Mutagenetix > Incidental Mutation

Incidental Mutation 'R2128:Dnah5'

227772

Institutional Source

Beutler Lab

Gene Symbol

Dnah5

Ensembl Gene

ENSMUSG00000022262

Gene Name

dynein, axonemal, heavy chain 5

Synonyms

b2b1565Clo, b2b1134Clo, Mdnah5, b2b1537Clo, b2b1154Clo, Dnahc5

MMRRC Submission

040131-MU

Accession Numbers

NCBI RefSeq: NM_133365.3; MGI: 107718

Essential gene?

Probably essential (E-score: 0.776) question?

Stock #

R2128 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

28203752-28472052 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 28408321 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Arginine at position 3484 (Q3484R)

Ref Sequence

ENSEMBL: ENSMUSP00000069751 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000067048]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000067048
AA Change: Q3484R

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000069751
Gene: ENSMUSG00000022262
AA Change: Q3484R

Domain	Start	End	E-Value	Type
Pfam:DHC_N1	247	802	2.3e-163	PFAM
low complexity region	1077	1088	N/A	INTRINSIC
low complexity region	1113	1128	N/A	INTRINSIC
Pfam:DHC_N2	1399	1807	2.3e-134	PFAM
AAA	1972	2108	2e-3	SMART
AAA	2251	2424	4.3e-3	SMART
AAA	2579	2777	2.2e-3	SMART
low complexity region	2874	2889	N/A	INTRINSIC
Pfam:AAA_8	2914	3186	3.2e-70	PFAM
Pfam:MT	3198	3546	1e-44	PFAM
Pfam:AAA_9	3567	3792	1.4e-86	PFAM
low complexity region	3889	3899	N/A	INTRINSIC
Pfam:Dynein_heavy	3930	4618	4.4e-246	PFAM

Meta Mutation Damage Score

0.0719

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.4%
20x: 95.4%

Validation Efficiency

MGI Phenotype

Strain: 2180081
Lethality: D14-D21
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a dynein protein, which is part of a microtubule-associated motor protein complex consisting of heavy, light, and intermediate chains. This protein is an axonemal heavy chain dynein. It functions as a force-generating protein with ATPase activity, whereby the release of ADP is thought to produce the force-producing power stroke. Mutations in this gene cause primary ciliary dyskinesia type 3, as well as Kartagener syndrome, which are both diseases due to ciliary defects. [provided by RefSeq, Oct 2009]
PHENOTYPE: Mice homozygous for a disruption in this gene display postnatal lethality, hydrocephalus, respiratory infections, situs inversus and ciliary immotility. [provided by MGI curators]

Allele List at MGI

All alleles(11) : Targeted(2) Gene trapped(1) Transgenic(1) Chemically induced(7)

