Incidental Mutation 'R2069:Skint6'
| ID |
226925 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Skint6
|
| Ensembl Gene |
ENSMUSG00000087194 |
| Gene Name |
selection and upkeep of intraepithelial T cells 6 |
| Synonyms |
OTTMUSG00000008519 |
| MMRRC Submission |
040074-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.063)
|
| Stock # |
R2069 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
4 |
| Chromosomal Location |
112661813-113144170 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 113095329 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Threonine
at position 110
(I110T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000132312
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000138966]
[ENSMUST00000171224]
|
| AlphaFold |
A7XUZ6 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000138966
AA Change: I110T
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000121870
Gene: ENSMUSG00000087194
AA Change: I110T
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
IGv
|
44 |
125 |
2.32e-8 |
SMART |
|
internal_repeat_1
|
219 |
594 |
1.11e-41 |
PROSPERO |
|
low complexity region
|
601 |
610 |
N/A |
INTRINSIC |
|
low complexity region
|
678 |
690 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
701 |
1076 |
1.11e-41 |
PROSPERO |
|
transmembrane domain
|
1087 |
1104 |
N/A |
INTRINSIC |
|
transmembrane domain
|
1164 |
1186 |
N/A |
INTRINSIC |
|
transmembrane domain
|
1206 |
1228 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000171224
AA Change: I110T
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000132312
Gene: ENSMUSG00000087194
AA Change: I110T
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
IGv
|
44 |
125 |
2.32e-8 |
SMART |
|
internal_repeat_1
|
219 |
594 |
1.11e-41 |
PROSPERO |
|
low complexity region
|
601 |
610 |
N/A |
INTRINSIC |
|
low complexity region
|
678 |
690 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
701 |
1076 |
1.11e-41 |
PROSPERO |
|
transmembrane domain
|
1087 |
1104 |
N/A |
INTRINSIC |
|
transmembrane domain
|
1164 |
1186 |
N/A |
INTRINSIC |
|
transmembrane domain
|
1206 |
1228 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.6467 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.4%
- 20x: 95.4%
|
| Validation Efficiency |
100% (104/104) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 104 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930519G04Rik |
T |
C |
5: 115,012,341 (GRCm39) |
V86A |
probably benign |
Het |
| Abcc3 |
A |
T |
11: 94,255,243 (GRCm39) |
I601N |
probably damaging |
Het |
| Abl2 |
T |
A |
1: 156,448,397 (GRCm39) |
|
probably null |
Het |
| Adgrf4 |
C |
T |
17: 42,977,789 (GRCm39) |
R518Q |
possibly damaging |
Het |
| Ahi1 |
C |
T |
10: 20,835,895 (GRCm39) |
T76I |
probably damaging |
Het |
| Arhgap42 |
C |
T |
9: 9,035,601 (GRCm39) |
G247D |
probably damaging |
Het |
| Arid2 |
C |
T |
15: 96,260,471 (GRCm39) |
L407F |
probably damaging |
Het |
| Atp13a1 |
T |
C |
8: 70,252,423 (GRCm39) |
F606L |
probably benign |
Het |
| Avl9 |
T |
A |
6: 56,713,420 (GRCm39) |
|
probably benign |
Het |
| B3glct |
C |
T |
5: 149,632,845 (GRCm39) |
A65V |
probably damaging |
Het |
| Bcorl1 |
T |
C |
X: 47,490,794 (GRCm39) |
|
probably benign |
Het |
| Bdp1 |
T |
C |
13: 100,187,496 (GRCm39) |
T1624A |
probably benign |
Het |
| Bmp15 |
A |
G |
X: 6,228,075 (GRCm39) |
M263T |
probably benign |
Het |
| Brd8 |
T |
C |
18: 34,747,532 (GRCm39) |
K110E |
probably damaging |
Het |
| Cachd1 |
A |
G |
4: 100,848,041 (GRCm39) |
D1052G |
probably damaging |
Het |
| Capn9 |
G |
A |
