Mutagenetix > Incidental Mutation

Incidental Mutation 'R2063:Nlrp1b'

228873

Institutional Source

Beutler Lab

Gene Symbol

Nlrp1b

Ensembl Gene

ENSMUSG00000070390

Gene Name

NLR family, pyrin domain containing 1B

Synonyms

Nalp1b

MMRRC Submission

040068-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.065) question?

Stock #

R2063 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

71043928-71121559 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 71051912 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Aspartic acid at position 1012 (N1012D)

Ref Sequence

ENSEMBL: ENSMUSP00000104155 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094046] [ENSMUST00000108514] [ENSMUST00000108515] [ENSMUST00000108516] [ENSMUST00000136493]

AlphaFold

A1Z198

Predicted Effect

probably benign
Transcript: ENSMUST00000094046
AA Change: N1009D

PolyPhen 2 Score 0.044 (Sensitivity: 0.94; Specificity: 0.83)

SMART Domains

Protein: ENSMUSP00000091588
Gene: ENSMUSG00000070390
AA Change: N1009D

Domain	Start	End	E-Value	Type
Pfam:NACHT	131	300	6.7e-43	PFAM
LRR	627	654	2.24e0	SMART
LRR	656	683	8.82e0	SMART
LRR	684	711	3.49e-5	SMART
Pfam:FIIND	812	1064	8.2e-104	PFAM
Pfam:CARD	1083	1166	3.1e-22	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000108514
AA Change: N1012D

PolyPhen 2 Score 0.086 (Sensitivity: 0.93; Specificity: 0.85)

SMART Domains

Protein: ENSMUSP00000104154
Gene: ENSMUSG00000070390
AA Change: N1012D

Domain	Start	End	E-Value	Type
Pfam:NACHT	131	300	2.1e-40	PFAM
LRR	630	657	2.24e0	SMART
LRR	659	686	8.82e0	SMART
LRR	687	714	3.49e-5	SMART
Pfam:FIIND	814	1068	2.4e-136	PFAM
Pfam:CARD	1086	1169	3.7e-22	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000108515
AA Change: N1012D

PolyPhen 2 Score 0.086 (Sensitivity: 0.93; Specificity: 0.85)

SMART Domains

Protein: ENSMUSP00000104155
Gene: ENSMUSG00000070390
AA Change: N1012D

Domain	Start	End	E-Value	Type
Pfam:NACHT	131	300	6.9e-41	PFAM
LRR	630	657	2.24e0	SMART
LRR	659	686	8.82e0	SMART
LRR	687	714	3.49e-5	SMART
Pfam:FIIND	815	1067	5e-104	PFAM
Pfam:CARD	1086	1169	1e-22	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000108516
AA Change: N1009D

PolyPhen 2 Score 0.044 (Sensitivity: 0.94; Specificity: 0.83)

SMART Domains

Protein: ENSMUSP00000104156
Gene: ENSMUSG00000070390
AA Change: N1009D

Domain	Start	End	E-Value	Type
Pfam:NACHT	131	300	2.2e-42	PFAM
LRR	627	654	2.24e0	SMART
LRR	656	683	8.82e0	SMART
LRR	684	711	3.49e-5	SMART
Pfam:FIIND	811	1065	3.9e-136	PFAM
Pfam:CARD	1083	1166	1.1e-21	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000136493

SMART Domains

Protein: ENSMUSP00000121155
Gene: ENSMUSG00000070390

Domain	Start	End	E-Value	Type
Pfam:NACHT	131	300	8.9e-43	PFAM
PDB:4IM6\|A	610	662	6e-10	PDB
Blast:LRR	627	654	3e-11	BLAST

