Incidental Mutation 'R2071:Vmn2r103'
| ID |
227180 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r103
|
| Ensembl Gene |
ENSMUSG00000091771 |
| Gene Name |
vomeronasal 2, receptor 103 |
| Synonyms |
EG627636 |
| MMRRC Submission |
040076-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.059)
|
| Stock # |
R2071 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
19773363-19812536 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 19793794 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Leucine
at position 283
(I283L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126756
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000172203]
|
| AlphaFold |
E9PWW0 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000172203
AA Change: I283L
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000126756
Gene: ENSMUSG00000091771
AA Change: I283L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
449 |
1.3e-37 |
PFAM |
|
Pfam:NCD3G
|
509 |
562 |
3.5e-22 |
PFAM |
|
Pfam:7tm_3
|
595 |
830 |
1.1e-51 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.4%
- 20x: 95.4%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 75 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700066M21Rik |
T |
A |
1: 57,383,315 (GRCm38) |
H283Q |
probably damaging |
Het |
| 2810021J22Rik |
A |
G |
11: 58,876,769 (GRCm38) |
K31E |
probably damaging |
Het |
| Abcc10 |
G |
C |
17: 46,303,565 (GRCm38) |
N1477K |
probably benign |
Het |
| Adam33 |
T |
C |
2: 131,055,346 (GRCm38) |
T310A |
probably benign |
Het |
| Afm |
A |
G |
5: 90,523,735 (GRCm38) |
D92G |
probably benign |
Het |
| Arg1 |
C |
T |
10: 24,922,663 (GRCm38) |
A30T |
probably benign |
Het |
| Ash1l |
C |
G |
3: 88,966,203 (GRCm38) |
P98A |
probably damaging |
Het |
| Atad5 |
A |
T |
11: 80,098,052 (GRCm38) |
|
probably null |
Het |
| Atg2a |
T |
C |
19: 6,257,458 (GRCm38) |
V1474A |
probably benign |
Het |
| Atp12a |
A |
G |
14: 56,366,009 (GRCm38) |
K24E |
probably benign |
Het |
| Auh |
G |
A |
13: 52,835,496 (GRCm38) |
P308L |
probably benign |
Het |
| B3gnt4 |
A |
T |
5: 123,511,370 (GRCm38) |
H266L |
probably benign |
Het |
| Bora |
T |
C |
14: 99,062,278 (GRCm38) |
S229P |
probably damaging |
Het |
| C87414 |
T |
G |
5: 93,636,516 (GRCm38) |
Q363P |
probably damaging |
Het |
| Cdsn |
A |
T |
17: 35,554,694 (GRCm38) |
D40V |
probably damaging |
Het |
| Cep295 |
T |
C |
9: 15,341,564 (GRCm38) |
R323G |
probably damaging |
Het |
| Chek2 |
T |
C |
5: 110,841,246 (GRCm38) |
|
probably benign |
Het |
| Chga |
A |
T |
12: 102,562,863 (GRCm38) |
K366N |
probably damaging |
Het |
| Chrm5 |
T |
C |
2: 112,479,227 (GRCm38) |
K515E |
probably null |
Het |
| Cmtr1 |
A |
G |
17: 29,694,783 (GRCm38) |
|
probably null |
Het |
| Cyr61 |
C |
T |
3: 145,648,673 (GRCm38) |
W161* |
probably null |
Het |
| Dsg3 |
T |
C |
18: 20,536,825 (GRCm38) |
L632S |
probably damaging |
Het |
| Fam129a |
T |
C |
1: 151,636,430 (GRCm38) |
F28L |
probably damaging |
Het |
| Fzd3 |
A |
G |
14: 65,235,563 (GRCm38) |
F252S |
probably damaging |
Het |
| Gas2l2 |
T |
C |
11: 83,421,949 (GRCm38) |
K846E |
probably benign |
Het |
| Gm21761 |
A |
T |
13: 119,912,300 (GRCm38) |
D151E |
probably benign |
Het |
| Gm8300 |
T |
A |
12: 87,517,052 (GRCm38) |
F52L |
probably benign |
Het |
| Gpatch11 |
T |
C |
17: 78,841,085 (GRCm38) |
|
probably null |
Het |
| Gucy2g |
T |
A |
19: 55,222,340 (GRCm38) |
Y661F |
possibly damaging |
Het |
