCm39) |
D1052G |
probably damaging |
Het |
| Capn9 |
G |
A |
8: 125,332,450 (GRCm39) |
G430R |
possibly damaging |
Het |
| Ccdc113 |
G |
A |
8: 96,283,924 (GRCm39) |
E333K |
probably benign |
Het |
| Ccnl2 |
A |
T |
4: 155,896,938 (GRCm39) |
|
probably null |
Het |
| Ccr9 |
T |
C |
9: 123,608,429 (GRCm39) |
F37S |
probably benign |
Het |
| Cdh20 |
A |
T |
1: 110,065,889 (GRCm39) |
D721V |
probably damaging |
Het |
| Ceacam10 |
A |
T |
7: 24,477,797 (GRCm39) |
N104I |
probably damaging |
Het |
| Cenpk |
T |
A |
13: 104,372,684 (GRCm39) |
|
probably benign |
Het |
| Cfi |
A |
G |
3: 129,652,453 (GRCm39) |
|
probably null |
Het |
| Chd1 |
T |
C |
17: 15,962,556 (GRCm39) |
F771S |
probably damaging |
Het |
| Chil4 |
G |
A |
3: 106,126,771 (GRCm39) |
L4F |
probably benign |
Het |
| Cilp |
G |
A |
9: 65,185,372 (GRCm39) |
R489Q |
possibly damaging |
Het |
| Cntnap5b |
G |
A |
1: 100,286,450 (GRCm39) |
G402R |
probably benign |
Het |
| Coq8b |
A |
G |
7: 26,956,802 (GRCm39) |
E485G |
probably damaging |
Het |
| Cse1l |
A |
G |
2: 166,783,412 (GRCm39) |
S733G |
probably benign |
Het |
| Dnah5 |
G |
A |
15: 28,312,534 (GRCm39) |
|
probably null |
Het |
| Dnmt3l |
T |
C |
10: 77,888,566 (GRCm39) |
V156A |
probably damaging |
Het |
| Duox2 |
T |
C |
2: 122,117,589 (GRCm39) |
D915G |
probably benign |
Het |
| Efcab5 |
A |
T |
11: 77,063,147 (GRCm39) |
M115K |
probably benign |
Het |
| Eif2s1 |
G |
A |
12: 78,923,959 (GRCm39) |
D139N |
probably benign |
Het |
| Erg |
A |
G |
16: 95,161,937 (GRCm39) |
F390L |
probably damaging |
Het |
| Fam193b |
A |
T |
13: 55,690,811 (GRCm39) |
S650R |
probably damaging |
Het |
| Fbp2 |
T |
A |
13: 63,001,875 (GRCm39) |
K113N |
possibly damaging |
Het |
| Fnbp4 |
T |
G |
2: 90,588,716 (GRCm39) |
S496A |
probably damaging |
Het |
| Gab3 |
C |
A |
X: 74,043,701 (GRCm39) |
R475L |
probably damaging |
Het |
| Gsap |
T |
C |
5: 21,431,837 (GRCm39) |
|
probably benign |
Het |
| Gucy1a2 |
C |
T |
9: 3,582,697 (GRCm39) |
L160F |
probably damaging |
Het |
| Hivep1 |
C |
T |
13: 42,337,262 (GRCm39) |
A2447V |
possibly damaging |
Het |
| Insc |
G |
T |
7: 114,403,828 (GRCm39) |
|
probably null |
Het |
| Jph2 |
A |
G |
2: 163,181,605 (GRCm39) |
S520P |
possibly damaging |
Het |
| Kidins220 |
T |
A |
12: 25,037,005 (GRCm39) |
|
probably benign |
Het |
| Krtap29-1 |
A |
G |
11: 99,869,438 (GRCm39) |
S148P |
probably damaging |
Het |
| Ltbp2 |
A |
C |
12: 84,840,507 (GRCm39) |
C1000G |
probably damaging |
Het |
| Map2k3 |
T |
C |
11: 60,840,853 (GRCm39) |
F294S |
probably damaging |
Het |
| Map4k2 |
C |
A |
19: 6,392,768 (GRCm39) |
|
probably benign |
Het |
| Mboat2 |
T |
C |
12: 25,001,442 (GRCm39) |
V281A |
probably benign |
Het |
| Mdga2 |
G |
A |
12: 66,615,691 (GRCm39) |
R570* |
probably null |
Het |
| Mlxipl |
A |
G |
5: 135,135,859 (GRCm39) |
D28G |
probably damaging |
Het |
| Morc2b |
T |
C |
17: 33,355,734 (GRCm39) |
I679M |
probably benign |
Het |
| Myh4 |
T |
C |
11: 67,137,192 (GRCm39) |
|
probably benign |
Het |
| Nfib |
A |
C |
4: 82,416,852 (GRCm39) |
L61R |
probably damaging |
Het |
| Noc2l |
C |
A |
4: 156,325,907 (GRCm39) |