Coding Region Coverage

1x: 99.2%
3x: 98.7%
10x: 97.4%
20x: 95.5%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit protection from anthrax lethal toxin-induced lung injury and pyroptosis of macrophages. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 89 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4933436I01Rik	T	A	X: 66,964,308 (GRCm39)	I184L	probably benign	Het
9530002B09Rik	T	A	4: 122,583,115 (GRCm39)		probably benign	Het
Abca15	A	T	7: 119,960,127 (GRCm39)	T637S	possibly damaging	Het
Adgrv1	T	C	13: 81,709,588 (GRCm39)	K1135R	possibly damaging	Het
Afap1l1	A	T	18: 61,872,193 (GRCm39)		probably null	Het
AI467606	A	G	7: 126,692,009 (GRCm39)	S195G	probably damaging	Het
Alox12e	G	A	11: 70,206,828 (GRCm39)	R620W	probably damaging	Het
Ascc2	A	T	11: 4,631,496 (GRCm39)	M646L	probably benign	Het
Ccnt1	A	T	15: 98,449,823 (GRCm39)	H156Q	probably benign	Het
Cic	T	A	7: 24,972,876 (GRCm39)	V869E	probably damaging	Het
Cpsf2	A	G	12: 101,949,722 (GRCm39)	D118G	probably damaging	Het
Csnk1g1	A	G	9: 65,909,512 (GRCm39)	S210G	probably damaging	Het
Cyp2c40	T	A	19: 39,775,224 (GRCm39)	M343L	probably benign	Het
Cyp4a12b	A	T	4: 115,290,700 (GRCm39)	D274V	possibly damaging	Het
Dnaaf3	T	C	7: 4,526,798 (GRCm39)	I426M	possibly damaging	Het
Dnah3	C	T	7: 119,551,132 (GRCm39)	M3062I	probably damaging	Het
Dtx2	C	T	5: 136,059,431 (GRCm39)	S493F	probably damaging	Het
Elavl2	A	T	4: 91,141,687 (GRCm39)	S278R	possibly damaging	Het
Emilin2	T	C	17: 71,581,950 (GRCm39)	S259G	probably benign	Het
Endov	T	C	11: 119,390,408 (GRCm39)	F12S	probably damaging	Het
Faim2	G	A	15: 99,412,314 (GRCm39)	T140I	probably damaging	Het
Fbxo21	T	C	5: 118,115,031 (GRCm39)	S56P	probably benign	Het
Fgb	C	A	3: 82,956,996 (GRCm39)	D25Y	probably benign	Het
Foxj2	A	T	6: 122,817,200 (GRCm39)	H509L	probably benign	Het
Fth1	T	A	19: 9,961,576 (GRCm39)	L49Q	probably damaging	Het
Gbp11	C	A	5: 105,476,450 (GRCm39)	E220*	probably null	Het
Gm12695	T	C	4: 96,657,963 (GRCm39)	T69A	probably benign	Het
Gm1527	C	A	3: 28,980,796 (GRCm39)	T632N	probably benign	Het
Gm4787	A	T	12: 81,425,694 (GRCm39)	S155T	probably benign	Het
Gtf2f2	A	G	14: 76,155,136 (GRCm39)	S142P	possibly damaging	Het
Helb	T	C	10: 119,941,671 (GRCm39)	Y339C	probably benign	Het
Hs3st4	A	G	7: 123,996,236 (GRCm39)	I301V	probably benign	Het
Hunk	A	G	16: 90,290,368 (GRCm39)	D382G	probably damaging	Het
Ifnb1	T	A	4: 88,440,996 (GRCm39)	I6F	possibly damaging	Het
Il10	T	C	1: 130,947,770 (GRCm39)	L41P	probably damaging	Het
Il2rg	A	G	X: 100,311,416 (GRCm39)	L57P	possibly damaging	Het
Invs	T	A	4: 48,396,287 (GRCm39)	L320Q	probably damaging	Het
Itpr3	G	A	17: 27,317,050 (GRCm39)	M768I	probably benign	Het
Krt90	T	C	15: 101,466,794 (GRCm39)	E263G	probably benign	Het
Lama2	C	T	10: 27,040,922 (GRCm39)	C1467Y	probably damaging	Het
Maco1	A	T	4: 134,555,590 (GRCm39)	N294K	possibly damaging	Het
Med24	A	G	11: 98,606,472 (GRCm39)	L330P	probably damaging	Het