8: 125,332,450 (GRCm39) |
G430R |
possibly damaging |
Het |
| Ccdc113 |
G |
A |
8: 96,283,924 (GRCm39) |
E333K |
probably benign |
Het |
| Ccnl2 |
A |
T |
4: 155,896,938 (GRCm39) |
|
probably null |
Het |
| Ccr9 |
T |
C |
9: 123,608,429 (GRCm39) |
F37S |
probably benign |
Het |
| Cdh20 |
A |
T |
1: 110,065,889 (GRCm39) |
D721V |
probably damaging |
Het |
| Ceacam10 |
A |
T |
7: 24,477,797 (GRCm39) |
N104I |
probably damaging |
Het |
| Cenpk |
T |
A |
13: 104,372,684 (GRCm39) |
|
probably benign |
Het |
| Cfi |
A |
G |
3: 129,652,453 (GRCm39) |
|
probably null |
Het |
| Chd1 |
T |
C |
17: 15,962,556 (GRCm39) |
F771S |
probably damaging |
Het |
| Chil4 |
G |
A |
3: 106,126,771 (GRCm39) |
L4F |
probably benign |
Het |
| Cilp |
G |
A |
9: 65,185,372 (GRCm39) |
R489Q |
possibly damaging |
Het |
| Cntnap5b |
G |
A |
1: 100,286,450 (GRCm39) |
G402R |
probably benign |
Het |
| Coq8b |
A |
G |
7: 26,956,802 (GRCm39) |
E485G |
probably damaging |
Het |
| Cse1l |
A |
G |
2: 166,783,412 (GRCm39) |
S733G |
probably benign |
Het |
| Dnah5 |
G |
A |
15: 28,312,534 (GRCm39) |
|
probably null |
Het |
| Dnmt3l |
T |
C |
10: 77,888,566 (GRCm39) |
V156A |
probably damaging |
Het |
| Duox1 |
A |
T |
2: 122,163,543 (GRCm39) |
T792S |
probably benign |
Het |
| Duox2 |
T |
C |
2: 122,117,589 (GRCm39) |
D915G |
probably benign |
Het |
| Efcab5 |
A |
T |
11: 77,063,147 (GRCm39) |
M115K |
probably benign |
Het |
| Eif2s1 |
G |
A |
12: 78,923,959 (GRCm39) |
D139N |
probably benign |
Het |
| Erg |
A |
G |
16: 95,161,937 (GRCm39) |
F390L |
probably damaging |
Het |
| Fam193b |
A |
T |
13: 55,690,811 (GRCm39) |
S650R |
probably damaging |
Het |
| Fbp2 |
T |
A |
13: 63,001,875 (GRCm39) |
K113N |
possibly damaging |
Het |
| Fnbp4 |
T |
G |
2: 90,588,716 (GRCm39) |
S496A |
probably damaging |
Het |
| Gab3 |
C |
A |
X: 74,043,701 (GRCm39) |
R475L |
probably damaging |
Het |
| Gsap |
T |
C |
5: 21,431,837 (GRCm39) |
|
probably benign |
Het |
| Gucy1a2 |
C |
T |
9: 3,582,697 (GRCm39) |
L160F |
probably damaging |
Het |
| Hivep1 |
C |
T |
13: 42,337,262 (GRCm39) |
A2447V |
possibly damaging |
Het |
| Insc |
G |
T |
7: 114,403,828 (GRCm39) |
|
probably null |
Het |
| Jph2 |
A |
G |
2: 163,181,605 (GRCm39) |
S520P |
possibly damaging |
Het |
| Kidins220 |
T |
A |
12: 25,037,005 (GRCm39) |
|
probably benign |
Het |
| Krtap29-1 |
A |
G |
11: 99,869,438 (GRCm39) |
S148P |
probably damaging |
Het |
| Ltbp2 |
A |
C |
12: 84,840,507 (GRCm39) |
C1000G |
probably damaging |
Het |
| Map2k3 |
T |
C |
11: 60,840,853 (GRCm39) |
F294S |
probably damaging |
Het |
| Map4k2 |
C |
A |
19: 6,392,768 (GRCm39) |
|
probably benign |
Het |
| Mboat2 |
T |
C |
12: 25,001,442 (GRCm39) |
V281A |
probably benign |
Het |
| Mdga2 |
G |
A |
12: 66,615,691 (GRCm39) |
R570* |
probably null |
Het |
| Mlxipl |
A |
G |
5: 135,135,859 (GRCm39) |
D28G |
probably damaging |
Het |
| Morc2b |
T |
C |
17: 33,355,734 (GRCm39) |
I679M |
probably benign |
Het |
| Myh4 |
T |
C |
11: 67,137,192 (GRCm39) |
|
probably benign |
Het |
| Nfib |
A |
C |
4: 82,416,852 (GRCm39) |
L61R |
probably damaging |
Het |
| Noc2l |
C |
A |
4: 156,325,907 (GRCm39) |
Y227* |
probably null |
Het |
| Nrde2 |
A |
G |
12: 100,108,491 (GRCm39) |
S367P |
probably damaging |
Het |
| Nup93 |
C |
A |
8: 94,970,367 (GRCm39) |
P89T |
probably damaging |
Het |
| Obsl1 |
G |
A |
1: 75,486,756 (GRCm38) |
T1764M |
probably benign |
Het |
| Or10a2 |
A |
T |
7: 106,673,826 (GRCm39) |
K264* |
probably null |
Het |
| Or11h4 |
T |
A |
14: 50,974,033 (GRCm39) |
E195D |
possibly damaging |
Het |
| Or4a68 |
