Incidental Mutation 'R2069:Mdga2'
ID 226972
Institutional Source Beutler Lab
Gene Symbol Mdga2
Ensembl Gene ENSMUSG00000034912
Gene Name MAM domain containing glycosylphosphatidylinositol anchor 2
Synonyms 6720489L24Rik, Mdga2, Adp, 9330209L04Rik, Mamdc1
MMRRC Submission 040074-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R2069 (G1)
Quality Score 225
Status Validated
Chromosome 12
Chromosomal Location 66512834-67269323 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to A at 66615691 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Stop codon at position 570 (R570*)
Ref Sequence ENSEMBL: ENSMUSP00000152613 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000037181] [ENSMUST00000222167] [ENSMUST00000223141]
AlphaFold P60755
Predicted Effect probably null
Transcript: ENSMUST00000037181
AA Change: R639*
SMART Domains Protein: ENSMUSP00000046761
Gene: ENSMUSG00000034912
AA Change: R639*

DomainStartEndE-ValueType
IGc2 122 186 1.38e-15 SMART
IG 213 307 1.79e0 SMART
IGc2 324 386 1.56e-14 SMART
IGc2 419 493 4.43e-5 SMART
low complexity region 495 507 N/A INTRINSIC
IGc2 525 591 1.97e-11 SMART
IG_like 621 687 2.5e0 SMART
Blast:FN3 707 795 4e-40 BLAST
MAM 812 990 3.4e-49 SMART
transmembrane domain 999 1021 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000101379
SMART Domains Protein: ENSMUSP00000098930
Gene: ENSMUSG00000034912

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
SCOP:d1cs6a1 40 72 2e-5 SMART
Blast:IG 47 72 9e-11 BLAST
Predicted Effect probably null
Transcript: ENSMUST00000178814
AA Change: R629*
SMART Domains Protein: ENSMUSP00000137608
Gene: ENSMUSG00000034912
AA Change: R629*

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
IGc2 53 117 1.38e-15 SMART
IG 144 238 1.79e0 SMART
IGc2 255 317 1.56e-14 SMART
IGc2 350 424 4.43e-5 SMART
low complexity region 426 438 N/A INTRINSIC
IGc2 456 522 1.97e-11 SMART
IG_like 552 618 2.5e0 SMART
Blast:FN3 638 726 3e-40 BLAST
MAM 736 914 1.38e-49 SMART
transmembrane domain 923 945 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000222167
AA Change: R570*
Predicted Effect probably null
Transcript: ENSMUST00000223141
AA Change: R570*
Predicted Effect noncoding transcript
Transcript: ENSMUST00000223289
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.4%
Validation Efficiency 100% (104/104)
MGI Phenotype PHENOTYPE: Mice that paternally inherit an allele disrupted by transgene insertion exhibit varying degrees of abnormalities in the skull, paw, and tail. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 104 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930519G04Rik T C 5: 115,012,341 (GRCm39) V86A probably benign Het
Abcc3 A T 11: 94,255,243 (GRCm39) I601N probably damaging Het
Abl2 T A 1: 156,448,397 (GRCm39) probably null Het
Adgrf4 C T 17: 42,977,789 (GRCm39) R518Q possibly damaging Het
Ahi1 C T 10: 20,835,895 (GRCm39) T76I probably damaging Het
Arhgap42 C T 9: 9,035,601 (GRCm39) G247D probably damaging Het
Arid2 C T 15: 96,260,471 (GRCm39) L407F probably damaging Het
