Incidental Mutation 'R2131:Lmo7'
| ID |
228124 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Lmo7
|
| Ensembl Gene |
ENSMUSG00000033060 |
| Gene Name |
LIM domain only 7 |
| Synonyms |
FBXO20, LOC380928 |
| MMRRC Submission |
040134-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.133)
|
| Stock # |
R2131 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
14 |
| Chromosomal Location |
101967393-102172146 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 102137674 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Valine
at position 670
(D670V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000123706
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000100337]
[ENSMUST00000159026]
[ENSMUST00000159258]
[ENSMUST00000159314]
[ENSMUST00000159597]
|
| AlphaFold |
E9PYF4 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000100337
AA Change: D792V
PolyPhen 2
Score 0.911 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000097910
Gene: ENSMUSG00000033060
AA Change: D792V
| Domain | Start | End | E-Value | Type |
|---|
|
CH
|
14 |
124 |
2.57e-13 |
SMART |
|
low complexity region
|
200 |
211 |
N/A |
INTRINSIC |
|
Pfam:DUF4757
|
242 |
348 |
2.2e-14 |
PFAM |
|
low complexity region
|
448 |
462 |
N/A |
INTRINSIC |
|
Pfam:DUF4757
|
568 |
735 |
1.8e-46 |
PFAM |
|
low complexity region
|
861 |
879 |
N/A |
INTRINSIC |
|
low complexity region
|
979 |
991 |
N/A |
INTRINSIC |
|
low complexity region
|
1003 |
1015 |
N/A |
INTRINSIC |
|
PDZ
|
1047 |
1119 |
1.05e-8 |
SMART |
|
coiled coil region
|
1222 |
1275 |
N/A |
INTRINSIC |
|
coiled coil region
|
1319 |
1411 |
N/A |
INTRINSIC |
|
low complexity region
|
1585 |
1596 |
N/A |
INTRINSIC |
|
low complexity region
|
1599 |
1617 |
N/A |
INTRINSIC |
|
LIM
|
1629 |
1687 |
6.54e-10 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000159026
|
| SMART Domains |
Protein: ENSMUSP00000124605
Gene: ENSMUSG00000033060
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
215 |
229 |
N/A |
INTRINSIC |
|
coiled coil region
|
435 |
471 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000159258
|
| SMART Domains |
Protein: ENSMUSP00000125465
Gene: ENSMUSG00000033060
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
215 |
229 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000159314
AA Change: D559V
PolyPhen 2
Score 0.834 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000124349
Gene: ENSMUSG00000033060
AA Change: D559V
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
215 |
229 |
N/A |
INTRINSIC |
|
coiled coil region
|
435 |
492 |
N/A |
INTRINSIC |
|
low complexity region
|
628 |
646 |
N/A |
INTRINSIC |
|
low complexity region
|
746 |
758 |
N/A |
INTRINSIC |
|
low complexity region
|
770 |
782 |
N/A |
INTRINSIC |
|
PDZ
|
814 |
886 |
1.05e-8 |
SMART |
|
coiled coil region
|
989 |
1042 |
N/A |
INTRINSIC |
|
coiled coil region
|
1086 |
1178 |
N/A |
INTRINSIC |
|
low complexity region
|
1352 |
1363 |
N/A |
INTRINSIC |
|
low complexity region
|
1366 |
1384 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000159597
AA Change: D670V
PolyPhen 2
Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000123706
Gene: ENSMUSG00000033060
AA Change: D670V
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
78 |