Mrto4	T	C	4: 139,076,334 (GRCm39)	K86E	probably benign	Het
Mtcl1	T	C	17: 66,653,350 (GRCm39)	R1065G	probably damaging	Het
Mtmr14	G	A	6: 113,217,322 (GRCm39)	G38D	probably damaging	Het
Mtus1	T	C	8: 41,535,745 (GRCm39)	E657G	probably damaging	Het
Muc21	T	A	17: 35,932,297 (GRCm39)		probably benign	Het
Myo5c	A	T	9: 75,189,150 (GRCm39)	Q1020L	probably benign	Het
Nav1	C	T	1: 135,376,742 (GRCm39)	R1694Q	probably damaging	Het
Nckap1	T	C	2: 80,400,494 (GRCm39)	K69R	probably damaging	Het
Ntrk2	A	C	13: 59,007,111 (GRCm39)	K238Q	probably damaging	Het
Oas1g	T	C	5: 121,023,946 (GRCm39)	E121G	probably damaging	Het
Or2ab1	A	G	11: 58,488,396 (GRCm39)	N58S	probably damaging	Het
Or52n2b	T	C	7: 104,565,982 (GRCm39)	N174D	probably benign	Het
Pcdh8	A	T	14: 80,005,651 (GRCm39)	S912R	probably damaging	Het
Pfpl	C	T	19: 12,407,237 (GRCm39)	S496L	probably damaging	Het
Phc2	T	C	4: 128,640,929 (GRCm39)	F672S	probably damaging	Het
Pkhd1l1	A	T	15: 44,414,148 (GRCm39)	H2805L	possibly damaging	Het
Pla2g4a	T	C	1: 149,716,427 (GRCm39)	N678S	possibly damaging	Het
Plxnb3	T	A	X: 72,815,357 (GRCm39)	Y1845*	probably null	Het
Polr1a	T	G	6: 71,913,269 (GRCm39)		probably null	Het
Prl3d3	A	C	13: 27,346,304 (GRCm39)	E180D	probably benign	Het
Prl7a2	T	A	13: 27,844,870 (GRCm39)	Y172F	probably damaging	Het
Prpf3	A	T	3: 95,751,551 (GRCm39)	D383E	probably benign	Het
Psmc4	A	T	7: 27,748,322 (GRCm39)	L73H	probably damaging	Het
Rapgef3	C	A	15: 97,664,842 (GRCm39)	G7V	probably damaging	Het
Rasl12	G	A	9: 65,318,106 (GRCm39)	G157R	probably damaging	Het
Rnf38	A	C	4: 44,149,098 (GRCm39)	V83G	probably damaging	Het
Rnls	A	C	19: 33,179,944 (GRCm39)	S51A	probably benign	Het
Siglecf	A	G	7: 43,001,804 (GRCm39)	T205A	possibly damaging	Het
Skint1	T	A	4: 111,882,730 (GRCm39)	V258D	probably benign	Het
Slc12a5	C	T	2: 164,839,067 (GRCm39)	R1072W	probably damaging	Het
Spata13	GTTAGGCT	GT	14: 60,998,320 (GRCm39)		probably benign	Het
Specc1	T	G	11: 62,009,122 (GRCm39)	S293A	probably benign	Het
Speer2	T	G	16: 69,657,385 (GRCm39)	Q86P	probably benign	Het
Tbc1d15	T	C	10: 115,065,078 (GRCm39)	D169G	probably benign	Het
Tbx20	C	A	9: 24,681,067 (GRCm39)	E142*	probably null	Het
Tcp1	T	A	17: 13,139,699 (GRCm39)	L199H	probably damaging	Het
Tex26	A	T	5: 149,363,204 (GRCm39)	R5W	probably damaging	Het
Tg	C	A	15: 66,700,402 (GRCm39)	A120E	probably damaging	Het
Thrap3	T	C	4: 126,069,189 (GRCm39)	Y654C	possibly damaging	Het
Troap	T	C	15: 98,980,344 (GRCm39)	L508P	probably benign	Het
Ubap2	C	T	4: 41,199,872 (GRCm39)	A752T	probably benign	Het
Ush1c	T	C	7: 45,878,905 (GRCm39)	Y74C	probably damaging	Het
Vmn1r55	A	G	7: 5,150,048 (GRCm39)	V125A	possibly damaging	Het
Vmn2r120	T	A	17: 57,831,553 (GRCm39)	H412L	possibly damaging	Het
Vps54	C	T	11: 21,227,955 (GRCm39)	T176I	probably damaging	Het
Wdr95	T	C	5: 149,502,627 (GRCm39)		probably null	Het
Zfp81	T	C	17: 33,554,278 (GRCm39)	T179A	probably benign	Het

