Mutagenetix > Incidental Mutation

Incidental Mutation 'R2128:Dync1h1'

227759

Institutional Source

Beutler Lab

Gene Symbol

Dync1h1

Ensembl Gene

ENSMUSG00000018707

Gene Name

dynein cytoplasmic 1 heavy chain 1

Synonyms

9930018I23Rik, Dnchc1, dynein heavy chain, retrograde transport, Swl, MAP1C, Loa, Dnec1

MMRRC Submission

040131-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R2128 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

110601452-110666945 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 110640882 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Histidine at position 2636 (Y2636H)

Ref Sequence

ENSEMBL: ENSMUSP00000018851 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000018851]

AlphaFold

no structure available at present

PDB Structure

Microtubule binding domain from mouse cytoplasmic dynein as a fusion with seryl-tRNA synthetase [X-RAY DIFFRACTION]
High affinity dynein microtubule binding domain - tubulin complex [ELECTRON MICROSCOPY]
Low affinity dynein microtubule binding domain - tubulin complex [ELECTRON MICROSCOPY]
Structure of the entire stalk region of the dynein motor domain [X-RAY DIFFRACTION]

Predicted Effect

probably damaging
Transcript: ENSMUST00000018851
AA Change: Y2636H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000018851
Gene: ENSMUSG00000018707
AA Change: Y2636H

Domain	Start	End	E-Value	Type
low complexity region	46	61	N/A	INTRINSIC
low complexity region	83	95	N/A	INTRINSIC
Pfam:DHC_N1	237	830	1.9e-145	PFAM
coiled coil region	1171	1198	N/A	INTRINSIC
Pfam:DHC_N2	1317	1721	3.3e-116	PFAM
AAA	1899	2043	5.39e-2	SMART
low complexity region	2102	2116	N/A	INTRINSIC
AAA	2214	2365	2.13e0	SMART
low complexity region	2394	2405	N/A	INTRINSIC
AAA	2585	2735	8.6e-7	SMART
Blast:AAA	2777	2811	2e-13	BLAST
AAA	2927	3093	4.79e-5	SMART
Pfam:MT	3197	3534	1.1e-44	PFAM
Pfam:AAA_9	3554	3778	8.5e-75	PFAM
Pfam:Dynein_heavy	3919	4642	4.3e-163	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000172218