C |
T |
2: 89,269,927 (GRCm39) |
R232H |
probably benign |
Het |
| Or4k77 |
A |
G |
2: 111,199,440 (GRCm39) |
I154M |
probably benign |
Het |
| Or6b9 |
A |
T |
7: 106,555,494 (GRCm39) |
Y216* |
probably null |
Het |
| Or9r7 |
A |
G |
10: 129,962,074 (GRCm39) |
I284T |
possibly damaging |
Het |
| Oxct1 |
G |
T |
15: 4,122,007 (GRCm39) |
A319S |
probably null |
Het |
| P2ry10 |
A |
G |
X: 106,146,859 (GRCm39) |
S265G |
probably benign |
Het |
| Peak1 |
A |
T |
9: 56,166,043 (GRCm39) |
N628K |
probably damaging |
Het |
| Pkdrej |
T |
A |
15: 85,705,432 (GRCm39) |
Q168L |
probably benign |
Het |
| Plaat5 |
T |
C |
19: 7,590,003 (GRCm39) |
S10P |
possibly damaging |
Het |
| Plec |
A |
G |
15: 76,073,126 (GRCm39) |
M604T |
probably benign |
Het |
| Pmfbp1 |
A |
T |
8: 110,258,735 (GRCm39) |
N680I |
possibly damaging |
Het |
| Pnma8b |
T |
C |
7: 16,679,714 (GRCm39) |
W233R |
probably damaging |
Het |
| Pxn |
A |
G |
5: 115,683,726 (GRCm39) |
N186S |
probably benign |
Het |
| Rsad1 |
A |
C |
11: 94,439,951 (GRCm39) |
|
probably benign |
Het |
| Runx2 |
A |
G |
17: 45,046,229 (GRCm39) |
I112T |
probably benign |
Het |
| S1pr2 |
A |
T |
9: 20,878,790 (GRCm39) |
L346Q |
probably damaging |
Het |
| Slc36a4 |
T |
A |
9: 15,638,276 (GRCm39) |
F234Y |
probably damaging |
Het |
| Slitrk2 |
T |
A |
X: 65,698,235 (GRCm39) |
V242D |
probably damaging |
Het |
| Sp100 |
A |
G |
1: 85,608,863 (GRCm39) |
|
probably null |
Het |
| Spryd3 |
A |
C |
15: 102,026,616 (GRCm39) |
L352V |
probably benign |
Het |
| Ssc4d |
A |
C |
5: 135,999,171 (GRCm39) |
W11G |
possibly damaging |
Het |
| Stx17 |
T |
A |
4: 48,158,870 (GRCm39) |
D83E |
probably damaging |
Het |
| Tlk2 |
A |
T |
11: 105,131,266 (GRCm39) |
Q204L |
probably benign |
Het |
| Tnfrsf21 |
A |
T |
17: 43,348,829 (GRCm39) |
H147L |
possibly damaging |
Het |
| Tnrc18 |
A |
T |
5: 142,751,842 (GRCm39) |
D1154E |
unknown |
Het |
| Trap1 |
A |
G |
16: 3,886,200 (GRCm39) |
S86P |
probably benign |
Het |
| Trim32 |
T |
A |
4: 65,533,013 (GRCm39) |
C523* |
probably null |
Het |
| Ttc38 |
G |
T |
15: 85,722,989 (GRCm39) |
D146Y |
probably damaging |
Het |
| Ttc9 |
T |
A |
12: 81,678,570 (GRCm39) |
L131Q |
probably damaging |
Het |
| Ttn |
T |
C |
2: 76,557,192 (GRCm39) |
|
probably benign |
Het |
| Ttn |
C |
T |
2: 76,643,683 (GRCm39) |
G11436R |
probably damaging |
Het |
| Ubash3b |
G |
A |
9: 40,954,869 (GRCm39) |
P92S |
possibly damaging |
Het |
| Ube4a |
T |
C |
9: 44,859,397 (GRCm39) |
N367S |
probably damaging |
Het |
| Ubr4 |
T |
A |
4: 139,206,851 (GRCm39) |
H4899Q |
possibly damaging |
Het |
| Ufl1 |
C |
T |
4: 25,269,036 (GRCm39) |
G265D |
possibly damaging |
Het |
| Vmn2r27 |
T |
A |
6: 124,201,442 (GRCm39) |
I172F |
probably damaging |
Het |
| Vmn2r6 |
A |
T |
3: 64,463,519 (GRCm39) |
H438Q |
possibly damaging |
Het |
| Vmn2r61 |
A |
G |
7: 41,949,425 (GRCm39) |
D615G |
probably benign |
Het |
| Wdr24 |
T |
A |
17: 26,045,256 (GRCm39) |
D330E |
probably damaging |
Het |
| Zbbx |
A |
T |
3: 74,985,719 (GRCm39) |
N444K |
probably benign |
Het |
| Zc3h7b |
A |
T |
15: 81,676,529 (GRCm39) |
Q757L |
probably damaging |
Het |
| Zpld2 |
T |
G |
4: 133,929,252 (GRCm39) |
N351T |
possibly damaging |
Het |
|
| Other mutations in Skint6 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01123:Skint6
|
APN |
4 |
112,661,879 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL01296:Skint6
|
APN |
4 |
113,093,637 (GRCm39) |
missense |
probably benign |
0.37 |
|
IGL01343:Skint6
|
APN |
4 |
113,140,823 (GRCm39) |
missense |
probably benign |
0.07 |
