Incidental Mutation 'R2127:Cenpe'
| ID |
227594 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Cenpe
|
| Ensembl Gene |
ENSMUSG00000045328 |
| Gene Name |
centromere protein E |
| Synonyms |
312kDa, CENP-E, Kif10, N-7 kinesin |
| MMRRC Submission |
040130-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R2127 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
3 |
| Chromosomal Location |
135212537-135273611 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to G
at 135239780 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Lysine
at position 1018
(N1018K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000057938
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000062893]
[ENSMUST00000197369]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000062893
AA Change: N1018K
PolyPhen 2
Score 0.083 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000057938
Gene: ENSMUSG00000045328
AA Change: N1018K
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
4 |
337 |
2.4e-172 |
SMART |
|
coiled coil region
|
493 |
612 |
N/A |
INTRINSIC |
|
coiled coil region
|
637 |
752 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
768 |
801 |
3.5e-5 |
PROSPERO |
|
coiled coil region
|
821 |
991 |
N/A |
INTRINSIC |
|
low complexity region
|
1119 |
1143 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
1225 |
1238 |
6.26e-5 |
PROSPERO |
|
low complexity region
|
1446 |
1467 |
N/A |
INTRINSIC |
|
low complexity region
|
1480 |
1498 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
1614 |
1627 |
6.26e-5 |
PROSPERO |
|
internal_repeat_1
|
2018 |
2051 |
3.5e-5 |
PROSPERO |
|
coiled coil region
|
2226 |
2247 |
N/A |
INTRINSIC |
|
coiled coil region
|
2316 |
2363 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000197369
|
| SMART Domains |
Protein: ENSMUSP00000143435
Gene: ENSMUSG00000045328
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
2 |
49 |
N/A |
INTRINSIC |
|
coiled coil region
|
85 |
172 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.7%
- 10x: 97.5%
- 20x: 95.9%
|
| Validation Efficiency |
98% (93/95) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Centrosome-associated protein E (CENPE) is a kinesin-like motor protein that accumulates in the G2 phase of the cell cycle. Unlike other centrosome-associated proteins, it is not present during interphase and first appears at the centromere region of chromosomes during prometaphase. This protein is required for stable spindle microtubule capture at kinetochores which is a necessary step in chromosome alignment during prometaphase. This protein also couples chromosome position to microtubule depolymerizing activity. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Nov 2014]
PHENOTYPE: Mice homozygous for a knock-out allele display early embryonic lethality. Mutant embryos grown in culture exhibit inner cell mass growth defects and mitotic chromosome misalignment. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 93 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930449I24Rik |
T |
A |
5: 146,504,942 (GRCm38) |
S300T |
possibly damaging |
Het |
| A2ml1 |
A |
C |
6: 128,558,437 (GRCm38) |
V770G |
probably damaging |
Het |
| Abca6 |
A |
G |
11: 110,219,649 (GRCm38) |
I558T |
probably benign |
Het |
| Abhd17c |
C |
A |
7: 84,110,662 (GRCm38) |
G295W |
probably damaging |
Het |
| Actn3 |
G |
A |
19: 4,871,675 (GRCm38) |
