Mutagenetix > Incidental Mutation

Incidental Mutation 'R2069:Dnah5'

226985

Institutional Source

Beutler Lab

Gene Symbol

Dnah5

Ensembl Gene

ENSMUSG00000022262

Gene Name

dynein, axonemal, heavy chain 5

Synonyms

b2b1565Clo, b2b1134Clo, Mdnah5, b2b1537Clo, b2b1154Clo, Dnahc5

MMRRC Submission

040074-MU

Accession Numbers

NCBI RefSeq: NM_133365.3; MGI: 107718

Essential gene?

Probably essential (E-score: 0.776) question?

Stock #

R2069 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

28203752-28472052 bp(+) (GRCm38)

Type of Mutation

splice site (5 bp from exon)

DNA Base Change (assembly)

G to A at 28312388 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000069751 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000067048]

AlphaFold

no structure available at present

Predicted Effect

probably null
Transcript: ENSMUST00000067048

SMART Domains

Protein: ENSMUSP00000069751
Gene: ENSMUSG00000022262

Domain	Start	End	E-Value	Type
Pfam:DHC_N1	247	802	2.3e-163	PFAM
low complexity region	1077	1088	N/A	INTRINSIC
low complexity region	1113	1128	N/A	INTRINSIC
Pfam:DHC_N2	1399	1807	2.3e-134	PFAM
AAA	1972	2108	2e-3	SMART
AAA	2251	2424	4.3e-3	SMART
AAA	2579	2777	2.2e-3	SMART
low complexity region	2874	2889	N/A	INTRINSIC
Pfam:AAA_8	2914	3186	3.2e-70	PFAM
Pfam:MT	3198	3546	1e-44	PFAM
Pfam:AAA_9	3567	3792	1.4e-86	PFAM
low complexity region	3889	3899	N/A	INTRINSIC
Pfam:Dynein_heavy	3930	4618	4.4e-246	PFAM

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.4%
20x: 95.4%

Validation Efficiency

100% (104/104)

MGI Phenotype

Strain: 2180081
Lethality: D14-D21
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a dynein protein, which is part of a microtubule-associated motor protein complex consisting of heavy, light, and intermediate chains. This protein is an axonemal heavy chain dynein. It functions as a force-generating protein with ATPase activity, whereby the release of ADP is thought to produce the force-producing power stroke. Mutations in this gene cause primary ciliary dyskinesia type 3, as well as Kartagener syndrome, which are both diseases due to ciliary defects. [provided by RefSeq, Oct 2009]
PHENOTYPE: Mice homozygous for a disruption in this gene display postnatal lethality, hydrocephalus, respiratory infections, situs inversus and ciliary immotility. [provided by MGI curators]

Allele List at MGI

All alleles(11) : Targeted(2) Gene trapped(1) Transgenic(1) Chemically induced(7)