|
IGL01543:Skint6
|
APN |
4 |
112,757,160 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL01633:Skint6
|
APN |
4 |
113,095,246 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01818:Skint6
|
APN |
4 |
112,805,766 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL02124:Skint6
|
APN |
4 |
112,944,993 (GRCm39) |
missense |
probably benign |
|
|
IGL02517:Skint6
|
APN |
4 |
112,805,737 (GRCm39) |
splice site |
probably benign |
|
|
IGL02647:Skint6
|
APN |
4 |
112,985,088 (GRCm39) |
splice site |
probably benign |
|
|
IGL02887:Skint6
|
APN |
4 |
113,095,381 (GRCm39) |
nonsense |
probably null |
|
|
IGL03026:Skint6
|
APN |
4 |
112,848,441 (GRCm39) |
splice site |
probably null |
|
|
IGL03030:Skint6
|
APN |
4 |
112,870,153 (GRCm39) |
missense |
probably benign |
0.03 |
|
meissner
|
UTSW |
4 |
112,661,891 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
Tegmentum
|
UTSW |
4 |
112,700,019 (GRCm39) |
splice site |
probably null |
|
|
PIT4576001:Skint6
|
UTSW |
4 |
112,910,564 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R0058:Skint6
|
UTSW |
4 |
112,904,012 (GRCm39) |
splice site |
probably benign |
|
|
R0058:Skint6
|
UTSW |
4 |
112,904,012 (GRCm39) |
splice site |
probably benign |
|
|
R0099:Skint6
|
UTSW |
4 |
112,668,698 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R0158:Skint6
|
UTSW |
4 |
113,042,011 (GRCm39) |
splice site |
probably benign |
|
|
R0164:Skint6
|
UTSW |
4 |
112,848,433 (GRCm39) |
splice site |
probably benign |
|
|
R0312:Skint6
|
UTSW |
4 |
112,666,297 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R0591:Skint6
|
UTSW |
4 |
112,715,366 (GRCm39) |
splice site |
probably benign |
|
|
R0762:Skint6
|
UTSW |
4 |
112,722,848 (GRCm39) |
splice site |
probably benign |
|
|
R0941:Skint6
|
UTSW |
4 |
113,095,555 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1023:Skint6
|
UTSW |
4 |
113,095,300 (GRCm39) |
missense |
probably benign |
0.20 |
|
R1132:Skint6
|
UTSW |
4 |
112,755,296 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1228:Skint6
|
UTSW |
4 |
112,711,649 (GRCm39) |
missense |
probably benign |
|
|
R1338:Skint6
|
UTSW |
4 |
112,870,158 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R1432:Skint6
|
UTSW |
4 |
112,726,721 (GRCm39) |
splice site |
probably benign |
|
|
R1512:Skint6
|
UTSW |
4 |
113,095,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1577:Skint6
|
UTSW |
4 |
113,005,720 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R1733:Skint6
|
UTSW |
4 |
113,034,234 (GRCm39) |
splice site |
probably benign |
|
|
R1762:Skint6
|
UTSW |
4 |
113,093,678 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1891:Skint6
|
UTSW |
4 |
112,703,893 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R1908:Skint6
|
UTSW |
4 |
112,749,187 (GRCm39) |
missense |
probably benign |
|
|
R2089:Skint6
|
UTSW |
4 |
112,703,881 (GRCm39) |
missense |
probably benign |
|
|
R2091:Skint6
|
UTSW |
4 |
112,703,881 (GRCm39) |
missense |
probably benign |
|
|
R2091:Skint6
|
UTSW |
4 |
112,703,881 (GRCm39) |
missense |
probably benign |
|
|
R2144:Skint6
|
UTSW |
4 |
113,093,457 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R2166:Skint6
|
UTSW |
4 |
112,711,649 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2192:Skint6
|
UTSW |
4 |
112,722,909 (GRCm39) |
nonsense |
probably null |
|
|
R2267:Skint6
|
UTSW |
4 |
112,700,019 (GRCm39) |
splice site |
probably null |
|
|
R2312:Skint6
|
UTSW |
4 |
113,095,339 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2324:Skint6
|
UTSW |
4 |
112,729,654 (GRCm39) |
splice site |