89 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
111 |
141 |
6.96e-5 |
PROSPERO |
|
internal_repeat_1
|
218 |
248 |
6.96e-5 |
PROSPERO |
|
low complexity region
|
326 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
546 |
603 |
N/A |
INTRINSIC |
|
low complexity region
|
739 |
757 |
N/A |
INTRINSIC |
|
low complexity region
|
857 |
869 |
N/A |
INTRINSIC |
|
low complexity region
|
881 |
893 |
N/A |
INTRINSIC |
|
PDZ
|
925 |
997 |
1.05e-8 |
SMART |
|
coiled coil region
|
1127 |
1180 |
N/A |
INTRINSIC |
|
coiled coil region
|
1224 |
1316 |
N/A |
INTRINSIC |
|
low complexity region
|
1490 |
1501 |
N/A |
INTRINSIC |
|
low complexity region
|
1504 |
1522 |
N/A |
INTRINSIC |
|
LIM
|
1534 |
1592 |
6.54e-10 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000159806
AA Change: D281V
|
| SMART Domains |
Protein: ENSMUSP00000124300
Gene: ENSMUSG00000033060
AA Change: D281V
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
45 |
N/A |
INTRINSIC |
|
Pfam:DUF4757
|
76 |
225 |
4.5e-53 |
PFAM |
|
low complexity region
|
351 |
369 |
N/A |
INTRINSIC |
|
low complexity region
|
469 |
481 |
N/A |
INTRINSIC |
|
low complexity region
|
493 |
505 |
N/A |
INTRINSIC |
|
PDZ
|
537 |
609 |
1.05e-8 |
SMART |
|
internal_repeat_1
|
620 |
691 |
9.31e-5 |
PROSPERO |
|
coiled coil region
|
711 |
764 |
N/A |
INTRINSIC |
|
coiled coil region
|
808 |
900 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
921 |
976 |
9.31e-5 |
PROSPERO |
|
low complexity region
|
1075 |
1086 |
N/A |
INTRINSIC |
|
low complexity region
|
1089 |
1107 |
N/A |
INTRINSIC |
|
LIM
|
1119 |
1177 |
6.54e-10 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000159948
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000160876
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 95.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein containing a calponin homology (CH) domain, a PDZ domain, and a LIM domain, and may be involved in protein-protein interactions. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, however, the full-length nature of some variants is not known. [provided by RefSeq, Jan 2009]
PHENOTYPE: Targeted mutations in this gene result in postnatal lethality, growth defects, skeletal muscle abnormalities and retinal defects reflective of retinal degeneration. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 123 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A2ml1 |
T |
A |
6: 128,553,223 (GRCm39) |
N178I |
probably damaging |
Het |
| Acvr2b |
A |
G |
9: 119,261,874 (GRCm39) |
R437G |
probably damaging |
Het |
| Adamtsl3 |
C |
A |
7: 82,227,802 (GRCm39) |
A1329E |
probably damaging |
Het |
| Adgrl2 |
T |
C |
3: 148,596,124 (GRCm39) |
I71V |
probably damaging |
Het |
| Adra1a |
A |
T |
14: 66,964,981 (GRCm39) |
I324F |
possibly damaging |
Het |
| Akap13 |
G |
T |
7: 75,261,182 (GRCm39) |
A1269S |
probably benign |
Het |
| Ampd1 |
G |
T |
3: 103,002,194 (GRCm39) |
|
probably null |
Het |
| Ankrd16 |
T |
A |
2: 11,788,506 (GRCm39) |
D211E |
probably damaging |
Het |
| Aopep |
T |
A |
13: 63,357,963 (GRCm39) |
C656S |
probably benign |
Het |
| Aox3 |
A |
G |
1: 58,209,002 (GRCm39) |
H845R |
probably damaging |
Het |
| Apc |
C |
A |
18: 34,445,098 (GRCm39) |
Q665K |
possibly damaging |
Het |
| Arap2 |
T |
C |