Other mutations in this stock

Total: 104 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930519G04Rik	T	C	5: 114,874,280 (GRCm38)	V86A	probably benign	Het
Abcc3	A	T	11: 94,364,417 (GRCm38)	I601N	probably damaging	Het
Abl2	T	A	1: 156,620,827 (GRCm38)		probably null	Het
Adgrf4	C	T	17: 42,666,898 (GRCm38)	R518Q	possibly damaging	Het
Ahi1	C	T	10: 20,959,996 (GRCm38)	T76I	probably damaging	Het
Arhgap42	C	T	9: 9,035,600 (GRCm38)	G247D	probably damaging	Het
Arid2	C	T	15: 96,362,590 (GRCm38)	L407F	probably damaging	Het
Atp13a1	T	C	8: 69,799,773 (GRCm38)	F606L	probably benign	Het
Avl9	T	A	6: 56,736,435 (GRCm38)		probably benign	Het
B3glct	C	T	5: 149,709,380 (GRCm38)	A65V	probably damaging	Het
Bcorl1	T	C	X: 48,401,917 (GRCm38)		probably benign	Het
Bdp1	T	C	13: 100,050,988 (GRCm38)	T1624A	probably benign	Het
Bmp15	A	G	X: 6,316,021 (GRCm38)	M263T	probably benign	Het
Brd8	T	C	18: 34,614,479 (GRCm38)	K110E	probably damaging	Het
Cachd1	A	G	4: 100,990,844 (GRCm38)	D1052G	probably damaging	Het
Capn9	G	A	8: 124,605,711 (GRCm38)	G430R	possibly damaging	Het
Ccdc113	G	A	8: 95,557,296 (GRCm38)	E333K	probably benign	Het
Ccnl2	A	T	4: 155,812,481 (GRCm38)		probably null	Het
Ccr9	T	C	9: 123,779,364 (GRCm38)	F37S	probably benign	Het
Cdh7	A	T	1: 110,138,159 (GRCm38)	D721V	probably damaging	Het
Ceacam10	A	T	7: 24,778,372 (GRCm38)	N104I	probably damaging	Het
Cenpk	T	A	13: 104,236,176 (GRCm38)		probably benign	Het
Cfi	A	G	3: 129,858,804 (GRCm38)		probably null	Het
Chd1	T	C	17: 15,742,294 (GRCm38)	F771S	probably damaging	Het
Chil4	G	A	3: 106,219,455 (GRCm38)	L4F	probably benign	Het
Cilp	G	A	9: 65,278,090 (GRCm38)	R489Q	possibly damaging	Het
Cntnap5b	G	A	1: 100,358,725 (GRCm38)	G402R	probably benign	Het
Coq8b	A	G	7: 27,257,377 (GRCm38)	E485G	probably damaging	Het
Cse1l	A	G	2: 166,941,492 (GRCm38)	S733G	probably benign	Het
Dnmt3l	T	C	10: 78,052,732 (GRCm38)	V156A	probably damaging	Het
Duox1	A	T	2: 122,333,062 (GRCm38)	T792S	probably benign	Het
Duox2	T	C	2: 122,287,108 (GRCm38)	D915G	probably benign	Het
Efcab5	A	T	11: 77,172,321 (GRCm38)	M115K	probably benign	Het
Eif2s1	G	A	12: 78,877,185 (GRCm38)	D139N	probably benign	Het
Erg	A	G	16: 95,361,078 (GRCm38)	F390L	probably damaging	Het
Fam193b	A	T	13: 55,542,998 (GRCm38)	S650R	probably damaging	Het
Fbp2	T	A	13: 62,854,061 (GRCm38)	K113N	possibly damaging	Het
Fnbp4	T	G	2: 90,758,372 (GRCm38)	S496A	probably damaging	Het
Gab3	C	A	X: 75,000,095 (GRCm38)	R475L	probably damaging	Het
Gm7534	T	G	4: 134,201,941 (GRCm38)	N351T	possibly damaging	Het
Gsap	T	C	5: 21,226,839 (GRCm38)		probably benign	Het
Gucy1a2	C	T	9: 3,582,697 (GRCm38)	L160F	probably damaging	Het
Hivep1	C	T	13: 42,183,786 (GRCm38)	A2447V	possibly damaging	Het
Hrasls5	T	C	19: 7,612,638 (GRCm38)	S10P	possibly damaging	Het
Insc	G	T	7: 114,804,593 (GRCm38)		probably null	Het
Jph2	A	G	2: 163,339,685 (GRCm38)	S520P	possibly damaging	Het
Kidins220	T	A	12: 24,987,006 (GRCm38)		probably benign	Het
Krtap29-1	A	G	11: 99,978,612 (GRCm38)	S148P	probably damaging	Het
Ltbp2	A	C	12: 84,793,733 (GRCm38)	C1000G	probably damaging	Het
Map2k3	T	C	11: 60,950,027 (GRCm38)	F294S	probably damaging	Het
Map4k2	C	A	19: 6,342,738 (GRCm38)		probably benign	Het
Mboat2	T	C	12: 24,951,443 (GRCm38)	V281A	probably benign	Het
Mdga2	G	A	12: 66,568,917 (GRCm38)	R570*	probably null	Het
Mlxipl	A	G	5: 135,107,005 (GRCm38)	D28G	probably damaging	Het
Morc2b	T	C	17: 33,136,760 (GRCm38)	I679M	probably benign	Het
Myh4	T	C	11: 67,246,366 (GRCm38)		probably benign	Het
Nfib	A	C	4: 82,498,615 (GRCm38)	L61R	probably damaging	Het
Noc2l	C	A	4: 156,241,450 (GRCm38)	Y227*	probably null	Het
Nrde2	A	G	12: 100,142,232 (GRCm38)	S367P	probably damaging	Het
Nup93	C	A	8: 94,243,739 (GRCm38)	P89T	probably damaging	Het
Obsl1	G	A	1: 75,486,756 (GRCm38)	T1764M	probably benign	Het
Olfr1240	C	T	2: 89,439,583 (GRCm38)	R232H	probably benign	Het
Olfr1283	A	G	2: 111,369,095 (GRCm38)	I154M	probably benign	Het
Olfr6	A	T	7: 106,956,287 (GRCm38)	Y216*	probably null	Het
Olfr714	A	T	7: 107,074,619 (GRCm38)	K264*	probably null	Het
Olfr749	T	A	14: 50,736,576 (GRCm38)	E195D	possibly damaging	Het
Olfr824	A	G	10: 130,126,205 (GRCm38)	I284T	possibly damaging	Het
Oxct1	G	T	15: 4,092,525 (GRCm38)	A319S	probably null	Het
P2ry10	A	G	X: 107,103,253 (GRCm38)	S265G	probably benign	Het
Peak1	A	T	9: 56,258,759 (GRCm38)	N628K	probably damaging	Het
Pkdrej	T	A	15: 85,821,231 (GRCm38)	Q168L	probably benign	Het
Plec	A	G	15: 76,188,926 (GRCm38)	M604T	probably benign	Het
Pmfbp1	A	T	8: 109,532,103 (GRCm38)	N680I	possibly damaging	Het
Pnmal2	T	C	7: 16,945,789 (GRCm38)	W233R	probably damaging	Het
Pxn	A	G	5: 115,545,667 (GRCm38)	N186S	probably benign	Het
Rsad1	A	C	11: 94,549,125 (GRCm38)		probably benign	Het
Runx2	A	G	17: 44,735,342 (GRCm38)	I112T	probably benign	Het
S1pr2	A	T	9: 20,967,494 (GRCm38)	L346Q	probably damaging	Het
Skint6	A	G	4: 113,238,132 (GRCm38)	I110T	probably damaging	Het
Slc36a4	T	A	9: 15,726,980 (GRCm38)	F234Y	probably damaging	Het
Slitrk2	T	A	X: 66,654,629 (GRCm38)	V242D	probably damaging	Het
Sp100	A	G	1: 85,681,142 (GRCm38)		probably null	Het
Spryd3	A	C	15: 102,118,181 (GRCm38)	L352V	probably benign	Het
Ssc4d	A	C	5: 135,970,317 (GRCm38)	W11G	possibly damaging	Het
Stx17	T	A	4: 48,158,870 (GRCm38)	D83E	probably damaging	Het
Tlk2	A	T	11: 105,240,440 (GRCm38)	Q204L	probably benign	Het
Tnfrsf21	A	T	17: 43,037,938 (GRCm38)	H147L	possibly damaging	Het
Tnrc18	A	T	5: 142,766,087 (GRCm38)	D1154E	unknown	Het
Trap1	A	G	16: 4,068,336 (GRCm38)	S86P	probably benign	Het
Trim32	T	A	4: 65,614,776 (GRCm38)	C523*	probably null	Het
Ttc38	G	T	15: 85,838,788 (GRCm38)	D146Y	probably damaging	Het
Ttc9	T	A	12: 81,631,796 (GRCm38)	L131Q	probably damaging	Het
Ttn	C	T	2: 76,813,339 (GRCm38)	G11436R	probably damaging	Het
Ttn	T	C	2: 76,726,848 (GRCm38)		probably benign	Het
Ubash3b	G	A	9: 41,043,573 (GRCm38)	P92S	possibly damaging	Het
Ube4a	T	C	9: 44,948,099 (GRCm38)	N367S	probably damaging	Het
Ubr4	T	A	4: 139,479,540 (GRCm38)	H4899Q	possibly damaging	Het
Ufl1	C	T	4: 25,269,036 (GRCm38)	G265D	possibly damaging	Het
Vmn2r27	T	A	6: 124,224,483 (GRCm38)	I172F	probably damaging	Het
Vmn2r6	A	T	3: 64,556,098 (GRCm38)	H438Q	possibly damaging	Het
Vmn2r61	A	G	7: 42,300,001 (GRCm38)	D615G	probably benign	Het
Wdr24	T	A	17: 25,826,282 (GRCm38)	D330E	probably damaging	Het
Zbbx	A	T	3: 75,078,412 (GRCm38)	N444K	probably benign	Het
Zc3h7b	A	T	15: 81,792,328 (GRCm38)	Q757L	probably damaging	Het