Y227* |
probably null |
Het |
| Nrde2 |
A |
G |
12: 100,108,491 (GRCm39) |
S367P |
probably damaging |
Het |
| Nup93 |
C |
A |
8: 94,970,367 (GRCm39) |
P89T |
probably damaging |
Het |
| Obsl1 |
G |
A |
1: 75,486,756 (GRCm38) |
T1764M |
probably benign |
Het |
| Or10a2 |
A |
T |
7: 106,673,826 (GRCm39) |
K264* |
probably null |
Het |
| Or11h4 |
T |
A |
14: 50,974,033 (GRCm39) |
E195D |
possibly damaging |
Het |
| Or4a68 |
C |
T |
2: 89,269,927 (GRCm39) |
R232H |
probably benign |
Het |
| Or4k77 |
A |
G |
2: 111,199,440 (GRCm39) |
I154M |
probably benign |
Het |
| Or6b9 |
A |
T |
7: 106,555,494 (GRCm39) |
Y216* |
probably null |
Het |
| Or9r7 |
A |
G |
10: 129,962,074 (GRCm39) |
I284T |
possibly damaging |
Het |
| Oxct1 |
G |
T |
15: 4,122,007 (GRCm39) |
A319S |
probably null |
Het |
| P2ry10 |
A |
G |
X: 106,146,859 (GRCm39) |
S265G |
probably benign |
Het |
| Peak1 |
A |
T |
9: 56,166,043 (GRCm39) |
N628K |
probably damaging |
Het |
| Pkdrej |
T |
A |
15: 85,705,432 (GRCm39) |
Q168L |
probably benign |
Het |
| Plaat5 |
T |
C |
19: 7,590,003 (GRCm39) |
S10P |
possibly damaging |
Het |
| Plec |
A |
G |
15: 76,073,126 (GRCm39) |
M604T |
probably benign |
Het |
| Pmfbp1 |
A |
T |
8: 110,258,735 (GRCm39) |
N680I |
possibly damaging |
Het |
| Pnma8b |
T |
C |
7: 16,679,714 (GRCm39) |
W233R |
probably damaging |
Het |
| Pxn |
A |
G |
5: 115,683,726 (GRCm39) |
N186S |
probably benign |
Het |
| Rsad1 |
A |
C |
11: 94,439,951 (GRCm39) |
|
probably benign |
Het |
| Runx2 |
A |
G |
17: 45,046,229 (GRCm39) |
I112T |
probably benign |
Het |
| S1pr2 |
A |
T |
9: 20,878,790 (GRCm39) |
L346Q |
probably damaging |
Het |
| Skint6 |
A |
G |
4: 113,095,329 (GRCm39) |
I110T |
probably damaging |
Het |
| Slc36a4 |
T |
A |
9: 15,638,276 (GRCm39) |
F234Y |
probably damaging |
Het |
| Slitrk2 |
T |
A |
X: 65,698,235 (GRCm39) |
V242D |
probably damaging |
Het |
| Sp100 |
A |
G |
1: 85,608,863 (GRCm39) |
|
probably null |
Het |
| Spryd3 |
A |
C |
15: 102,026,616 (GRCm39) |
L352V |
probably benign |
Het |
| Ssc4d |
A |
C |
5: 135,999,171 (GRCm39) |
W11G |
possibly damaging |
Het |
| Stx17 |
T |
A |
4: 48,158,870 (GRCm39) |
D83E |
probably damaging |
Het |
| Tlk2 |
A |
T |
11: 105,131,266 (GRCm39) |
Q204L |
probably benign |
Het |
| Tnfrsf21 |
A |
T |
17: 43,348,829 (GRCm39) |
H147L |
possibly damaging |
Het |
| Tnrc18 |
A |
T |
5: 142,751,842 (GRCm39) |
D1154E |
unknown |
Het |
| Trap1 |
A |
G |
16: 3,886,200 (GRCm39) |
S86P |
probably benign |
Het |
| Trim32 |
T |
A |
4: 65,533,013 (GRCm39) |
C523* |
probably null |
Het |
| Ttc38 |
G |
T |
15: 85,722,989 (GRCm39) |
D146Y |
probably damaging |
Het |
| Ttc9 |
T |
A |
12: 81,678,570 (GRCm39) |
L131Q |
probably damaging |
Het |
| Ttn |
T |
C |
2: 76,557,192 (GRCm39) |
|
probably benign |
Het |
| Ttn |
C |
T |
2: 76,643,683 (GRCm39) |
G11436R |
probably damaging |
Het |
| Ubash3b |
G |
A |
9: 40,954,869 (GRCm39) |
P92S |
possibly damaging |
Het |
| Ube4a |
T |
C |
9: 44,859,397 (GRCm39) |
N367S |
probably damaging |
Het |
| Ubr4 |
T |
A |
4: 139,206,851 (GRCm39) |
H4899Q |
possibly damaging |
Het |
| Ufl1 |
C |
T |