Atp13a1 T C 8: 70,252,423 (GRCm39) F606L probably benign Het
Avl9 T A 6: 56,713,420 (GRCm39) probably benign Het
B3glct C T 5: 149,632,845 (GRCm39) A65V probably damaging Het
Bcorl1 T C X: 47,490,794 (GRCm39) probably benign Het
Bdp1 T C 13: 100,187,496 (GRCm39) T1624A probably benign Het
Bmp15 A G X: 6,228,075 (GRCm39) M263T probably benign Het
Brd8 T C 18: 34,747,532 (GRCm39) K110E probably damaging Het
Cachd1 A G 4: 100,848,041 (GRCm39) D1052G probably damaging Het
Capn9 G A 8: 125,332,450 (GRCm39) G430R possibly damaging Het
Ccdc113 G A 8: 96,283,924 (GRCm39) E333K probably benign Het
Ccnl2 A T 4: 155,896,938 (GRCm39) probably null Het
Ccr9 T C 9: 123,608,429 (GRCm39) F37S probably benign Het
Cdh20 A T 1: 110,065,889 (GRCm39) D721V probably damaging Het
Ceacam10 A T 7: 24,477,797 (GRCm39) N104I probably damaging Het
Cenpk T A 13: 104,372,684 (GRCm39) probably benign Het
Cfi A G 3: 129,652,453 (GRCm39) probably null Het
Chd1 T C 17: 15,962,556 (GRCm39) F771S probably damaging Het
Chil4 G A 3: 106,126,771 (GRCm39) L4F probably benign Het
Cilp G A 9: 65,185,372 (GRCm39) R489Q possibly damaging Het
Cntnap5b G A 1: 100,286,450 (GRCm39) G402R probably benign Het
Coq8b A G 7: 26,956,802 (GRCm39) E485G probably damaging Het
Cse1l A G 2: 166,783,412 (GRCm39) S733G probably benign Het
Dnah5 G A 15: 28,312,534 (GRCm39) probably null Het
Dnmt3l T C 10: 77,888,566 (GRCm39) V156A probably damaging Het
Duox1 A T 2: 122,163,543 (GRCm39) T792S probably benign Het
Duox2 T C 2: 122,117,589 (GRCm39) D915G probably benign Het
Efcab5 A T 11: 77,063,147 (GRCm39) M115K probably benign Het
Eif2s1 G A 12: 78,923,959 (GRCm39) D139N probably benign Het
Erg A G 16: 95,161,937 (GRCm39) F390L probably damaging Het
Fam193b A T 13: 55,690,811 (GRCm39) S650R probably damaging Het
Fbp2 T A 13: 63,001,875 (GRCm39) K113N possibly damaging Het
Fnbp4 T G 2: 90,588,716 (GRCm39) S496A probably damaging Het
Gab3 C A X: 74,043,701 (GRCm39) R475L probably damaging Het
Gsap T C 5: 21,431,837 (GRCm39) probably benign Het
Gucy1a2 C T 9: 3,582,697 (GRCm39) L160F probably damaging Het
Hivep1 C T 13: 42,337,262 (GRCm39) A2447V possibly damaging Het
Insc G T 7: 114,403,828 (GRCm39) probably null Het
Jph2 A G 2: 163,181,605 (GRCm39) S520P possibly damaging Het
Kidins220 T A 12: 25,037,005 (GRCm39) probably benign Het
Krtap29-1 A G 11: 99,869,438 (GRCm39) S148P probably damaging Het
Ltbp2 A C 12: 84,840,507 (GRCm39) C1000G probably damaging Het
Map2k3 T C 11: 60,840,853 (GRCm39) F294S probably damaging Het
Map4k2 C A 19: 6,392,768 (GRCm39) probably benign Het
Mboat2 T C 12: 25,001,442 (GRCm39) V281A probably benign Het
Mlxipl A G 5: 135,135,859 (GRCm39) D28G probably damaging Het
Morc2b T C 17: 33,355,734 (GRCm39) I679M probably benign Het
Myh4 T C 11: 67,137,192 (GRCm39) probably benign Het
Nfib A C 4: 82,416,852 (GRCm39) L61R probably damaging Het
Noc2l C A 4: 156,325,907 (GRCm39) Y227* probably null Het
Nrde2 A G 12: 100,108,491 (GRCm39) S367P probably damaging Het