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.4%
20x: 95.4%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Dyneins are a group of microtubule-activated ATPases that function as molecular motors. They are divided into two subgroups of axonemal and cytoplasmic dyneins. The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains.This gene encodes a member of the cytoplasmic dynein heavy chain family. [provided by RefSeq, Oct 2008]
PHENOTYPE: Mice homozygous for either the Cra1 or Loa ENU mutation exhibit neonatal lethality with reduced anterior horn cell number, abnormal motor neuron innervation, neuronal inclusions, and abnormal axonal transport. Heterozygotes display motor neuron degeneration and muscle spasms. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 94 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700113H08Rik	A	G	10: 87,230,204 (GRCm38)	E249G	possibly damaging	Het
2610028H24Rik	A	G	10: 76,457,515 (GRCm38)	M136V	possibly damaging	Het
4930523C07Rik	A	T	1: 160,075,375 (GRCm38)	K72*	probably null	Het
Abca6	A	G	11: 110,219,649 (GRCm38)	I558T	probably benign	Het
Acot10	T	C	15: 20,666,626 (GRCm38)	T10A	probably benign	Het
Adgrl4	T	A	3: 151,500,201 (GRCm38)	D233E	probably benign	Het
Adgrv1	A	T	13: 81,557,080 (GRCm38)	F1537Y	probably damaging	Het
Akap2	A	G	4: 57,854,890 (GRCm38)	Y134C	probably benign	Het
Aqp3	T	A	4: 41,098,061 (GRCm38)	I17F	probably benign	Het
Arap1	T	A	7: 101,409,320 (GRCm38)	L1375H	probably damaging	Het
Aspm	T	C	1: 139,457,635 (GRCm38)	V339A	probably benign	Het
Atp13a3	G	A	16: 30,354,276 (GRCm38)	A261V	probably damaging	Het
Casp8ap2	T	C	4: 32,640,142 (GRCm38)	Y399H	probably benign	Het
Cept1	A	G	3: 106,512,879 (GRCm38)	V213A	probably damaging	Het
Cit	A	G	5: 115,985,507 (GRCm38)	D1469G	possibly damaging	Het
Cnga2	A	G	X: 72,007,788 (GRCm38)	Y182C	possibly damaging	Het
Cox20	A	G	1: 178,321,947 (GRCm38)	I54V	probably benign	Het
Dhx8	C	A	11: 101,738,409 (GRCm38)	D261E	probably benign	Het
Dnah2	A	T	11: 69,458,185 (GRCm38)	I2486N	probably benign	Het
Dnah5	A	G	15: 28,408,321 (GRCm38)	Q3484R	probably benign	Het
Drd1	T	C	13: 54,053,553 (GRCm38)	Y207C	probably damaging	Het
Dtl	C	T	1: 191,558,110 (GRCm38)	V222I	probably damaging	Het
Endog	C	A	2: 30,172,036 (GRCm38)	D154E	probably benign	Het
Epc1	A	T	18: 6,462,954 (GRCm38)	V14E	probably damaging	Het
Ercc4	C	A	16: 13,147,934 (GRCm38)	T810K	probably damaging	Het
Fam43b	T	A	4: 138,395,988 (GRCm38)	N7I	possibly damaging	Het
Fgd1	T	C	X: 151,086,217 (GRCm38)		probably null	Het
Filip1	G	T	9: 79,819,330 (GRCm38)	T669N	probably damaging	Het
Fndc1	A	G	17: 7,778,665 (GRCm38)		probably benign	Het
Foxk1	C	A	5: 142,435,188 (GRCm38)	S189*	probably null	Het
Gatm	T	C	2: 122,600,536 (GRCm38)	N274S	probably damaging	Het
Gdf9	A	G	11: 53,437,507 (GRCm38)	Y430C	probably damaging	Het
Gga1	C	T	15: 78,888,448 (GRCm38)	P260S	probably damaging	Het
Gm11595	A	T	11: 99,772,501 (GRCm38)	C118S	unknown	Het
Gm382	G	T	X: 127,062,651 (GRCm38)	V820L	possibly damaging	Het
Gzmk	T	A	13: 113,172,014 (GRCm38)	I179F	probably damaging	Het
Hsp90b1	T	C	10: 86,695,706 (GRCm38)	D421G	probably damaging	Het
Hus1	A	G	11: 9,006,011 (GRCm38)	M174T	probably damaging	Het
Ifngr2	T	A	16: 91,562,873 (GRCm38)	Y289*	probably null	Het
Il6st	T	A	13: 112,504,175 (GRCm38)	H828Q	probably benign	Het