Other mutations in this stock

Total: 94 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700113H08Rik	A	G	10: 87,230,204 (GRCm38)	E249G	possibly damaging	Het
2610028H24Rik	A	G	10: 76,457,515 (GRCm38)	M136V	possibly damaging	Het
4930523C07Rik	A	T	1: 160,075,375 (GRCm38)	K72*	probably null	Het
Abca6	A	G	11: 110,219,649 (GRCm38)	I558T	probably benign	Het
Acot10	T	C	15: 20,666,626 (GRCm38)	T10A	probably benign	Het
Adgrl4	T	A	3: 151,500,201 (GRCm38)	D233E	probably benign	Het
Adgrv1	A	T	13: 81,557,080 (GRCm38)	F1537Y	probably damaging	Het
Akap2	A	G	4: 57,854,890 (GRCm38)	Y134C	probably benign	Het
Aqp3	T	A	4: 41,098,061 (GRCm38)	I17F	probably benign	Het
Arap1	T	A	7: 101,409,320 (GRCm38)	L1375H	probably damaging	Het
Aspm	T	C	1: 139,457,635 (GRCm38)	V339A	probably benign	Het
Atp13a3	G	A	16: 30,354,276 (GRCm38)	A261V	probably damaging	Het
Casp8ap2	T	C	4: 32,640,142 (GRCm38)	Y399H	probably benign	Het
Cept1	A	G	3: 106,512,879 (GRCm38)	V213A	probably damaging	Het
Cit	A	G	5: 115,985,507 (GRCm38)	D1469G	possibly damaging	Het
Cnga2	A	G	X: 72,007,788 (GRCm38)	Y182C	possibly damaging	Het
Cox20	A	G	1: 178,321,947 (GRCm38)	I54V	probably benign	Het
Dhx8	C	A	11: 101,738,409 (GRCm38)	D261E	probably benign	Het
Dnah2	A	T	11: 69,458,185 (GRCm38)	I2486N	probably benign	Het
Drd1	T	C	13: 54,053,553 (GRCm38)	Y207C	probably damaging	Het
Dtl	C	T	1: 191,558,110 (GRCm38)	V222I	probably damaging	Het
Dync1h1	T	C	12: 110,640,882 (GRCm38)	Y2636H	probably damaging	Het
Endog	C	A	2: 30,172,036 (GRCm38)	D154E	probably benign	Het
Epc1	A	T	18: 6,462,954 (GRCm38)	V14E	probably damaging	Het
Ercc4	C	A	16: 13,147,934 (GRCm38)	T810K	probably damaging	Het
Fam43b	T	A	4: 138,395,988 (GRCm38)	N7I	possibly damaging	Het
Fgd1	T	C	X: 151,086,217 (GRCm38)		probably null	Het
Filip1	G	T	9: 79,819,330 (GRCm38)	T669N	probably damaging	Het
Fndc1	A	G	17: 7,778,665 (GRCm38)		probably benign	Het
Foxk1	C	A	5: 142,435,188 (GRCm38)	S189*	probably null	Het
Gatm	T	C	2: 122,600,536 (GRCm38)	N274S	probably damaging	Het
Gdf9	A	G	11: 53,437,507 (GRCm38)	Y430C	probably damaging	Het
Gga1	C	T	15: 78,888,448 (GRCm38)	P260S	probably damaging	Het
Gm11595	A	T	11: 99,772,501 (GRCm38)	C118S	unknown	Het
Gm382	G	T	X: 127,062,651 (GRCm38)	V820L	possibly damaging	Het
Gzmk	T	A	13: 113,172,014 (GRCm38)	I179F	probably damaging	Het
Hsp90b1	T	C	10: 86,695,706 (GRCm38)	D421G	probably damaging	Het
Hus1	A	G	11: 9,006,011 (GRCm38)	M174T	probably damaging	Het
Ifngr2	T	A	16: 91,562,873 (GRCm38)	Y289*	probably null	Het
Il6st	T	A	13: 112,504,175 (GRCm38)	H828Q	probably benign	Het
Impg2	T	A	16: 56,218,379 (GRCm38)	Y127N	probably damaging	Het
Irf3	T	A	7: 45,001,744 (GRCm38)	W345R	probably damaging	Het
Kif1b	G	A	4: 149,187,640 (GRCm38)	S1568L	possibly damaging	Het
Klhl42	A	G	6: 147,101,753 (GRCm38)	T342A	probably benign	Het
Kndc1	G	T	7: 139,930,112 (GRCm38)	R1289L	probably damaging	Het
Knl1	A	T	2: 119,071,819 (GRCm38)	T1334S	possibly damaging	Het
L3mbtl3	G	T	10: 26,313,868 (GRCm38)	D499E	unknown	Het
Ldhd	T	A	8: 111,627,048 (GRCm38)	M478L	probably benign	Het
Loxl4	C	G	19: 42,603,963 (GRCm38)	E385D	probably damaging	Het
Lrriq1	G	A	10: 103,214,857 (GRCm38)	T678I	probably benign	Het
Macf1	T	A	4: 123,492,774 (GRCm38)	I1017F	probably benign	Het
Madcam1	A	G	10: 79,665,572 (GRCm38)	E157G	possibly damaging	Het
Mamdc4	T	C	2: 25,569,258 (GRCm38)	D195G	probably damaging	Het
Mctp1	A	G	13: 76,824,822 (GRCm38)	D648G	probably damaging	Het
Mycbp2	T	C	14: 103,201,230 (GRCm38)	M2072V	probably benign	Het
Nck1	A	G	9: 100,497,547 (GRCm38)		probably null	Het
Ndufaf4	G	T	4: 24,898,608 (GRCm38)	D55Y	probably damaging	Het
Nek11	A	T	9: 105,300,361 (GRCm38)	D230E	probably benign	Het
Nit2	T	C	16: 57,161,196 (GRCm38)	K67E	possibly damaging	Het
Olfr2	T	C	7: 107,001,248 (GRCm38)	D204G	probably damaging	Het
Olfr290	T	C	7: 84,916,493 (GRCm38)	F238S	probably damaging	Het
Olfr527	C	T	7: 140,336,429 (GRCm38)	T189M	probably damaging	Het
Olfr802	A	T	10: 129,682,532 (GRCm38)	V69E	possibly damaging	Het
Pccb	G	C	9: 100,985,831 (GRCm38)	D347E	probably damaging	Het
Plcl1	T	A	1: 55,697,838 (GRCm38)	F779L	probably damaging	Het
Prune2	C	A	19: 17,122,422 (GRCm38)	D1763E	probably benign	Het
Pwwp2a	A	G	11: 43,705,318 (GRCm38)	S437G	probably benign	Het
Rabgap1l	A	T	1: 160,738,957 (GRCm38)	D90E	probably benign	Het
Rapgef4	T	A	2: 72,226,553 (GRCm38)	I552N	possibly damaging	Het
Scn7a	A	T	2: 66,697,986 (GRCm38)	I720K	probably damaging	Het
Scn9a	T	A	2: 66,526,654 (GRCm38)	N1101I	probably damaging	Het
Siglec1	A	T	2: 131,080,497 (GRCm38)	Y553N	probably damaging	Het
Slc22a23	A	G	13: 34,203,970 (GRCm38)	L381P	possibly damaging	Het
Slc7a11	T	A	3: 50,384,109 (GRCm38)	T284S	probably damaging	Het
Slc8a2	T	A	7: 16,140,492 (GRCm38)		probably null	Het
Snx29	T	A	16: 11,400,971 (GRCm38)	S224T	probably damaging	Het
Stox1	T	C	10: 62,664,535 (GRCm38)	T749A	probably benign	Het
Tg	A	G	15: 66,694,894 (GRCm38)	I1264V	probably benign	Het
Tmem110	T	C	14: 30,866,624 (GRCm38)	Y103H	probably damaging	Het
Top2a	A	C	11: 99,009,807 (GRCm38)	V609G	probably damaging	Het
Trmt44	G	A	5: 35,574,832 (GRCm38)	P72S	probably benign	Het
Ttll3	G	C	6: 113,412,934 (GRCm38)	S760T	probably benign	Het
Ttn	G	A	2: 76,833,897 (GRCm38)		probably benign	Het
Ttn	T	C	2: 76,748,678 (GRCm38)	D23957G	probably damaging	Het
Ubxn1	T	G	19: 8,872,070 (GRCm38)	V59G	probably benign	Het
Ubxn4	T	C	1: 128,244,510 (GRCm38)	S14P	probably benign	Het
Uso1	T	A	5: 92,195,370 (GRCm38)	M771K	probably benign	Het
Utp20	A	G	10: 88,814,055 (GRCm38)	F431S	probably damaging	Het
Vmn1r206	T	C	13: 22,620,612 (GRCm38)	S142G	probably benign	Het
Vmn2r19	A	G	6: 123,308,330 (GRCm38)		probably null	Het
Vps36	G	T	8: 22,218,289 (GRCm38)		probably null	Het
Wnt3	A	G	11: 103,812,648 (GRCm38)	H319R	possibly damaging	Het
Zbtb26	G	T	2: 37,436,551 (GRCm38)	Q158K	probably benign	Het
Zfp648	T	C	1: 154,204,607 (GRCm38)	S171P	probably benign	Het