Other mutations in Dnah5

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00226:Dnah5	APN	15	28,272,342 (GRCm38)	missense	probably benign
IGL00331:Dnah5	APN	15	28,421,620 (GRCm38)	missense	probably damaging	1.00
IGL00519:Dnah5	APN	15	28,444,218 (GRCm38)	missense	probably benign	0.10
IGL00537:Dnah5	APN	15	28,458,702 (GRCm38)	critical splice donor site	probably null
IGL01102:Dnah5	APN	15	28,410,003 (GRCm38)	critical splice donor site	probably null
IGL01126:Dnah5	APN	15	28,302,399 (GRCm38)	missense	possibly damaging	0.85
IGL01154:Dnah5	APN	15	28,458,656 (GRCm38)	missense	possibly damaging	0.75
IGL01349:Dnah5	APN	15	28,294,913 (GRCm38)	splice site	probably benign
IGL01353:Dnah5	APN	15	28,233,272 (GRCm38)	missense	probably benign	0.00
IGL01372:Dnah5	APN	15	28,230,490 (GRCm38)	missense	probably benign	0.00
IGL01390:Dnah5	APN	15	28,411,540 (GRCm38)	missense	probably benign	0.00
IGL01446:Dnah5	APN	15	28,326,669 (GRCm38)	missense	probably damaging	1.00
IGL01472:Dnah5	APN	15	28,331,726 (GRCm38)	missense	probably damaging	1.00
IGL01485:Dnah5	APN	15	28,331,726 (GRCm38)	missense	probably damaging	1.00
IGL01568:Dnah5	APN	15	28,229,652 (GRCm38)	missense	probably benign	0.01
IGL01592:Dnah5	APN	15	28,236,637 (GRCm38)	missense	probably benign	0.01
IGL01594:Dnah5	APN	15	28,311,334 (GRCm38)	missense	possibly damaging	0.87
IGL01677:Dnah5	APN	15	28,367,782 (GRCm38)	missense	probably damaging	1.00
IGL01845:Dnah5	APN	15	28,449,169 (GRCm38)	missense	probably benign	0.06
IGL01904:Dnah5	APN	15	28,307,364 (GRCm38)	missense	probably benign	0.09
IGL01913:Dnah5	APN	15	28,313,753 (GRCm38)	missense	possibly damaging	0.50
IGL01950:Dnah5	APN	15	28,290,289 (GRCm38)	missense	probably null	1.00
IGL01963:Dnah5	APN	15	28,370,536 (GRCm38)	missense	probably benign	0.12
IGL02008:Dnah5	APN	15	28,343,552 (GRCm38)	missense	probably damaging	0.98
IGL02088:Dnah5	APN	15	28,459,118 (GRCm38)	critical splice acceptor site	probably null
IGL02090:Dnah5	APN	15	28,240,041 (GRCm38)	splice site	probably benign
IGL02114:Dnah5	APN	15	28,397,124 (GRCm38)	missense	probably damaging	0.97
IGL02135:Dnah5	APN	15	28,247,885 (GRCm38)	missense	possibly damaging	0.50
IGL02232:Dnah5	APN	15	28,299,240 (GRCm38)	missense	probably damaging	1.00
IGL02386:Dnah5	APN	15	28,340,381 (GRCm38)	missense	probably damaging	1.00
IGL02475:Dnah5	APN	15	28,219,150 (GRCm38)	missense	probably benign	0.09
IGL02626:Dnah5	APN	15	28,307,276 (GRCm38)	missense	possibly damaging	0.94
IGL02650:Dnah5	APN	15	28,289,047 (GRCm38)	splice site	probably benign
IGL02651:Dnah5	APN	15	28,350,622 (GRCm38)	missense	probably benign	0.05
IGL02652:Dnah5	APN	15	28,366,187 (GRCm38)	missense	probably damaging	0.99
IGL02670:Dnah5	APN	15	28,409,296 (GRCm38)	missense	probably damaging	1.00
IGL02697:Dnah5	APN	15	28,445,143 (GRCm38)	missense	probably benign	0.00
IGL02721:Dnah5	APN	15	28,234,243 (GRCm38)	critical splice acceptor site	probably null
IGL02858:Dnah5	APN	15	28,453,212 (GRCm38)	missense	possibly damaging	0.65
IGL02859:Dnah5	APN	15	28,383,625 (GRCm38)	missense	probably benign	0.01
IGL02945:Dnah5	APN	15	28,270,426 (GRCm38)	missense	probably benign	0.00
IGL02949:Dnah5	APN	15	28,272,185 (GRCm38)	missense	probably benign	0.32
IGL02971:Dnah5	APN	15	28,384,461 (GRCm38)	missense	probably damaging	1.00
IGL03017:Dnah5	APN	15	28,340,325 (GRCm38)	missense	possibly damaging	0.93
IGL03177:Dnah5	APN	15	28,295,399 (GRCm38)	missense	probably damaging	0.97
IGL03212:Dnah5	APN	15	28,290,163 (GRCm38)	missense	probably benign	0.08
IGL03224:Dnah5	APN	15	28,459,154 (GRCm38)	missense	probably damaging	1.00
IGL03231:Dnah5	APN	15	28,311,148 (GRCm38)	missense	probably damaging	1.00
IGL03273:Dnah5	APN	15	28,458,649 (GRCm38)	missense	probably damaging	0.98
IGL03294:Dnah5	APN	15	28,233,295 (GRCm38)	critical splice donor site	probably null
IGL03331:Dnah5	APN	15	28,419,940 (GRCm38)	missense	probably damaging	1.00