Impg2	T	A	16: 56,218,379 (GRCm38)	Y127N	probably damaging	Het
Irf3	T	A	7: 45,001,744 (GRCm38)	W345R	probably damaging	Het
Kif1b	G	A	4: 149,187,640 (GRCm38)	S1568L	possibly damaging	Het
Klhl42	A	G	6: 147,101,753 (GRCm38)	T342A	probably benign	Het
Kndc1	G	T	7: 139,930,112 (GRCm38)	R1289L	probably damaging	Het
Knl1	A	T	2: 119,071,819 (GRCm38)	T1334S	possibly damaging	Het
L3mbtl3	G	T	10: 26,313,868 (GRCm38)	D499E	unknown	Het
Ldhd	T	A	8: 111,627,048 (GRCm38)	M478L	probably benign	Het
Loxl4	C	G	19: 42,603,963 (GRCm38)	E385D	probably damaging	Het
Lrriq1	G	A	10: 103,214,857 (GRCm38)	T678I	probably benign	Het
Macf1	T	A	4: 123,492,774 (GRCm38)	I1017F	probably benign	Het
Madcam1	A	G	10: 79,665,572 (GRCm38)	E157G	possibly damaging	Het
Mamdc4	T	C	2: 25,569,258 (GRCm38)	D195G	probably damaging	Het
Mctp1	A	G	13: 76,824,822 (GRCm38)	D648G	probably damaging	Het
Mycbp2	T	C	14: 103,201,230 (GRCm38)	M2072V	probably benign	Het
Nck1	A	G	9: 100,497,547 (GRCm38)		probably null	Het
Ndufaf4	G	T	4: 24,898,608 (GRCm38)	D55Y	probably damaging	Het
Nek11	A	T	9: 105,300,361 (GRCm38)	D230E	probably benign	Het
Nit2	T	C	16: 57,161,196 (GRCm38)	K67E	possibly damaging	Het
Olfr2	T	C	7: 107,001,248 (GRCm38)	D204G	probably damaging	Het
Olfr290	T	C	7: 84,916,493 (GRCm38)	F238S	probably damaging	Het
Olfr527	C	T	7: 140,336,429 (GRCm38)	T189M	probably damaging	Het
Olfr802	A	T	10: 129,682,532 (GRCm38)	V69E	possibly damaging	Het
Pccb	G	C	9: 100,985,831 (GRCm38)	D347E	probably damaging	Het
Plcl1	T	A	1: 55,697,838 (GRCm38)	F779L	probably damaging	Het
Prune2	C	A	19: 17,122,422 (GRCm38)	D1763E	probably benign	Het
Pwwp2a	A	G	11: 43,705,318 (GRCm38)	S437G	probably benign	Het
Rabgap1l	A	T	1: 160,738,957 (GRCm38)	D90E	probably benign	Het
Rapgef4	T	A	2: 72,226,553 (GRCm38)	I552N	possibly damaging	Het
Scn7a	A	T	2: 66,697,986 (GRCm38)	I720K	probably damaging	Het
Scn9a	T	A	2: 66,526,654 (GRCm38)	N1101I	probably damaging	Het
Siglec1	A	T	2: 131,080,497 (GRCm38)	Y553N	probably damaging	Het
Slc22a23	A	G	13: 34,203,970 (GRCm38)	L381P	possibly damaging	Het
Slc7a11	T	A	3: 50,384,109 (GRCm38)	T284S	probably damaging	Het
Slc8a2	T	A	7: 16,140,492 (GRCm38)		probably null	Het
Snx29	T	A	16: 11,400,971 (GRCm38)	S224T	probably damaging	Het
Stox1	T	C	10: 62,664,535 (GRCm38)	T749A	probably benign	Het
Tg	A	G	15: 66,694,894 (GRCm38)	I1264V	probably benign	Het
Tmem110	T	C	14: 30,866,624 (GRCm38)	Y103H	probably damaging	Het
Top2a	A	C	11: 99,009,807 (GRCm38)	V609G	probably damaging	Het
Trmt44	G	A	5: 35,574,832 (GRCm38)	P72S	probably benign	Het
Ttll3	G	C	6: 113,412,934 (GRCm38)	S760T	probably benign	Het
Ttn	G	A	2: 76,833,897 (GRCm38)		probably benign	Het
Ttn	T	C	2: 76,748,678 (GRCm38)	D23957G	probably damaging	Het
Ubxn1	T	G	19: 8,872,070 (GRCm38)	V59G	probably benign	Het
Ubxn4	T	C	1: 128,244,510 (GRCm38)	S14P	probably benign	Het
Uso1	T	A	5: 92,195,370 (GRCm38)	M771K	probably benign	Het
Utp20	A	G	10: 88,814,055 (GRCm38)	F431S	probably damaging	Het
Vmn1r206	T	C	13: 22,620,612 (GRCm38)	S142G	probably benign	Het
Vmn2r19	A	G	6: 123,308,330 (GRCm38)		probably null	Het
Vps36	G	T	8: 22,218,289 (GRCm38)		probably null	Het
Wnt3	A	G	11: 103,812,648 (GRCm38)	H319R	possibly damaging	Het
Zbtb26	G	T	2: 37,436,551 (GRCm38)	Q158K	probably benign	Het
Zfp648	T	C	1: 154,204,607 (GRCm38)	S171P	probably benign	Het

