Incidental Mutation 'R2072:Vmn2r15'
| ID |
227216 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r15
|
| Ensembl Gene |
ENSMUSG00000091375 |
| Gene Name |
vomeronasal 2, receptor 15 |
| Synonyms |
EG211223 |
| MMRRC Submission |
040077-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.101)
|
| Stock # |
R2072 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
109434135-109445422 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 109434619 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Lysine
at position 695
(M695K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000128333
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000167133]
|
| AlphaFold |
L7N2A0 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000167133
AA Change: M695K
PolyPhen 2
Score 0.655 (Sensitivity: 0.87; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000128333
Gene: ENSMUSG00000091375
AA Change: M695K
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
75 |
472 |
1e-29 |
PFAM |
|
Pfam:NCD3G
|
514 |
568 |
5.8e-18 |
PFAM |
|
Pfam:7tm_3
|
601 |
836 |
9.1e-55 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.4%
- 20x: 95.3%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 76 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 0610040J01Rik |
G |
C |
5: 64,056,080 (GRCm39) |
R272P |
possibly damaging |
Het |
| Ablim3 |
A |
T |
18: 61,990,159 (GRCm39) |
D83E |
possibly damaging |
Het |
| Aco1 |
G |
A |
4: 40,183,605 (GRCm39) |
G508S |
probably damaging |
Het |
| Adamts13 |
C |
A |
2: 26,895,437 (GRCm39) |
T1176N |
probably benign |
Het |
| Adgre5 |
T |
C |
8: 84,454,433 (GRCm39) |
T357A |
probably benign |
Het |
| Akap8l |
C |
T |
17: 32,551,457 (GRCm39) |
R511H |
probably damaging |
Het |
| Ankrd33 |
T |
C |
15: 101,017,517 (GRCm39) |
V310A |
probably benign |
Het |
| Armh3 |
A |
T |
19: 45,953,820 (GRCm39) |
I188K |
probably damaging |
Het |
| Bnipl |
C |
T |
3: 95,151,522 (GRCm39) |
G232E |
probably damaging |
Het |
| Btbd17 |
A |
T |
11: 114,682,778 (GRCm39) |
|
probably null |
Het |
| Cacna1s |
G |
A |
1: 136,007,242 (GRCm39) |
V173I |
probably benign |
Het |
| Ccdc122 |
T |
C |
14: 77,306,391 (GRCm39) |
|
probably null |
Het |
| Ces1a |
T |
A |
8: 93,774,703 (GRCm39) |
N12Y |
probably benign |
Het |
| Chrdl1 |
T |
C |
X: 142,086,414 (GRCm39) |
I231V |
probably benign |
Het |
| Ciita |
C |
T |
16: 10,336,217 (GRCm39) |
T958I |
probably benign |
Het |
| Cnot1 |
G |
T |
8: 96,466,461 (GRCm39) |
T1592K |
possibly damaging |
Het |
| Dcaf15 |
T |
C |
8: 84,828,370 (GRCm39) |
D240G |
probably damaging |
Het |
| Dlgap1 |
C |
T |
17: 70,969,765 (GRCm39) |
R524C |
probably damaging |
Het |
| Dmd |
G |
C |
X: 83,356,089 (GRCm39) |
A2257P |
probably benign |
Het |
| Dsg1c |
A |
G |
18: 20,408,309 (GRCm39) |
M453V |
probably benign |
Het |
| Ednrb |
G |
T |
14: 104,054,535 (GRCm39) |
N432K |
probably benign |
Het |
| Fcgbp |
G |
A |
7: 27,819,814 (GRCm39) |
G2514S |
probably damaging |
Het |
| Fez1 |
A |
G |
9: 36,779,241 (GRCm39) |
K306R |
probably benign |
Het |
| Fmo4 |
A |
G |
1: 162,637,456 (GRCm39) |
V12A |
probably benign |
Het |
| Fpgt |
T |
C |
3: 154,793,511 (GRCm39) |
Y172C |
probably damaging |
Het |
| Fsip2 |
T |
A |
2: 82,839,159 (GRCm39) |
F6976I |
possibly damaging |
Het |
| Galnt12 |
C |
T |
4: 47,108,477 (GRCm39) |
R205* |
probably null |
Het |
| Grik5 |
A |
T |
7: 24,714,738 (GRCm39) |
M752K |
possibly damaging |
Het |
| Herc2 |
A |
G |
7: 55,876,712 (GRCm39) |
N4516S |
probably damaging |
Het |
| Ifrd2 |
A |
T |
9: 107,469,744 (GRCm39) |
D439V |
probably damaging |
Het |
| Igsf3 |
A |
G |
3: 101,346,831 (GRCm39) |
T609A |