IGL03337:Dnah5	APN	15	28,290,141 (GRCm38)	missense	probably benign	0.10
IGL03367:Dnah5	APN	15	28,234,327 (GRCm38)	missense	possibly damaging	0.95
Firtel	UTSW	15	28,448,367 (GRCm38)	missense	possibly damaging	0.95
lowbar	UTSW	15	28,311,133 (GRCm38)	splice site	probably null
notherone	UTSW	15	28,340,406 (GRCm38)	missense	probably benign	0.13
scheffler	UTSW	15	28,438,091 (GRCm38)	splice site	probably benign
IGL02837:Dnah5	UTSW	15	28,269,400 (GRCm38)	missense	probably benign
P0008:Dnah5	UTSW	15	28,302,387 (GRCm38)	missense	probably damaging	1.00
P0014:Dnah5	UTSW	15	28,403,473 (GRCm38)	missense	probably damaging	1.00
PIT4687001:Dnah5	UTSW	15	28,383,577 (GRCm38)	missense	probably damaging	0.98
R0030:Dnah5	UTSW	15	28,451,517 (GRCm38)	missense	probably benign	0.34
R0087:Dnah5	UTSW	15	28,350,613 (GRCm38)	missense	probably damaging	1.00
R0099:Dnah5	UTSW	15	28,239,934 (GRCm38)	missense	probably damaging	1.00
R0102:Dnah5	UTSW	15	28,245,751 (GRCm38)	splice site	probably benign
R0102:Dnah5	UTSW	15	28,245,751 (GRCm38)	splice site	probably benign
R0104:Dnah5	UTSW	15	28,453,353 (GRCm38)	missense	possibly damaging	0.88
R0112:Dnah5	UTSW	15	28,263,679 (GRCm38)	missense	probably benign	0.00
R0122:Dnah5	UTSW	15	28,378,363 (GRCm38)	missense	probably damaging	1.00
R0126:Dnah5	UTSW	15	28,246,319 (GRCm38)	missense	probably benign	0.00
R0127:Dnah5	UTSW	15	28,294,925 (GRCm38)	missense	probably damaging	1.00
R0233:Dnah5	UTSW	15	28,333,070 (GRCm38)	missense	probably damaging	1.00
R0310:Dnah5	UTSW	15	28,299,110 (GRCm38)	missense	probably benign	0.19
R0386:Dnah5	UTSW	15	28,383,581 (GRCm38)	missense	probably damaging	1.00
R0421:Dnah5	UTSW	15	28,229,541 (GRCm38)	missense	possibly damaging	0.79
R0481:Dnah5	UTSW	15	28,383,599 (GRCm38)	missense	probably benign	0.31
R0514:Dnah5	UTSW	15	28,366,321 (GRCm38)	missense	probably damaging	1.00
R0609:Dnah5	UTSW	15	28,327,779 (GRCm38)	missense	probably benign
R0720:Dnah5	UTSW	15	28,313,861 (GRCm38)	missense	probably null	0.98
R0731:Dnah5	UTSW	15	28,311,143 (GRCm38)	missense	possibly damaging	0.78
R0747:Dnah5	UTSW	15	28,444,187 (GRCm38)	missense	possibly damaging	0.64
R0747:Dnah5	UTSW	15	28,444,186 (GRCm38)	missense	probably damaging	0.99
R0766:Dnah5	UTSW	15	28,448,487 (GRCm38)	missense	probably null	0.89
R0849:Dnah5	UTSW	15	28,263,599 (GRCm38)	missense	probably damaging	0.96
R1034:Dnah5	UTSW	15	28,302,471 (GRCm38)	missense	probably damaging	1.00
R1084:Dnah5	UTSW	15	28,343,452 (GRCm38)	missense	probably benign	0.01
R1148:Dnah5	UTSW	15	28,421,690 (GRCm38)	missense	probably damaging	1.00
R1148:Dnah5	UTSW	15	28,421,690 (GRCm38)	missense	probably damaging	1.00
R1200:Dnah5	UTSW	15	28,246,257 (GRCm38)	missense	possibly damaging	0.88
R1208:Dnah5	UTSW	15	28,327,731 (GRCm38)	missense	probably damaging	1.00
R1208:Dnah5	UTSW	15	28,327,731 (GRCm38)	missense	probably damaging	1.00
R1269:Dnah5	UTSW	15	28,238,511 (GRCm38)	missense	probably damaging	1.00
R1373:Dnah5	UTSW	15	28,313,918 (GRCm38)	splice site	probably benign
R1401:Dnah5	UTSW	15	28,401,913 (GRCm38)	missense	probably damaging	1.00
R1413:Dnah5	UTSW	15	28,370,409 (GRCm38)	missense	probably benign
R1430:Dnah5	UTSW	15	28,345,857 (GRCm38)	missense	probably benign	0.37
R1457:Dnah5	UTSW	15	28,403,542 (GRCm38)	critical splice donor site	probably null
R1468:Dnah5	UTSW	15	28,230,463 (GRCm38)	nonsense	probably null
R1468:Dnah5	UTSW	15	28,230,463 (GRCm38)	nonsense	probably null
R1560:Dnah5	UTSW	15	28,420,003 (GRCm38)	missense	probably damaging	1.00
R1568:Dnah5	UTSW	15	28,409,177 (GRCm38)	missense	probably damaging	0.98
R1574:Dnah5	UTSW	15	28,252,423 (GRCm38)	missense	probably benign	0.00
R1574:Dnah5	UTSW	15	28,252,423 (GRCm38)	missense	probably benign	0.00
R1603:Dnah5	UTSW	15	28,449,180 (GRCm38)	missense	probably benign	0.09
R1603:Dnah5	UTSW	15	28,294,985 (GRCm38)	splice site	probably benign
R1673:Dnah5	UTSW	15	28,290,148 (GRCm38)	missense	probably benign