Other mutations in Dync1h1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01291:Dync1h1	APN	12	110,649,104 (GRCm38)	missense	probably benign	0.31
IGL01299:Dync1h1	APN	12	110,614,107 (GRCm38)	missense	probably benign	0.04
IGL01321:Dync1h1	APN	12	110,625,607 (GRCm38)	splice site	probably benign
IGL01324:Dync1h1	APN	12	110,626,865 (GRCm38)	missense	probably damaging	0.99
IGL01327:Dync1h1	APN	12	110,616,692 (GRCm38)	splice site	probably benign
IGL01371:Dync1h1	APN	12	110,638,851 (GRCm38)	missense	probably benign	0.05
IGL01598:Dync1h1	APN	12	110,658,128 (GRCm38)	missense	probably damaging	0.99
IGL01782:Dync1h1	APN	12	110,614,940 (GRCm38)	missense	probably damaging	1.00
IGL01791:Dync1h1	APN	12	110,658,930 (GRCm38)	missense	probably damaging	0.99
IGL01797:Dync1h1	APN	12	110,652,196 (GRCm38)	critical splice donor site	probably null
IGL02040:Dync1h1	APN	12	110,637,124 (GRCm38)	missense	probably benign	0.21
IGL02096:Dync1h1	APN	12	110,632,820 (GRCm38)	missense	possibly damaging	0.68
IGL02164:Dync1h1	APN	12	110,662,559 (GRCm38)	missense	probably damaging	1.00
IGL02216:Dync1h1	APN	12	110,663,002 (GRCm38)	missense	probably damaging	0.98
IGL02298:Dync1h1	APN	12	110,640,888 (GRCm38)	missense	probably damaging	1.00
IGL02422:Dync1h1	APN	12	110,640,210 (GRCm38)	missense	possibly damaging	0.68
IGL02610:Dync1h1	APN	12	110,659,232 (GRCm38)	nonsense	probably null
IGL02643:Dync1h1	APN	12	110,659,272 (GRCm38)	unclassified	probably benign
IGL03076:Dync1h1	APN	12	110,657,893 (GRCm38)	missense	probably damaging	1.00
IGL03292:Dync1h1	APN	12	110,666,555 (GRCm38)	splice site	probably null
IGL03293:Dync1h1	APN	12	110,628,734 (GRCm38)	missense	probably benign	0.12
IGL03299:Dync1h1	APN	12	110,619,210 (GRCm38)	missense	possibly damaging	0.49
chinashop	UTSW	12	110,658,134 (GRCm38)	missense	probably damaging	1.00
Gesund	UTSW	12	110,616,404 (GRCm38)	missense	probably benign	0.35
gymnast	UTSW	12	110,618,368 (GRCm38)	missense	probably damaging	1.00
Lightfoot	UTSW	12	110,617,920 (GRCm38)	missense	probably damaging	1.00
Lissom	UTSW	12	110,632,820 (GRCm38)	missense	possibly damaging	0.68
Strong	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
waters	UTSW	12	110,629,679 (GRCm38)	missense	probably damaging	1.00
ANU05:Dync1h1	UTSW	12	110,649,104 (GRCm38)	missense	probably benign	0.31
H8562:Dync1h1	UTSW	12	110,616,807 (GRCm38)	missense	probably benign	0.01
R0082:Dync1h1	UTSW	12	110,636,446 (GRCm38)	missense	probably benign
R0110:Dync1h1	UTSW	12	110,639,944 (GRCm38)	missense	probably benign	0.42
R0130:Dync1h1	UTSW	12	110,618,674 (GRCm38)	missense	probably benign	0.16
R0233:Dync1h1	UTSW	12	110,640,980 (GRCm38)	missense	probably benign	0.45
R0233:Dync1h1	UTSW	12	110,640,980 (GRCm38)	missense	probably benign	0.45
R0242:Dync1h1	UTSW	12	110,649,851 (GRCm38)	missense	possibly damaging	0.67
R0242:Dync1h1	UTSW	12	110,649,851 (GRCm38)	missense	possibly damaging	0.67
R0408:Dync1h1	UTSW	12	110,631,692 (GRCm38)	missense	probably benign
R0450:Dync1h1	UTSW	12	110,639,944 (GRCm38)	missense	probably benign	0.42
R0611:Dync1h1	UTSW	12	110,632,788 (GRCm38)	missense	probably damaging	0.97