Other mutations in Dnah5

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00226:Dnah5	APN	15	28,272,342 (GRCm38)	missense	probably benign
IGL00331:Dnah5	APN	15	28,421,620 (GRCm38)	missense	probably damaging	1.00
IGL00519:Dnah5	APN	15	28,444,218 (GRCm38)	missense	probably benign	0.10
IGL00537:Dnah5	APN	15	28,458,702 (GRCm38)	critical splice donor site	probably null
IGL01102:Dnah5	APN	15	28,410,003 (GRCm38)	critical splice donor site	probably null
IGL01126:Dnah5	APN	15	28,302,399 (GRCm38)	missense	possibly damaging	0.85
IGL01154:Dnah5	APN	15	28,458,656 (GRCm38)	missense	possibly damaging	0.75
IGL01349:Dnah5	APN	15	28,294,913 (GRCm38)	splice site	probably benign
IGL01353:Dnah5	APN	15	28,233,272 (GRCm38)	missense	probably benign	0.00
IGL01372:Dnah5	APN	15	28,230,490 (GRCm38)	missense	probably benign	0.00
IGL01390:Dnah5	APN	15	28,411,540 (GRCm38)	missense	probably benign	0.00
IGL01446:Dnah5	APN	15	28,326,669 (GRCm38)	missense	probably damaging	1.00
IGL01472:Dnah5	APN	15	28,331,726 (GRCm38)	missense	probably damaging	1.00
IGL01485:Dnah5	APN	15	28,331,726 (GRCm38)	missense	probably damaging	1.00
IGL01568:Dnah5	APN	15	28,229,652 (GRCm38)	missense	probably benign	0.01
IGL01592:Dnah5	APN	15	28,236,637 (GRCm38)	missense	probably benign	0.01
IGL01594:Dnah5	APN	15	28,311,334 (GRCm38)	missense	possibly damaging	0.87
IGL01677:Dnah5	APN	15	28,367,782 (GRCm38)	missense	probably damaging	1.00
IGL01845:Dnah5	APN	15	28,449,169 (GRCm38)	missense	probably benign	0.06
IGL01904:Dnah5	APN	15	28,307,364 (GRCm38)	missense	probably benign	0.09
IGL01913:Dnah5	APN	15	28,313,753 (GRCm38)	missense	possibly damaging	0.50
IGL01950:Dnah5	APN	15	28,290,289 (GRCm38)	missense	probably null	1.00
IGL01963:Dnah5	APN	15	28,370,536 (GRCm38)	missense	probably benign	0.12
IGL02008:Dnah5	APN	15	28,343,552 (GRCm38)	missense	probably damaging	0.98
IGL02088:Dnah5	APN	15	28,459,118 (GRCm38)	critical splice acceptor site	probably null
IGL02090:Dnah5	APN	15	28,240,041 (GRCm38)	splice site	probably benign
IGL02114:Dnah5	APN	15	28,397,124 (GRCm38)	missense	probably damaging	0.97
IGL02135:Dnah5	APN	15	28,247,885 (GRCm38)	missense	possibly damaging	0.50
IGL02232:Dnah5	APN	15	28,299,240 (GRCm38)	missense	probably damaging	1.00
IGL02386:Dnah5	APN	15	28,340,381 (GRCm38)	missense	probably damaging	1.00
IGL02475:Dnah5	APN	15	28,219,150 (GRCm38)	missense	probably benign	0.09
IGL02626:Dnah5	APN	15	28,307,276 (GRCm38)	missense	possibly damaging	0.94
IGL02650:Dnah5	APN	15	28,289,047 (GRCm38)	splice site	probably benign
IGL02651:Dnah5	APN	15	28,350,622 (GRCm38)	missense	probably benign	0.05
IGL02652:Dnah5	APN	15	28,366,187 (GRCm38)	missense	probably damaging	0.99
IGL02670:Dnah5	APN	15	28,409,296 (GRCm38)	missense	probably damaging	1.00
IGL02697:Dnah5	APN	15	28,445,143 (GRCm38)	missense	probably benign	0.00
IGL02721:Dnah5	APN	15	28,234,243 (GRCm38)	critical splice acceptor site	probably null
IGL02858:Dnah5	APN	15	28,453,212 (GRCm38)	missense	possibly damaging	0.65
IGL02859:Dnah5	APN	15	28,383,625 (GRCm38)	missense	probably benign	0.01
IGL02945:Dnah5	APN	15	28,270,426 (GRCm38)	missense	probably benign	0.00
IGL02949:Dnah5	APN	15	28,272,185 (GRCm38)	missense	probably benign	0.32
IGL02971:Dnah5	APN	15	28,384,461 (GRCm38)	missense	probably damaging	1.00
IGL03017:Dnah5	APN	15	28,340,325 (GRCm38)	missense	possibly damaging	0.93
IGL03177:Dnah5	APN	15	28,295,399 (GRCm38)	missense	probably damaging	0.97
IGL03212:Dnah5	APN	15	28,290,163 (GRCm38)	missense	probably benign	0.08
IGL03224:Dnah5	APN	15	28,459,154 (GRCm38)	missense	probably damaging	1.00
IGL03231:Dnah5	APN	15	28,311,148 (GRCm38)	missense	probably damaging	1.00
IGL03273:Dnah5	APN	15	28,458,649 (GRCm38)	missense	probably damaging	0.98
IGL03294:Dnah5	APN	15	28,233,295 (GRCm38)	critical splice donor site	probably null
IGL03331:Dnah5	APN	15	28,419,940 (GRCm38)	missense	probably damaging	1.00
