Incidental Mutation 'R0152:Vmn2r1'
ID 22772
Institutional Source Beutler Lab
Gene Symbol Vmn2r1
Ensembl Gene ENSMUSG00000027824
Gene Name vomeronasal 2, receptor 1
Synonyms V2r83, EG56544
MMRRC Submission 038435-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.133) question?
Stock # R0152 (G1)
Quality Score 225
Status Validated (trace)
Chromosome 3
Chromosomal Location 63988968-64016905 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 63989240 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 60 (S60P)
Ref Sequence ENSEMBL: ENSMUSP00000029406 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029406]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000029406
AA Change: S60P

PolyPhen 2 Score 0.921 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000029406
Gene: ENSMUSG00000027824
AA Change: S60P

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Pfam:ANF_receptor 86 504 6e-92 PFAM
Pfam:NCD3G 546 599 2.4e-17 PFAM
Pfam:7tm_3 632 866 4.1e-48 PFAM
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 97.9%
  • 10x: 95.3%
  • 20x: 89.5%
Validation Efficiency 87% (40/46)
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aass T C 6: 23,074,688 (GRCm39) D834G probably damaging Het
Abca13 T A 11: 9,531,724 (GRCm39) H4650Q probably damaging Het
Aqr T A 2: 113,989,491 (GRCm39) T111S probably benign Het
Arfip2 G A 7: 105,286,430 (GRCm39) T124M probably damaging Het
Arhgap44 G T 11: 64,902,745 (GRCm39) A574E probably benign Het
Arhgef26 T C 3: 62,330,965 (GRCm39) S560P probably damaging Het
Car5a T A 8: 122,643,185 (GRCm39) N273I probably damaging Het
Cd4 G A 6: 124,844,709 (GRCm39) Q359* probably null Het
Cgrrf1 G A 14: 47,091,370 (GRCm39) C298Y probably damaging Het
Clip3 G A 7: 30,002,857 (GRCm39) A416T probably benign Het
Dst C T 1: 34,228,200 (GRCm39) P1606L probably damaging Het
Eif3e G A 15: 43,115,632 (GRCm39) A378V possibly damaging Het
Ercc6 C G 14: 32,268,862 (GRCm39) probably benign Het
Eri2 A G 7: 119,389,606 (GRCm39) V104A probably damaging Het
Exph5 T A 9: 53,264,504 (GRCm39) probably null Het
Hmcn1 A T 1: 150,539,630 (GRCm39) Y2954N probably benign Het
Itga2 C T 13: 115,002,850 (GRCm39) G547R probably benign Het
Kbtbd11 T C 8: 15,077,428 (GRCm39) V9A probably damaging Het
Ldb2 T C 5: 44,699,141 (GRCm39) D99G possibly damaging Het
Mfsd12 G T 10: 81,193,633 (GRCm39) D68Y probably damaging Het
Mgarp T C 3: 51,296,384 (GRCm39) D228G probably benign Het
Myh14 A T 7: 44,272,605 (GRCm39) L1441Q probably damaging Het
Obscn T C 11: 58,943,402 (GRCm39) D4810G probably benign Het
Or10ak9 T A 4: 118,726,083 (GRCm39) I34N possibly damaging Het
Or14c40 A T 7: 86,313,719 (GRCm39) Y283F probably damaging Het
Or2z8 C T 8: 72,812,244 (GRCm39) T240M probably damaging Het
Or5b12 A G 19: 12,897,472 (GRCm39) V67A possibly damaging Het
Or8g30 A G 9: 39,230,757 (GRCm39) I51T probably benign Het
Pdhx A G 2: 102,858,625 (GRCm39) V393A probably benign Het
Pdpk1 C T 17: 24,325,920 (GRCm39) R92H possibly damaging Het