probably null |
|
|
R2342:Skint6
|
UTSW |
4 |
113,034,180 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3028:Skint6
|
UTSW |
4 |
113,093,690 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R3704:Skint6
|
UTSW |
4 |
112,993,669 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R3752:Skint6
|
UTSW |
4 |
112,700,096 (GRCm39) |
splice site |
probably benign |
|
|
R3760:Skint6
|
UTSW |
4 |
112,794,655 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R3827:Skint6
|
UTSW |
4 |
112,794,634 (GRCm39) |
missense |
probably benign |
|
|
R4377:Skint6
|
UTSW |
4 |
113,093,715 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R4406:Skint6
|
UTSW |
4 |
113,013,683 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4611:Skint6
|
UTSW |
4 |
112,931,273 (GRCm39) |
missense |
probably benign |
|
|
R4780:Skint6
|
UTSW |
4 |
113,093,594 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4788:Skint6
|
UTSW |
4 |
113,095,533 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R4818:Skint6
|
UTSW |
4 |
112,812,589 (GRCm39) |
intron |
probably benign |
|
|
R4900:Skint6
|
UTSW |
4 |
112,924,667 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4972:Skint6
|
UTSW |
4 |
112,692,265 (GRCm39) |
missense |
probably benign |
|
|
R5008:Skint6
|
UTSW |
4 |
112,848,452 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R5016:Skint6
|
UTSW |
4 |
113,028,730 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R5085:Skint6
|
UTSW |
4 |
113,093,465 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5165:Skint6
|
UTSW |
4 |
112,722,865 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R5221:Skint6
|
UTSW |
4 |
112,752,121 (GRCm39) |
splice site |
probably null |
|
|
R5310:Skint6
|
UTSW |
4 |
113,041,965 (GRCm39) |
nonsense |
probably null |
|
|
R5423:Skint6
|
UTSW |
4 |
112,707,937 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5436:Skint6
|
UTSW |
4 |
112,953,788 (GRCm39) |
missense |
probably benign |
0.08 |
|
R5447:Skint6
|
UTSW |
4 |
112,963,106 (GRCm39) |
missense |
probably benign |
0.34 |
|
R5564:Skint6
|
UTSW |
4 |
112,846,162 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R5629:Skint6
|
UTSW |
4 |
112,870,176 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R5936:Skint6
|
UTSW |
4 |
112,953,790 (GRCm39) |
missense |
probably benign |
0.33 |
|
R5993:Skint6
|
UTSW |
4 |
112,666,276 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6027:Skint6
|
UTSW |
4 |
112,953,761 (GRCm39) |
splice site |
probably null |
|
|
R6174:Skint6
|
UTSW |
4 |
112,696,510 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R6497:Skint6
|
UTSW |
4 |
113,093,595 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6552:Skint6
|
UTSW |
4 |
112,924,687 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R6645:Skint6
|
UTSW |
4 |
112,749,235 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R6810:Skint6
|
UTSW |
4 |
112,805,577 (GRCm39) |
splice site |
probably null |
|
|
R7003:Skint6
|
UTSW |
4 |
112,963,109 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7211:Skint6
|
UTSW |
4 |
113,095,566 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7269:Skint6
|
UTSW |
4 |
112,711,686 (GRCm39) |
splice site |
probably null |
|
|
R7398:Skint6
|
UTSW |
4 |
112,755,335 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7438:Skint6
|
UTSW |
4 |
113,095,425 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7461:Skint6
|
UTSW |
4 |
113,034,243 (GRCm39) |
splice site |
probably null |
|
|
R7536:Skint6
|
UTSW |
4 |
112,668,744 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7613:Skint6