5: 62,835,301 (GRCm39) |
N747S |
probably damaging |
Het |
| Arsk |
A |
T |
13: 76,239,931 (GRCm39) |
C47* |
probably null |
Het |
| Atp8b5 |
T |
A |
4: 43,370,726 (GRCm39) |
F1001I |
probably benign |
Het |
| Bap1 |
T |
A |
14: 30,980,288 (GRCm39) |
Y645* |
probably null |
Het |
| Brca2 |
A |
G |
5: 150,480,594 (GRCm39) |
Y2760C |
probably damaging |
Het |
| Cad |
T |
A |
5: 31,215,416 (GRCm39) |
F76I |
probably damaging |
Het |
| Capn9 |
G |
A |
8: 125,332,450 (GRCm39) |
G430R |
possibly damaging |
Het |
| Castor2 |
G |
A |
5: 134,164,992 (GRCm39) |
C187Y |
probably damaging |
Het |
| Ccdc27 |
TTCCTCCTCCTCCTCCTCCTC |
TTCCTCCTCCTCCTCCTC |
4: 154,120,763 (GRCm39) |
|
probably benign |
Het |
| Cdkn2c |
A |
C |
4: 109,522,260 (GRCm39) |
N28K |
probably null |
Het |
| Celsr1 |
T |
A |
15: 85,847,424 (GRCm39) |
I1438F |
probably benign |
Het |
| Cfhr2 |
T |
G |
1: 139,758,893 (GRCm39) |
R52S |
probably benign |
Het |
| Cldn1 |
G |
C |
16: 26,190,300 (GRCm39) |
A26G |
probably damaging |
Het |
| Col20a1 |
T |
A |
2: 180,634,366 (GRCm39) |
F110L |
probably damaging |
Het |
| Creg2 |
T |
C |
1: 39,664,146 (GRCm39) |
N204S |
probably benign |
Het |
| Cx3cl1 |
C |
A |
8: 95,506,201 (GRCm39) |
Q69K |
probably benign |
Het |
| Cyfip2 |
T |
C |
11: 46,176,958 (GRCm39) |
E74G |
possibly damaging |
Het |
| Cyp2g1 |
A |
T |
7: 26,520,135 (GRCm39) |
I456F |
probably damaging |
Het |
| Dapk1 |
A |
G |
13: 60,877,345 (GRCm39) |
E528G |
possibly damaging |
Het |
| Dapk1 |
T |
A |
13: 60,909,481 (GRCm39) |
W1365R |
possibly damaging |
Het |
| Dbt |
T |
A |
3: 116,332,773 (GRCm39) |
D16E |
probably damaging |
Het |
| Depdc5 |
T |
A |
5: 33,148,125 (GRCm39) |
L1469* |
probably null |
Het |
| Dnah3 |
T |
A |
7: 119,566,982 (GRCm39) |
T2415S |
possibly damaging |
Het |
| Dnmbp |
A |
G |
19: 43,842,750 (GRCm39) |
L1210S |
probably damaging |
Het |
| Dpyd |
T |
C |
3: 118,468,217 (GRCm39) |
V77A |
probably benign |
Het |
| Eps15l1 |
A |
T |
8: 73,140,712 (GRCm39) |
V260D |
probably benign |
Het |
| Eya1 |
A |
G |
1: 14,241,198 (GRCm39) |
V573A |
probably benign |
Het |
| Fam171b |
T |
A |
2: 83,710,202 (GRCm39) |
S625T |
probably damaging |
Het |
| Fam186a |
T |
C |
15: 99,831,557 (GRCm39) |
|
probably benign |
Het |
| Gabra4 |
G |
T |
5: 71,798,567 (GRCm39) |
D137E |
probably benign |
Het |
| Gemin4 |
G |
C |
11: 76,101,876 (GRCm39) |
P962A |
probably damaging |
Het |
| Gm43302 |
T |
C |
5: 105,422,610 (GRCm39) |
D474G |
probably damaging |
Het |
| Golim4 |
A |
T |
3: 75,815,456 (GRCm39) |
V116D |
probably damaging |
Het |
| Gpr19 |
T |
C |
6: 134,847,405 (GRCm39) |
M1V |
probably null |
Het |
| Hnf4a |
T |
A |
2: 163,389,338 (GRCm39) |
N29K |
probably benign |
Het |
| Htt |
A |
G |
5: 35,034,453 (GRCm39) |
R1975G |
possibly damaging |
Het |
| Ift20 |
G |
A |
11: 78,430,860 (GRCm39) |
E68K |
probably damaging |
Het |
| Il4i1 |
G |
A |
7: 44,489,494 (GRCm39) |
V420M |
probably damaging |
Het |
| Insrr |
G |
A |
3: 87,717,879 (GRCm39) |
|
probably null |
Het |
| Ipo9 |
ATCCTCCTCCTCCTCCTC |
ATCCTCCTCCTCCTCCTCCTC |
1: 135,314,006 (GRCm39) |
|
probably benign |
Het |
| Ipo9 |
A |
G |
1: 135,329,988 (GRCm39) |
V484A |
probably benign |
Het |
| Jmjd4 |
A |
T |
11: 59,345,781 (GRCm39) |
H287L |
probably damaging |
Het |