IGL03337:Dnah5	APN	15	28,290,141 (GRCm38)	missense	probably benign	0.10
IGL03367:Dnah5	APN	15	28,234,327 (GRCm38)	missense	possibly damaging	0.95
Firtel	UTSW	15	28,448,367 (GRCm38)	missense	possibly damaging	0.95
lowbar	UTSW	15	28,311,133 (GRCm38)	splice site	probably null
notherone	UTSW	15	28,340,406 (GRCm38)	missense	probably benign	0.13
scheffler	UTSW	15	28,438,091 (GRCm38)	splice site	probably benign
IGL02837:Dnah5	UTSW	15	28,269,400 (GRCm38)	missense	probably benign
P0008:Dnah5	UTSW	15	28,302,387 (GRCm38)	missense	probably damaging	1.00
P0014:Dnah5	UTSW	15	28,403,473 (GRCm38)	missense	probably damaging	1.00
PIT4687001:Dnah5	UTSW	15	28,383,577 (GRCm38)	missense	probably damaging	0.98
R0030:Dnah5	UTSW	15	28,451,517 (GRCm38)	missense	probably benign	0.34
R0087:Dnah5	UTSW	15	28,350,613 (GRCm38)	missense	probably damaging	1.00
R0099:Dnah5	UTSW	15	28,239,934 (GRCm38)	missense	probably damaging	1.00
R0102:Dnah5	UTSW	15	28,245,751 (GRCm38)	splice site	probably benign
R0102:Dnah5	UTSW	15	28,245,751 (GRCm38)	splice site	probably benign
R0104:Dnah5	UTSW	15	28,453,353 (GRCm38)	missense	possibly damaging	0.88
R0112:Dnah5	UTSW	15	28,263,679 (GRCm38)	missense	probably benign	0.00
R0122:Dnah5	UTSW	15	28,378,363 (GRCm38)	missense	probably damaging	1.00
R0126:Dnah5	UTSW	15	28,246,319 (GRCm38)	missense	probably benign	0.00
R0127:Dnah5	UTSW	15	28,294,925 (GRCm38)	missense	probably damaging	1.00
R0233:Dnah5	UTSW	15	28,333,070 (GRCm38)	missense	probably damaging	1.00
R0310:Dnah5	UTSW	15	28,299,110 (GRCm38)	missense	probably benign	0.19
R0386:Dnah5	UTSW	15	28,383,581 (GRCm38)	missense	probably damaging	1.00
R0421:Dnah5	UTSW	15	28,229,541 (GRCm38)	missense	possibly damaging	0.79
R0481:Dnah5	UTSW	15	28,383,599 (GRCm38)	missense	probably benign	0.31
R0514:Dnah5	UTSW	15	28,366,321 (GRCm38)	missense	probably damaging	1.00
R0609:Dnah5	UTSW	15	28,327,779 (GRCm38)	missense	probably benign
R0720:Dnah5	UTSW	15	28,313,861 (GRCm38)	missense	probably null	0.98
R0731:Dnah5	UTSW	15	28,311,143 (GRCm38)	missense	possibly damaging	0.78
R0747:Dnah5	UTSW	15	28,444,187 (GRCm38)	missense	possibly damaging	0.64
R0747:Dnah5	UTSW	15	28,444,186 (GRCm38)	missense	probably damaging	0.99
R0766:Dnah5	UTSW	15	28,448,487 (GRCm38)	missense	probably null	0.89
R0849:Dnah5	UTSW	15	28,263,599 (GRCm38)	missense	probably damaging	0.96
R1034:Dnah5	UTSW	15	28,302,471 (GRCm38)	missense	probably damaging	1.00
R1084:Dnah5	UTSW	15	28,343,452 (GRCm38)	missense	probably benign	0.01
R1148:Dnah5	UTSW	15	28,421,690 (GRCm38)	missense	probably damaging	1.00
R1148:Dnah5	UTSW	15	28,421,690 (GRCm38)	missense	probably damaging	1.00
R1200:Dnah5	UTSW	15	28,246,257 (GRCm38)	missense	possibly damaging	0.88
R1208:Dnah5	UTSW	15	28,327,731 (GRCm38)	missense	probably damaging	1.00
R1208:Dnah5	UTSW	15	28,327,731 (GRCm38)	missense	probably damaging	1.00
R1269:Dnah5	UTSW	15	28,238,511 (GRCm38)	missense	probably damaging	1.00
R1373:Dnah5	UTSW	15	28,313,918 (GRCm38)	splice site	probably benign
R1401:Dnah5	UTSW	15	28,401,913 (GRCm38)	missense	probably damaging	1.00
R1413:Dnah5	UTSW	15	28,370,409 (GRCm38)	missense	probably benign
R1430:Dnah5	UTSW	15	28,345,857 (GRCm38)	missense	probably benign	0.37
R1457:Dnah5	UTSW	15	28,403,542 (GRCm38)	critical splice donor site	probably null
R1468:Dnah5	UTSW	15	28,230,463 (GRCm38)	nonsense	probably null
R1468:Dnah5	UTSW	15	28,230,463 (GRCm38)	nonsense	probably null
R1560:Dnah5	UTSW	15	28,420,003 (GRCm38)	missense	probably damaging	1.00
R1568:Dnah5	UTSW	15	28,409,177 (GRCm38)	missense	probably damaging	0.98
R1574:Dnah5	UTSW	15	28,252,423 (GRCm38)	missense	probably benign	0.00
R1574:Dnah5	UTSW	15	28,252,423 (GRCm38)	missense	probably benign	0.00
R1603:Dnah5	UTSW	15	28,449,180 (GRCm38)	missense	probably benign	0.09
R1603:Dnah5	UTSW	15	28,294,985 (GRCm38)	splice site	probably benign
R1673:Dnah5	UTSW	15	28,290,148 (GRCm38)	missense	probably benign