4: 25,269,036 (GRCm39) |
G265D |
possibly damaging |
Het |
| Vmn2r27 |
T |
A |
6: 124,201,442 (GRCm39) |
I172F |
probably damaging |
Het |
| Vmn2r6 |
A |
T |
3: 64,463,519 (GRCm39) |
H438Q |
possibly damaging |
Het |
| Vmn2r61 |
A |
G |
7: 41,949,425 (GRCm39) |
D615G |
probably benign |
Het |
| Wdr24 |
T |
A |
17: 26,045,256 (GRCm39) |
D330E |
probably damaging |
Het |
| Zbbx |
A |
T |
3: 74,985,719 (GRCm39) |
N444K |
probably benign |
Het |
| Zc3h7b |
A |
T |
15: 81,676,529 (GRCm39) |
Q757L |
probably damaging |
Het |
| Zpld2 |
T |
G |
4: 133,929,252 (GRCm39) |
N351T |
possibly damaging |
Het |
|
| Other mutations in Duox1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00650:Duox1
|
APN |
2 |
122,163,622 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
IGL00956:Duox1
|
APN |
2 |
122,153,787 (GRCm39) |
missense |
probably benign |
0.42 |
|
IGL01413:Duox1
|
APN |
2 |
122,151,191 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01444:Duox1
|
APN |
2 |
122,170,571 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01633:Duox1
|
APN |
2 |
122,164,279 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01814:Duox1
|
APN |
2 |
122,176,753 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01868:Duox1
|
APN |
2 |
122,168,888 (GRCm39) |
missense |
probably benign |
|
|
IGL02096:Duox1
|
APN |
2 |
122,174,655 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02126:Duox1
|
APN |
2 |
122,176,817 (GRCm39) |
missense |
probably benign |
0.21 |
|
IGL02342:Duox1
|
APN |
2 |
122,177,793 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02687:Duox1
|
APN |
2 |
122,166,896 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02708:Duox1
|
APN |
2 |
122,156,498 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL02935:Duox1
|
APN |
2 |
122,155,000 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
antiquity
|
UTSW |
2 |
122,170,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Dejavous
|
UTSW |
2 |
122,151,345 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1706_Duox1_051
|
UTSW |
2 |
122,149,953 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5032_duox1_732
|
UTSW |
2 |
122,167,798 (GRCm39) |
missense |
probably benign |
|
|
Vaguely
|
UTSW |
2 |
122,156,616 (GRCm39) |
nonsense |
probably null |
|
|
D4043:Duox1
|
UTSW |
2 |
122,175,276 (GRCm39) |
missense |
probably benign |
|
|
R0047:Duox1
|
UTSW |
2 |
122,177,122 (GRCm39) |
unclassified |
probably benign |
|
|
R0047:Duox1
|
UTSW |
2 |
122,177,122 (GRCm39) |
unclassified |
probably benign |
|
|
R0241:Duox1
|
UTSW |
2 |
122,163,878 (GRCm39) |
splice site |
probably benign |
|
|
R0479:Duox1
|
UTSW |
2 |
122,176,861 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0834:Duox1
|
UTSW |
2 |
122,176,982 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1105:Duox1
|
UTSW |
2 |
122,168,183 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1205:Duox1
|
UTSW |
2 |
122,158,406 (GRCm39) |
nonsense |
probably null |
|
|
R1281:Duox1
|
UTSW |
2 |
122,157,569 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1302:Duox1
|
UTSW |
2 |
122,177,760 (GRCm39) |
missense |
probably benign |
0.24 |