| Hhip |
A |
G |
8: 80,057,302 (GRCm38) |
F72L |
probably benign |
Het |
| Kat14 |
T |
C |
2: 144,389,216 (GRCm38) |
L181P |
probably damaging |
Het |
| Kifc3 |
A |
T |
8: 95,108,353 (GRCm38) |
|
probably null |
Het |
| Kntc1 |
G |
T |
5: 123,794,277 (GRCm38) |
|
probably null |
Het |
| Man2b1 |
G |
T |
8: 85,085,384 (GRCm38) |
V156L |
possibly damaging |
Het |
| Mast1 |
T |
C |
8: 84,921,194 (GRCm38) |
D517G |
probably damaging |
Het |
| Mc1r |
T |
C |
8: 123,408,369 (GRCm38) |
L287P |
possibly damaging |
Het |
| Mctp1 |
A |
T |
13: 76,759,724 (GRCm38) |
E238V |
probably damaging |
Het |
| Mmp12 |
T |
A |
9: 7,349,725 (GRCm38) |
I52N |
probably damaging |
Het |
| Morc1 |
C |
T |
16: 48,592,611 (GRCm38) |
T705I |
probably benign |
Het |
| Mrpl24 |
T |
C |
3: 87,923,067 (GRCm38) |
|
probably null |
Het |
| Nap1l1 |
C |
T |
10: 111,492,900 (GRCm38) |
T230I |
possibly damaging |
Het |
| Nmral1 |
T |
A |
16: 4,716,347 (GRCm38) |
I77F |
probably damaging |
Het |
| Nudt13 |
T |
A |
14: 20,303,977 (GRCm38) |
D36E |
probably damaging |
Het |
| Oxsm |
A |
G |
14: 16,241,983 (GRCm38) |
L262P |
probably benign |
Het |
| Pde10a |
A |
T |
17: 8,961,995 (GRCm38) |
I754F |
probably benign |
Het |
| Pdzph1 |
T |
C |
17: 58,974,097 (GRCm38) |
R397G |
probably benign |
Het |
| Polr1a |
T |
A |
6: 71,976,074 (GRCm38) |
V567E |
possibly damaging |
Het |
| Pou3f2 |
A |
G |
4: 22,488,076 (GRCm38) |
V19A |
probably benign |
Het |
| Pth1r |
A |
G |
9: 110,727,013 (GRCm38) |
I264T |
probably benign |
Het |
| Ptprn |
C |
A |
1: 75,255,144 (GRCm38) |
G504C |
probably damaging |
Het |
| Rbak |
A |
G |
5: 143,176,584 (GRCm38) |
L8P |
probably damaging |
Het |
| Rev3l |
T |
A |
10: 39,824,353 (GRCm38) |
D1615E |
probably benign |
Het |
| Rhob |
A |
G |
12: 8,499,232 (GRCm38) |
M134T |
probably benign |
Het |
| Slc10a4 |
T |
C |
5: 73,007,497 (GRCm38) |
L144P |
probably damaging |
Het |
| Slc45a3 |
T |
C |
1: 131,977,632 (GRCm38) |
L131P |
probably damaging |
Het |
| Slf1 |
T |
A |
13: 77,104,624 (GRCm38) |
E259D |
probably benign |
Het |
| Slitrk5 |
A |
G |
14: 111,680,189 (GRCm38) |
Y415C |
probably damaging |
Het |
| Sohlh2 |
A |
G |
3: 55,207,622 (GRCm38) |
I343V |
probably benign |
Het |
| Sorl1 |
T |
C |
9: 41,979,457 (GRCm38) |
D1922G |
possibly damaging |
Het |
| Spats2l |
T |
A |
1: 57,940,464 (GRCm38) |
I243N |
possibly damaging |
Het |
| Specc1 |
A |
C |
11: 62,117,875 (GRCm38) |
K152N |
probably damaging |
Het |
| Sv2a |
G |
A |
3: 96,193,875 (GRCm38) |
A730T |
possibly damaging |
Het |
| Tars2 |
C |
A |
3: 95,747,638 (GRCm38) |
G113C |
probably damaging |
Het |
| Tep1 |
T |
C |
14: 50,854,282 (GRCm38) |
K601E |
probably benign |
Het |
| Tmem8 |
T |
C |
17: 26,122,043 (GRCm38) |
Y176H |
probably damaging |
Het |
| Trp53 |
A |
G |
11: 69,589,632 (GRCm38) |
D278G |
probably damaging |
Het |
| Ttc39d |
G |
A |
17: 80,216,601 (GRCm38) |
G230R |
probably damaging |
Het |
| Tubb2b |
T |
A |
13: 34,128,261 (GRCm38) |
Y183F |
probably damaging |
Het |
| Ubxn7 |
T |
A |
16: 32,372,469 (GRCm38) |
C160S |
possibly damaging |
Het |
| Vcp |
A |
G |
4: 42,995,894 (GRCm38) |
|
probably null |
Het |
| Vmn1r201 |
T |
C |
13: 22,474,825 (GRCm38) |
F70L |
probably benign |
Het |
| Vmn1r49 |
C |
T |
6: 90,072,202 (GRCm38) |
V273I |
probably benign |
Het |
| Xpr1 |
T |
C |
1: 155,290,280 (GRCm38) |
T574A |
probably benign |
Het |
| Zfp408 |
A |
G |
2: 91,646,018 (GRCm38) |
F364L |