R1755:Dnah5	UTSW	15	28,326,636 (GRCm38)	missense	probably damaging	0.99
R1785:Dnah5	UTSW	15	28,313,786 (GRCm38)	missense	probably damaging	1.00
R1786:Dnah5	UTSW	15	28,313,786 (GRCm38)	missense	probably damaging	1.00
R1789:Dnah5	UTSW	15	28,270,426 (GRCm38)	missense	probably benign	0.00
R1817:Dnah5	UTSW	15	28,246,400 (GRCm38)	nonsense	probably null
R1819:Dnah5	UTSW	15	28,246,400 (GRCm38)	nonsense	probably null
R1834:Dnah5	UTSW	15	28,409,124 (GRCm38)	missense	probably benign	0.00
R1855:Dnah5	UTSW	15	28,411,669 (GRCm38)	missense	possibly damaging	0.88
R1870:Dnah5	UTSW	15	28,331,713 (GRCm38)	nonsense	probably null
R1871:Dnah5	UTSW	15	28,331,713 (GRCm38)	nonsense	probably null
R1987:Dnah5	UTSW	15	28,343,591 (GRCm38)	missense	probably damaging	0.99
R1988:Dnah5	UTSW	15	28,343,591 (GRCm38)	missense	probably damaging	0.99
R1989:Dnah5	UTSW	15	28,343,591 (GRCm38)	missense	probably damaging	0.99
R2062:Dnah5	UTSW	15	28,366,270 (GRCm38)	missense	probably damaging	1.00
R2069:Dnah5	UTSW	15	28,312,388 (GRCm38)	splice site	probably null
R2121:Dnah5	UTSW	15	28,297,005 (GRCm38)	splice site	probably benign
R2129:Dnah5	UTSW	15	28,408,321 (GRCm38)	missense	probably benign	0.00
R2151:Dnah5	UTSW	15	28,444,091 (GRCm38)	missense	probably damaging	1.00
R2159:Dnah5	UTSW	15	28,252,545 (GRCm38)	missense	probably benign	0.00
R2207:Dnah5	UTSW	15	28,343,671 (GRCm38)	missense	probably benign	0.11
R2231:Dnah5	UTSW	15	28,408,417 (GRCm38)	critical splice donor site	probably null
R2232:Dnah5	UTSW	15	28,408,417 (GRCm38)	critical splice donor site	probably null
R2282:Dnah5	UTSW	15	28,327,302 (GRCm38)	missense	probably damaging	0.99
R2305:Dnah5	UTSW	15	28,387,767 (GRCm38)	missense	probably benign	0.25
R2339:Dnah5	UTSW	15	28,313,882 (GRCm38)	missense	probably benign	0.00
R2437:Dnah5	UTSW	15	28,307,391 (GRCm38)	critical splice donor site	probably null
R2696:Dnah5	UTSW	15	28,278,576 (GRCm38)	missense	probably benign	0.00
R3156:Dnah5	UTSW	15	28,438,091 (GRCm38)	splice site	probably benign
R3431:Dnah5	UTSW	15	28,295,267 (GRCm38)	missense	probably benign	0.20
R3700:Dnah5	UTSW	15	28,387,791 (GRCm38)	missense	possibly damaging	0.72
R3724:Dnah5	UTSW	15	28,270,420 (GRCm38)	missense	probably benign	0.08
R3732:Dnah5	UTSW	15	28,409,122 (GRCm38)	missense	possibly damaging	0.64
R3872:Dnah5	UTSW	15	28,411,510 (GRCm38)	missense	possibly damaging	0.50
R4063:Dnah5	UTSW	15	28,420,998 (GRCm38)	missense	probably damaging	0.98
R4072:Dnah5	UTSW	15	28,340,298 (GRCm38)	nonsense	probably null
R4075:Dnah5	UTSW	15	28,293,791 (GRCm38)	missense	probably benign
R4245:Dnah5	UTSW	15	28,219,189 (GRCm38)	missense	probably benign
R4254:Dnah5	UTSW	15	28,438,102 (GRCm38)	missense	probably benign	0.07
R4255:Dnah5	UTSW	15	28,438,102 (GRCm38)	missense	probably benign	0.07
R4392:Dnah5	UTSW	15	28,289,229 (GRCm38)	missense	probably benign	0.19
R4552:Dnah5	UTSW	15	28,397,154 (GRCm38)	missense	probably benign	0.19
R4574:Dnah5	UTSW	15	28,367,763 (GRCm38)	missense	probably benign	0.05
R4577:Dnah5	UTSW	15	28,289,250 (GRCm38)	missense	probably benign	0.06
R4587:Dnah5	UTSW	15	28,304,599 (GRCm38)	missense	probably damaging	1.00
R4631:Dnah5	UTSW	15	28,419,994 (GRCm38)	missense	probably damaging	1.00
R4631:Dnah5	UTSW	15	28,401,953 (GRCm38)	missense	probably damaging	1.00
R4676:Dnah5	UTSW	15	28,295,260 (GRCm38)	missense	possibly damaging	0.65
R4707:Dnah5	UTSW	15	28,372,375 (GRCm38)	missense	probably damaging	0.97
R4754:Dnah5	UTSW	15	28,420,955 (GRCm38)	splice site	probably null
R4767:Dnah5	UTSW	15	28,270,474 (GRCm38)	missense	probably benign	0.02
R4857:Dnah5	UTSW	15	28,345,807 (GRCm38)	missense	probably benign	0.00
R4883:Dnah5	UTSW	15	28,343,638 (GRCm38)	missense	probably benign	0.00
R4889:Dnah5	UTSW	15	28,235,792 (GRCm38)	missense	probably benign	0.01
R4946:Dnah5	UTSW	15	28,387,904 (GRCm38)	missense	probably damaging	1.00
R4946:Dnah5	UTSW	15	28,326,557 (GRCm38)	missense	probably damaging	0.96
R4947:Dnah5	UTSW	15	28,272,372 (GRCm38)	missense	probably benign