probably benign |
Het |
| Kif5a |
T |
C |
10: 127,081,238 (GRCm39) |
D232G |
probably damaging |
Het |
| Lgi2 |
A |
G |
5: 52,695,847 (GRCm39) |
S371P |
probably damaging |
Het |
| Marchf3 |
A |
T |
18: 56,944,925 (GRCm39) |
V56E |
possibly damaging |
Het |
| Mib2 |
T |
C |
4: 155,744,158 (GRCm39) |
D168G |
probably damaging |
Het |
| Nhs |
T |
A |
X: 160,625,717 (GRCm39) |
H544L |
probably damaging |
Het |
| Nlrp2 |
A |
G |
7: 5,328,005 (GRCm39) |
S683P |
probably damaging |
Het |
| Onecut3 |
T |
G |
10: 80,330,848 (GRCm39) |
L3V |
unknown |
Het |
| Or12j2 |
T |
C |
7: 139,916,566 (GRCm39) |
S264P |
possibly damaging |
Het |
| Or4c35 |
C |
A |
2: 89,808,557 (GRCm39) |
T145K |
probably benign |
Het |
| Or5b102 |
A |
T |
19: 13,041,044 (GRCm39) |
M90L |
probably benign |
Het |
| Otogl |
C |
T |
10: 107,616,904 (GRCm39) |
C1791Y |
probably damaging |
Het |
| Paip1 |
T |
C |
13: 119,566,798 (GRCm39) |
V128A |
possibly damaging |
Het |
| Pcnx2 |
A |
T |
8: 126,488,481 (GRCm39) |
C1688S |
possibly damaging |
Het |
| Pdzd2 |
A |
G |
15: 12,385,905 (GRCm39) |
L955P |
probably damaging |
Het |
| Phlpp2 |
T |
C |
8: 110,655,124 (GRCm39) |
S605P |
possibly damaging |
Het |
| Pkhd1l1 |
G |
T |
15: 44,422,035 (GRCm39) |
A3102S |
probably damaging |
Het |
| Plxnb2 |
G |
T |
15: 89,042,654 (GRCm39) |
R1545S |
probably damaging |
Het |
| Ppp4c |
T |
C |
7: 126,386,520 (GRCm39) |
|
probably null |
Het |
| Prune1 |
C |
T |
3: 95,162,719 (GRCm39) |
R318Q |
probably benign |
Het |
| Psg27 |
T |
C |
7: 18,294,342 (GRCm39) |
D355G |
probably damaging |
Het |
| Psg27 |
A |
G |
7: 18,298,934 (GRCm39) |
L129P |
probably benign |
Het |
| Psmc6 |
A |
G |
14: 45,567,323 (GRCm39) |
K7E |
possibly damaging |
Het |
| Reln |
A |
T |
5: 22,124,175 (GRCm39) |
V2777E |
probably damaging |
Het |
| Rigi |
A |
T |
4: 40,224,069 (GRCm39) |
|
probably null |
Het |
| Scn11a |
G |
T |
9: 119,640,274 (GRCm39) |
A207E |
possibly damaging |
Het |
| Slc5a5 |
C |
T |
8: 71,345,083 (GRCm39) |
G75R |
possibly damaging |
Het |
| Smarcd2 |
A |
T |
11: 106,156,133 (GRCm39) |
L42* |
probably null |
Het |
| Smg1 |
T |
C |
7: 117,762,389 (GRCm39) |
|
probably benign |
Het |
| Smurf2 |
T |
A |
11: 106,732,595 (GRCm39) |
Q335L |
probably benign |
Het |
| Sspo |
A |
T |
6: 48,450,451 (GRCm39) |
H2580L |
probably benign |
Het |
| Stk3 |
T |
C |
15: 34,959,195 (GRCm39) |
M256V |
possibly damaging |
Het |
| Syt1 |
A |
G |
10: 108,419,833 (GRCm39) |
I276T |
probably damaging |
Het |
| Syt10 |
C |
T |
15: 89,674,979 (GRCm39) |
D456N |
probably damaging |
Het |
| Taar9 |
A |
T |
10: 23,984,877 (GRCm39) |
C186S |
probably damaging |
Het |
| Tnrc6b |
C |
T |
15: 80,767,166 (GRCm39) |
P977L |
possibly damaging |
Het |
| Trp53bp2 |
A |
G |
1: 182,286,432 (GRCm39) |
T1091A |
probably benign |
Het |
| Ttn |
G |
T |
2: 76,768,120 (GRCm39) |
T2947N |
probably damaging |
Het |
| Ube2q1 |
T |
C |
3: 89,686,878 (GRCm39) |
|
probably null |
Het |
| Ube3c |
A |
G |
5: 29,840,638 (GRCm39) |
E671G |
probably benign |
Het |
| Upf3a |
A |
G |
8: 13,835,850 (GRCm39) |
K56R |
possibly damaging |
Het |
| Vmn2r3 |
A |
T |
3: 64,182,493 (GRCm39) |
M402K |
possibly damaging |
Het |
| Zfp354b |
T |
A |
11: 50,813,279 (GRCm39) |
R549* |
probably null |
Het |
| Zfp37 |
A |
T |
4: 62,109,945 (GRCm39) |
M411K |
probably damaging |
Het |
| Zfp747 |
T |
A |
7: 126,973,142 (GRCm39) |
T343S |
possibly damaging |
Het |
| Zfp853 |
T |
A |
5: 143,275,137 (GRCm39) |
Q161L |
unknown |
Het |
|
| Other mutations in Vmn2r15 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01335:Vmn2r15
|
APN |
5 |
109,434,602 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