| Kcnj13 |
A |
G |
1: 87,314,256 (GRCm39) |
V322A |
probably benign |
Het |
| Kdm5d |
T |
C |
Y: 941,483 (GRCm39) |
L1228P |
probably benign |
Het |
| Klra3 |
A |
G |
6: 130,312,738 (GRCm39) |
S9P |
probably benign |
Het |
| Ldhd |
C |
T |
8: 112,355,169 (GRCm39) |
|
probably null |
Het |
| Lmo2 |
T |
C |
2: 103,811,407 (GRCm39) |
Y147H |
probably damaging |
Het |
| Lmtk2 |
C |
T |
5: 144,111,806 (GRCm39) |
T842I |
possibly damaging |
Het |
| Lrp5 |
T |
C |
19: 3,672,708 (GRCm39) |
T534A |
possibly damaging |
Het |
| Lrrc24 |
A |
T |
15: 76,599,781 (GRCm39) |
F453I |
possibly damaging |
Het |
| Magel2 |
A |
T |
7: 62,027,486 (GRCm39) |
H130L |
unknown |
Het |
| Mcpt8 |
T |
C |
14: 56,319,740 (GRCm39) |
I237V |
probably damaging |
Het |
| Med4 |
A |
G |
14: 73,755,436 (GRCm39) |
N248S |
possibly damaging |
Het |
| Mest |
C |
T |
6: 30,745,884 (GRCm39) |
L269F |
probably damaging |
Het |
| Mib2 |
C |
T |
4: 155,739,695 (GRCm39) |
|
probably null |
Het |
| Mki67 |
T |
A |
7: 135,305,970 (GRCm39) |
|
probably null |
Het |
| Mnx1 |
T |
A |
5: 29,679,187 (GRCm39) |
S299C |
unknown |
Het |
| Nbr1 |
T |
A |
11: 101,457,017 (GRCm39) |
|
probably null |
Het |
| Ncapd3 |
T |
G |
9: 26,994,642 (GRCm39) |
V1174G |
probably damaging |
Het |
| Nyap1 |
A |
C |
5: 137,731,943 (GRCm39) |
|
probably null |
Het |
| Olfml3 |
T |
A |
3: 103,643,185 (GRCm39) |
M399L |
probably benign |
Het |
| Oosp1 |
T |
C |
19: 11,668,314 (GRCm39) |
D23G |
probably damaging |
Het |
| Optc |
A |
T |
1: 133,831,534 (GRCm39) |
|
probably null |
Het |
| Or1j13 |
A |
G |
2: 36,370,059 (GRCm39) |
S28P |
possibly damaging |
Het |
| Or6c205 |
T |
C |
10: 129,086,943 (GRCm39) |
F180S |
probably benign |
Het |
| Osbpl6 |
T |
A |
2: 76,416,558 (GRCm39) |
I546K |
probably damaging |
Het |
| Otog |
A |
T |
7: 45,899,524 (GRCm39) |
N275I |
probably damaging |
Het |
| Pcdhb14 |
C |
A |
18: 37,580,923 (GRCm39) |
Q10K |
probably benign |
Het |
| Pcx |
T |
C |
19: 4,652,579 (GRCm39) |
F189L |
probably benign |
Het |
| Pde6b |
A |
G |
5: 108,576,069 (GRCm39) |
D718G |
probably damaging |
Het |
| Pklr |
C |
A |
3: 89,049,967 (GRCm39) |
P314Q |
probably damaging |
Het |
| Plcb1 |
T |
A |
2: 135,167,587 (GRCm39) |
Y460* |
probably null |
Het |
| Plekha6 |
C |
A |
1: 133,207,103 (GRCm39) |
|
probably null |
Het |
| Plekho1 |
A |
G |
3: 95,896,429 (GRCm39) |
S347P |
probably damaging |
Het |
| Plxna2 |
G |
A |
1: 194,327,058 (GRCm39) |
D331N |
probably benign |
Het |
| Prelp |
C |
T |
1: 133,842,869 (GRCm39) |
R92K |
probably benign |
Het |
| Prkra |
A |
T |
2: 76,477,480 (GRCm39) |
I75K |
probably damaging |
Het |
| Ptpn11 |
G |
A |
5: 121,310,089 (GRCm39) |
A31V |
probably damaging |
Het |
| Pzp |
T |
C |
6: 128,468,124 (GRCm39) |
|
probably null |
Het |
| Rbm12 |
A |
T |
2: 155,937,430 (GRCm39) |
C947* |
probably null |
Het |
| Ren1 |
C |
G |
1: 133,278,516 (GRCm39) |
|
probably null |
Het |
| Ro60 |
T |
C |
1: 143,635,772 (GRCm39) |
D458G |
probably benign |
Het |
| Sarm1 |
A |
T |
11: 78,366,133 (GRCm39) |
C649S |
probably benign |
Het |
| Septin12 |
T |
A |
16: 4,809,643 (GRCm39) |
Q223L |
probably damaging |
Het |
| Septin4 |
A |
T |
11: 87,474,262 (GRCm39) |
Q60L |
probably benign |
Het |
| Slc22a21 |
A |
T |
11: 53,870,559 (GRCm39) |
L42Q |