Other mutations in Nlrp1b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00161:Nlrp1b	APN	11	71,072,007 (GRCm39)	intron	probably benign
IGL00571:Nlrp1b	APN	11	71,054,799 (GRCm39)	missense	probably null	0.48
IGL01358:Nlrp1b	APN	11	71,072,682 (GRCm39)	missense	possibly damaging	0.91
IGL01937:Nlrp1b	APN	11	71,072,233 (GRCm39)	missense	probably damaging	0.98
IGL01945:Nlrp1b	APN	11	71,072,233 (GRCm39)	missense	probably damaging	0.98
IGL02375:Nlrp1b	APN	11	71,052,506 (GRCm39)	missense	probably damaging	1.00
IGL02552:Nlrp1b	APN	11	71,063,057 (GRCm39)	missense	possibly damaging	0.96
IGL02552:Nlrp1b	APN	11	71,072,878 (GRCm39)	missense	possibly damaging	0.57
IGL02588:Nlrp1b	APN	11	71,073,105 (GRCm39)	nonsense	probably null
IGL02833:Nlrp1b	APN	11	71,051,998 (GRCm39)	missense	probably benign
IGL02955:Nlrp1b	APN	11	71,060,637 (GRCm39)	missense	possibly damaging	0.73
IGL03002:Nlrp1b	APN	11	71,059,685 (GRCm39)	missense	probably benign	0.00
IGL03033:Nlrp1b	APN	11	71,052,665 (GRCm39)	missense	probably benign	0.22
IGL03122:Nlrp1b	APN	11	71,072,659 (GRCm39)	missense	probably benign	0.00
IGL03131:Nlrp1b	APN	11	71,052,741 (GRCm39)	missense	possibly damaging	0.82
androcles	UTSW	11	71,062,901 (GRCm39)	nonsense	probably null
Fangled	UTSW	11	71,062,997 (GRCm39)	missense	possibly damaging	0.94
glitz	UTSW	11	71,072,376 (GRCm39)	missense	possibly damaging	0.89
honeydew	UTSW	11	71,108,710 (GRCm39)	missense	possibly damaging	0.93
Mush	UTSW	11	71,046,905 (GRCm39)	missense	probably damaging	1.00
Thorn	UTSW	11	71,047,126 (GRCm39)	splice site	probably benign
R0001:Nlrp1b	UTSW	11	71,052,585 (GRCm39)	missense	probably damaging	1.00
R0022:Nlrp1b	UTSW	11	71,052,755 (GRCm39)	missense	possibly damaging	0.61
R0022:Nlrp1b	UTSW	11	71,052,755 (GRCm39)	missense	possibly damaging	0.61
R0038:Nlrp1b	UTSW	11	71,062,997 (GRCm39)	missense	possibly damaging	0.94
R0038:Nlrp1b	UTSW	11	71,062,997 (GRCm39)	missense	possibly damaging	0.94
R0164:Nlrp1b	UTSW	11	71,054,925 (GRCm39)	missense	probably damaging	1.00
R0164:Nlrp1b	UTSW	11	71,054,925 (GRCm39)	missense	probably damaging	1.00
R0271:Nlrp1b	UTSW	11	71,052,591 (GRCm39)	missense	possibly damaging	0.51
R0464:Nlrp1b	UTSW	11	71,109,070 (GRCm39)	missense	probably damaging	1.00
R0504:Nlrp1b	UTSW	11	71,073,241 (GRCm39)	missense	probably damaging	0.99
R0605:Nlrp1b	UTSW	11	71,047,005 (GRCm39)	missense	possibly damaging	0.88
R0863:Nlrp1b	UTSW	11	71,072,173 (GRCm39)	missense	probably benign	0.00
R1075:Nlrp1b	UTSW	11	71,072,512 (GRCm39)	missense	probably benign	0.35
R1221:Nlrp1b	UTSW	11	71,072,290 (GRCm39)	missense	probably benign	0.07