R1755:Dnah5	UTSW	15	28,326,636 (GRCm38)	missense	probably damaging	0.99
R1785:Dnah5	UTSW	15	28,313,786 (GRCm38)	missense	probably damaging	1.00
R1786:Dnah5	UTSW	15	28,313,786 (GRCm38)	missense	probably damaging	1.00
R1789:Dnah5	UTSW	15	28,270,426 (GRCm38)	missense	probably benign	0.00
R1817:Dnah5	UTSW	15	28,246,400 (GRCm38)	nonsense	probably null
R1819:Dnah5	UTSW	15	28,246,400 (GRCm38)	nonsense	probably null
R1834:Dnah5	UTSW	15	28,409,124 (GRCm38)	missense	probably benign	0.00
R1855:Dnah5	UTSW	15	28,411,669 (GRCm38)	missense	possibly damaging	0.88
R1870:Dnah5	UTSW	15	28,331,713 (GRCm38)	nonsense	probably null
R1871:Dnah5	UTSW	15	28,331,713 (GRCm38)	nonsense	probably null
R1987:Dnah5	UTSW	15	28,343,591 (GRCm38)	missense	probably damaging	0.99
R1988:Dnah5	UTSW	15	28,343,591 (GRCm38)	missense	probably damaging	0.99
R1989:Dnah5	UTSW	15	28,343,591 (GRCm38)	missense	probably damaging	0.99
R2062:Dnah5	UTSW	15	28,366,270 (GRCm38)	missense	probably damaging	1.00
R2121:Dnah5	UTSW	15	28,297,005 (GRCm38)	splice site	probably benign
R2128:Dnah5	UTSW	15	28,408,321 (GRCm38)	missense	probably benign	0.00
R2129:Dnah5	UTSW	15	28,408,321 (GRCm38)	missense	probably benign	0.00
R2151:Dnah5	UTSW	15	28,444,091 (GRCm38)	missense	probably damaging	1.00
R2159:Dnah5	UTSW	15	28,252,545 (GRCm38)	missense	probably benign	0.00
R2207:Dnah5	UTSW	15	28,343,671 (GRCm38)	missense	probably benign	0.11
R2231:Dnah5	UTSW	15	28,408,417 (GRCm38)	critical splice donor site	probably null
R2232:Dnah5	UTSW	15	28,408,417 (GRCm38)	critical splice donor site	probably null
R2282:Dnah5	UTSW	15	28,327,302 (GRCm38)	missense	probably damaging	0.99
R2305:Dnah5	UTSW	15	28,387,767 (GRCm38)	missense	probably benign	0.25
R2339:Dnah5	UTSW	15	28,313,882 (GRCm38)	missense	probably benign	0.00
R2437:Dnah5	UTSW	15	28,307,391 (GRCm38)	critical splice donor site	probably null
R2696:Dnah5	UTSW	15	28,278,576 (GRCm38)	missense	probably benign	0.00
R3156:Dnah5	UTSW	15	28,438,091 (GRCm38)	splice site	probably benign
R3431:Dnah5	UTSW	15	28,295,267 (GRCm38)	missense	probably benign	0.20
R3700:Dnah5	UTSW	15	28,387,791 (GRCm38)	missense	possibly damaging	0.72
R3724:Dnah5	UTSW	15	28,270,420 (GRCm38)	missense	probably benign	0.08
R3732:Dnah5	UTSW	15	28,409,122 (GRCm38)	missense	possibly damaging	0.64
R3872:Dnah5	UTSW	15	28,411,510 (GRCm38)	missense	possibly damaging	0.50
R4063:Dnah5	UTSW	15	28,420,998 (GRCm38)	missense	probably damaging	0.98
R4072:Dnah5	UTSW	15	28,340,298 (GRCm38)	nonsense	probably null
R4075:Dnah5	UTSW	15	28,293,791 (GRCm38)	missense	probably benign
R4245:Dnah5	UTSW	15	28,219,189 (GRCm38)	missense	probably benign
R4254:Dnah5	UTSW	15	28,438,102 (GRCm38)	missense	probably benign	0.07
R4255:Dnah5	UTSW	15	28,438,102 (GRCm38)	missense	probably benign	0.07
R4392:Dnah5	UTSW	15	28,289,229 (GRCm38)	missense	probably benign	0.19
R4552:Dnah5	UTSW	15	28,397,154 (GRCm38)	missense	probably benign	0.19
R4574:Dnah5	UTSW	15	28,367,763 (GRCm38)	missense	probably benign	0.05
R4577:Dnah5	UTSW	15	28,289,250 (GRCm38)	missense	probably benign	0.06
R4587:Dnah5	UTSW	15	28,304,599 (GRCm38)	missense	probably damaging	1.00
R4631:Dnah5	UTSW	15	28,419,994 (GRCm38)	missense	probably damaging	1.00
R4631:Dnah5	UTSW	15	28,401,953 (GRCm38)	missense	probably damaging	1.00
R4676:Dnah5	UTSW	15	28,295,260 (GRCm38)	missense	possibly damaging	0.65
R4707:Dnah5	UTSW	15	28,372,375 (GRCm38)	missense	probably damaging	0.97
R4754:Dnah5	UTSW	15	28,420,955 (GRCm38)	splice site	probably null
R4767:Dnah5	UTSW	15	28,270,474 (GRCm38)	missense	probably benign	0.02
R4857:Dnah5	UTSW	15	28,345,807 (GRCm38)	missense	probably benign	0.00
R4883:Dnah5	UTSW	15	28,343,638 (GRCm38)	missense	probably benign	0.00
R4889:Dnah5	UTSW	15	28,235,792 (GRCm38)	missense	probably benign	0.01
R4946:Dnah5	UTSW	15	28,387,904 (GRCm38)	missense	probably damaging	1.00
R4946:Dnah5	UTSW	15	28,326,557 (GRCm38)	missense	probably damaging	0.96
R4947:Dnah5	UTSW	15	28,272,372 (GRCm38)	missense	probably benign