probably damaging |
Het |
| Slc44a1 |
GCCC |
GCCCCCCC |
4: 53,563,246 (GRCm39) |
|
probably null |
Het |
| Slc9a4 |
T |
G |
1: 40,646,901 (GRCm39) |
|
probably null |
Het |
| Sort1 |
T |
A |
3: 108,259,002 (GRCm39) |
F678Y |
probably benign |
Het |
| Spag6 |
T |
A |
2: 18,737,908 (GRCm39) |
C259* |
probably null |
Het |
| Spata31e2 |
T |
C |
1: 26,724,935 (GRCm39) |
R82G |
probably benign |
Het |
| Stard13 |
T |
C |
5: 150,968,633 (GRCm39) |
Y879C |
probably damaging |
Het |
| Stk24 |
A |
T |
14: 121,539,623 (GRCm39) |
I191N |
probably damaging |
Het |
| Tacc1 |
A |
T |
8: 25,654,509 (GRCm39) |
N271K |
probably damaging |
Het |
| Tacc2 |
T |
A |
7: 130,223,587 (GRCm39) |
S91T |
possibly damaging |
Het |
| Tacr3 |
T |
C |
3: 134,637,941 (GRCm39) |
V366A |
probably benign |
Het |
| Tasor |
A |
G |
14: 27,198,571 (GRCm39) |
N1301S |
possibly damaging |
Het |
| Tbccd1 |
A |
G |
16: 22,660,739 (GRCm39) |
S26P |
probably benign |
Het |
| Tecpr1 |
T |
A |
5: 144,145,463 (GRCm39) |
T595S |
probably benign |
Het |
| Tjp3 |
T |
A |
10: 81,113,888 (GRCm39) |
M457L |
possibly damaging |
Het |
| Tor1aip2 |
A |
G |
1: 155,941,095 (GRCm39) |
Y467C |
probably damaging |
Het |
| Ttc9b |
T |
A |
7: 27,353,774 (GRCm39) |
|
probably null |
Het |
| Tti1 |
T |
C |
2: 157,842,663 (GRCm39) |
R789G |
probably benign |
Het |
| Ttn |
A |
T |
2: 76,662,561 (GRCm39) |
|
probably null |
Het |
| Txk |
T |
A |
5: 72,853,922 (GRCm39) |
T472S |
probably damaging |
Het |
| Ube3d |
A |
T |
9: 86,254,540 (GRCm39) |
|
probably null |
Het |
| Vav2 |
C |
A |
2: 27,189,408 (GRCm39) |
R176L |
possibly damaging |
Het |
| Vps35l |
T |
C |
7: 118,393,798 (GRCm39) |
Y516H |
probably damaging |
Het |
| Wdr27 |
T |
A |
17: 15,148,594 (GRCm39) |
D133V |
probably damaging |
Het |
| Zc3h7a |
A |
T |
16: 10,968,469 (GRCm39) |
Y503* |
probably null |
Het |
| Zdhhc13 |
T |
A |
7: 48,474,392 (GRCm39) |
L548Q |
possibly damaging |
Het |
| Zfp467 |
A |
C |
6: 48,419,595 (GRCm39) |
S38A |
probably damaging |
Het |
|
| Other mutations in Lmo7 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00569:Lmo7
|
APN |
14 |
102,124,487 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL00733:Lmo7
|
APN |
14 |
102,153,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00778:Lmo7
|
APN |
14 |
102,148,321 (GRCm39) |
splice site |
probably benign |
|
|
IGL01014:Lmo7
|
APN |
14 |
102,157,993 (GRCm39) |
splice site |
probably benign |
|
|
IGL01401:Lmo7
|
APN |
14 |
102,031,713 (GRCm39) |
nonsense |
probably null |
|
|
IGL01550:Lmo7
|
APN |
14 |
102,163,576 (GRCm39) |
utr 3 prime |
probably benign |
|
|
IGL01570:Lmo7
|
APN |
14 |
102,139,807 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01602:Lmo7
|
APN |
14 |
102,148,192 (GRCm39) |
splice site |
probably benign |
|
|
IGL01605:Lmo7
|
APN |
14 |
102,148,192 (GRCm39) |
splice site |
probably benign |
|
|
IGL02012:Lmo7
|
APN |
14 |
102,126,152 (GRCm39) |
intron |
probably benign |
|
|
IGL02145:Lmo7
|
APN |
14 |
102,139,659 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02236:Lmo7
|
APN |
14 |
102,163,524 (GRCm39) |
splice site |
probably benign |
|
|
IGL02318:Lmo7
|
APN |
14 |
102,137,502 (GRCm39) |
splice site |
probably benign |
|
|
IGL02345:Lmo7
|
APN |
14 |