A159V |
probably damaging |
Het |
| Adgrv1 |
A |
T |
13: 81,557,080 (GRCm38) |
F1537Y |
probably damaging |
Het |
| Agbl1 |
G |
T |
7: 76,419,880 (GRCm38) |
V373F |
possibly damaging |
Het |
| Aldh1a1 |
A |
T |
19: 20,642,915 (GRCm38) |
E485D |
probably benign |
Het |
| Amdhd2 |
A |
G |
17: 24,158,308 (GRCm38) |
|
probably null |
Het |
| Armc3 |
A |
G |
2: 19,201,811 (GRCm38) |
D15G |
probably damaging |
Het |
| Atp2b2 |
A |
G |
6: 113,760,650 (GRCm38) |
L921P |
probably damaging |
Het |
| Btbd16 |
A |
G |
7: 130,784,308 (GRCm38) |
N88S |
probably benign |
Het |
| Capn10 |
T |
A |
1: 92,938,034 (GRCm38) |
C77* |
probably null |
Het |
| Caskin1 |
T |
C |
17: 24,496,996 (GRCm38) |
|
probably null |
Het |
| Catsper4 |
T |
C |
4: 134,213,806 (GRCm38) |
D254G |
probably benign |
Het |
| Catsperg1 |
T |
C |
7: 29,185,040 (GRCm38) |
D958G |
probably damaging |
Het |
| Ccar2 |
T |
G |
14: 70,139,651 (GRCm38) |
K787Q |
probably benign |
Het |
| Ccdc191 |
C |
T |
16: 43,908,635 (GRCm38) |
T244I |
probably benign |
Het |
| Cd33 |
A |
T |
7: 43,530,275 (GRCm38) |
L243Q |
possibly damaging |
Het |
| Cdc37 |
T |
C |
9: 21,149,847 (GRCm38) |
Y4C |
probably damaging |
Het |
| Crocc |
G |
A |
4: 141,017,096 (GRCm38) |
R1830C |
probably damaging |
Het |
| Csmd1 |
T |
C |
8: 15,917,392 (GRCm38) |
D3157G |
probably damaging |
Het |
| Dhx57 |
C |
T |
17: 80,273,048 (GRCm38) |
V492M |
probably damaging |
Het |
| Dnah2 |
A |
T |
11: 69,458,185 (GRCm38) |
I2486N |
probably benign |
Het |
| Dnhd1 |
C |
T |
7: 105,693,721 (GRCm38) |
T1424I |
possibly damaging |
Het |
| Dsc3 |
C |
T |
18: 19,968,354 (GRCm38) |
A661T |
probably benign |
Het |
| F930015N05Rik |
A |
G |
11: 64,435,403 (GRCm38) |
|
probably benign |
Het |
| Fbxo34 |
C |
A |
14: 47,530,106 (GRCm38) |
R308S |
probably damaging |
Het |
| Gm10608 |
CAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGA |
CAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGA |
9: 119,160,716 (GRCm38) |
|
probably benign |
Het |
| Gm11595 |
A |
T |
11: 99,772,501 (GRCm38) |
C118S |
unknown |
Het |
| Gm9742 |
A |
T |
13: 8,034,975 (GRCm38) |
|
noncoding transcript |
Het |
| Gmeb2 |
G |
A |
2: 181,259,049 (GRCm38) |
A185V |
probably benign |
Het |
| Gpr15 |
A |
G |
16: 58,718,255 (GRCm38) |
V157A |
possibly damaging |
Het |
| Gpr3 |
C |
T |
4: 133,210,621 (GRCm38) |
A247T |
probably damaging |
Het |
| Grin2b |
A |
C |
6: 135,778,700 (GRCm38) |
S539A |
probably benign |
Het |
| Hmbs |
T |
C |
9: 44,340,707 (GRCm38) |
T92A |
probably benign |
Het |
| Inpp4a |
A |
G |
1: 37,366,919 (GRCm38) |
M173V |
probably benign |
Het |
| Irx4 |
T |
A |
13: 73,265,476 (GRCm38) |
S22T |
probably benign |
Het |
| Jph3 |
C |
T |
8: 121,785,142 (GRCm38) |
A623V |
probably benign |
Het |
| Kif1b |
G |
A |
4: 149,187,640 (GRCm38) |
S1568L |
possibly damaging |
Het |
| Ksr1 |
G |
A |
11: 79,033,313 (GRCm38) |
S361L |
probably damaging |
Het |
| Lyst |
T |
G |
13: 13,635,262 (GRCm38) |
Y506D |
probably damaging |
Het |
| Mctp1 |
A |
G |
13: 76,824,822 (GRCm38) |
D648G |
probably damaging |
Het |
| Megf8 |
T |
C |
7: 25,364,582 (GRCm38) |
S2788P |
possibly damaging |
Het |
| Mfsd2b |
T |
A |
12: 4,867,659 (GRCm38) |
Y129F |
probably benign |
Het |
| Mindy4 |
T |
C |
6: 55,218,265 (GRCm38) |
S155P |
probably benign |
Het |
| Mospd4 |
A |
G |
18: 46,465,664 (GRCm38) |
|
noncoding transcript |