probably damaging |
Het |
| Zfyve26 |
A |
G |
12: 79,287,446 (GRCm38) |
L266P |
possibly damaging |
Het |
|
| Other mutations in Vmn2r103 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00333:Vmn2r103
|
APN |
17 |
19,793,102 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL00939:Vmn2r103
|
APN |
17 |
19,794,965 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL01120:Vmn2r103
|
APN |
17 |
19,792,997 (GRCm38) |
missense |
probably benign |
0.06 |
|
IGL01403:Vmn2r103
|
APN |
17 |
19,792,967 (GRCm38) |
missense |
probably benign |
|
|
IGL01404:Vmn2r103
|
APN |
17 |
19,812,434 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01713:Vmn2r103
|
APN |
17 |
19,794,068 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01802:Vmn2r103
|
APN |
17 |
19,799,208 (GRCm38) |
missense |
probably benign |
|
|
IGL02251:Vmn2r103
|
APN |
17 |
19,793,969 (GRCm38) |
missense |
possibly damaging |
0.84 |
|
IGL02466:Vmn2r103
|
APN |
17 |
19,773,369 (GRCm38) |
missense |
probably benign |
|
|
IGL02555:Vmn2r103
|
APN |
17 |
19,811,611 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02668:Vmn2r103
|
APN |
17 |
19,794,127 (GRCm38) |
missense |
probably benign |
0.03 |
|
IGL02715:Vmn2r103
|
APN |
17 |
19,793,956 (GRCm38) |
missense |
probably damaging |
0.97 |
|
IGL02735:Vmn2r103
|
APN |
17 |
19,812,248 (GRCm38) |
missense |
probably benign |
0.27 |
|
IGL03101:Vmn2r103
|
APN |
17 |
19,773,520 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R0003:Vmn2r103
|
UTSW |
17 |
19,811,979 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R0052:Vmn2r103
|
UTSW |
17 |
19,811,641 (GRCm38) |
missense |
probably benign |
0.01 |
|
R0375:Vmn2r103
|
UTSW |
17 |
19,793,464 (GRCm38) |
missense |
probably benign |
0.12 |
|
R0375:Vmn2r103
|
UTSW |
17 |
19,792,859 (GRCm38) |
missense |
probably benign |
0.06 |
|
R0755:Vmn2r103
|
UTSW |
17 |
19,773,568 (GRCm38) |
missense |
probably benign |
0.01 |
|
R0837:Vmn2r103
|
UTSW |
17 |
19,793,927 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1345:Vmn2r103
|
UTSW |
17 |
19,794,247 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1396:Vmn2r103
|
UTSW |
17 |
19,792,968 (GRCm38) |
missense |
probably benign |
|
|
R1488:Vmn2r103
|
UTSW |
17 |
19,793,660 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R1533:Vmn2r103
|
UTSW |
17 |
19,773,400 (GRCm38) |
missense |
probably benign |
0.01 |
|
R1590:Vmn2r103
|
UTSW |
17 |
19,794,234 (GRCm38) |
missense |
probably benign |
|
|
R1928:Vmn2r103
|
UTSW |
17 |
19,811,767 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R1942:Vmn2r103
|
UTSW |
17 |
19,812,300 (GRCm38) |
missense |
probably benign |
0.02 |
|
R2219:Vmn2r103
|
UTSW |
17 |
19,793,647 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2442:Vmn2r103
|
UTSW |
17 |
19,773,531 (GRCm38) |
missense |
probably benign |
0.00 |
|
R2889:Vmn2r103
|
UTSW |
17 |
19,793,600 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3762:Vmn2r103
|
UTSW |
17 |
19,812,149 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R4014:Vmn2r103
|
UTSW |
17 |
19,793,604 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R4331:Vmn2r103
|
UTSW |
17 |
19,794,233 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4630:Vmn2r103
|
UTSW |
17 |
19,793,696 (GRCm38) |
missense |
probably benign |
0.04 |
|
R4631:Vmn2r103
|
UTSW |
17 |
19,793,696 (GRCm38) |
missense |
probably benign |
0.04 |
|
R4632:Vmn2r103
|
UTSW |
17 |
19,793,696 (GRCm38) |
missense |