IGL01367:Vmn2r15
|
APN |
5 |
109,441,075 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01844:Vmn2r15
|
APN |
5 |
109,434,135 (GRCm39) |
makesense |
probably null |
|
|
IGL02190:Vmn2r15
|
APN |
5 |
109,441,240 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02754:Vmn2r15
|
APN |
5 |
109,441,134 (GRCm39) |
nonsense |
probably null |
|
|
IGL02797:Vmn2r15
|
APN |
5 |
109,445,250 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL03301:Vmn2r15
|
APN |
5 |
109,445,221 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03407:Vmn2r15
|
APN |
5 |
109,434,185 (GRCm39) |
nonsense |
probably null |
|
|
BB001:Vmn2r15
|
UTSW |
5 |
109,434,254 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB011:Vmn2r15
|
UTSW |
5 |
109,434,254 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4445001:Vmn2r15
|
UTSW |
5 |
109,435,008 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4520001:Vmn2r15
|
UTSW |
5 |
109,434,871 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0038:Vmn2r15
|
UTSW |
5 |
109,441,010 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R0111:Vmn2r15
|
UTSW |
5 |
109,435,022 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R0379:Vmn2r15
|
UTSW |
5 |
109,434,344 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0427:Vmn2r15
|
UTSW |
5 |
109,434,953 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0639:Vmn2r15
|
UTSW |
5 |
109,440,881 (GRCm39) |
missense |
probably benign |
0.22 |
|
R0964:Vmn2r15
|
UTSW |
5 |
109,445,401 (GRCm39) |
missense |
probably benign |
0.34 |
|
R1147:Vmn2r15
|
UTSW |
5 |
109,441,072 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1147:Vmn2r15
|
UTSW |
5 |
109,441,072 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1232:Vmn2r15
|
UTSW |
5 |
109,441,168 (GRCm39) |
missense |
probably benign |
0.39 |
|
R1241:Vmn2r15
|
UTSW |
5 |
109,440,770 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1244:Vmn2r15
|
UTSW |
5 |
109,441,092 (GRCm39) |
nonsense |
probably null |
|
|
R1394:Vmn2r15
|
UTSW |
5 |
109,442,014 (GRCm39) |
missense |
probably benign |
0.44 |
|
R1395:Vmn2r15
|
UTSW |
5 |
109,442,014 (GRCm39) |
missense |
probably benign |
0.44 |
|
R1423:Vmn2r15
|
UTSW |
5 |
109,441,093 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1439:Vmn2r15
|
UTSW |
5 |
109,441,953 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1513:Vmn2r15
|
UTSW |
5 |
109,441,195 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1777:Vmn2r15
|
UTSW |
5 |
109,442,136 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R1844:Vmn2r15
|
UTSW |
5 |
109,434,860 (GRCm39) |
nonsense |
probably null |
|
|
R2074:Vmn2r15
|
UTSW |
5 |
109,434,619 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R2122:Vmn2r15
|
UTSW |
5 |
109,434,322 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2208:Vmn2r15
|
UTSW |
5 |
109,445,309 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R2268:Vmn2r15
|
UTSW |
5 |
109,441,073 (GRCm39) |
missense |
probably benign |
0.31 |
|
R2831:Vmn2r15
|
UTSW |
5 |
109,434,458 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3848:Vmn2r15
|
UTSW |
5 |
109,445,312 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4058:Vmn2r15
|
UTSW |
5 |
109,441,312 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4615:Vmn2r15
|
UTSW |
5 |
109,441,348 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4663:Vmn2r15
|
UTSW |
5 |
109,441,940 (GRCm39) |
missense |
probably benign |
|
|
R4681:Vmn2r15
|
UTSW |
5 |
109,434,488 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4751:Vmn2r15
|
UTSW |
5 |
109,434,620 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5095:Vmn2r15