R1501:Nlrp1b	UTSW	11	71,046,885 (GRCm39)	missense	probably damaging	1.00
R1654:Nlrp1b	UTSW	11	71,072,124 (GRCm39)	missense	probably damaging	0.99
R1671:Nlrp1b	UTSW	11	71,092,085 (GRCm39)	missense	probably benign	0.45
R1676:Nlrp1b	UTSW	11	71,073,637 (GRCm39)	missense	probably benign	0.13
R1694:Nlrp1b	UTSW	11	71,107,681 (GRCm39)	critical splice donor site	probably null
R1709:Nlrp1b	UTSW	11	71,092,099 (GRCm39)	missense	probably benign	0.11
R1770:Nlrp1b	UTSW	11	71,050,979 (GRCm39)	missense	probably benign	0.22
R1775:Nlrp1b	UTSW	11	71,052,647 (GRCm39)	missense	probably damaging	1.00
R1851:Nlrp1b	UTSW	11	71,073,442 (GRCm39)	missense	possibly damaging	0.96
R1932:Nlrp1b	UTSW	11	71,072,964 (GRCm39)	missense	probably damaging	0.96
R2189:Nlrp1b	UTSW	11	71,060,621 (GRCm39)	missense	probably damaging	1.00
R2223:Nlrp1b	UTSW	11	71,046,815 (GRCm39)	splice site	probably benign
R2284:Nlrp1b	UTSW	11	71,047,110 (GRCm39)	missense	probably benign	0.00
R2434:Nlrp1b	UTSW	11	71,047,552 (GRCm39)	splice site	probably null
R3079:Nlrp1b	UTSW	11	71,108,794 (GRCm39)	missense	probably benign	0.27
R3775:Nlrp1b	UTSW	11	71,047,126 (GRCm39)	splice site	probably benign
R3980:Nlrp1b	UTSW	11	71,072,437 (GRCm39)	missense	possibly damaging	0.56
R4016:Nlrp1b	UTSW	11	71,063,911 (GRCm39)	missense	probably damaging	1.00
R4085:Nlrp1b	UTSW	11	71,052,588 (GRCm39)	missense	probably damaging	0.98
R4542:Nlrp1b	UTSW	11	71,119,151 (GRCm39)	missense	probably damaging	1.00
R4623:Nlrp1b	UTSW	11	71,052,669 (GRCm39)	missense	probably benign	0.00
R4726:Nlrp1b	UTSW	11	71,072,232 (GRCm39)	missense	probably benign	0.10
R4764:Nlrp1b	UTSW	11	71,073,489 (GRCm39)	missense	probably damaging	1.00
R4885:Nlrp1b	UTSW	11	71,108,710 (GRCm39)	missense	possibly damaging	0.93
R4910:Nlrp1b	UTSW	11	71,108,103 (GRCm39)	missense	probably benign	0.09
R4997:Nlrp1b	UTSW	11	71,109,160 (GRCm39)	missense	probably damaging	1.00
R5046:Nlrp1b	UTSW	11	71,050,898 (GRCm39)	missense	possibly damaging	0.95
R5126:Nlrp1b	UTSW	11	71,072,359 (GRCm39)	missense	possibly damaging	0.67
R5369:Nlrp1b	UTSW	11	71,072,625 (GRCm39)	missense	probably benign
R5388:Nlrp1b	UTSW	11	71,062,967 (GRCm39)	missense	probably damaging	1.00
R5445:Nlrp1b	UTSW	11	71,108,701 (GRCm39)	missense	probably benign	0.21
R5546:Nlrp1b	UTSW	11	71,108,102 (GRCm39)	missense	probably benign	0.04
R5567:Nlrp1b	UTSW	11	71,072,229 (GRCm39)	missense	probably benign
R5826:Nlrp1b	UTSW	11	71,072,022 (GRCm39)	missense	probably benign	0.17
R5955:Nlrp1b	UTSW	11	71,108,691 (GRCm39)	missense	probably damaging	1.00
R5995:Nlrp1b	UTSW	11	71,072,572 (GRCm39)	missense	probably damaging	1.00
R6059:Nlrp1b	UTSW	11	71,107,836 (GRCm39)	missense	possibly damaging	0.53