Nup93 C A 8: 94,970,367 (GRCm39) P89T probably damaging Het
Obsl1 G A 1: 75,486,756 (GRCm38) T1764M probably benign Het
Or10a2 A T 7: 106,673,826 (GRCm39) K264* probably null Het
Or11h4 T A 14: 50,974,033 (GRCm39) E195D possibly damaging Het
Or4a68 C T 2: 89,269,927 (GRCm39) R232H probably benign Het
Or4k77 A G 2: 111,199,440 (GRCm39) I154M probably benign Het
Or6b9 A T 7: 106,555,494 (GRCm39) Y216* probably null Het
Or9r7 A G 10: 129,962,074 (GRCm39) I284T possibly damaging Het
Oxct1 G T 15: 4,122,007 (GRCm39) A319S probably null Het
P2ry10 A G X: 106,146,859 (GRCm39) S265G probably benign Het
Peak1 A T 9: 56,166,043 (GRCm39) N628K probably damaging Het
Pkdrej T A 15: 85,705,432 (GRCm39) Q168L probably benign Het
Plaat5 T C 19: 7,590,003 (GRCm39) S10P possibly damaging Het
Plec A G 15: 76,073,126 (GRCm39) M604T probably benign Het
Pmfbp1 A T 8: 110,258,735 (GRCm39) N680I possibly damaging Het
Pnma8b T C 7: 16,679,714 (GRCm39) W233R probably damaging Het
Pxn A G 5: 115,683,726 (GRCm39) N186S probably benign Het
Rsad1 A C 11: 94,439,951 (GRCm39) probably benign Het
Runx2 A G 17: 45,046,229 (GRCm39) I112T probably benign Het
S1pr2 A T 9: 20,878,790 (GRCm39) L346Q probably damaging Het
Skint6 A G 4: 113,095,329 (GRCm39) I110T probably damaging Het
Slc36a4 T A 9: 15,638,276 (GRCm39) F234Y probably damaging Het
Slitrk2 T A X: 65,698,235 (GRCm39) V242D probably damaging Het
Sp100 A G 1: 85,608,863 (GRCm39) probably null Het
Spryd3 A C 15: 102,026,616 (GRCm39) L352V probably benign Het
Ssc4d A C 5: 135,999,171 (GRCm39) W11G possibly damaging Het
Stx17 T A 4: 48,158,870 (GRCm39) D83E probably damaging Het
Tlk2 A T 11: 105,131,266 (GRCm39) Q204L probably benign Het
Tnfrsf21 A T 17: 43,348,829 (GRCm39) H147L possibly damaging Het
Tnrc18 A T 5: 142,751,842 (GRCm39) D1154E unknown Het
Trap1 A G 16: 3,886,200 (GRCm39) S86P probably benign Het
Trim32 T A 4: 65,533,013 (GRCm39) C523* probably null Het
Ttc38 G T 15: 85,722,989 (GRCm39) D146Y probably damaging Het
Ttc9 T A 12: 81,678,570 (GRCm39) L131Q probably damaging Het
Ttn T C 2: 76,557,192 (GRCm39) probably benign Het
Ttn C T 2: 76,643,683 (GRCm39) G11436R probably damaging Het
Ubash3b G A 9: 40,954,869 (GRCm39) P92S possibly damaging Het
Ube4a T C 9: 44,859,397 (GRCm39) N367S probably damaging Het
Ubr4 T A 4: 139,206,851 (GRCm39) H4899Q possibly damaging Het
Ufl1 C T 4: 25,269,036 (GRCm39) G265D possibly damaging Het
Vmn2r27 T A 6: 124,201,442 (GRCm39) I172F probably damaging Het
Vmn2r6 A T 3: 64,463,519 (GRCm39) H438Q possibly damaging Het
Vmn2r61 A G 7: 41,949,425 (GRCm39) D615G probably benign Het
Wdr24 T A 17: 26,045,256 (GRCm39) D330E probably damaging Het
Zbbx A T 3: 74,985,719 (GRCm39) N444K probably benign Het
Zc3h7b A T 15: 81,676,529 (GRCm39) Q757L probably damaging Het
Zpld2 T G 4: 133,929,252 (GRCm39) N351T possibly damaging Het
Other mutations in Mdga2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01343:Mdga2 APN 12 66,769,883 (GRCm39) missense probably damaging 0.97