R0612:Dync1h1	UTSW	12	110,616,496 (GRCm38)	missense	probably damaging	1.00
R0624:Dync1h1	UTSW	12	110,651,747 (GRCm38)	unclassified	probably benign
R0685:Dync1h1	UTSW	12	110,657,192 (GRCm38)	missense	probably damaging	1.00
R0747:Dync1h1	UTSW	12	110,629,284 (GRCm38)	missense	probably damaging	0.99
R0747:Dync1h1	UTSW	12	110,612,411 (GRCm38)	missense	probably benign
R0843:Dync1h1	UTSW	12	110,665,213 (GRCm38)	missense	possibly damaging	0.81
R0970:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1161:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1211:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1214:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1215:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1227:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1230:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1232:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1237:Dync1h1	UTSW	12	110,665,959 (GRCm38)	missense	probably benign	0.00
R1274:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1275:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1289:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1290:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1331:Dync1h1	UTSW	12	110,649,264 (GRCm38)	missense	probably damaging	0.98
R1340:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1383:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1394:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1396:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1397:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1413:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1432:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1500:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1661:Dync1h1	UTSW	12	110,656,357 (GRCm38)	missense	probably damaging	1.00
R1678:Dync1h1	UTSW	12	110,665,662 (GRCm38)	critical splice acceptor site	probably null
R1698:Dync1h1	UTSW	12	110,626,992 (GRCm38)	missense	possibly damaging	0.88
R1767:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1776:Dync1h1	UTSW	12	110,632,928 (GRCm38)	splice site	probably benign
R1812:Dync1h1	UTSW	12	110,662,900 (GRCm38)	missense	possibly damaging	0.46
R1831:Dync1h1	UTSW	12	110,614,059 (GRCm38)	missense	probably damaging	1.00
R1832:Dync1h1	UTSW	12	110,614,059 (GRCm38)	missense	probably damaging	1.00
R1856:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1857:Dync1h1	UTSW	12	110,662,625 (GRCm38)	missense	probably damaging	0.96
R1879:Dync1h1	UTSW	12	110,624,636 (GRCm38)	missense	probably benign	0.04
R1892:Dync1h1	UTSW	12	110,646,304 (GRCm38)	missense	probably damaging	1.00
R1909:Dync1h1	UTSW	12	110,662,629 (GRCm38)	missense	probably damaging	1.00
R1962:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1974:Dync1h1	UTSW	12	110,625,732 (GRCm38)	missense	possibly damaging	0.80
R1999:Dync1h1	UTSW	12	110,666,423 (GRCm38)	critical splice donor site	probably null
R2073:Dync1h1	UTSW	12	110,614,592 (GRCm38)	missense	probably damaging	1.00
R2091:Dync1h1	UTSW	12	110,649,588 (GRCm38)	missense	probably benign	0.07
R2113:Dync1h1	UTSW	12	110,629,986 (GRCm38)	missense	probably damaging	1.00