R6170:Nlrp1b	UTSW	11	71,046,905 (GRCm39)	missense	probably damaging	1.00
R6191:Nlrp1b	UTSW	11	71,109,283 (GRCm39)	nonsense	probably null
R6250:Nlrp1b	UTSW	11	71,072,625 (GRCm39)	missense	probably benign	0.11
R6312:Nlrp1b	UTSW	11	71,119,223 (GRCm39)	missense	probably benign	0.38
R6352:Nlrp1b	UTSW	11	71,072,527 (GRCm39)	missense	probably damaging	0.99
R6807:Nlrp1b	UTSW	11	71,108,530 (GRCm39)	missense	probably damaging	1.00
R6854:Nlrp1b	UTSW	11	71,119,259 (GRCm39)	missense	possibly damaging	0.93
R6908:Nlrp1b	UTSW	11	71,108,122 (GRCm39)	missense	probably benign
R6938:Nlrp1b	UTSW	11	71,109,042 (GRCm39)	missense	probably damaging	1.00
R7098:Nlrp1b	UTSW	11	71,109,100 (GRCm39)	missense	possibly damaging	0.89
R7142:Nlrp1b	UTSW	11	71,062,901 (GRCm39)	nonsense	probably null
R7149:Nlrp1b	UTSW	11	71,072,482 (GRCm39)	nonsense	probably null
R7349:Nlrp1b	UTSW	11	71,072,943 (GRCm39)	missense	probably benign	0.36
R7354:Nlrp1b	UTSW	11	71,072,376 (GRCm39)	missense	possibly damaging	0.89
R7750:Nlrp1b	UTSW	11	71,059,665 (GRCm39)	missense	probably benign	0.11
R7913:Nlrp1b	UTSW	11	71,108,537 (GRCm39)	missense	possibly damaging	0.93
R8031:Nlrp1b	UTSW	11	71,107,747 (GRCm39)	missense	probably benign	0.15
R8087:Nlrp1b	UTSW	11	71,062,897 (GRCm39)	missense	probably benign	0.04
R8164:Nlrp1b	UTSW	11	71,119,243 (GRCm39)	missense	possibly damaging	0.78
R8378:Nlrp1b	UTSW	11	71,052,545 (GRCm39)	missense	possibly damaging	0.95
R8405:Nlrp1b	UTSW	11	71,073,356 (GRCm39)	missense	possibly damaging	0.66
R8441:Nlrp1b	UTSW	11	71,073,204 (GRCm39)	missense	probably damaging	1.00
R8792:Nlrp1b	UTSW	11	71,050,919 (GRCm39)	missense	probably benign	0.02
R8898:Nlrp1b	UTSW	11	71,073,288 (GRCm39)	missense	probably damaging	1.00
R8953:Nlrp1b	UTSW	11	71,052,632 (GRCm39)	missense	probably damaging	0.96
R8963:Nlrp1b	UTSW	11	71,108,658 (GRCm39)	missense	probably damaging	1.00
R9145:Nlrp1b	UTSW	11	71,109,193 (GRCm39)	missense	probably benign
R9184:Nlrp1b	UTSW	11	71,072,067 (GRCm39)	missense	probably damaging	1.00
R9286:Nlrp1b	UTSW	11	71,060,573 (GRCm39)	missense	probably benign
R9322:Nlrp1b	UTSW	11	71,108,118 (GRCm39)	missense	probably benign	0.12
R9453:Nlrp1b	UTSW	11	71,072,913 (GRCm39)	missense	probably damaging	0.98
R9533:Nlrp1b	UTSW	11	71,109,095 (GRCm39)	missense	probably benign	0.12
R9659:Nlrp1b	UTSW	11	71,073,132 (GRCm39)	missense	possibly damaging	0.77
Z1176:Nlrp1b	UTSW	11	71,073,096 (GRCm39)	missense	probably damaging	1.00
Z1177:Nlrp1b	UTSW	11	71,108,050 (GRCm39)	missense	probably benign	0.03
Z1177:Nlrp1b	UTSW	11	71,072,125 (GRCm39)	nonsense	probably null