IGL01632:Mdga2 APN 12 66,676,672 (GRCm39) splice site probably benign
IGL01843:Mdga2 APN 12 66,769,905 (GRCm39) critical splice acceptor site probably null
IGL02230:Mdga2 APN 12 66,702,197 (GRCm39) nonsense probably null
IGL02348:Mdga2 APN 12 66,597,349 (GRCm39) missense probably damaging 1.00
IGL02473:Mdga2 APN 12 66,597,385 (GRCm39) missense possibly damaging 0.73
IGL02795:Mdga2 APN 12 66,736,206 (GRCm39) missense probably benign 0.00
IGL02901:Mdga2 APN 12 66,844,583 (GRCm39) splice site probably benign
IGL03373:Mdga2 APN 12 66,763,496 (GRCm39) missense probably damaging 0.99
PIT4362001:Mdga2 UTSW 12 66,844,542 (GRCm39) missense possibly damaging 0.83
PIT4377001:Mdga2 UTSW 12 66,763,469 (GRCm39) missense probably damaging 0.99
R0106:Mdga2 UTSW 12 66,763,480 (GRCm39) missense probably damaging 1.00
R0106:Mdga2 UTSW 12 66,763,480 (GRCm39) missense probably damaging 1.00
R0110:Mdga2 UTSW 12 66,517,700 (GRCm39) missense possibly damaging 0.66
R0218:Mdga2 UTSW 12 66,701,894 (GRCm39) missense probably damaging 1.00
R0450:Mdga2 UTSW 12 66,517,700 (GRCm39) missense possibly damaging 0.66
R0801:Mdga2 UTSW 12 66,533,507 (GRCm39) missense probably damaging 1.00
R0847:Mdga2 UTSW 12 66,769,854 (GRCm39) missense probably damaging 1.00
R1056:Mdga2 UTSW 12 66,769,894 (GRCm39) missense probably damaging 0.97
R1086:Mdga2 UTSW 12 66,552,876 (GRCm39) splice site probably benign
R1335:Mdga2 UTSW 12 66,763,516 (GRCm39) splice site probably null
R1382:Mdga2 UTSW 12 66,517,690 (GRCm39) missense possibly damaging 0.68
R1490:Mdga2 UTSW 12 66,844,530 (GRCm39) missense probably benign 0.01
R1521:Mdga2 UTSW 12 66,615,700 (GRCm39) missense probably benign 0.00
R1556:Mdga2 UTSW 12 66,597,367 (GRCm39) missense possibly damaging 0.92
R1676:Mdga2 UTSW 12 66,615,547 (GRCm39) nonsense probably null
R1676:Mdga2 UTSW 12 66,615,546 (GRCm39) missense probably damaging 1.00
R1698:Mdga2 UTSW 12 66,736,109 (GRCm39) missense probably damaging 0.97
R1954:Mdga2 UTSW 12 66,533,482 (GRCm39) splice site probably benign
R2077:Mdga2 UTSW 12 66,702,136 (GRCm39) missense probably damaging 1.00
R2118:Mdga2 UTSW 12 66,915,526 (GRCm39) missense probably damaging 1.00
R2146:Mdga2 UTSW 12 66,915,515 (GRCm39) missense probably damaging 1.00
R2158:Mdga2 UTSW 12 66,736,155 (GRCm39) missense possibly damaging 0.64
R2189:Mdga2 UTSW 12 66,519,970 (GRCm39) splice site probably null
R2293:Mdga2 UTSW 12 66,615,759 (GRCm39) nonsense probably null
R2886:Mdga2 UTSW 12 66,553,044 (GRCm39) splice site probably benign
R2960:Mdga2 UTSW 12 66,676,752 (GRCm39) nonsense probably null
R3937:Mdga2 UTSW 12 67,267,980 (GRCm39) unclassified probably benign
R4437:Mdga2 UTSW 12 66,519,972 (GRCm39) splice site probably null
R4514:Mdga2 UTSW 12 66,763,496 (GRCm39) missense probably damaging 0.99
R4693:Mdga2 UTSW 12 66,844,407 (GRCm39) missense possibly damaging 0.81
R4719:Mdga2 UTSW 12 66,517,775 (GRCm39) unclassified probably benign
R4744:Mdga2 UTSW 12 66,844,501 (GRCm39) missense probably benign 0.01
R4756:Mdga2 UTSW 12 66,844,427 (GRCm39) missense probably damaging 1.00