Het |
| Myo18b |
A |
T |
5: 112,831,078 (GRCm38) |
L1223Q |
probably damaging |
Het |
| Nckipsd |
A |
G |
9: 108,811,733 (GRCm38) |
T156A |
probably benign |
Het |
| Ndst1 |
G |
A |
18: 60,691,208 (GRCm38) |
T799I |
probably benign |
Het |
| Npffr2 |
A |
T |
5: 89,568,065 (GRCm38) |
I84F |
probably damaging |
Het |
| Nphp3 |
G |
A |
9: 104,008,243 (GRCm38) |
V167M |
probably damaging |
Het |
| Nup107 |
C |
A |
10: 117,774,475 (GRCm38) |
R354L |
possibly damaging |
Het |
| Olfml2a |
T |
C |
2: 38,941,687 (GRCm38) |
C93R |
probably damaging |
Het |
| Or12e10 |
A |
G |
2: 87,810,341 (GRCm38) |
I174V |
probably benign |
Het |
| Or1e25 |
C |
G |
11: 73,602,805 (GRCm38) |
S75C |
possibly damaging |
Het |
| Or5l14 |
A |
T |
2: 87,962,832 (GRCm38) |
V20D |
probably benign |
Het |
| Pappa |
T |
A |
4: 65,297,257 (GRCm38) |
L1134M |
probably damaging |
Het |
| Plscr4 |
T |
G |
9: 92,488,630 (GRCm38) |
F217V |
possibly damaging |
Het |
| Pnpla8 |
T |
A |
12: 44,308,057 (GRCm38) |
Y667N |
probably benign |
Het |
| Polg |
A |
G |
7: 79,464,928 (GRCm38) |
L95P |
probably damaging |
Het |
| Psg20 |
T |
G |
7: 18,682,718 (GRCm38) |
I158L |
probably damaging |
Het |
| Pwwp2a |
A |
G |
11: 43,705,318 (GRCm38) |
S437G |
probably benign |
Het |
| Rdx |
A |
G |
9: 52,069,732 (GRCm38) |
M305V |
possibly damaging |
Het |
| Rinl |
A |
G |
7: 28,796,743 (GRCm38) |
E383G |
probably damaging |
Het |
| Ror1 |
A |
G |
4: 100,442,093 (GRCm38) |
M888V |
probably benign |
Het |
| Rps12 |
A |
T |
10: 23,786,878 (GRCm38) |
I22K |
possibly damaging |
Het |
| Rtca |
C |
A |
3: 116,497,674 (GRCm38) |
R219L |
possibly damaging |
Het |
| Ryr2 |
G |
A |
13: 11,712,195 (GRCm38) |
P2427S |
probably damaging |
Het |
| Slc10a6 |
A |
G |
5: 103,609,056 (GRCm38) |
Y281H |
probably benign |
Het |
| Slc39a11 |
A |
G |
11: 113,369,803 (GRCm38) |
S176P |
probably benign |
Het |
| Slfn10-ps |
A |
G |
11: 83,030,342 (GRCm38) |
|
noncoding transcript |
Het |
| Spef2 |
T |
C |
15: 9,729,661 (GRCm38) |
T124A |
possibly damaging |
Het |
| Sult2a4 |
G |
T |
7: 13,915,260 (GRCm38) |
P207Q |
probably damaging |
Het |
| Tas1r3 |
G |
A |
4: 155,860,470 (GRCm38) |
R765C |
probably damaging |
Het |
| Tcstv1 |
T |
C |
13: 119,893,746 (GRCm38) |
T117A |
probably damaging |
Het |
| Tha1 |
A |
G |
11: 117,869,774 (GRCm38) |
V208A |
probably damaging |
Het |
| Tmbim4 |
T |
A |
10: 120,224,753 (GRCm38) |
I215N |
probably damaging |
Het |
| Tmem202 |
T |
A |
9: 59,520,200 (GRCm38) |
I122F |
probably benign |
Het |
| Tomm70a |
T |
C |
16: 57,121,871 (GRCm38) |
S4P |
unknown |
Het |
| Tpcn2 |
A |
G |
7: 145,273,975 (GRCm38) |
|
probably benign |
Het |
| Trim36 |
A |
T |
18: 46,212,337 (GRCm38) |
F10I |
probably benign |
Het |
| Usp30 |
A |
G |
5: 114,111,163 (GRCm38) |
E176G |
probably damaging |
Het |
| Usp8 |
T |
G |
2: 126,737,575 (GRCm38) |
|
probably null |
Het |
| Vmn1r32 |
T |
A |
6: 66,553,549 (GRCm38) |
Y81F |
probably benign |
Het |
| Vps36 |
G |
T |
8: 22,218,289 (GRCm38) |
|
probably null |
Het |
| Wdr87-ps |
T |
C |
7: 29,537,140 (GRCm38) |
|
noncoding transcript |
Het |
| Wnt3 |
A |
G |
11: 103,812,648 (GRCm38) |
H319R |
possibly damaging |
Het |
| Zfp319 |
A |
T |
8: 95,323,763 (GRCm38) |
|
probably benign |
Het |
| Zfp408 |
T |
C |
2: 91,645,174 (GRCm38) |
E545G |
probably damaging |
Het |
| Zfp799 |
C |
T |
17: 32,819,498 (GRCm38) |
R598Q |
possibly damaging |
