Mutagenetix > Incidental Mutation

Incidental Mutation 'R2073:Vmn2r109'

227374

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r109

Ensembl Gene

ENSMUSG00000090572

Gene Name

vomeronasal 2, receptor 109

Synonyms

EG627814

MMRRC Submission

040078-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.074) question?

Stock #

R2073 (G1)

Quality Score

220

Status

Not validated

Chromosome

Chromosomal Location

20540517-20564756 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 20564712 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Asparagine at position 15 (K15N)

Ref Sequence

ENSEMBL: ENSMUSP00000132641 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000167093]

AlphaFold

K7N747

Predicted Effect

probably benign
Transcript: ENSMUST00000167093
AA Change: K15N

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000132641
Gene: ENSMUSG00000090572
AA Change: K15N

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	83	467	1.4e-35	PFAM
Pfam:NCD3G	510	563	3.1e-21	PFAM
Pfam:7tm_3	596	831	7.4e-52	PFAM

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.3%
20x: 95.2%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 86 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110017D15Rik	A	G	4: 41,507,519 (GRCm38)		probably null	Het
2310057M21Rik	T	C	7: 131,357,513 (GRCm38)	R153G	probably benign	Het
4930430A15Rik	T	C	2: 111,200,418 (GRCm38)	E382G	probably damaging	Het
5730596B20Rik	C	A	6: 52,178,982 (GRCm38)	Y9*	probably null	Het
9130011E15Rik	A	T	19: 45,965,381 (GRCm38)	I188K	probably damaging	Het
Aco1	G	A	4: 40,183,605 (GRCm38)	G508S	probably damaging	Het
Acot3	A	G	12: 84,053,456 (GRCm38)	H2R	possibly damaging	Het
Adamts13	T	A	2: 27,006,314 (GRCm38)	C1240S	probably damaging	Het
Adra1b	T	C	11: 43,835,871 (GRCm38)	N73S	probably damaging	Het
Aebp2	G	A	6: 140,633,694 (GRCm38)	S219N	probably benign	Het
Akap8l	C	T	17: 32,332,483 (GRCm38)	R511H	probably damaging	Het
Ank	T	C	15: 27,565,022 (GRCm38)	S270P	probably benign	Het
Ankle1	G	A	8: 71,409,329 (GRCm38)	R492H	possibly damaging	Het
Ankub1	G	A	3: 57,692,292 (GRCm38)	H19Y	possibly damaging	Het
Anln	C	A	9: 22,333,168 (GRCm38)	W1083L	probably benign	Het
Apaf1	G	T	10: 91,031,694 (GRCm38)	S763*	probably null	Het
Apba3	A	G	10: 81,269,294 (GRCm38)	T134A	probably benign	Het
Bod1l	C	T	5: 41,819,189 (GRCm38)	S1594N	probably benign	Het
C7	T	C	15: 4,990,428 (GRCm38)	M746V	probably benign	Het
Cdkn2a	T	A	4: 89,294,493 (GRCm38)	I11F	possibly damaging	Het
Cideb	T	C	14: 55,755,160 (GRCm38)	M100V	possibly damaging	Het
Cntnap5c	T	C	17: 58,305,552 (GRCm38)	L862P	possibly damaging	Het
Coch	A	T	12: 51,602,689 (GRCm38)	D261V	probably benign	Het
Cyp2ab1	A	G	16: 20,313,889 (GRCm38)	F220L	possibly damaging	Het
Ddx10	A	T	9: 53,240,505 (GRCm38)	D73E	probably benign	Het
Dgkg	A	G	16: 22,565,317 (GRCm38)	F462S	probably damaging	Het
Dlgap3	C	T	4: 127,195,366 (GRCm38)	H252Y	probably damaging	Het
Dmd	G	C	X: 84,312,483 (GRCm38)	A2257P	probably benign	Het
Dtnb	A	G	12: 3,781,273 (GRCm38)	T658A	probably benign	Het
Duox2	T	A	2: 122,295,158 (GRCm38)	S323C	probably damaging	Het
Dync1h1	T	A	12: 110,614,592 (GRCm38)	I251N	probably damaging	Het
Eml5	A	G	12: 98,802,446 (GRCm38)	S1457P	probably damaging	Het
Fam114a1	T	A	5: 64,995,904 (GRCm38)		probably null	Het
