Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00229:Ddx25'

2291

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ddx25

Ensembl Gene

ENSMUSG00000032101

Gene Name

DEAD box helicase 25

Synonyms

DEAD (Asp-Glu-Ala-Asp) box polypeptide 25, GRTH

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.330) question?

Stock #

IGL00229

Quality Score

Status

Chromosome

Chromosomal Location

35453144-35469766 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to C at 35454891 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000034612 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000034612]

AlphaFold

Q9QY15

Predicted Effect

probably benign
Transcript: ENSMUST00000034612

SMART Domains

Protein: ENSMUSP00000034612
Gene: ENSMUSG00000032101

Domain	Start	End	E-Value	Type
low complexity region	50	61	N/A	INTRINSIC
low complexity region	101	111	N/A	INTRINSIC
DEXDc	117	316	1.26e-41	SMART
HELICc	353	440	6.18e-27	SMART

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The encoded protein is a gonadotropin-regulated and developmentally expressed testicular RNA helicase. It may serve to maintain testicular functions related to steroidogenesis and spermatogenesis. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mice display male infertility, arrest of spermatogenesis at step 8, abnormal Leydig cells, and increased germ cell apoptosis in males. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 68 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca4	A	G	3: 121,964,603 (GRCm39)	T929A	probably damaging	Het
Adam6b	G	A	12: 113,455,013 (GRCm39)	R610H	probably damaging	Het
Adamts12	T	A	15: 11,311,685 (GRCm39)	M1314K	probably benign	Het
Alg6	T	A	4: 99,641,291 (GRCm39)	F152I	probably damaging	Het
Aopep	A	G	13: 63,347,314 (GRCm39)		probably benign	Het
Arid5b	A	G	10: 67,964,805 (GRCm39)	S289P	probably damaging	Het
Axin1	T	C	17: 26,413,046 (GRCm39)	F780L	probably damaging	Het
C9	C	T	15: 6,512,712 (GRCm39)	S278L	possibly damaging	Het
Calr4	A	T	4: 109,101,312 (GRCm39)	I65F	probably damaging	Het
Cdh23	A	G	10: 60,359,327 (GRCm39)	V260A	probably benign	Het
Dppa4	A	G	16: 48,111,446 (GRCm39)	T92A	possibly damaging	Het
Ercc5	T	C	1: 44,203,058 (GRCm39)	Y232H	probably damaging	Het
Exoc4	A	G	6: 33,895,334 (GRCm39)		probably null	Het
Fam149a	A	G	8: 45,804,823 (GRCm39)	V253A	probably damaging	Het
Fam209	C	T	2: 172,316,102 (GRCm39)	T159I	probably damaging	Het
Gcfc2	A	T	6: 81,912,996 (GRCm39)	N265I	probably damaging	Het
Glud1	T	C	14: 34,058,087 (GRCm39)	V366A	probably benign	Het
Hdac10	T	C	15: 89,012,645 (GRCm39)	T3A	probably damaging	Het
Ifnar1	T	C	16: 91,286,670 (GRCm39)	S54P	probably damaging	Het
Itpr2	T	C	6: 146,045,683 (GRCm39)	Y2561C	probably damaging	Het
Klhl30	A	G	1: 91,281,879 (GRCm39)	E160G	possibly damaging	Het
Kmt2d	A	T	15: 98,760,214 (GRCm39)	S1015T	unknown	Het
Lactb2	A	G	1: 13,730,598 (GRCm39)	M26T	probably damaging	Het
Lactbl1	A	T	4: 136,358,362 (GRCm39)	D111V	probably damaging	Het
Lig4	T	C	8: 10,022,775 (GRCm39)	Y335C	probably damaging	Het
Lrrc8e	T	A	8: 4,285,921 (GRCm39)	D715E	probably benign	Het
Med6	A	T	12: 81,626,348 (GRCm39)	V142D	possibly damaging	Het
Men1	G	A	19: 6,387,237 (GRCm39)		probably null	Het
Mettl13	A	G	1: 162,363,434 (GRCm39)	V600A	possibly damaging	Het
Mpdz	A	T	4: 81,228,461 (GRCm39)	C1314*	probably null	Het
Nbeal2	A	G	9: 110,464,937 (GRCm39)	V1009A	probably damaging	Het
Nmur2	A	G	11: 55,931,603 (GRCm39)	L36P	probably damaging	Het
Nudt2	T	A	4: 41,480,474 (GRCm39)	L119Q	probably damaging	Het
Or5b117	T	C	19: 13,431,204 (GRCm39)	M226V	possibly damaging	Het
Osbpl3	C	T	6: 50,300,048 (GRCm39)	E519K	probably damaging	Het
Pak6	A	T	2: 118,520,326 (GRCm39)	T106S	possibly damaging	Het
Pggt1b	T	G	18: 46,413,786 (GRCm39)	Q34P	probably benign	Het
Phactr4	T	C	4: 132,098,303 (GRCm39)	T322A	possibly damaging	Het
Plekhj1	T	C	10: 80,632,436 (GRCm39)		probably null	Het
Pnpt1	T	C	11: 29,104,217 (GRCm39)		probably null	Het
Pramel32	A	G	4: 88,547,290 (GRCm39)	I214T	probably damaging	Het
Prr14l	T	C	5: 32,988,020 (GRCm39)	I492V	probably benign	Het
Ranbp2	C	A	10: 58,313,078 (GRCm39)	A1266E	probably damaging	Het
Riok3	G	A	18: 12,270,077 (GRCm39)	D140N	probably damaging	Het
Rsph4a	G	A	10: 33,790,339 (GRCm39)	E643K	probably damaging	Het
Scara3	T	G	14: 66,170,570 (GRCm39)	E103A	probably benign	Het
Sgk3	T	C	1: 9,938,609 (GRCm39)	V33A	probably damaging	Het
Slc38a4	A	G	15: 96,897,375 (GRCm39)	F480S	probably damaging	Het
Slc44a1	G	A	4: 53,543,571 (GRCm39)	V372M	probably damaging	Het
Slc9a2	A	G	1: 40,806,897 (GRCm39)	Y728C	probably benign	Het
Sox4	C	A	13: 29,136,956 (GRCm39)	G17W	probably damaging	Het
Spidr	A	T	16: 15,713,442 (GRCm39)	L847Q	probably damaging	Het
Sptb	A	G	12: 76,667,527 (GRCm39)	S857P	probably benign	Het
Syde1	A	G	10: 78,421,643 (GRCm39)	V636A	probably damaging	Het
Syna	A	G	5: 134,588,571 (GRCm39)	L126P	possibly damaging	Het
Taar2	A	G	10: 23,817,266 (GRCm39)	T269A	possibly damaging	Het
Tapbp	C	T	17: 34,144,678 (GRCm39)	T258I	probably damaging	Het
Tcf20	T	A	15: 82,741,343 (GRCm39)	Q36L	possibly damaging	Het
Tmem131l	A	T	3: 83,849,807 (GRCm39)	M260K	probably damaging	Het
Tnc	T	A	4: 63,935,061 (GRCm39)		probably benign	Het
Ugp2	T	A	11: 21,304,345 (GRCm39)	E27D	probably benign	Het
Vps35l	T	A	7: 118,403,414 (GRCm39)		probably benign	Het
Wdr27	A	T	17: 15,148,572 (GRCm39)	C140*	probably null	Het
Wnt2b	T	C	3: 104,860,449 (GRCm39)	T153A	possibly damaging	Het
Xirp2	A	T	2: 67,343,719 (GRCm39)	T1987S	probably benign	Het
Zfp36l1	C	A	12: 80,157,238 (GRCm39)	G48C	probably damaging	Het
Zfp474	A	T	18: 52,771,565 (GRCm39)	I73F	possibly damaging	Het
Zfp790	T	A	7: 29,527,988 (GRCm39)	F224L	probably benign	Het