R2134:Dync1h1	UTSW	12	110,656,631 (GRCm38)	missense	possibly damaging	0.68
R2496:Dync1h1	UTSW	12	110,641,220 (GRCm38)	missense	possibly damaging	0.65
R2680:Dync1h1	UTSW	12	110,643,247 (GRCm38)	missense	probably damaging	1.00
R2890:Dync1h1	UTSW	12	110,616,891 (GRCm38)	missense	probably damaging	1.00
R2964:Dync1h1	UTSW	12	110,641,026 (GRCm38)	critical splice donor site	probably null
R3705:Dync1h1	UTSW	12	110,640,586 (GRCm38)	missense	possibly damaging	0.80
R3708:Dync1h1	UTSW	12	110,643,129 (GRCm38)	missense	probably damaging	0.96
R3735:Dync1h1	UTSW	12	110,631,675 (GRCm38)	missense	probably benign
R3736:Dync1h1	UTSW	12	110,631,675 (GRCm38)	missense	probably benign
R3882:Dync1h1	UTSW	12	110,629,058 (GRCm38)	missense	probably benign	0.41
R3971:Dync1h1	UTSW	12	110,665,965 (GRCm38)	missense	probably benign	0.00
R4017:Dync1h1	UTSW	12	110,643,190 (GRCm38)	missense	probably damaging	1.00
R4032:Dync1h1	UTSW	12	110,618,049 (GRCm38)	nonsense	probably null
R4355:Dync1h1	UTSW	12	110,632,899 (GRCm38)	missense	possibly damaging	0.55
R4514:Dync1h1	UTSW	12	110,657,139 (GRCm38)	missense	possibly damaging	0.76
R4586:Dync1h1	UTSW	12	110,649,483 (GRCm38)	missense	probably benign	0.30
R4619:Dync1h1	UTSW	12	110,638,844 (GRCm38)	missense	probably benign	0.09
R4659:Dync1h1	UTSW	12	110,628,767 (GRCm38)	missense	possibly damaging	0.50
R4676:Dync1h1	UTSW	12	110,662,541 (GRCm38)	missense	probably damaging	0.99
R4688:Dync1h1	UTSW	12	110,655,528 (GRCm38)	missense	probably damaging	0.99
R4732:Dync1h1	UTSW	12	110,649,507 (GRCm38)	nonsense	probably null
R4733:Dync1h1	UTSW	12	110,649,507 (GRCm38)	nonsense	probably null
R4780:Dync1h1	UTSW	12	110,661,196 (GRCm38)	missense	probably damaging	1.00
R4846:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4861:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4861:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4865:Dync1h1	UTSW	12	110,639,801 (GRCm38)	missense	possibly damaging	0.84
R4872:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4873:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4874:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4875:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4927:Dync1h1	UTSW	12	110,662,855 (GRCm38)	missense	possibly damaging	0.82
R4949:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4954:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4956:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4957:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4958:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4984:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4985:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4988:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R5029:Dync1h1	UTSW	12	110,618,010 (GRCm38)	missense	possibly damaging	0.46
R5032:Dync1h1	UTSW	12	110,626,892 (GRCm38)	nonsense	probably null
R5036:Dync1h1	UTSW	12	110,630,535 (GRCm38)	missense	probably damaging	1.00
R5037:Dync1h1	UTSW	12	110,640,907 (GRCm38)	missense	probably benign	0.09
R5105:Dync1h1	UTSW	12	110,617,932 (GRCm38)	missense	probably damaging	0.99
R5122:Dync1h1	UTSW	12	110,629,680 (GRCm38)	missense	probably damaging	1.00