Fcho1	A	T	8: 71,710,489 (GRCm38)	L632Q	probably damaging	Het
Gm12695	T	C	4: 96,723,945 (GRCm38)	Y527C	possibly damaging	Het
Gm16223	T	C	5: 42,214,599 (GRCm38)	C111R	unknown	Het
H2-Q4	T	A	17: 35,380,402 (GRCm38)	S154T	possibly damaging	Het
Hhat	A	G	1: 192,727,379 (GRCm38)	F125L	possibly damaging	Het
Ier5l	T	A	2: 30,473,056 (GRCm38)	D319V	probably damaging	Het
Kif5a	T	C	10: 127,245,369 (GRCm38)	D232G	probably damaging	Het
M1ap	A	G	6: 82,981,882 (GRCm38)	I165V	probably benign	Het
Map2k4	A	C	11: 65,693,456 (GRCm38)	F334V	probably damaging	Het
Mmp19	G	A	10: 128,794,979 (GRCm38)	R156H	probably damaging	Het
Mpped2	T	A	2: 106,744,802 (GRCm38)	Y77*	probably null	Het
Nhs	T	A	X: 161,842,721 (GRCm38)	H544L	probably damaging	Het
Nr4a1	C	A	15: 101,274,067 (GRCm38)	H541N	probably damaging	Het
Olfr1247	A	G	2: 89,609,478 (GRCm38)	V208A	probably benign	Het
Olfr1484	A	T	19: 13,585,601 (GRCm38)	Q99L	probably damaging	Het
Pak6	A	C	2: 118,688,851 (GRCm38)	N17T	probably damaging	Het
Pcnt	T	A	10: 76,380,380 (GRCm38)	T2225S	possibly damaging	Het
Pdzd2	A	G	15: 12,385,819 (GRCm38)	L955P	probably damaging	Het
Phf21a	A	G	2: 92,348,036 (GRCm38)	D357G	probably damaging	Het
Pih1d3	A	G	1: 31,222,996 (GRCm38)	S20G	probably benign	Het
Pkhd1l1	G	T	15: 44,558,639 (GRCm38)	A3102S	probably damaging	Het
Plch2	A	T	4: 154,989,909 (GRCm38)	L754Q	probably damaging	Het
Plekhd1	A	G	12: 80,721,292 (GRCm38)	N335D	probably benign	Het
Pole	C	A	5: 110,325,551 (GRCm38)	T1737N	probably damaging	Het
Pramel6	G	A	2: 87,508,744 (GRCm38)	S96N	probably damaging	Het
Prdm14	A	C	1: 13,125,730 (GRCm38)	Y36D	possibly damaging	Het
Psg27	T	C	7: 18,560,417 (GRCm38)	D355G	probably damaging	Het
Rfc1	A	T	5: 65,301,939 (GRCm38)	D225E	probably damaging	Het
Sec16a	A	G	2: 26,440,239 (GRCm38)	I588T	probably damaging	Het
Setd6	G	A	8: 95,716,788 (GRCm38)	V60M	probably damaging	Het
Sgk3	A	G	1: 9,891,424 (GRCm38)	I432V	probably benign	Het
Six2	A	G	17: 85,687,505 (GRCm38)	S150P	probably damaging	Het
Slc1a6	T	C	10: 78,800,130 (GRCm38)	V343A	possibly damaging	Het
Slc43a3	T	C	2: 84,944,612 (GRCm38)		probably null	Het
Smc3	A	G	19: 53,631,533 (GRCm38)	D620G	probably benign	Het
Smg6	C	G	11: 74,930,294 (GRCm38)	P464A	probably damaging	Het
Sox11	T	C	12: 27,342,279 (GRCm38)	T44A	possibly damaging	Het
Spata22	A	G	11: 73,336,226 (GRCm38)	R89G	possibly damaging	Het
Stk3	T	C	15: 34,959,049 (GRCm38)	M256V	possibly damaging	Het
Syne2	A	G	12: 76,015,579 (GRCm38)	D4226G	possibly damaging	Het
Tecpr2	T	C	12: 110,968,429 (GRCm38)	S1370P	possibly damaging	Het
Tek	A	G	4: 94,827,729 (GRCm38)	I463V	probably benign	Het
Trib1	T	A	15: 59,654,340 (GRCm38)	I253N	probably damaging	Het
Triobp	G	T	15: 78,973,895 (GRCm38)	G1232V	probably damaging	Het
Trpm6	G	A	19: 18,876,042 (GRCm38)	V1809M	probably damaging	Het
Tsc22d4	A	G	5: 137,762,487 (GRCm38)	K57E	possibly damaging	Het
Wdr78	G	A	4: 103,050,193 (GRCm38)	T632M	probably damaging	Het
Wnt9a	A	G	11: 59,331,229 (GRCm38)	N318D	probably damaging	Het
Wwp1	A	G	4: 19,662,181 (GRCm38)	V138A	possibly damaging	Het
Zfp37	A	T	4: 62,191,708 (GRCm38)	M411K	probably damaging	Het
Zfp715	T	A	7: 43,311,120 (GRCm38)	T16S	probably benign	Het
Zfp932	A	G	5: 110,009,818 (GRCm38)	T461A	possibly damaging	Het
Zscan29	A	T	2: 121,160,855 (GRCm38)	C817*	probably null	Het