R5033:Dnah5	UTSW	15	28,421,678 (GRCm38)	missense	probably damaging	0.96
R5164:Dnah5	UTSW	15	28,408,292 (GRCm38)	missense	probably benign	0.00
R5175:Dnah5	UTSW	15	28,448,404 (GRCm38)	missense	probably damaging	1.00
R5182:Dnah5	UTSW	15	28,311,278 (GRCm38)	missense	probably damaging	0.99
R5187:Dnah5	UTSW	15	28,272,172 (GRCm38)	missense	probably benign	0.41
R5272:Dnah5	UTSW	15	28,350,665 (GRCm38)	missense	probably benign
R5308:Dnah5	UTSW	15	28,229,651 (GRCm38)	missense	possibly damaging	0.80
R5310:Dnah5	UTSW	15	28,311,328 (GRCm38)	missense	probably damaging	1.00
R5322:Dnah5	UTSW	15	28,384,244 (GRCm38)	missense	probably benign	0.41
R5398:Dnah5	UTSW	15	28,293,726 (GRCm38)	missense	probably benign
R5596:Dnah5	UTSW	15	28,343,608 (GRCm38)	missense	probably damaging	1.00
R5603:Dnah5	UTSW	15	28,419,932 (GRCm38)	missense	probably damaging	1.00
R5619:Dnah5	UTSW	15	28,302,435 (GRCm38)	missense	probably damaging	1.00
R5656:Dnah5	UTSW	15	28,421,064 (GRCm38)	missense	probably benign	0.03
R5741:Dnah5	UTSW	15	28,246,367 (GRCm38)	missense	probably benign	0.11
R5754:Dnah5	UTSW	15	28,401,868 (GRCm38)	missense	probably benign	0.01
R5763:Dnah5	UTSW	15	28,311,152 (GRCm38)	missense	probably damaging	1.00
R5824:Dnah5	UTSW	15	28,313,821 (GRCm38)	missense	probably benign	0.00
R5836:Dnah5	UTSW	15	28,383,592 (GRCm38)	missense	probably damaging	1.00
R5838:Dnah5	UTSW	15	28,290,195 (GRCm38)	missense	probably benign	0.00
R5864:Dnah5	UTSW	15	28,297,013 (GRCm38)	missense	possibly damaging	0.83
R5895:Dnah5	UTSW	15	28,234,453 (GRCm38)	splice site	probably null
R5896:Dnah5	UTSW	15	28,272,060 (GRCm38)	missense	probably benign
R5899:Dnah5	UTSW	15	28,448,367 (GRCm38)	missense	possibly damaging	0.95
R5905:Dnah5	UTSW	15	28,387,833 (GRCm38)	missense	probably damaging	1.00
R5924:Dnah5	UTSW	15	28,307,327 (GRCm38)	missense	probably benign	0.41
R5927:Dnah5	UTSW	15	28,335,718 (GRCm38)	missense	probably benign	0.00
R5929:Dnah5	UTSW	15	28,311,208 (GRCm38)	missense	probably damaging	1.00
R5929:Dnah5	UTSW	15	28,311,207 (GRCm38)	missense	probably benign	0.01
R5931:Dnah5	UTSW	15	28,453,279 (GRCm38)	missense	probably damaging	0.99
R5964:Dnah5	UTSW	15	28,458,584 (GRCm38)	missense	possibly damaging	0.49
R5975:Dnah5	UTSW	15	28,234,282 (GRCm38)	missense	probably damaging	1.00
R5993:Dnah5	UTSW	15	28,299,226 (GRCm38)	missense	probably benign	0.09
R6016:Dnah5	UTSW	15	28,327,884 (GRCm38)	missense	probably damaging	1.00
R6028:Dnah5	UTSW	15	28,387,833 (GRCm38)	missense	probably damaging	1.00
R6065:Dnah5	UTSW	15	28,230,468 (GRCm38)	missense	possibly damaging	0.47
R6117:Dnah5	UTSW	15	28,270,420 (GRCm38)	missense	probably damaging	0.99
R6143:Dnah5	UTSW	15	28,233,231 (GRCm38)	missense	probably benign	0.05
R6146:Dnah5	UTSW	15	28,459,185 (GRCm38)	missense	probably benign
R6154:Dnah5	UTSW	15	28,204,031 (GRCm38)	missense	probably benign	0.15
R6164:Dnah5	UTSW	15	28,378,343 (GRCm38)	missense	probably benign	0.08
R6266:Dnah5	UTSW	15	28,335,627 (GRCm38)	missense	possibly damaging	0.67
R6321:Dnah5	UTSW	15	28,372,411 (GRCm38)	missense	probably damaging	0.99
R6349:Dnah5	UTSW	15	28,238,511 (GRCm38)	missense	probably damaging	1.00
R6431:Dnah5	UTSW	15	28,349,824 (GRCm38)	missense	possibly damaging	0.52
R6467:Dnah5	UTSW	15	28,438,183 (GRCm38)	missense	probably benign	0.10
R6564:Dnah5	UTSW	15	28,367,745 (GRCm38)	missense	probably benign
R6607:Dnah5	UTSW	15	28,445,200 (GRCm38)	missense	possibly damaging	0.95
R6619:Dnah5	UTSW	15	28,409,120 (GRCm38)	missense	probably benign	0.03
R6633:Dnah5	UTSW	15	28,293,787 (GRCm38)	missense	probably benign	0.27
R6647:Dnah5	UTSW	15	28,403,487 (GRCm38)	missense	probably benign	0.02
R6782:Dnah5	UTSW	15	28,449,156 (GRCm38)	missense	possibly damaging	0.89
R6797:Dnah5	UTSW	15	28,233,238 (GRCm38)	nonsense	probably null
R6797:Dnah5	UTSW	15	28,451,463 (GRCm38)	missense	probably damaging	1.00
R6831:Dnah5	UTSW	15	28,411,515 (GRCm38)	missense	possibly damaging	0.88