Z1186:Nlrp1b	UTSW	11	71,073,370 (GRCm39)	missense	probably benign	0.00
Z1186:Nlrp1b	UTSW	11	71,073,280 (GRCm39)	missense	probably benign	0.00
Z1186:Nlrp1b	UTSW	11	71,073,266 (GRCm39)	missense	probably benign
Z1186:Nlrp1b	UTSW	11	71,073,148 (GRCm39)	missense	probably benign
Z1186:Nlrp1b	UTSW	11	71,073,135 (GRCm39)	missense	probably benign
Z1186:Nlrp1b	UTSW	11	71,072,625 (GRCm39)	missense	probably benign
Z1186:Nlrp1b	UTSW	11	71,072,539 (GRCm39)	missense	probably benign
Z1186:Nlrp1b	UTSW	11	71,072,534 (GRCm39)	missense	probably benign	0.02
Z1186:Nlrp1b	UTSW	11	71,073,503 (GRCm39)	missense	probably benign
Z1186:Nlrp1b	UTSW	11	71,073,396 (GRCm39)	missense	probably benign	0.02
Z1186:Nlrp1b	UTSW	11	71,073,378 (GRCm39)	missense	probably benign
Z1187:Nlrp1b	UTSW	11	71,073,370 (GRCm39)	missense	probably benign	0.00
Z1187:Nlrp1b	UTSW	11	71,073,280 (GRCm39)	missense	probably benign	0.00
Z1187:Nlrp1b	UTSW	11	71,073,266 (GRCm39)	missense	probably benign
Z1187:Nlrp1b	UTSW	11	71,073,148 (GRCm39)	missense	probably benign
Z1187:Nlrp1b	UTSW	11	71,072,625 (GRCm39)	missense	probably benign
Z1187:Nlrp1b	UTSW	11	71,072,539 (GRCm39)	missense	probably benign
Z1187:Nlrp1b	UTSW	11	71,072,534 (GRCm39)	missense	probably benign	0.02
Z1187:Nlrp1b	UTSW	11	71,073,503 (GRCm39)	missense	probably benign
Z1187:Nlrp1b	UTSW	11	71,073,396 (GRCm39)	missense	probably benign	0.02
Z1187:Nlrp1b	UTSW	11	71,073,378 (GRCm39)	missense	probably benign
Z1188:Nlrp1b	UTSW	11	71,073,378 (GRCm39)	missense	probably benign
Z1188:Nlrp1b	UTSW	11	71,073,396 (GRCm39)	missense	probably benign	0.02
Z1188:Nlrp1b	UTSW	11	71,073,503 (GRCm39)	missense	probably benign
Z1188:Nlrp1b	UTSW	11	71,072,534 (GRCm39)	missense	probably benign	0.02
Z1188:Nlrp1b	UTSW	11	71,072,539 (GRCm39)	missense	probably benign
Z1188:Nlrp1b	UTSW	11	71,072,625 (GRCm39)	missense	probably benign
Z1188:Nlrp1b	UTSW	11	71,073,135 (GRCm39)	missense	probably benign
Z1188:Nlrp1b	UTSW	11	71,073,148 (GRCm39)	missense	probably benign
Z1188:Nlrp1b	UTSW	11	71,073,266 (GRCm39)	missense	probably benign
Z1188:Nlrp1b	UTSW	11	71,073,280 (GRCm39)	missense	probably benign	0.00
Z1188:Nlrp1b	UTSW	11	71,073,370 (GRCm39)	missense	probably benign	0.00
Z1189:Nlrp1b	UTSW	11	71,073,370 (GRCm39)	missense	probably benign	0.00
Z1189:Nlrp1b	UTSW	11	71,073,280 (GRCm39)	missense	probably benign	0.00
Z1189:Nlrp1b	UTSW	11	71,073,266 (GRCm39)	missense	probably benign
Z1189:Nlrp1b	UTSW	11	71,073,148 (GRCm39)	missense	probably benign
Z1189:Nlrp1b	UTSW	11	71,073,135 (GRCm39)	missense	probably benign
Z1189:Nlrp1b	UTSW	11	71,072,625 (GRCm39)	missense	probably benign
Z1189:Nlrp1b	UTSW	11	71,072,539 (GRCm39)	missense	probably benign