|
UTSW |
4 |
113,034,243 (GRCm39) |
splice site |
probably null |
|
|
R7956:Skint6
|
UTSW |
4 |
112,703,894 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8118:Skint6
|
UTSW |
4 |
113,013,691 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8118:Skint6
|
UTSW |
4 |
112,722,872 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8197:Skint6
|
UTSW |
4 |
112,752,040 (GRCm39) |
splice site |
probably null |
|
|
R8218:Skint6
|
UTSW |
4 |
112,696,471 (GRCm39) |
splice site |
probably null |
|
|
R8344:Skint6
|
UTSW |
4 |
113,093,642 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8518:Skint6
|
UTSW |
4 |
113,095,465 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R8776:Skint6
|
UTSW |
4 |
112,661,885 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R8776-TAIL:Skint6
|
UTSW |
4 |
112,661,885 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R8794:Skint6
|
UTSW |
4 |
113,049,869 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8796:Skint6
|
UTSW |
4 |
112,661,891 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R8812:Skint6
|
UTSW |
4 |
112,846,149 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8866:Skint6
|
UTSW |
4 |
112,711,650 (GRCm39) |
missense |
probably benign |
|
|
R8881:Skint6
|
UTSW |
4 |
112,672,716 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8949:Skint6
|
UTSW |
4 |
112,931,296 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8967:Skint6
|
UTSW |
4 |
112,729,701 (GRCm39) |
nonsense |
probably null |
|
|
R9005:Skint6
|
UTSW |
4 |
113,095,347 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9007:Skint6
|
UTSW |
4 |
113,095,347 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9053:Skint6
|
UTSW |
4 |
113,095,347 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9055:Skint6
|
UTSW |
4 |
113,095,347 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9144:Skint6
|
UTSW |
4 |
112,985,102 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R9149:Skint6
|
UTSW |
4 |
113,034,173 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9297:Skint6
|
UTSW |
4 |
112,668,717 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9388:Skint6
|
UTSW |
4 |
113,049,838 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R9407:Skint6
|
UTSW |
4 |
113,034,224 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R9475:Skint6
|
UTSW |
4 |
112,664,037 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9515:Skint6
|
UTSW |
4 |
112,715,375 (GRCm39) |
missense |
probably benign |
|
|
R9572:Skint6
|
UTSW |
4 |
112,985,128 (GRCm39) |
missense |
probably benign |
|
|
R9689:Skint6
|
UTSW |
4 |
113,093,546 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9744:Skint6
|
UTSW |
4 |
112,666,360 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9785:Skint6
|
UTSW |
4 |
112,740,884 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
Z1176:Skint6
|
UTSW |
4 |
113,095,491 (GRCm39) |
missense |
probably damaging |
0.96 |
|
Z1176:Skint6
|
UTSW |
4 |
112,749,211 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
Z1176:Skint6
|
UTSW |
4 |
113,095,492 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
Z1177:Skint6
|
UTSW |
4 |
112,963,158 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Z1177:Skint6
|
UTSW |
4 |
112,664,125 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
| Predicted Primers |
PCR Primer
(F):5'- GATCATCTTGTTAGTCAATCCATGC -3'
(R):5'- TCTAGAACTCAGTTGTCAGTTGTC -3'
Sequencing Primer
(F):5'- TGTTAGTCAATCCATGCAATAAGAG -3'
(R):5'- AGAACTCAGTTGTCAGTTGTCTCCAC -3'
|
| Posted On |
2014-09-17 |
Incidental Mutation