102,124,909 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02498:Lmo7
|
APN |
14 |
102,044,918 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02583:Lmo7
|
APN |
14 |
102,171,360 (GRCm39) |
utr 3 prime |
probably benign |
|
|
IGL02670:Lmo7
|
APN |
14 |
102,118,416 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02694:Lmo7
|
APN |
14 |
102,124,606 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03026:Lmo7
|
APN |
14 |
102,166,769 (GRCm39) |
utr 3 prime |
probably benign |
|
|
IGL03062:Lmo7
|
APN |
14 |
102,149,515 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
IGL03068:Lmo7
|
APN |
14 |
102,112,928 (GRCm39) |
unclassified |
probably benign |
|
|
IGL03178:Lmo7
|
APN |
14 |
102,166,696 (GRCm39) |
nonsense |
probably null |
|
|
IGL03279:Lmo7
|
APN |
14 |
102,137,944 (GRCm39) |
missense |
probably benign |
0.30 |
|
PIT4458001:Lmo7
|
UTSW |
14 |
102,124,923 (GRCm39) |
nonsense |
probably null |
|
|
R0029:Lmo7
|
UTSW |
14 |
102,171,357 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R0112:Lmo7
|
UTSW |
14 |
102,124,629 (GRCm39) |
nonsense |
probably null |
|
|
R0345:Lmo7
|
UTSW |
14 |
102,114,313 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0372:Lmo7
|
UTSW |
14 |
102,155,489 (GRCm39) |
splice site |
probably benign |
|
|
R0393:Lmo7
|
UTSW |
14 |
102,137,892 (GRCm39) |
missense |
probably benign |
|
|
R0514:Lmo7
|
UTSW |
14 |
102,133,995 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0514:Lmo7
|
UTSW |
14 |
102,124,609 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0526:Lmo7
|
UTSW |
14 |
102,137,996 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0615:Lmo7
|
UTSW |
14 |
102,114,295 (GRCm39) |
nonsense |
probably null |
|
|
R0900:Lmo7
|
UTSW |
14 |
102,124,624 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0961:Lmo7
|
UTSW |
14 |
102,031,705 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0964:Lmo7
|
UTSW |
14 |
102,158,003 (GRCm39) |
splice site |
probably benign |
|
|
R1078:Lmo7
|
UTSW |
14 |
102,157,910 (GRCm39) |
splice site |
probably benign |
|
|
R1252:Lmo7
|
UTSW |
14 |
102,138,019 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1527:Lmo7
|
UTSW |
14 |
102,114,264 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1537:Lmo7
|
UTSW |
14 |
102,166,700 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R1565:Lmo7
|
UTSW |
14 |
102,124,957 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1637:Lmo7
|
UTSW |
14 |
102,118,268 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1943:Lmo7
|
UTSW |
14 |
102,139,738 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1967:Lmo7
|
UTSW |
14 |
102,137,651 (GRCm39) |
missense |
probably benign |
0.36 |
|
R2002:Lmo7
|
UTSW |
14 |
102,124,497 (GRCm39) |
missense |
probably benign |
0.13 |
|
R2057:Lmo7
|
UTSW |
14 |
102,124,614 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2153:Lmo7
|
UTSW |
14 |
102,157,951 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R2257:Lmo7
|
UTSW |
14 |
102,137,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2355:Lmo7
|
UTSW |
14 |
102,126,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2356:Lmo7
|
UTSW |
14 |
102,124,381 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2898:Lmo7
|
UTSW |
14 |
102,114,350 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3847:Lmo7