R5033:Dnah5	UTSW	15	28,421,678 (GRCm38)	missense	probably damaging	0.96
R5164:Dnah5	UTSW	15	28,408,292 (GRCm38)	missense	probably benign	0.00
R5175:Dnah5	UTSW	15	28,448,404 (GRCm38)	missense	probably damaging	1.00
R5182:Dnah5	UTSW	15	28,311,278 (GRCm38)	missense	probably damaging	0.99
R5187:Dnah5	UTSW	15	28,272,172 (GRCm38)	missense	probably benign	0.41
R5272:Dnah5	UTSW	15	28,350,665 (GRCm38)	missense	probably benign
R5308:Dnah5	UTSW	15	28,229,651 (GRCm38)	missense	possibly damaging	0.80
R5310:Dnah5	UTSW	15	28,311,328 (GRCm38)	missense	probably damaging	1.00
R5322:Dnah5	UTSW	15	28,384,244 (GRCm38)	missense	probably benign	0.41
R5398:Dnah5	UTSW	15	28,293,726 (GRCm38)	missense	probably benign
R5596:Dnah5	UTSW	15	28,343,608 (GRCm38)	missense	probably damaging	1.00
R5603:Dnah5	UTSW	15	28,419,932 (GRCm38)	missense	probably damaging	1.00
R5619:Dnah5	UTSW	15	28,302,435 (GRCm38)	missense	probably damaging	1.00
R5656:Dnah5	UTSW	15	28,421,064 (GRCm38)	missense	probably benign	0.03
R5741:Dnah5	UTSW	15	28,246,367 (GRCm38)	missense	probably benign	0.11
R5754:Dnah5	UTSW	15	28,401,868 (GRCm38)	missense	probably benign	0.01
R5763:Dnah5	UTSW	15	28,311,152 (GRCm38)	missense	probably damaging	1.00
R5824:Dnah5	UTSW	15	28,313,821 (GRCm38)	missense	probably benign	0.00
R5836:Dnah5	UTSW	15	28,383,592 (GRCm38)	missense	probably damaging	1.00
R5838:Dnah5	UTSW	15	28,290,195 (GRCm38)	missense	probably benign	0.00
R5864:Dnah5	UTSW	15	28,297,013 (GRCm38)	missense	possibly damaging	0.83
R5895:Dnah5	UTSW	15	28,234,453 (GRCm38)	splice site	probably null
R5896:Dnah5	UTSW	15	28,272,060 (GRCm38)	missense	probably benign
R5899:Dnah5	UTSW	15	28,448,367 (GRCm38)	missense	possibly damaging	0.95
R5905:Dnah5	UTSW	15	28,387,833 (GRCm38)	missense	probably damaging	1.00
R5924:Dnah5	UTSW	15	28,307,327 (GRCm38)	missense	probably benign	0.41
R5927:Dnah5	UTSW	15	28,335,718 (GRCm38)	missense	probably benign	0.00
R5929:Dnah5	UTSW	15	28,311,208 (GRCm38)	missense	probably damaging	1.00
R5929:Dnah5	UTSW	15	28,311,207 (GRCm38)	missense	probably benign	0.01
R5931:Dnah5	UTSW	15	28,453,279 (GRCm38)	missense	probably damaging	0.99
R5964:Dnah5	UTSW	15	28,458,584 (GRCm38)	missense	possibly damaging	0.49
R5975:Dnah5	UTSW	15	28,234,282 (GRCm38)	missense	probably damaging	1.00
R5993:Dnah5	UTSW	15	28,299,226 (GRCm38)	missense	probably benign	0.09
R6016:Dnah5	UTSW	15	28,327,884 (GRCm38)	missense	probably damaging	1.00
R6028:Dnah5	UTSW	15	28,387,833 (GRCm38)	missense	probably damaging	1.00
R6065:Dnah5	UTSW	15	28,230,468 (GRCm38)	missense	possibly damaging	0.47
R6117:Dnah5	UTSW	15	28,270,420 (GRCm38)	missense	probably damaging	0.99
R6143:Dnah5	UTSW	15	28,233,231 (GRCm38)	missense	probably benign	0.05
R6146:Dnah5	UTSW	15	28,459,185 (GRCm38)	missense	probably benign
R6154:Dnah5	UTSW	15	28,204,031 (GRCm38)	missense	probably benign	0.15
R6164:Dnah5	UTSW	15	28,378,343 (GRCm38)	missense	probably benign	0.08
R6266:Dnah5	UTSW	15	28,335,627 (GRCm38)	missense	possibly damaging	0.67
R6321:Dnah5	UTSW	15	28,372,411 (GRCm38)	missense	probably damaging	0.99
R6349:Dnah5	UTSW	15	28,238,511 (GRCm38)	missense	probably damaging	1.00
R6431:Dnah5	UTSW	15	28,349,824 (GRCm38)	missense	possibly damaging	0.52
R6467:Dnah5	UTSW	15	28,438,183 (GRCm38)	missense	probably benign	0.10
R6564:Dnah5	UTSW	15	28,367,745 (GRCm38)	missense	probably benign
R6607:Dnah5	UTSW	15	28,445,200 (GRCm38)	missense	possibly damaging	0.95
R6619:Dnah5	UTSW	15	28,409,120 (GRCm38)	missense	probably benign	0.03
R6633:Dnah5	UTSW	15	28,293,787 (GRCm38)	missense	probably benign	0.27
R6647:Dnah5	UTSW	15	28,403,487 (GRCm38)	missense	probably benign	0.02
R6782:Dnah5	UTSW	15	28,449,156 (GRCm38)	missense	possibly damaging	0.89
R6797:Dnah5	UTSW	15	28,233,238 (GRCm38)	nonsense	probably null
R6797:Dnah5	UTSW	15	28,451,463 (GRCm38)	missense	probably damaging	1.00
R6831:Dnah5	UTSW	15	28,411,515 (GRCm38)	missense	possibly damaging	0.88