R6849:Dnah5	UTSW	15	28,278,624 (GRCm38)	missense	probably benign	0.14
R6871:Dnah5	UTSW	15	28,229,640 (GRCm38)	missense	probably benign	0.32
R6936:Dnah5	UTSW	15	28,409,268 (GRCm38)	missense	probably damaging	1.00
R6943:Dnah5	UTSW	15	28,235,720 (GRCm38)	missense	probably damaging	1.00
R7030:Dnah5	UTSW	15	28,333,062 (GRCm38)	missense	probably benign	0.00
R7030:Dnah5	UTSW	15	28,238,592 (GRCm38)	missense	probably benign
R7032:Dnah5	UTSW	15	28,326,650 (GRCm38)	missense	probably damaging	1.00
R7063:Dnah5	UTSW	15	28,233,248 (GRCm38)	missense	probably benign	0.00
R7094:Dnah5	UTSW	15	28,453,336 (GRCm38)	missense	probably damaging	0.98
R7097:Dnah5	UTSW	15	28,453,264 (GRCm38)	missense	probably benign	0.00
R7126:Dnah5	UTSW	15	28,349,837 (GRCm38)	missense	probably benign	0.03
R7153:Dnah5	UTSW	15	28,365,522 (GRCm38)	splice site	probably null
R7209:Dnah5	UTSW	15	28,459,225 (GRCm38)	missense	possibly damaging	0.71
R7276:Dnah5	UTSW	15	28,367,838 (GRCm38)	missense	probably damaging	1.00
R7320:Dnah5	UTSW	15	28,270,470 (GRCm38)	missense	probably null	0.33
R7350:Dnah5	UTSW	15	28,235,819 (GRCm38)	critical splice donor site	probably null
R7380:Dnah5	UTSW	15	28,370,378 (GRCm38)	missense	probably damaging	1.00
R7438:Dnah5	UTSW	15	28,346,952 (GRCm38)	missense	probably damaging	0.99
R7499:Dnah5	UTSW	15	28,302,450 (GRCm38)	missense	probably damaging	1.00
R7513:Dnah5	UTSW	15	28,370,415 (GRCm38)	missense	probably benign
R7519:Dnah5	UTSW	15	28,390,483 (GRCm38)	missense	probably damaging	0.98
R7524:Dnah5	UTSW	15	28,297,066 (GRCm38)	missense	possibly damaging	0.50
R7556:Dnah5	UTSW	15	28,290,243 (GRCm38)	missense	probably null	0.43
R7570:Dnah5	UTSW	15	28,346,952 (GRCm38)	missense	probably damaging	1.00
R7585:Dnah5	UTSW	15	28,401,868 (GRCm38)	missense	probably benign	0.09
R7642:Dnah5	UTSW	15	28,247,979 (GRCm38)	critical splice donor site	probably null
R7670:Dnah5	UTSW	15	28,246,232 (GRCm38)	splice site	probably null
R7763:Dnah5	UTSW	15	28,313,855 (GRCm38)	missense	probably damaging	1.00
R7821:Dnah5	UTSW	15	28,411,532 (GRCm38)	missense	possibly damaging	0.89
R7826:Dnah5	UTSW	15	28,367,812 (GRCm38)	missense	probably damaging	1.00
R7872:Dnah5	UTSW	15	28,245,684 (GRCm38)	missense	probably damaging	0.99
R7889:Dnah5	UTSW	15	28,448,414 (GRCm38)	nonsense	probably null
R7919:Dnah5	UTSW	15	28,350,596 (GRCm38)	missense	probably damaging	1.00
R7920:Dnah5	UTSW	15	28,453,222 (GRCm38)	missense	probably benign	0.00
R7936:Dnah5	UTSW	15	28,345,837 (GRCm38)	missense	possibly damaging	0.64
R7996:Dnah5	UTSW	15	28,409,177 (GRCm38)	missense	probably damaging	0.98
R8063:Dnah5	UTSW	15	28,230,583 (GRCm38)	missense	probably benign
R8084:Dnah5	UTSW	15	28,387,953 (GRCm38)	missense	probably damaging	1.00
R8105:Dnah5	UTSW	15	28,372,402 (GRCm38)	missense	probably benign
R8114:Dnah5	UTSW	15	28,239,976 (GRCm38)	missense	probably benign	0.01
R8142:Dnah5	UTSW	15	28,384,373 (GRCm38)	missense	probably benign	0.36
R8153:Dnah5	UTSW	15	28,384,430 (GRCm38)	missense	probably damaging	1.00
R8161:Dnah5	UTSW	15	28,350,704 (GRCm38)	missense	possibly damaging	0.79
R8174:Dnah5	UTSW	15	28,311,133 (GRCm38)	splice site	probably null
R8187:Dnah5	UTSW	15	28,384,209 (GRCm38)	missense	probably damaging	1.00
R8194:Dnah5	UTSW	15	28,453,268 (GRCm38)	missense	probably damaging	0.99
R8280:Dnah5	UTSW	15	28,408,392 (GRCm38)	missense	probably benign	0.01
R8291:Dnah5	UTSW	15	28,263,597 (GRCm38)	missense	probably benign	0.03
R8324:Dnah5	UTSW	15	28,346,865 (GRCm38)	missense	probably damaging	1.00
R8347:Dnah5	UTSW	15	28,236,666 (GRCm38)	missense	possibly damaging	0.90
R8356:Dnah5	UTSW	15	28,444,167 (GRCm38)	missense	probably benign	0.03
R8356:Dnah5	UTSW	15	28,444,323 (GRCm38)	missense	probably null	0.02
R8361:Dnah5	UTSW	15	28,331,810 (GRCm38)	missense	probably damaging	0.98
R8375:Dnah5	UTSW	15	28,327,343 (GRCm38)	missense	probably benign	0.00