Z1189:Nlrp1b	UTSW	11	71,072,534 (GRCm39)	missense	probably benign	0.02
Z1189:Nlrp1b	UTSW	11	71,073,503 (GRCm39)	missense	probably benign
Z1189:Nlrp1b	UTSW	11	71,073,396 (GRCm39)	missense	probably benign	0.02
Z1189:Nlrp1b	UTSW	11	71,073,378 (GRCm39)	missense	probably benign
Z1190:Nlrp1b	UTSW	11	71,073,370 (GRCm39)	missense	probably benign	0.00
Z1190:Nlrp1b	UTSW	11	71,073,378 (GRCm39)	missense	probably benign
Z1190:Nlrp1b	UTSW	11	71,073,396 (GRCm39)	missense	probably benign	0.02
Z1190:Nlrp1b	UTSW	11	71,073,503 (GRCm39)	missense	probably benign
Z1190:Nlrp1b	UTSW	11	71,072,534 (GRCm39)	missense	probably benign	0.02
Z1190:Nlrp1b	UTSW	11	71,072,539 (GRCm39)	missense	probably benign
Z1190:Nlrp1b	UTSW	11	71,072,625 (GRCm39)	missense	probably benign
Z1190:Nlrp1b	UTSW	11	71,073,135 (GRCm39)	missense	probably benign
Z1190:Nlrp1b	UTSW	11	71,073,148 (GRCm39)	missense	probably benign
Z1190:Nlrp1b	UTSW	11	71,073,266 (GRCm39)	missense	probably benign
Z1190:Nlrp1b	UTSW	11	71,073,280 (GRCm39)	missense	probably benign	0.00
Z1191:Nlrp1b	UTSW	11	71,073,280 (GRCm39)	missense	probably benign	0.00
Z1191:Nlrp1b	UTSW	11	71,073,266 (GRCm39)	missense	probably benign
Z1191:Nlrp1b	UTSW	11	71,073,148 (GRCm39)	missense	probably benign
Z1191:Nlrp1b	UTSW	11	71,073,135 (GRCm39)	missense	probably benign
Z1191:Nlrp1b	UTSW	11	71,072,625 (GRCm39)	missense	probably benign
Z1191:Nlrp1b	UTSW	11	71,072,539 (GRCm39)	missense	probably benign
Z1191:Nlrp1b	UTSW	11	71,072,534 (GRCm39)	missense	probably benign	0.02
Z1191:Nlrp1b	UTSW	11	71,073,503 (GRCm39)	missense	probably benign
Z1191:Nlrp1b	UTSW	11	71,073,396 (GRCm39)	missense	probably benign	0.02
Z1191:Nlrp1b	UTSW	11	71,073,378 (GRCm39)	missense	probably benign
Z1191:Nlrp1b	UTSW	11	71,073,370 (GRCm39)	missense	probably benign	0.00
Z1192:Nlrp1b	UTSW	11	71,073,396 (GRCm39)	missense	probably benign	0.02
Z1192:Nlrp1b	UTSW	11	71,073,378 (GRCm39)	missense	probably benign
Z1192:Nlrp1b	UTSW	11	71,073,370 (GRCm39)	missense	probably benign	0.00
Z1192:Nlrp1b	UTSW	11	71,073,280 (GRCm39)	missense	probably benign	0.00
Z1192:Nlrp1b	UTSW	11	71,073,266 (GRCm39)	missense	probably benign
Z1192:Nlrp1b	UTSW	11	71,073,148 (GRCm39)	missense	probably benign
Z1192:Nlrp1b	UTSW	11	71,072,625 (GRCm39)	missense	probably benign
Z1192:Nlrp1b	UTSW	11	71,072,534 (GRCm39)	missense	probably benign	0.02
Z1192:Nlrp1b	UTSW	11	71,073,503 (GRCm39)	missense	probably benign

Predicted Primers

PCR Primer
(F):5'- GCTGTGTGCTTCCTTAAAACTC -3'
(R):5'- AGGAGATGTCACCACCCTATC -3'

Sequencing Primer
(F):5'- GTGCTTCCTTAAAACTCTACCTAAC -3'
(R):5'- AATCAACCACCTTGCCTCATTTAG -3'

Posted On

2014-09-17