Pgr A T 9: 8,965,023 (GRCm39) I889F probably benign Het
Pum2 T A 12: 8,778,754 (GRCm39) I468K possibly damaging Het
Recql5 A G 11: 115,785,499 (GRCm39) S666P probably benign Het
Rims4 C T 2: 163,705,849 (GRCm39) V262M possibly damaging Het
Slc17a3 C T 13: 24,039,841 (GRCm39) S293F probably damaging Het
Slc26a4 T C 12: 31,579,497 (GRCm39) I588M probably damaging Het
Slc9a2 A G 1: 40,781,964 (GRCm39) T398A probably damaging Het
Snapc1 C T 12: 74,021,806 (GRCm39) R81C probably damaging Het
Tub A T 7: 108,620,134 (GRCm39) N93Y probably damaging Het
Usp3 T C 9: 66,447,432 (GRCm39) T181A probably damaging Het
Vars2 A G 17: 35,970,919 (GRCm39) L637P probably damaging Het
Wdcp A G 12: 4,901,583 (GRCm39) S480G probably benign Het
Zbtb38 T C 9: 96,568,333 (GRCm39) Y917C probably damaging Het
Zfp68 T C 5: 138,604,875 (GRCm39) K445E probably damaging Het
Zmynd10 A G 9: 107,428,144 (GRCm39) probably null Het
Other mutations in Vmn2r1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00233:Vmn2r1 APN 3 64,012,389 (GRCm39) nonsense probably null
IGL00335:Vmn2r1 APN 3 64,012,809 (GRCm39) missense probably damaging 0.96
IGL01509:Vmn2r1 APN 3 64,010,466 (GRCm39) missense probably benign 0.03
IGL01641:Vmn2r1 APN 3 64,011,924 (GRCm39) missense probably benign 0.19
IGL01656:Vmn2r1 APN 3 63,989,274 (GRCm39) missense probably damaging 0.96
IGL01927:Vmn2r1 APN 3 63,989,105 (GRCm39) missense probably benign 0.01
IGL02093:Vmn2r1 APN 3 64,012,130 (GRCm39) missense probably benign
IGL02146:Vmn2r1 APN 3 64,012,104 (GRCm39) missense probably benign 0.39
IGL02186:Vmn2r1 APN 3 63,989,138 (GRCm39) missense probably benign 0.01
IGL02320:Vmn2r1 APN 3 63,989,180 (GRCm39) missense possibly damaging 0.61
IGL02423:Vmn2r1 APN 3 63,997,665 (GRCm39) missense probably benign 0.00
IGL02709:Vmn2r1 APN 3 64,012,355 (GRCm39) missense probably benign 0.24
R0034:Vmn2r1 UTSW 3 63,997,435 (GRCm39) missense probably damaging 1.00
R0064:Vmn2r1 UTSW 3 64,012,209 (GRCm39) missense possibly damaging 0.76
R0305:Vmn2r1 UTSW 3 63,997,087 (GRCm39) missense probably damaging 1.00
R0314:Vmn2r1 UTSW 3 63,993,980 (GRCm39) missense probably damaging 1.00
R0317:Vmn2r1 UTSW 3 63,989,240 (GRCm39) missense possibly damaging 0.92
R0465:Vmn2r1 UTSW 3 63,989,180 (GRCm39) missense possibly damaging 0.61
R1144:Vmn2r1 UTSW 3 63,997,541 (GRCm39) missense probably damaging 1.00
R1163:Vmn2r1 UTSW 3 63,994,046 (GRCm39) missense probably benign 0.03
R1448:Vmn2r1 UTSW 3 64,008,734 (GRCm39) missense probably damaging 1.00
R1491:Vmn2r1 UTSW 3 63,997,034 (GRCm39) missense probably damaging 1.00
R1543:Vmn2r1 UTSW 3 63,996,994 (GRCm39) missense probably damaging 1.00
R1611:Vmn2r1 UTSW 3 64,011,958 (GRCm39) nonsense probably null
R1676:Vmn2r1 UTSW 3 63,997,603 (GRCm39) nonsense probably null
R1727:Vmn2r1 UTSW 3 63,989,163 (GRCm39) missense probably benign
R1851:Vmn2r1 UTSW 3 64,008,926 (GRCm39) missense probably benign 0.32
R3080:Vmn2r1 UTSW 3 63,997,205 (GRCm39) missense probably damaging 1.00