R8474:Dnah5	UTSW	15	28,247,832 (GRCm38)	missense	probably benign	0.00
R8481:Dnah5	UTSW	15	28,419,795 (GRCm38)	missense	probably benign	0.00
R8494:Dnah5	UTSW	15	28,345,831 (GRCm38)	missense	probably benign	0.32
R8495:Dnah5	UTSW	15	28,409,268 (GRCm38)	missense	probably damaging	0.97
R8519:Dnah5	UTSW	15	28,299,099 (GRCm38)	missense	probably benign	0.07
R8683:Dnah5	UTSW	15	28,289,221 (GRCm38)	missense	probably benign	0.00
R8739:Dnah5	UTSW	15	28,345,860 (GRCm38)	missense	probably benign	0.01
R8752:Dnah5	UTSW	15	28,290,219 (GRCm38)	missense	probably benign	0.00
R8784:Dnah5	UTSW	15	28,387,951 (GRCm38)	missense	probably benign	0.16
R8813:Dnah5	UTSW	15	28,229,573 (GRCm38)	missense	probably damaging	1.00
R8862:Dnah5	UTSW	15	28,459,356 (GRCm38)	splice site	probably benign
R8873:Dnah5	UTSW	15	28,219,188 (GRCm38)	missense	probably benign
R8885:Dnah5	UTSW	15	28,327,740 (GRCm38)	missense	probably damaging	1.00
R8901:Dnah5	UTSW	15	28,365,569 (GRCm38)	missense	possibly damaging	0.76
R9025:Dnah5	UTSW	15	28,409,266 (GRCm38)	missense	probably damaging	1.00
R9037:Dnah5	UTSW	15	28,247,958 (GRCm38)	missense	probably benign	0.05
R9057:Dnah5	UTSW	15	28,390,868 (GRCm38)	missense	probably damaging	1.00
R9059:Dnah5	UTSW	15	28,245,666 (GRCm38)	missense	probably benign
R9065:Dnah5	UTSW	15	28,293,790 (GRCm38)	missense	probably benign	0.09
R9098:Dnah5	UTSW	15	28,419,961 (GRCm38)	missense
R9118:Dnah5	UTSW	15	28,401,848 (GRCm38)	frame shift	probably null
R9149:Dnah5	UTSW	15	28,387,768 (GRCm38)	missense	probably benign	0.00
R9184:Dnah5	UTSW	15	28,340,406 (GRCm38)	missense	probably benign	0.13
R9205:Dnah5	UTSW	15	28,448,334 (GRCm38)	missense	possibly damaging	0.88
R9297:Dnah5	UTSW	15	28,203,908 (GRCm38)	start gained	probably benign
R9302:Dnah5	UTSW	15	28,239,886 (GRCm38)	missense	probably benign	0.03
R9310:Dnah5	UTSW	15	28,448,433 (GRCm38)	missense	probably damaging	1.00
R9318:Dnah5	UTSW	15	28,203,908 (GRCm38)	start gained	probably benign
R9405:Dnah5	UTSW	15	28,272,160 (GRCm38)	missense	probably benign
R9424:Dnah5	UTSW	15	28,272,140 (GRCm38)	missense	probably benign	0.01
R9467:Dnah5	UTSW	15	28,366,147 (GRCm38)	missense	possibly damaging	0.94
R9469:Dnah5	UTSW	15	28,421,000 (GRCm38)	missense	probably benign	0.06
R9548:Dnah5	UTSW	15	28,327,879 (GRCm38)	missense	possibly damaging	0.79
R9564:Dnah5	UTSW	15	28,290,276 (GRCm38)	missense	probably benign	0.04
R9576:Dnah5	UTSW	15	28,272,140 (GRCm38)	missense	probably benign	0.01
R9593:Dnah5	UTSW	15	28,236,628 (GRCm38)	missense	probably benign
R9644:Dnah5	UTSW	15	28,230,504 (GRCm38)	missense	probably damaging	0.98
R9655:Dnah5	UTSW	15	28,242,754 (GRCm38)	missense	probably benign
R9657:Dnah5	UTSW	15	28,409,943 (GRCm38)	missense	probably damaging	1.00
R9704:Dnah5	UTSW	15	28,247,819 (GRCm38)	missense	probably benign	0.00
R9797:Dnah5	UTSW	15	28,233,170 (GRCm38)	missense	probably benign	0.34
RF009:Dnah5	UTSW	15	28,204,019 (GRCm38)	missense	probably benign	0.00
X0011:Dnah5	UTSW	15	28,408,381 (GRCm38)	missense	probably benign	0.16
X0018:Dnah5	UTSW	15	28,269,354 (GRCm38)	missense	probably benign	0.00
X0022:Dnah5	UTSW	15	28,270,411 (GRCm38)	missense	probably benign	0.01
X0023:Dnah5	UTSW	15	28,384,308 (GRCm38)	missense	probably damaging	0.99
X0028:Dnah5	UTSW	15	28,470,477 (GRCm38)	missense	probably damaging	1.00
Z1088:Dnah5	UTSW	15	28,366,357 (GRCm38)	missense	probably null	0.10
Z1088:Dnah5	UTSW	15	28,384,230 (GRCm38)	missense	probably damaging	1.00
Z1177:Dnah5	UTSW	15	28,295,311 (GRCm38)	missense	probably damaging	0.98
Z1177:Dnah5	UTSW	15	28,270,403 (GRCm38)	missense	probably benign	0.00
Z1177:Dnah5	UTSW	15	28,270,354 (GRCm38)	missense	probably benign	0.32
Z1177:Dnah5	UTSW	15	28,387,763 (GRCm38)	missense	possibly damaging	0.72

Predicted Primers

PCR Primer
(F):5'- AGAAGCCCTTCGAAATGCC -3'
(R):5'- CTCGTTGTCCCAGTGATGTG -3'

Sequencing Primer
(F):5'- AGCCCTTCGAAATGCCAAGTTTG -3'
(R):5'- CCCAGTGATGTGGTATAGATTATCAG -3'

Posted On

2014-09-17