R6849:Dnah5	UTSW	15	28,278,624 (GRCm38)	missense	probably benign	0.14
R6871:Dnah5	UTSW	15	28,229,640 (GRCm38)	missense	probably benign	0.32
R6936:Dnah5	UTSW	15	28,409,268 (GRCm38)	missense	probably damaging	1.00
R6943:Dnah5	UTSW	15	28,235,720 (GRCm38)	missense	probably damaging	1.00
R7030:Dnah5	UTSW	15	28,333,062 (GRCm38)	missense	probably benign	0.00
R7030:Dnah5	UTSW	15	28,238,592 (GRCm38)	missense	probably benign
R7032:Dnah5	UTSW	15	28,326,650 (GRCm38)	missense	probably damaging	1.00
R7063:Dnah5	UTSW	15	28,233,248 (GRCm38)	missense	probably benign	0.00
R7094:Dnah5	UTSW	15	28,453,336 (GRCm38)	missense	probably damaging	0.98
R7097:Dnah5	UTSW	15	28,453,264 (GRCm38)	missense	probably benign	0.00
R7126:Dnah5	UTSW	15	28,349,837 (GRCm38)	missense	probably benign	0.03
R7153:Dnah5	UTSW	15	28,365,522 (GRCm38)	splice site	probably null
R7209:Dnah5	UTSW	15	28,459,225 (GRCm38)	missense	possibly damaging	0.71
R7276:Dnah5	UTSW	15	28,367,838 (GRCm38)	missense	probably damaging	1.00
R7320:Dnah5	UTSW	15	28,270,470 (GRCm38)	missense	probably null	0.33
R7350:Dnah5	UTSW	15	28,235,819 (GRCm38)	critical splice donor site	probably null
R7380:Dnah5	UTSW	15	28,370,378 (GRCm38)	missense	probably damaging	1.00
R7438:Dnah5	UTSW	15	28,346,952 (GRCm38)	missense	probably damaging	0.99
R7499:Dnah5	UTSW	15	28,302,450 (GRCm38)	missense	probably damaging	1.00
R7513:Dnah5	UTSW	15	28,370,415 (GRCm38)	missense	probably benign
R7519:Dnah5	UTSW	15	28,390,483 (GRCm38)	missense	probably damaging	0.98
R7524:Dnah5	UTSW	15	28,297,066 (GRCm38)	missense	possibly damaging	0.50
R7556:Dnah5	UTSW	15	28,290,243 (GRCm38)	missense	probably null	0.43
R7570:Dnah5	UTSW	15	28,346,952 (GRCm38)	missense	probably damaging	1.00
R7585:Dnah5	UTSW	15	28,401,868 (GRCm38)	missense	probably benign	0.09
R7642:Dnah5	UTSW	15	28,247,979 (GRCm38)	critical splice donor site	probably null
R7670:Dnah5	UTSW	15	28,246,232 (GRCm38)	splice site	probably null
R7763:Dnah5	UTSW	15	28,313,855 (GRCm38)	missense	probably damaging	1.00
R7821:Dnah5	UTSW	15	28,411,532 (GRCm38)	missense	possibly damaging	0.89
R7826:Dnah5	UTSW	15	28,367,812 (GRCm38)	missense	probably damaging	1.00
R7872:Dnah5	UTSW	15	28,245,684 (GRCm38)	missense	probably damaging	0.99
R7889:Dnah5	UTSW	15	28,448,414 (GRCm38)	nonsense	probably null
R7919:Dnah5	UTSW	15	28,350,596 (GRCm38)	missense	probably damaging	1.00
R7920:Dnah5	UTSW	15	28,453,222 (GRCm38)	missense	probably benign	0.00
R7936:Dnah5	UTSW	15	28,345,837 (GRCm38)	missense	possibly damaging	0.64
R7996:Dnah5	UTSW	15	28,409,177 (GRCm38)	missense	probably damaging	0.98
R8063:Dnah5	UTSW	15	28,230,583 (GRCm38)	missense	probably benign
R8084:Dnah5	UTSW	15	28,387,953 (GRCm38)	missense	probably damaging	1.00
R8105:Dnah5	UTSW	15	28,372,402 (GRCm38)	missense	probably benign
R8114:Dnah5	UTSW	15	28,239,976 (GRCm38)	missense	probably benign	0.01
R8142:Dnah5	UTSW	15	28,384,373 (GRCm38)	missense	probably benign	0.36
R8153:Dnah5	UTSW	15	28,384,430 (GRCm38)	missense	probably damaging	1.00
R8161:Dnah5	UTSW	15	28,350,704 (GRCm38)	missense	possibly damaging	0.79
R8174:Dnah5	UTSW	15	28,311,133 (GRCm38)	splice site	probably null
R8187:Dnah5	UTSW	15	28,384,209 (GRCm38)	missense	probably damaging	1.00
R8194:Dnah5	UTSW	15	28,453,268 (GRCm38)	missense	probably damaging	0.99
R8280:Dnah5	UTSW	15	28,408,392 (GRCm38)	missense	probably benign	0.01
R8291:Dnah5	UTSW	15	28,263,597 (GRCm38)	missense	probably benign	0.03
R8324:Dnah5	UTSW	15	28,346,865 (GRCm38)	missense	probably damaging	1.00
R8347:Dnah5	UTSW	15	28,236,666 (GRCm38)	missense	possibly damaging	0.90
R8356:Dnah5	UTSW	15	28,444,167 (GRCm38)	missense	probably benign	0.03
R8356:Dnah5	UTSW	15	28,444,323 (GRCm38)	missense	probably null	0.02
R8361:Dnah5	UTSW	15	28,331,810 (GRCm38)	missense	probably damaging	0.98
R8375:Dnah5	UTSW	15	28,327,343 (GRCm38)	missense	probably benign	0.00