R5156:Dync1h1	UTSW	12	110,628,830 (GRCm38)	missense	probably benign	0.00
R5290:Dync1h1	UTSW	12	110,615,068 (GRCm38)	missense	probably benign	0.03
R5453:Dync1h1	UTSW	12	110,632,665 (GRCm38)	missense	probably benign	0.12
R5540:Dync1h1	UTSW	12	110,660,950 (GRCm38)	missense	probably benign	0.00
R5613:Dync1h1	UTSW	12	110,632,820 (GRCm38)	missense	possibly damaging	0.68
R5626:Dync1h1	UTSW	12	110,641,141 (GRCm38)	missense	probably benign	0.01
R5652:Dync1h1	UTSW	12	110,665,988 (GRCm38)	missense	possibly damaging	0.70
R5655:Dync1h1	UTSW	12	110,629,062 (GRCm38)	missense	probably benign	0.03
R5686:Dync1h1	UTSW	12	110,616,404 (GRCm38)	missense	probably benign	0.35
R5772:Dync1h1	UTSW	12	110,646,273 (GRCm38)	nonsense	probably null
R5806:Dync1h1	UTSW	12	110,651,653 (GRCm38)	missense	probably damaging	1.00
R5891:Dync1h1	UTSW	12	110,614,220 (GRCm38)	critical splice donor site	probably null
R5921:Dync1h1	UTSW	12	110,618,368 (GRCm38)	missense	probably damaging	1.00
R5965:Dync1h1	UTSW	12	110,632,778 (GRCm38)	missense	probably benign
R6113:Dync1h1	UTSW	12	110,620,414 (GRCm38)	missense	probably benign
R6119:Dync1h1	UTSW	12	110,628,006 (GRCm38)	missense	possibly damaging	0.82
R6154:Dync1h1	UTSW	12	110,617,993 (GRCm38)	missense	probably damaging	1.00
R6339:Dync1h1	UTSW	12	110,646,205 (GRCm38)	missense	probably damaging	0.97
R6522:Dync1h1	UTSW	12	110,616,737 (GRCm38)	missense	probably damaging	0.99
R6531:Dync1h1	UTSW	12	110,617,920 (GRCm38)	missense	probably damaging	1.00
R6554:Dync1h1	UTSW	12	110,649,848 (GRCm38)	missense	probably benign	0.06
R6672:Dync1h1	UTSW	12	110,658,134 (GRCm38)	missense	probably damaging	1.00
R6746:Dync1h1	UTSW	12	110,651,653 (GRCm38)	missense	probably damaging	1.00
R6785:Dync1h1	UTSW	12	110,629,679 (GRCm38)	missense	probably damaging	1.00
R6857:Dync1h1	UTSW	12	110,658,547 (GRCm38)	missense	possibly damaging	0.94
R6863:Dync1h1	UTSW	12	110,652,180 (GRCm38)	missense	probably benign	0.07
R6881:Dync1h1	UTSW	12	110,624,561 (GRCm38)	missense	probably damaging	1.00
R6892:Dync1h1	UTSW	12	110,638,901 (GRCm38)	missense	probably benign	0.00
R7015:Dync1h1	UTSW	12	110,666,087 (GRCm38)	nonsense	probably null
R7096:Dync1h1	UTSW	12	110,657,078 (GRCm38)	missense	probably damaging	0.99
R7173:Dync1h1	UTSW	12	110,601,739 (GRCm38)	missense	probably benign
R7224:Dync1h1	UTSW	12	110,617,762 (GRCm38)	missense	possibly damaging	0.93
R7295:Dync1h1	UTSW	12	110,664,749 (GRCm38)	critical splice donor site	probably null
R7308:Dync1h1	UTSW	12	110,665,162 (GRCm38)	missense	possibly damaging	0.91
R7346:Dync1h1	UTSW	12	110,635,642 (GRCm38)	missense	probably damaging	1.00
R7359:Dync1h1	UTSW	12	110,624,602 (GRCm38)	missense	probably benign	0.00
R7405:Dync1h1	UTSW	12	110,634,220 (GRCm38)	missense	probably damaging	1.00
R7439:Dync1h1	UTSW	12	110,636,453 (GRCm38)	missense	probably damaging	1.00
R7441:Dync1h1	UTSW	12	110,636,453 (GRCm38)	missense	probably damaging	1.00
R7472:Dync1h1	UTSW	12	110,665,675 (GRCm38)	missense	probably damaging	0.99
R7532:Dync1h1	UTSW	12	110,651,577 (GRCm38)	missense	probably benign	0.00
R7543:Dync1h1	UTSW	12	110,614,107 (GRCm38)	missense	probably benign	0.04