|
R1532:Duox1
|
UTSW |
2 |
122,175,204 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1706:Duox1
|
UTSW |
2 |
122,149,953 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1719:Duox1
|
UTSW |
2 |
122,169,125 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1753:Duox1
|
UTSW |
2 |
122,163,910 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1827:Duox1
|
UTSW |
2 |
122,177,861 (GRCm39) |
nonsense |
probably null |
|
|
R1828:Duox1
|
UTSW |
2 |
122,177,861 (GRCm39) |
nonsense |
probably null |
|
|
R1940:Duox1
|
UTSW |
2 |
122,156,465 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1944:Duox1
|
UTSW |
2 |
122,177,001 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2113:Duox1
|
UTSW |
2 |
122,167,735 (GRCm39) |
missense |
probably benign |
|
|
R2202:Duox1
|
UTSW |
2 |
122,175,194 (GRCm39) |
missense |
probably benign |
0.19 |
|
R2314:Duox1
|
UTSW |
2 |
122,164,211 (GRCm39) |
nonsense |
probably null |
|
|
R2507:Duox1
|
UTSW |
2 |
122,163,619 (GRCm39) |
missense |
probably benign |
0.34 |
|
R2508:Duox1
|
UTSW |
2 |
122,163,619 (GRCm39) |
missense |
probably benign |
0.34 |
|
R3177:Duox1
|
UTSW |
2 |
122,170,597 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3277:Duox1
|
UTSW |
2 |
122,170,597 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4124:Duox1
|
UTSW |
2 |
122,167,902 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4271:Duox1
|
UTSW |
2 |
122,154,856 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4411:Duox1
|
UTSW |
2 |
122,168,115 (GRCm39) |
missense |
probably benign |
0.30 |
|
R4419:Duox1
|
UTSW |
2 |
122,157,607 (GRCm39) |
missense |
probably benign |
|
|
R4420:Duox1
|
UTSW |
2 |
122,157,607 (GRCm39) |
missense |
probably benign |
|
|
R4578:Duox1
|
UTSW |
2 |
122,164,258 (GRCm39) |
missense |
probably benign |
0.15 |
|
R4628:Duox1
|
UTSW |
2 |
122,176,733 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4665:Duox1
|
UTSW |
2 |
122,149,956 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4666:Duox1
|
UTSW |
2 |
122,149,956 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4730:Duox1
|
UTSW |
2 |
122,164,312 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4767:Duox1
|
UTSW |
2 |
122,163,922 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R4857:Duox1
|
UTSW |
2 |
122,146,212 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4904:Duox1
|
UTSW |
2 |
122,151,345 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5032:Duox1
|
UTSW |
2 |
122,167,798 (GRCm39) |
missense |
probably benign |
|
|
R5201:Duox1
|
UTSW |
2 |
122,158,403 (GRCm39) |
missense |
probably benign |
|
|
R5474:Duox1
|
UTSW |
2 |
122,177,106 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5835:Duox1
|
UTSW |
2 |
122,158,341 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5939:Duox1
|
UTSW |
2 |
122,176,832 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5941:Duox1
|
UTSW |
2 |
122,174,637 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5943:Duox1
|
UTSW |
2 |
122,163,916 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5970:Duox1
|
UTSW |
2 |
122,170,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6023:Duox1