Het |
| Zfp831 |
T |
C |
2: 174,648,124 (GRCm38) |
V1228A |
probably benign |
Het |
| Zfp938 |
T |
C |
10: 82,226,042 (GRCm38) |
D248G |
probably benign |
Het |
|
| Other mutations in Cenpe |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00655:Cenpe
|
APN |
3 |
135,231,455 (GRCm38) |
critical splice donor site |
probably null |
|
|
IGL00799:Cenpe
|
APN |
3 |
135,228,917 (GRCm38) |
critical splice donor site |
probably null |
|
|
IGL00815:Cenpe
|
APN |
3 |
135,259,351 (GRCm38) |
missense |
probably benign |
|
|
IGL01446:Cenpe
|
APN |
3 |
135,237,539 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL01469:Cenpe
|
APN |
3 |
135,228,806 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01843:Cenpe
|
APN |
3 |
135,218,507 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
IGL02254:Cenpe
|
APN |
3 |
135,255,477 (GRCm38) |
missense |
probably benign |
|
|
IGL02337:Cenpe
|
APN |
3 |
135,220,276 (GRCm38) |
splice site |
probably benign |
|
|
IGL02382:Cenpe
|
APN |
3 |
135,247,386 (GRCm38) |
missense |
probably benign |
|
|
IGL02458:Cenpe
|
APN |
3 |
135,230,108 (GRCm38) |
nonsense |
probably null |
|
|
IGL02934:Cenpe
|
APN |
3 |
135,264,351 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03335:Cenpe
|
APN |
3 |
135,243,625 (GRCm38) |
missense |
probably benign |
|
|
R0086:Cenpe
|
UTSW |
3 |
135,264,424 (GRCm38) |
splice site |
probably benign |
|
|
R0173:Cenpe
|
UTSW |
3 |
135,259,983 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0394:Cenpe
|
UTSW |
3 |
135,216,425 (GRCm38) |
splice site |
probably benign |
|
|
R0411:Cenpe
|
UTSW |
3 |
135,222,255 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0624:Cenpe
|
UTSW |
3 |
135,246,586 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0634:Cenpe
|
UTSW |
3 |
135,246,827 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0648:Cenpe
|
UTSW |
3 |
135,230,082 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0691:Cenpe
|
UTSW |
3 |
135,217,305 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1184:Cenpe
|
UTSW |
3 |
135,264,422 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1530:Cenpe
|
UTSW |
3 |
135,246,902 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R1559:Cenpe
|
UTSW |
3 |
135,270,900 (GRCm38) |
missense |
probably benign |
0.07 |
|
R1562:Cenpe
|
UTSW |
3 |
135,238,394 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
R1568:Cenpe
|
UTSW |
3 |
135,239,758 (GRCm38) |
missense |
probably benign |
0.01 |
|
R1712:Cenpe
|
UTSW |
3 |
135,265,933 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1828:Cenpe
|
UTSW |
3 |
135,246,496 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1846:Cenpe
|
UTSW |
3 |
135,239,845 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1861:Cenpe
|
UTSW |
3 |
135,268,979 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1938:Cenpe
|
UTSW |
3 |
135,247,479 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R1961:Cenpe
|
UTSW |
3 |
135,242,493 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2062:Cenpe
|
UTSW |
3 |
135,222,321 (GRCm38) |
splice site |
probably benign |
|
|
R2118:Cenpe
|
UTSW |
3 |
135,246,884 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R2156:Cenpe
|
UTSW |
3 |
135,247,474 (GRCm38) |
missense |
probably benign |
0.34 |
|
R2265:Cenpe
|
UTSW |
3 |
135,261,636 (GRCm38) |
missense |
probably benign |
0.02 |
|
R2268:Cenpe
|
UTSW |
3 |