Other mutations in Ddx25

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00951:Ddx25	APN	9	35,464,131 (GRCm39)	critical splice donor site	probably null
IGL02237:Ddx25	APN	9	35,453,365 (GRCm39)	splice site	probably benign
IGL02270:Ddx25	APN	9	35,465,708 (GRCm39)	splice site	probably benign
IGL02273:Ddx25	APN	9	35,458,122 (GRCm39)	missense	possibly damaging	0.95
IGL02325:Ddx25	APN	9	35,465,804 (GRCm39)	unclassified	probably benign
IGL02422:Ddx25	APN	9	35,462,660 (GRCm39)	missense	probably null	1.00
IGL02440:Ddx25	APN	9	35,468,974 (GRCm39)	unclassified	probably benign
IGL02798:Ddx25	APN	9	35,462,693 (GRCm39)	missense	probably damaging	1.00
IGL03339:Ddx25	APN	9	35,453,299 (GRCm39)	missense	probably damaging	1.00
R0633:Ddx25	UTSW	9	35,457,268 (GRCm39)	missense	probably damaging	0.99
R0893:Ddx25	UTSW	9	35,465,686 (GRCm39)	nonsense	probably null
R1171:Ddx25	UTSW	9	35,458,142 (GRCm39)	nonsense	probably null
R1448:Ddx25	UTSW	9	35,469,034 (GRCm39)	missense	probably benign
R1453:Ddx25	UTSW	9	35,453,298 (GRCm39)	missense	probably damaging	1.00
R1582:Ddx25	UTSW	9	35,457,272 (GRCm39)	missense	probably damaging	0.97
R3055:Ddx25	UTSW	9	35,462,647 (GRCm39)	missense	probably damaging	1.00
R5960:Ddx25	UTSW	9	35,465,807 (GRCm39)	splice site	probably null
R7425:Ddx25	UTSW	9	35,465,882 (GRCm39)	missense	probably benign	0.08
R7535:Ddx25	UTSW	9	35,454,951 (GRCm39)	missense	possibly damaging	0.89
R7610:Ddx25	UTSW	9	35,465,893 (GRCm39)	missense	possibly damaging	0.90
R8758:Ddx25	UTSW	9	35,453,300 (GRCm39)	missense	probably benign
R8931:Ddx25	UTSW	9	35,465,864 (GRCm39)	missense	possibly damaging	0.85
R8984:Ddx25	UTSW	9	35,468,685 (GRCm39)	missense	probably benign
R9103:Ddx25	UTSW	9	35,458,085 (GRCm39)	missense	probably benign	0.24
R9585:Ddx25	UTSW	9	35,455,009 (GRCm39)	nonsense	probably null
R9759:Ddx25	UTSW	9	35,457,265 (GRCm39)	missense	probably benign	0.00

Posted On

2011-12-09