|
UTSW |
5 |
109,436,317 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R5300:Vmn2r15
|
UTSW |
5 |
109,441,974 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5309:Vmn2r15
|
UTSW |
5 |
109,440,956 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5335:Vmn2r15
|
UTSW |
5 |
109,434,673 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5421:Vmn2r15
|
UTSW |
5 |
109,434,401 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5805:Vmn2r15
|
UTSW |
5 |
109,434,806 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R6280:Vmn2r15
|
UTSW |
5 |
109,441,291 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R6324:Vmn2r15
|
UTSW |
5 |
109,434,137 (GRCm39) |
makesense |
probably null |
|
|
R6383:Vmn2r15
|
UTSW |
5 |
109,441,092 (GRCm39) |
nonsense |
probably null |
|
|
R6772:Vmn2r15
|
UTSW |
5 |
109,434,238 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6991:Vmn2r15
|
UTSW |
5 |
109,441,180 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7194:Vmn2r15
|
UTSW |
5 |
109,440,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7365:Vmn2r15
|
UTSW |
5 |
109,445,388 (GRCm39) |
missense |
probably benign |
0.15 |
|
R7365:Vmn2r15
|
UTSW |
5 |
109,441,105 (GRCm39) |
missense |
probably benign |
0.19 |
|
R7423:Vmn2r15
|
UTSW |
5 |
109,445,394 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7552:Vmn2r15
|
UTSW |
5 |
109,440,774 (GRCm39) |
nonsense |
probably null |
|
|
R7619:Vmn2r15
|
UTSW |
5 |
109,436,190 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7892:Vmn2r15
|
UTSW |
5 |
109,434,217 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7924:Vmn2r15
|
UTSW |
5 |
109,434,254 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8058:Vmn2r15
|
UTSW |
5 |
109,440,956 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8099:Vmn2r15
|
UTSW |
5 |
109,441,185 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R8189:Vmn2r15
|
UTSW |
5 |
109,434,713 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8275:Vmn2r15
|
UTSW |
5 |
109,434,150 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8277:Vmn2r15
|
UTSW |
5 |
109,441,310 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8277:Vmn2r15
|
UTSW |
5 |
109,440,970 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8465:Vmn2r15
|
UTSW |
5 |
109,445,302 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8679:Vmn2r15
|
UTSW |
5 |
109,434,779 (GRCm39) |
missense |
probably benign |
0.31 |
|
R8682:Vmn2r15
|
UTSW |
5 |
109,441,938 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8809:Vmn2r15
|
UTSW |
5 |
109,434,874 (GRCm39) |
missense |
probably benign |
0.22 |
|
R9016:Vmn2r15
|
UTSW |
5 |
109,442,109 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9372:Vmn2r15
|
UTSW |
5 |
109,441,953 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R9596:Vmn2r15
|
UTSW |
5 |
109,440,791 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9619:Vmn2r15
|
UTSW |
5 |
109,440,622 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R9685:Vmn2r15
|
UTSW |
5 |
109,440,598 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9716:Vmn2r15
|
UTSW |
5 |
109,445,224 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R9772:Vmn2r15
|
UTSW |
5 |
109,434,923 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0065:Vmn2r15
|
UTSW |
5 |
109,441,174 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1187:Vmn2r15
|
UTSW |
5 |
109,434,529 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGGAAGGCAATGACTGAGCC -3'
(R):5'- CCTATTGTGAAGGCCAATAACC -3'
Sequencing Primer
(F):5'- CAATGACTGAGCCTTTGTTGC -3'
(R):5'- TTGTGAAGGCCAATAACCGCATTG -3'
|
| Posted On |
2014-09-17 |
Incidental Mutation