R7555:Dync1h1	UTSW	12	110,630,625 (GRCm38)	missense	probably benign	0.03
R7632:Dync1h1	UTSW	12	110,660,893 (GRCm38)	missense	probably benign	0.10
R7701:Dync1h1	UTSW	12	110,618,646 (GRCm38)	missense	probably damaging	1.00
R7704:Dync1h1	UTSW	12	110,665,766 (GRCm38)	missense	probably damaging	1.00
R7808:Dync1h1	UTSW	12	110,655,459 (GRCm38)	missense	possibly damaging	0.53
R7891:Dync1h1	UTSW	12	110,643,156 (GRCm38)	missense	probably benign	0.02
R7895:Dync1h1	UTSW	12	110,616,457 (GRCm38)	missense	probably damaging	1.00
R7913:Dync1h1	UTSW	12	110,628,734 (GRCm38)	missense	probably benign	0.12
R8164:Dync1h1	UTSW	12	110,616,360 (GRCm38)	missense	possibly damaging	0.91
R8257:Dync1h1	UTSW	12	110,636,474 (GRCm38)	missense	probably damaging	1.00
R8346:Dync1h1	UTSW	12	110,665,792 (GRCm38)	missense	probably benign	0.21
R8432:Dync1h1	UTSW	12	110,618,142 (GRCm38)	missense	probably benign	0.00
R8510:Dync1h1	UTSW	12	110,616,743 (GRCm38)	missense	possibly damaging	0.94
R8731:Dync1h1	UTSW	12	110,640,584 (GRCm38)	missense	possibly damaging	0.93
R8739:Dync1h1	UTSW	12	110,614,580 (GRCm38)	missense	probably damaging	1.00
R8756:Dync1h1	UTSW	12	110,616,827 (GRCm38)	missense	probably benign	0.06
R8855:Dync1h1	UTSW	12	110,635,899 (GRCm38)	missense	probably damaging	1.00
R8866:Dync1h1	UTSW	12	110,635,899 (GRCm38)	missense	probably damaging	1.00
R8885:Dync1h1	UTSW	12	110,616,738 (GRCm38)	missense	probably damaging	1.00
R8893:Dync1h1	UTSW	12	110,642,043 (GRCm38)	missense	probably damaging	1.00
R8913:Dync1h1	UTSW	12	110,658,168 (GRCm38)	missense	probably benign	0.14
R8937:Dync1h1	UTSW	12	110,618,037 (GRCm38)	missense	probably damaging	1.00
R8958:Dync1h1	UTSW	12	110,620,371 (GRCm38)	missense	probably benign	0.00
R9000:Dync1h1	UTSW	12	110,639,963 (GRCm38)	missense	probably benign
R9036:Dync1h1	UTSW	12	110,639,752 (GRCm38)	missense	probably benign
R9090:Dync1h1	UTSW	12	110,616,876 (GRCm38)	missense	probably benign	0.06
R9108:Dync1h1	UTSW	12	110,656,272 (GRCm38)	intron	probably benign
R9161:Dync1h1	UTSW	12	110,658,589 (GRCm38)	missense	probably benign	0.01
R9185:Dync1h1	UTSW	12	110,635,503 (GRCm38)	missense	probably benign	0.33
R9271:Dync1h1	UTSW	12	110,616,876 (GRCm38)	missense	probably benign	0.06
R9436:Dync1h1	UTSW	12	110,616,541 (GRCm38)	missense	probably damaging	1.00
R9478:Dync1h1	UTSW	12	110,658,703 (GRCm38)	missense	probably benign	0.02
R9547:Dync1h1	UTSW	12	110,658,371 (GRCm38)	missense	probably damaging	1.00
R9561:Dync1h1	UTSW	12	110,649,099 (GRCm38)	missense	probably damaging	0.99
R9586:Dync1h1	UTSW	12	110,616,541 (GRCm38)	missense	probably damaging	1.00
R9609:Dync1h1	UTSW	12	110,640,928 (GRCm38)	missense	probably benign	0.01
Z1088:Dync1h1	UTSW	12	110,629,917 (GRCm38)	frame shift	probably null
Z1177:Dync1h1	UTSW	12	110,658,517 (GRCm38)	nonsense	probably null
Z1177:Dync1h1	UTSW	12	110,641,177 (GRCm38)	frame shift	probably null
Z1177:Dync1h1	UTSW	12	110,637,554 (GRCm38)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GCAAGACCATGACACTCTTCAG -3'
(R):5'- TGTAAAGTTAGCAAGCTGTGGATG -3'

Sequencing Primer
(F):5'- TTCAGTGCTCTCCGGGC -3'
(R):5'- CAAGCTGTGGATGAGCGCTG -3'

Posted On

2014-09-17