probably benign |
0.04 |
|
R4660:Vmn2r103
|
UTSW |
17 |
19,811,815 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4801:Vmn2r103
|
UTSW |
17 |
19,795,076 (GRCm38) |
missense |
probably benign |
0.06 |
|
R4802:Vmn2r103
|
UTSW |
17 |
19,795,076 (GRCm38) |
missense |
probably benign |
0.06 |
|
R4931:Vmn2r103
|
UTSW |
17 |
19,811,769 (GRCm38) |
missense |
probably benign |
0.01 |
|
R4995:Vmn2r103
|
UTSW |
17 |
19,773,511 (GRCm38) |
missense |
probably benign |
0.14 |
|
R5309:Vmn2r103
|
UTSW |
17 |
19,793,034 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5312:Vmn2r103
|
UTSW |
17 |
19,793,034 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5329:Vmn2r103
|
UTSW |
17 |
19,812,171 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5611:Vmn2r103
|
UTSW |
17 |
19,793,642 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5684:Vmn2r103
|
UTSW |
17 |
19,792,989 (GRCm38) |
missense |
probably benign |
0.02 |
|
R5715:Vmn2r103
|
UTSW |
17 |
19,794,939 (GRCm38) |
missense |
probably benign |
0.17 |
|
R5907:Vmn2r103
|
UTSW |
17 |
19,812,453 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R6029:Vmn2r103
|
UTSW |
17 |
19,794,216 (GRCm38) |
nonsense |
probably null |
|
|
R6114:Vmn2r103
|
UTSW |
17 |
19,812,325 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6285:Vmn2r103
|
UTSW |
17 |
19,812,144 (GRCm38) |
missense |
probably benign |
|
|
R6292:Vmn2r103
|
UTSW |
17 |
19,793,604 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R6334:Vmn2r103
|
UTSW |
17 |
19,794,082 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R6501:Vmn2r103
|
UTSW |
17 |
19,811,904 (GRCm38) |
missense |
probably benign |
0.29 |
|
R6710:Vmn2r103
|
UTSW |
17 |
19,811,977 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6774:Vmn2r103
|
UTSW |
17 |
19,773,511 (GRCm38) |
missense |
probably benign |
0.14 |
|
R6981:Vmn2r103
|
UTSW |
17 |
19,793,477 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7768:Vmn2r103
|
UTSW |
17 |
19,812,052 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R7816:Vmn2r103
|
UTSW |
17 |
19,794,214 (GRCm38) |
missense |
probably benign |
0.06 |
|
R7885:Vmn2r103
|
UTSW |
17 |
19,793,123 (GRCm38) |
missense |
probably benign |
0.25 |
|
R8002:Vmn2r103
|
UTSW |
17 |
19,799,249 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8031:Vmn2r103
|
UTSW |
17 |
19,793,497 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8140:Vmn2r103
|
UTSW |
17 |
19,811,796 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8186:Vmn2r103
|
UTSW |
17 |
19,811,943 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8559:Vmn2r103
|
UTSW |
17 |
19,812,384 (GRCm38) |
missense |
probably benign |
0.01 |
|
R9413:Vmn2r103
|
UTSW |
17 |
19,811,896 (GRCm38) |
missense |
possibly damaging |
0.54 |
|
R9591:Vmn2r103
|
UTSW |
17 |
19,811,659 (GRCm38) |
missense |
possibly damaging |
0.70 |
|
R9652:Vmn2r103
|
UTSW |
17 |
19,793,765 (GRCm38) |
missense |
probably benign |
0.01 |
|
R9680:Vmn2r103
|
UTSW |
17 |
19,799,263 (GRCm38) |
nonsense |
probably null |
|
|
R9743:Vmn2r103
|
UTSW |
17 |
19,812,213 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1088:Vmn2r103
|
UTSW |
17 |
19,795,047 (GRCm38) |
missense |
probably benign |
0.08 |
|
| Predicted Primers |
PCR Primer
(F):5'- CTCCCTGATGACCACAAAGG -3'
(R):5'- CAAATGCCACAGCTTAGGAAG -3'
Sequencing Primer
(F):5'- GCCACATGGACTTCACAT -3'
(R):5'- GCCACAGCTTAGGAAGATAAATATC -3'
|
| Posted On |
2014-09-17 |
Incidental Mutation