Other mutations in Vmn2r109

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01313:Vmn2r109	APN	17	20,550,157 (GRCm38)	missense	probably damaging	1.00
IGL01383:Vmn2r109	APN	17	20,541,121 (GRCm38)	missense	possibly damaging	0.89
IGL01469:Vmn2r109	APN	17	20,541,409 (GRCm38)	missense	probably damaging	1.00
IGL01762:Vmn2r109	APN	17	20,554,392 (GRCm38)	missense	probably benign
IGL01864:Vmn2r109	APN	17	20,541,134 (GRCm38)	missense	probably benign	0.28
IGL02028:Vmn2r109	APN	17	20,541,080 (GRCm38)	missense	probably benign	0.28
IGL02074:Vmn2r109	APN	17	20,554,341 (GRCm38)	missense	probably benign	0.05
IGL02162:Vmn2r109	APN	17	20,554,160 (GRCm38)	missense	probably benign	0.01
IGL02474:Vmn2r109	APN	17	20,540,888 (GRCm38)	missense	probably benign
IGL02490:Vmn2r109	APN	17	20,540,984 (GRCm38)	missense	possibly damaging	0.78
IGL02604:Vmn2r109	APN	17	20,540,701 (GRCm38)	missense	probably damaging	1.00
IGL02669:Vmn2r109	APN	17	20,554,256 (GRCm38)	missense	possibly damaging	0.64
IGL02705:Vmn2r109	APN	17	20,553,800 (GRCm38)	missense	probably benign
IGL02745:Vmn2r109	APN	17	20,541,250 (GRCm38)	missense	probably damaging	0.99
PIT4142001:Vmn2r109	UTSW	17	20,554,577 (GRCm38)	critical splice acceptor site	probably null
R0389:Vmn2r109	UTSW	17	20,541,074 (GRCm38)	missense	probably damaging	1.00
R0470:Vmn2r109	UTSW	17	20,552,886 (GRCm38)	missense	probably benign	0.06
R0570:Vmn2r109	UTSW	17	20,540,675 (GRCm38)	missense	probably damaging	0.99
R0855:Vmn2r109	UTSW	17	20,541,408 (GRCm38)	nonsense	probably null
R0882:Vmn2r109	UTSW	17	20,554,580 (GRCm38)	splice site	probably benign
R1241:Vmn2r109	UTSW	17	20,555,241 (GRCm38)	missense	possibly damaging	0.86
R1587:Vmn2r109	UTSW	17	20,540,740 (GRCm38)	missense	probably damaging	1.00
R1931:Vmn2r109	UTSW	17	20,553,810 (GRCm38)	nonsense	probably null
R1957:Vmn2r109	UTSW	17	20,564,707 (GRCm38)	missense	probably benign	0.11
R1962:Vmn2r109	UTSW	17	20,553,923 (GRCm38)	missense	probably damaging	0.99
R2020:Vmn2r109	UTSW	17	20,541,186 (GRCm38)	nonsense	probably null
R2436:Vmn2r109	UTSW	17	20,554,536 (GRCm38)	missense	probably damaging	0.99
R3123:Vmn2r109	UTSW	17	20,540,986 (GRCm38)	missense	probably damaging	1.00
R3839:Vmn2r109	UTSW	17	20,554,442 (GRCm38)	missense	probably damaging	1.00
R4019:Vmn2r109	UTSW	17	20,553,812 (GRCm38)	missense	probably benign
R4428:Vmn2r109	UTSW	17	20,553,024 (GRCm38)	missense	probably benign
R4584:Vmn2r109	UTSW	17	20,554,558 (GRCm38)	nonsense	probably null
R4652:Vmn2r109	UTSW	17	20,541,394 (GRCm38)	missense	probably damaging	1.00
R4708:Vmn2r109	UTSW	17	20,541,343 (GRCm38)	missense	probably damaging	0.97
R4823:Vmn2r109	UTSW	17	20,553,891 (GRCm38)	missense	probably damaging	1.00