R8474:Dnah5	UTSW	15	28,247,832 (GRCm38)	missense	probably benign	0.00
R8481:Dnah5	UTSW	15	28,419,795 (GRCm38)	missense	probably benign	0.00
R8494:Dnah5	UTSW	15	28,345,831 (GRCm38)	missense	probably benign	0.32
R8495:Dnah5	UTSW	15	28,409,268 (GRCm38)	missense	probably damaging	0.97
R8519:Dnah5	UTSW	15	28,299,099 (GRCm38)	missense	probably benign	0.07
R8683:Dnah5	UTSW	15	28,289,221 (GRCm38)	missense	probably benign	0.00
R8739:Dnah5	UTSW	15	28,345,860 (GRCm38)	missense	probably benign	0.01
R8752:Dnah5	UTSW	15	28,290,219 (GRCm38)	missense	probably benign	0.00
R8784:Dnah5	UTSW	15	28,387,951 (GRCm38)	missense	probably benign	0.16
R8813:Dnah5	UTSW	15	28,229,573 (GRCm38)	missense	probably damaging	1.00
R8862:Dnah5	UTSW	15	28,459,356 (GRCm38)	splice site	probably benign
R8873:Dnah5	UTSW	15	28,219,188 (GRCm38)	missense	probably benign
R8885:Dnah5	UTSW	15	28,327,740 (GRCm38)	missense	probably damaging	1.00
R8901:Dnah5	UTSW	15	28,365,569 (GRCm38)	missense	possibly damaging	0.76
R9025:Dnah5	UTSW	15	28,409,266 (GRCm38)	missense	probably damaging	1.00
R9037:Dnah5	UTSW	15	28,247,958 (GRCm38)	missense	probably benign	0.05
R9057:Dnah5	UTSW	15	28,390,868 (GRCm38)	missense	probably damaging	1.00
R9059:Dnah5	UTSW	15	28,245,666 (GRCm38)	missense	probably benign
R9065:Dnah5	UTSW	15	28,293,790 (GRCm38)	missense	probably benign	0.09
R9098:Dnah5	UTSW	15	28,419,961 (GRCm38)	missense
R9118:Dnah5	UTSW	15	28,401,848 (GRCm38)	frame shift	probably null
R9149:Dnah5	UTSW	15	28,387,768 (GRCm38)	missense	probably benign	0.00
R9184:Dnah5	UTSW	15	28,340,406 (GRCm38)	missense	probably benign	0.13
R9205:Dnah5	UTSW	15	28,448,334 (GRCm38)	missense	possibly damaging	0.88
R9297:Dnah5	UTSW	15	28,203,908 (GRCm38)	start gained	probably benign
R9302:Dnah5	UTSW	15	28,239,886 (GRCm38)	missense	probably benign	0.03
R9310:Dnah5	UTSW	15	28,448,433 (GRCm38)	missense	probably damaging	1.00
R9318:Dnah5	UTSW	15	28,203,908 (GRCm38)	start gained	probably benign
R9405:Dnah5	UTSW	15	28,272,160 (GRCm38)	missense	probably benign
R9424:Dnah5	UTSW	15	28,272,140 (GRCm38)	missense	probably benign	0.01
R9467:Dnah5	UTSW	15	28,366,147 (GRCm38)	missense	possibly damaging	0.94
R9469:Dnah5	UTSW	15	28,421,000 (GRCm38)	missense	probably benign	0.06
R9548:Dnah5	UTSW	15	28,327,879 (GRCm38)	missense	possibly damaging	0.79
R9564:Dnah5	UTSW	15	28,290,276 (GRCm38)	missense	probably benign	0.04
R9576:Dnah5	UTSW	15	28,272,140 (GRCm38)	missense	probably benign	0.01
R9593:Dnah5	UTSW	15	28,236,628 (GRCm38)	missense	probably benign
R9644:Dnah5	UTSW	15	28,230,504 (GRCm38)	missense	probably damaging	0.98
R9655:Dnah5	UTSW	15	28,242,754 (GRCm38)	missense	probably benign
R9657:Dnah5	UTSW	15	28,409,943 (GRCm38)	missense	probably damaging	1.00
R9704:Dnah5	UTSW	15	28,247,819 (GRCm38)	missense	probably benign	0.00
R9797:Dnah5	UTSW	15	28,233,170 (GRCm38)	missense	probably benign	0.34
RF009:Dnah5	UTSW	15	28,204,019 (GRCm38)	missense	probably benign	0.00
X0011:Dnah5	UTSW	15	28,408,381 (GRCm38)	missense	probably benign	0.16
X0018:Dnah5	UTSW	15	28,269,354 (GRCm38)	missense	probably benign	0.00
X0022:Dnah5	UTSW	15	28,270,411 (GRCm38)	missense	probably benign	0.01
X0023:Dnah5	UTSW	15	28,384,308 (GRCm38)	missense	probably damaging	0.99
X0028:Dnah5	UTSW	15	28,470,477 (GRCm38)	missense	probably damaging	1.00
Z1088:Dnah5	UTSW	15	28,366,357 (GRCm38)	missense	probably null	0.10
Z1088:Dnah5	UTSW	15	28,384,230 (GRCm38)	missense	probably damaging	1.00
Z1177:Dnah5	UTSW	15	28,295,311 (GRCm38)	missense	probably damaging	0.98
Z1177:Dnah5	UTSW	15	28,270,403 (GRCm38)	missense	probably benign	0.00
Z1177:Dnah5	UTSW	15	28,270,354 (GRCm38)	missense	probably benign	0.32
Z1177:Dnah5	UTSW	15	28,387,763 (GRCm38)	missense	possibly damaging	0.72

Predicted Primers

PCR Primer
(F):5'- TTGCTAGGCTCAAGGCACTG -3'
(R):5'- TTGATTCATGCTTAGGGCCTC -3'

Sequencing Primer
(F):5'- CACAGTCATACAAAGCTAGAATCTTG -3'
(R):5'- ATGCTTAGGGCCTCTGACAC -3'

Posted On

2014-09-17