R4781:Mdga2 UTSW 12 66,844,396 (GRCm39) splice site probably null
R5022:Mdga2 UTSW 12 66,517,534 (GRCm39) missense possibly damaging 0.83
R5108:Mdga2 UTSW 12 66,533,515 (GRCm39) missense probably benign 0.43
R5479:Mdga2 UTSW 12 66,701,950 (GRCm39) missense probably damaging 1.00
R5710:Mdga2 UTSW 12 66,553,556 (GRCm39) missense probably damaging 1.00
R5816:Mdga2 UTSW 12 66,701,956 (GRCm39) missense probably damaging 1.00
R5822:Mdga2 UTSW 12 66,702,109 (GRCm39) missense probably damaging 1.00
R5996:Mdga2 UTSW 12 66,844,537 (GRCm39) missense probably benign 0.00
R6038:Mdga2 UTSW 12 66,676,827 (GRCm39) missense probably damaging 1.00
R6038:Mdga2 UTSW 12 66,676,827 (GRCm39) missense probably damaging 1.00
R6297:Mdga2 UTSW 12 66,553,027 (GRCm39) missense probably damaging 1.00
R6484:Mdga2 UTSW 12 66,676,843 (GRCm39) missense possibly damaging 0.90
R6830:Mdga2 UTSW 12 66,769,775 (GRCm39) missense probably damaging 1.00
R6912:Mdga2 UTSW 12 66,552,889 (GRCm39) missense probably benign 0.01
R6971:Mdga2 UTSW 12 66,597,335 (GRCm39) missense probably damaging 1.00
R7053:Mdga2 UTSW 12 66,736,158 (GRCm39) missense probably benign 0.41
R7069:Mdga2 UTSW 12 66,533,526 (GRCm39) missense probably benign 0.31
R7381:Mdga2 UTSW 12 66,615,670 (GRCm39) missense probably benign 0.44
R7474:Mdga2 UTSW 12 66,533,535 (GRCm39) nonsense probably null
R7559:Mdga2 UTSW 12 66,520,003 (GRCm39) missense probably damaging 1.00
R7581:Mdga2 UTSW 12 66,553,029 (GRCm39) missense probably damaging 0.99
R7596:Mdga2 UTSW 12 66,552,897 (GRCm39) missense probably damaging 0.99
R7745:Mdga2 UTSW 12 66,736,125 (GRCm39) missense possibly damaging 0.63
R7745:Mdga2 UTSW 12 66,736,124 (GRCm39) missense probably damaging 0.99
R7852:Mdga2 UTSW 12 66,517,724 (GRCm39) missense possibly damaging 0.66
R8144:Mdga2 UTSW 12 66,702,037 (GRCm39) missense probably damaging 1.00
R8319:Mdga2 UTSW 12 67,267,803 (GRCm39) missense unknown
R8715:Mdga2 UTSW 12 66,915,526 (GRCm39) missense probably damaging 1.00
R8977:Mdga2 UTSW 12 66,844,409 (GRCm39) missense possibly damaging 0.88
R9138:Mdga2 UTSW 12 66,615,663 (GRCm39) missense possibly damaging 0.89
R9177:Mdga2 UTSW 12 66,517,481 (GRCm39) missense possibly damaging 0.66
R9223:Mdga2 UTSW 12 66,615,634 (GRCm39) missense possibly damaging 0.81
R9248:Mdga2 UTSW 12 66,736,226 (GRCm39) missense possibly damaging 0.87
R9264:Mdga2 UTSW 12 66,560,057 (GRCm39) missense probably damaging 1.00
R9381:Mdga2 UTSW 12 66,597,304 (GRCm39) missense possibly damaging 0.64
R9456:Mdga2 UTSW 12 66,615,532 (GRCm39) missense probably benign 0.44
R9633:Mdga2 UTSW 12 66,736,206 (GRCm39) missense probably benign 0.00
Z1176:Mdga2 UTSW 12 66,736,217 (GRCm39) missense probably damaging 1.00
Z1186:Mdga2 UTSW 12 66,615,727 (GRCm39) missense possibly damaging 0.90
Predicted Primers PCR Primer
(F):5'- AGAAAGCTGCATCTCCCTGC -3'
(R):5'- GGCTCAGTTTAAATATACTCTCCACC -3'

Sequencing Primer
(F):5'- CTGCTCCAGCTTCATTTATGATG -3'
(R):5'- TTAAAAATACGCCCTCTGCTGG -3'
Posted On 2014-09-17