135,261,636 (GRCm38) |
missense |
probably benign |
0.02 |
|
R2392:Cenpe
|
UTSW |
3 |
135,248,113 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2508:Cenpe
|
UTSW |
3 |
135,241,073 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R3084:Cenpe
|
UTSW |
3 |
135,241,021 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3779:Cenpe
|
UTSW |
3 |
135,256,576 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R3833:Cenpe
|
UTSW |
3 |
135,222,322 (GRCm38) |
splice site |
probably benign |
|
|
R3974:Cenpe
|
UTSW |
3 |
135,235,225 (GRCm38) |
splice site |
probably null |
|
|
R3975:Cenpe
|
UTSW |
3 |
135,238,472 (GRCm38) |
critical splice donor site |
probably null |
|
|
R3975:Cenpe
|
UTSW |
3 |
135,235,225 (GRCm38) |
splice site |
probably null |
|
|
R4151:Cenpe
|
UTSW |
3 |
135,215,153 (GRCm38) |
missense |
probably benign |
0.36 |
|
R4166:Cenpe
|
UTSW |
3 |
135,243,718 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4581:Cenpe
|
UTSW |
3 |
135,247,000 (GRCm38) |
missense |
probably benign |
0.30 |
|
R4622:Cenpe
|
UTSW |
3 |
135,243,708 (GRCm38) |
missense |
probably benign |
0.22 |
|
R4692:Cenpe
|
UTSW |
3 |
135,216,379 (GRCm38) |
missense |
probably benign |
0.29 |
|
R4769:Cenpe
|
UTSW |
3 |
135,248,151 (GRCm38) |
missense |
probably benign |
|
|
R4976:Cenpe
|
UTSW |
3 |
135,234,876 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4983:Cenpe
|
UTSW |
3 |
135,234,928 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4990:Cenpe
|
UTSW |
3 |
135,256,640 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5002:Cenpe
|
UTSW |
3 |
135,247,081 (GRCm38) |
missense |
probably benign |
|
|
R5057:Cenpe
|
UTSW |
3 |
135,220,313 (GRCm38) |
missense |
probably benign |
0.14 |
|
R5063:Cenpe
|
UTSW |
3 |
135,270,954 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5181:Cenpe
|
UTSW |
3 |
135,242,303 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5281:Cenpe
|
UTSW |
3 |
135,230,150 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R5389:Cenpe
|
UTSW |
3 |
135,259,388 (GRCm38) |
critical splice donor site |
probably null |
|
|
R5517:Cenpe
|
UTSW |
3 |
135,223,265 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5521:Cenpe
|
UTSW |
3 |
135,269,065 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5607:Cenpe
|
UTSW |
3 |
135,235,076 (GRCm38) |
nonsense |
probably null |
|
|
R5608:Cenpe
|
UTSW |
3 |
135,235,076 (GRCm38) |
nonsense |
probably null |
|
|
R5627:Cenpe
|
UTSW |
3 |
135,235,473 (GRCm38) |
missense |
possibly damaging |
0.51 |
|
R5766:Cenpe
|
UTSW |
3 |
135,248,413 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R5783:Cenpe
|
UTSW |
3 |
135,261,580 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5933:Cenpe
|
UTSW |
3 |
135,261,628 (GRCm38) |
missense |
probably benign |
0.03 |
|
R6073:Cenpe
|
UTSW |
3 |
135,260,073 (GRCm38) |
nonsense |
probably null |
|
|
R6163:Cenpe
|
UTSW |
3 |
135,269,003 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6192:Cenpe
|
UTSW |
3 |
135,248,530 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R6224:Cenpe
|
UTSW |
3 |
135,243,775 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R6313:Cenpe
|
UTSW |
3 |
135,230,175 (GRCm38) |
missense |
probably benign |
0.26 |
|
R6326:Cenpe
|
UTSW |
3 |
135,239,778 (GRCm38) |
missense |
probably benign |
0.15 |
|
R6383:Cenpe
|
UTSW |
3 |
135,251,528 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6418:Cenpe