|
UTSW |
2 |
122,168,165 (GRCm39) |
missense |
probably benign |
0.19 |
|
R6050:Duox1
|
UTSW |
2 |
122,149,956 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6064:Duox1
|
UTSW |
2 |
122,151,243 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6093:Duox1
|
UTSW |
2 |
122,177,755 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6188:Duox1
|
UTSW |
2 |
122,150,275 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6246:Duox1
|
UTSW |
2 |
122,157,655 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6259:Duox1
|
UTSW |
2 |
122,175,264 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6290:Duox1
|
UTSW |
2 |
122,164,288 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6300:Duox1
|
UTSW |
2 |
122,168,181 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6341:Duox1
|
UTSW |
2 |
122,168,202 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6498:Duox1
|
UTSW |
2 |
122,150,088 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6883:Duox1
|
UTSW |
2 |
122,155,065 (GRCm39) |
splice site |
probably null |
|
|
R7002:Duox1
|
UTSW |
2 |
122,150,358 (GRCm39) |
nonsense |
probably null |
|
|
R7410:Duox1
|
UTSW |
2 |
122,176,874 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7421:Duox1
|
UTSW |
2 |
122,153,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7608:Duox1
|
UTSW |
2 |
122,156,616 (GRCm39) |
nonsense |
probably null |
|
|
R7702:Duox1
|
UTSW |
2 |
122,160,120 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R7766:Duox1
|
UTSW |
2 |
122,167,782 (GRCm39) |
missense |
probably benign |
|
|
R7833:Duox1
|
UTSW |
2 |
122,154,869 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7980:Duox1
|
UTSW |
2 |
122,177,801 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R8275:Duox1
|
UTSW |
2 |
122,175,249 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8717:Duox1
|
UTSW |
2 |
122,168,152 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8992:Duox1
|
UTSW |
2 |
122,175,186 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9196:Duox1
|
UTSW |
2 |
122,150,689 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9344:Duox1
|
UTSW |
2 |
122,168,163 (GRCm39) |
missense |
probably benign |
0.14 |
|
R9397:Duox1
|
UTSW |
2 |
122,150,783 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R9491:Duox1
|
UTSW |
2 |
122,156,907 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9510:Duox1
|
UTSW |
2 |
122,160,023 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9521:Duox1
|
UTSW |
2 |
122,159,216 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R9562:Duox1
|
UTSW |
2 |
122,151,203 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9565:Duox1
|
UTSW |
2 |
122,151,203 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9569:Duox1
|
UTSW |
2 |
122,148,971 (GRCm39) |
missense |
probably benign |
|
|
Z1176:Duox1
|
UTSW |
2 |
122,163,519 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACTCACAGACTGCTTATGGTG -3'
(R):5'- ACATCAGTAGCCCACTTCTGTC -3'
Sequencing Primer
(F):5'- GGTGTGCTGGGCAAATATCTGC -3'
(R):5'- AGTAGCCCACTTCTGTCTGGAC -3'
|
| Posted On |
2014-09-17 |
Incidental Mutation