R4831:Vmn2r109	UTSW	17	20,541,232 (GRCm38)	missense	probably benign	0.01
R4907:Vmn2r109	UTSW	17	20,550,086 (GRCm38)	missense	probably damaging	1.00
R5011:Vmn2r109	UTSW	17	20,555,189 (GRCm38)	missense	probably damaging	1.00
R5296:Vmn2r109	UTSW	17	20,554,341 (GRCm38)	missense	possibly damaging	0.90
R5600:Vmn2r109	UTSW	17	20,540,927 (GRCm38)	missense	probably damaging	1.00
R5602:Vmn2r109	UTSW	17	20,540,671 (GRCm38)	missense	possibly damaging	0.94
R5652:Vmn2r109	UTSW	17	20,540,519 (GRCm38)	makesense	probably null
R5702:Vmn2r109	UTSW	17	20,554,145 (GRCm38)	missense	probably benign	0.42
R5706:Vmn2r109	UTSW	17	20,554,305 (GRCm38)	missense	probably benign	0.16
R5714:Vmn2r109	UTSW	17	20,552,859 (GRCm38)	missense	probably damaging	1.00
R5832:Vmn2r109	UTSW	17	20,541,056 (GRCm38)	missense	probably benign	0.10
R6008:Vmn2r109	UTSW	17	20,540,719 (GRCm38)	missense	probably damaging	1.00
R6334:Vmn2r109	UTSW	17	20,541,178 (GRCm38)	missense	probably benign	0.18
R6377:Vmn2r109	UTSW	17	20,564,534 (GRCm38)	critical splice donor site	probably null
R6738:Vmn2r109	UTSW	17	20,554,523 (GRCm38)	missense	possibly damaging	0.52
R6857:Vmn2r109	UTSW	17	20,540,670 (GRCm38)	missense	probably benign	0.45
R6953:Vmn2r109	UTSW	17	20,540,711 (GRCm38)	missense	possibly damaging	0.95
R7108:Vmn2r109	UTSW	17	20,564,744 (GRCm38)	missense	probably benign	0.03
R7229:Vmn2r109	UTSW	17	20,540,963 (GRCm38)	missense	possibly damaging	0.80
R7238:Vmn2r109	UTSW	17	20,541,074 (GRCm38)	missense	probably damaging	1.00
R7244:Vmn2r109	UTSW	17	20,540,683 (GRCm38)	missense	possibly damaging	0.70
R7292:Vmn2r109	UTSW	17	20,541,438 (GRCm38)	missense	probably benign	0.05
R7354:Vmn2r109	UTSW	17	20,540,781 (GRCm38)	missense	probably damaging	1.00
R7357:Vmn2r109	UTSW	17	20,541,274 (GRCm38)	missense	probably damaging	1.00
R7522:Vmn2r109	UTSW	17	20,554,403 (GRCm38)	missense	probably benign	0.11
R7596:Vmn2r109	UTSW	17	20,540,680 (GRCm38)	missense	probably damaging	0.98
R7728:Vmn2r109	UTSW	17	20,552,855 (GRCm38)	missense	probably damaging	0.99
R7859:Vmn2r109	UTSW	17	20,541,174 (GRCm38)	missense	probably damaging	1.00
R7871:Vmn2r109	UTSW	17	20,540,520 (GRCm38)	missense	probably benign	0.08
R8113:Vmn2r109	UTSW	17	20,554,467 (GRCm38)	missense	probably benign	0.01
R8153:Vmn2r109	UTSW	17	20,564,707 (GRCm38)	missense	probably benign	0.11
R8977:Vmn2r109	UTSW	17	20,554,269 (GRCm38)	missense	possibly damaging	0.96
R9687:Vmn2r109	UTSW	17	20,555,070 (GRCm38)	missense
Z1176:Vmn2r109	UTSW	17	20,552,994 (GRCm38)	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- TCAACAAAGTCAGGCTGAGATTAAG -3'
(R):5'- AATACAGGGCCTCAGCTGTAG -3'

Sequencing Primer
(F):5'- ATTTCATTCCCCCTGAGAGAGG -3'
(R):5'- GCTGTAGAGCCCAAGAGAAATTG -3'

Posted On

2014-09-17