|
UTSW |
3 |
135,251,544 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6797:Cenpe
|
UTSW |
3 |
135,238,138 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R6810:Cenpe
|
UTSW |
3 |
135,243,822 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6989:Cenpe
|
UTSW |
3 |
135,235,127 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7009:Cenpe
|
UTSW |
3 |
135,235,202 (GRCm38) |
missense |
probably benign |
0.02 |
|
R7009:Cenpe
|
UTSW |
3 |
135,235,201 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R7039:Cenpe
|
UTSW |
3 |
135,255,456 (GRCm38) |
missense |
probably benign |
0.28 |
|
R7387:Cenpe
|
UTSW |
3 |
135,247,037 (GRCm38) |
missense |
probably benign |
0.05 |
|
R7470:Cenpe
|
UTSW |
3 |
135,242,155 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7535:Cenpe
|
UTSW |
3 |
135,243,762 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R7562:Cenpe
|
UTSW |
3 |
135,248,634 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7573:Cenpe
|
UTSW |
3 |
135,247,459 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7613:Cenpe
|
UTSW |
3 |
135,242,302 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R7741:Cenpe
|
UTSW |
3 |
135,247,335 (GRCm38) |
splice site |
probably null |
|
|
R7771:Cenpe
|
UTSW |
3 |
135,240,941 (GRCm38) |
splice site |
probably null |
|
|
R7843:Cenpe
|
UTSW |
3 |
135,232,959 (GRCm38) |
nonsense |
probably null |
|
|
R7973:Cenpe
|
UTSW |
3 |
135,223,250 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8036:Cenpe
|
UTSW |
3 |
135,239,848 (GRCm38) |
frame shift |
probably null |
|
|
R8069:Cenpe
|
UTSW |
3 |
135,243,718 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8151:Cenpe
|
UTSW |
3 |
135,247,022 (GRCm38) |
missense |
probably benign |
0.28 |
|
R8176:Cenpe
|
UTSW |
3 |
135,230,090 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8191:Cenpe
|
UTSW |
3 |
135,251,614 (GRCm38) |
missense |
probably benign |
|
|
R8251:Cenpe
|
UTSW |
3 |
135,251,684 (GRCm38) |
critical splice donor site |
probably null |
|
|
R8425:Cenpe
|
UTSW |
3 |
135,242,627 (GRCm38) |
nonsense |
probably null |
|
|
R8488:Cenpe
|
UTSW |
3 |
135,259,241 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8811:Cenpe
|
UTSW |
3 |
135,223,240 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8850:Cenpe
|
UTSW |
3 |
135,225,016 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8879:Cenpe
|
UTSW |
3 |
135,260,101 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8899:Cenpe
|
UTSW |
3 |
135,239,883 (GRCm38) |
missense |
probably benign |
0.18 |
|
R9035:Cenpe
|
UTSW |
3 |
135,270,811 (GRCm38) |
missense |
probably benign |
0.01 |
|
R9038:Cenpe
|
UTSW |
3 |
135,218,036 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9093:Cenpe
|
UTSW |
3 |
135,239,880 (GRCm38) |
nonsense |
probably null |
|
|
R9221:Cenpe
|
UTSW |
3 |
135,230,078 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R9365:Cenpe
|
UTSW |
3 |
135,248,446 (GRCm38) |
missense |
possibly damaging |
0.56 |
|
R9443:Cenpe
|
UTSW |
3 |
135,270,848 (GRCm38) |
missense |
probably damaging |
0.99 |
|
Z1177:Cenpe
|
UTSW |
3 |
135,216,385 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACTTCTGGCCAGTGAACAG -3'
(R):5'- GCTAACTATAGAGAGCTAGATCCTACC -3'
Sequencing Primer
(F):5'- GAACCCAAAGCTAGCTGTCTGTATG -3'
(R):5'- GAGAGCTAGATCCTACCATTTCG -3'
|
| Posted On |
2014-09-17 |
Incidental Mutation