|
UTSW |
14 |
102,159,531 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R3848:Lmo7
|
UTSW |
14 |
102,159,531 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R3849:Lmo7
|
UTSW |
14 |
102,159,531 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R3916:Lmo7
|
UTSW |
14 |
102,166,778 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R4050:Lmo7
|
UTSW |
14 |
102,139,713 (GRCm39) |
nonsense |
probably null |
|
|
R4326:Lmo7
|
UTSW |
14 |
102,137,510 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4357:Lmo7
|
UTSW |
14 |
102,125,091 (GRCm39) |
missense |
probably null |
1.00 |
|
R4571:Lmo7
|
UTSW |
14 |
102,125,030 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4658:Lmo7
|
UTSW |
14 |
102,124,393 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4857:Lmo7
|
UTSW |
14 |
102,124,784 (GRCm39) |
splice site |
probably null |
|
|
R5006:Lmo7
|
UTSW |
14 |
102,163,673 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R5528:Lmo7
|
UTSW |
14 |
102,139,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5588:Lmo7
|
UTSW |
14 |
102,134,026 (GRCm39) |
splice site |
probably null |
|
|
R5643:Lmo7
|
UTSW |
14 |
102,166,772 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R5644:Lmo7
|
UTSW |
14 |
102,166,772 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R5650:Lmo7
|
UTSW |
14 |
102,136,110 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5737:Lmo7
|
UTSW |
14 |
102,124,672 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5832:Lmo7
|
UTSW |
14 |
102,121,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5966:Lmo7
|
UTSW |
14 |
102,137,938 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6026:Lmo7
|
UTSW |
14 |
102,118,426 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6072:Lmo7
|
UTSW |
14 |
102,166,772 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R6158:Lmo7
|
UTSW |
14 |
102,137,573 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6246:Lmo7
|
UTSW |
14 |
102,156,136 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6335:Lmo7
|
UTSW |
14 |
102,138,072 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6620:Lmo7
|
UTSW |
14 |
102,112,888 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6658:Lmo7
|
UTSW |
14 |
102,148,281 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6917:Lmo7
|
UTSW |
14 |
102,155,446 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7064:Lmo7
|
UTSW |
14 |
102,121,615 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7072:Lmo7
|
UTSW |
14 |
102,136,136 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7121:Lmo7
|
UTSW |
14 |
102,124,471 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7136:Lmo7
|
UTSW |
14 |
102,157,975 (GRCm39) |
missense |
unknown |
|
|
R7196:Lmo7
|
UTSW |
14 |
102,133,936 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R7228:Lmo7
|
UTSW |
14 |
102,133,971 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7337:Lmo7
|
UTSW |
14 |
102,121,640 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7341:Lmo7
|
UTSW |
14 |
102,122,948 (GRCm39) |
missense |
probably benign |
0.30 |
|
R7408:Lmo7
|
UTSW |
14 |
102,118,389 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7432:Lmo7
|
UTSW |
14 |
102,139,551 (GRCm39) |
missense |
probably benign |
0.42 |