R3790:Vmn2r1 UTSW 3 63,994,185 (GRCm39) critical splice donor site probably null
R4111:Vmn2r1 UTSW 3 63,997,176 (GRCm39) missense probably benign 0.23
R4689:Vmn2r1 UTSW 3 64,012,074 (GRCm39) missense possibly damaging 0.94
R4747:Vmn2r1 UTSW 3 63,989,267 (GRCm39) missense probably benign 0.00
R4970:Vmn2r1 UTSW 3 63,997,544 (GRCm39) missense possibly damaging 0.81
R5033:Vmn2r1 UTSW 3 64,012,501 (GRCm39) missense probably damaging 1.00
R5086:Vmn2r1 UTSW 3 63,997,418 (GRCm39) missense probably benign 0.00
R5112:Vmn2r1 UTSW 3 63,997,544 (GRCm39) missense possibly damaging 0.81
R5385:Vmn2r1 UTSW 3 64,008,819 (GRCm39) missense possibly damaging 0.89
R5629:Vmn2r1 UTSW 3 64,012,538 (GRCm39) missense possibly damaging 0.87
R5762:Vmn2r1 UTSW 3 63,997,474 (GRCm39) missense probably benign 0.24
R5867:Vmn2r1 UTSW 3 64,011,990 (GRCm39) missense probably benign
R5893:Vmn2r1 UTSW 3 63,993,974 (GRCm39) missense probably damaging 1.00
R6037:Vmn2r1 UTSW 3 63,989,150 (GRCm39) missense probably benign 0.00
R6037:Vmn2r1 UTSW 3 63,989,150 (GRCm39) missense probably benign 0.00
R6290:Vmn2r1 UTSW 3 64,012,873 (GRCm39) missense probably benign 0.02
R6443:Vmn2r1 UTSW 3 64,012,374 (GRCm39) missense possibly damaging 0.78
R6464:Vmn2r1 UTSW 3 64,008,766 (GRCm39) missense probably benign
R6826:Vmn2r1 UTSW 3 64,012,567 (GRCm39) nonsense probably null
R6874:Vmn2r1 UTSW 3 64,012,376 (GRCm39) missense probably damaging 1.00
R6882:Vmn2r1 UTSW 3 63,997,529 (GRCm39) missense possibly damaging 0.64
R6983:Vmn2r1 UTSW 3 63,989,118 (GRCm39) missense probably benign
R7010:Vmn2r1 UTSW 3 64,012,146 (GRCm39) missense probably benign 0.19
R7144:Vmn2r1 UTSW 3 63,997,362 (GRCm39) missense probably damaging 1.00
R7341:Vmn2r1 UTSW 3 64,012,877 (GRCm39) makesense probably null
R7510:Vmn2r1 UTSW 3 63,993,922 (GRCm39) missense probably damaging 1.00
R7557:Vmn2r1 UTSW 3 63,997,475 (GRCm39) missense probably damaging 0.99
R7895:Vmn2r1 UTSW 3 63,997,130 (GRCm39) missense possibly damaging 0.90
R8108:Vmn2r1 UTSW 3 64,010,471 (GRCm39) missense probably damaging 0.98
R8209:Vmn2r1 UTSW 3 63,997,199 (GRCm39) missense possibly damaging 0.64
R8365:Vmn2r1 UTSW 3 63,994,034 (GRCm39) missense possibly damaging 0.80
R8514:Vmn2r1 UTSW 3 63,993,942 (GRCm39) missense probably benign 0.11
R8554:Vmn2r1 UTSW 3 63,997,334 (GRCm39) missense probably damaging 0.98
R8980:Vmn2r1 UTSW 3 64,010,501 (GRCm39) missense
R9140:Vmn2r1 UTSW 3 63,997,465 (GRCm39) missense probably benign 0.05
R9239:Vmn2r1 UTSW 3 64,011,959 (GRCm39) missense probably damaging 0.99
R9441:Vmn2r1 UTSW 3 64,012,674 (GRCm39) missense probably damaging 1.00
R9549:Vmn2r1 UTSW 3 63,997,493 (GRCm39) missense probably benign 0.17
R9771:Vmn2r1 UTSW 3 63,997,559 (GRCm39) missense possibly damaging 0.79
X0065:Vmn2r1 UTSW 3 63,997,678 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- AGCAAGTAGTGACAAGCCAAGTCC -3'
(R):5'- GCTCAGATAAATCAGTGCTCCCCTG -3'

Sequencing Primer
(F):5'- GGCGCTTCACTAAAACGTG -3'
(R):5'- gcaagtctgagtagcagcc -3'
Posted On 2013-04-16