|
R7470:Lmo7
|
UTSW |
14 |
102,138,040 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7506:Lmo7
|
UTSW |
14 |
102,157,045 (GRCm39) |
missense |
unknown |
|
|
R7559:Lmo7
|
UTSW |
14 |
102,124,662 (GRCm39) |
nonsense |
probably null |
|
|
R7565:Lmo7
|
UTSW |
14 |
102,122,737 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7788:Lmo7
|
UTSW |
14 |
102,136,012 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R8095:Lmo7
|
UTSW |
14 |
102,124,855 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8100:Lmo7
|
UTSW |
14 |
102,137,899 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8121:Lmo7
|
UTSW |
14 |
102,163,736 (GRCm39) |
missense |
unknown |
|
|
R8308:Lmo7
|
UTSW |
14 |
102,139,807 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8371:Lmo7
|
UTSW |
14 |
102,124,444 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8403:Lmo7
|
UTSW |
14 |
102,139,800 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8690:Lmo7
|
UTSW |
14 |
102,168,644 (GRCm39) |
missense |
unknown |
|
|
R8778:Lmo7
|
UTSW |
14 |
102,156,655 (GRCm39) |
missense |
probably benign |
0.24 |
|
R8778:Lmo7
|
UTSW |
14 |
102,149,503 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8822:Lmo7
|
UTSW |
14 |
102,121,610 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8849:Lmo7
|
UTSW |
14 |
102,163,543 (GRCm39) |
missense |
unknown |
|
|
R8923:Lmo7
|
UTSW |
14 |
102,137,679 (GRCm39) |
missense |
probably benign |
0.31 |
|
R9006:Lmo7
|
UTSW |
14 |
102,155,072 (GRCm39) |
small deletion |
probably benign |
|
|
R9135:Lmo7
|
UTSW |
14 |
102,118,297 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9154:Lmo7
|
UTSW |
14 |
102,122,743 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9178:Lmo7
|
UTSW |
14 |
102,044,906 (GRCm39) |
nonsense |
probably null |
|
|
R9375:Lmo7
|
UTSW |
14 |
102,136,123 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9428:Lmo7
|
UTSW |
14 |
102,155,076 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9488:Lmo7
|
UTSW |
14 |
102,122,783 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R9493:Lmo7
|
UTSW |
14 |
102,137,907 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9594:Lmo7
|
UTSW |
14 |
102,156,136 (GRCm39) |
missense |
probably null |
0.98 |
|
R9674:Lmo7
|
UTSW |
14 |
102,078,340 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9736:Lmo7
|
UTSW |
14 |
102,157,929 (GRCm39) |
missense |
unknown |
|
|
X0066:Lmo7
|
UTSW |
14 |
102,124,897 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0067:Lmo7
|
UTSW |
14 |
102,124,369 (GRCm39) |
splice site |
probably null |
|
|
Z1176:Lmo7
|
UTSW |
14 |
102,156,717 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Lmo7
|
UTSW |
14 |
102,121,742 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1176:Lmo7
|
UTSW |
14 |
102,166,664 (GRCm39) |
missense |
unknown |
|
|
Z1176:Lmo7
|
UTSW |
14 |
102,156,879 (GRCm39) |
missense |
unknown |
|
|
Z1177:Lmo7
|
UTSW |
14 |
102,135,993 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Lmo7
|
UTSW |
14 |
102,133,954 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGCATAACTCTGTCGTAATGGCAC -3'
(R):5'- TGGTTCCTCGGAAGGCAAAG -3'
Sequencing Primer
(F):5'- ACATTTCTCTTTGCCCAGGGAATC -3'
(R):5'- CCTCGGAAGGCAAAGGGGTC -3'
|
| Posted On |
2014-09-17 |
Incidental Mutation