Mutagenetix > Incidental Mutations

Incidental Mutation 'R0157:Taar2'

22924

Institutional Source

Beutler Lab

Gene Symbol

Taar2

Ensembl Gene

ENSMUSG00000059763

Gene Name

trace amine-associated receptor 2

Synonyms

Gpr58

MMRRC Submission

038437-MU

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

R0157 (G1)

Quality Score

216

Status

Not validated

Chromosome

Chromosomal Location

23938572-23941583 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 23941491 bp

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Isoleucine at position 310 (F310I)

Ref Sequence

ENSEMBL: ENSMUSP00000078137 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000079134]

Predicted Effect

probably damaging
Transcript: ENSMUST00000079134
AA Change: F310I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000078137
Gene: ENSMUSG00000059763
AA Change: F310I

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srsx	42	318	2.4e-10	PFAM
Pfam:7tm_1	48	303	2.9e-54	PFAM

Coding Region Coverage

1x: 98.9%
3x: 97.9%
10x: 95.0%
20x: 88.5%

Validation Efficiency

64% (47/73)

Allele List at MGI

Other mutations in this stock

Total: 71 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adap2	T	A	11: 80,165,701	I180N	probably damaging	Het
Alk	T	A	17: 71,949,845	N673I	probably benign	Het
Ankrd7	T	C	6: 18,866,540	S20P	probably damaging	Het
Arhgef26	T	G	3: 62,380,971	D487E	probably damaging	Het
Arhgef4	A	G	1: 34,806,394	D1500G	probably damaging	Het
Arhgef7	A	G	8: 11,785,812	I39V	probably damaging	Het
Asap2	T	A	12: 21,206,325	I208N	probably damaging	Het
Atad5	T	C	11: 80,089,817	V16A	possibly damaging	Het
Atp2b1	T	C	10: 98,999,947	I518T	probably damaging	Het
B130006D01Rik	T	C	11: 95,726,385		probably benign	Het
BC028528	A	G	3: 95,884,968		probably null	Het
Bpifb6	T	A	2: 153,903,966	L74Q	probably benign	Het
Bptf	T	C	11: 107,074,658	T1122A	possibly damaging	Het
Cacna2d4	T	A	6: 119,312,424	D806E	probably benign	Het
Cdhr3	T	C	12: 33,061,650	Q287R	possibly damaging	Het
Cdk12	A	G	11: 98,249,776		probably benign	Het
Cenpf	T	A	1: 189,652,359	T2575S	probably benign	Het
Chd7	T	A	4: 8,833,759	I1171N	probably damaging	Het
Chd9	T	C	8: 91,008,836		probably null	Het
Ckmt1	A	G	2: 121,363,041	T361A	possibly damaging	Het
Clec4d	G	T	6: 123,267,136	R68L	probably benign	Het
Csmd2	G	T	4: 128,521,911	V2678F	probably benign	Het
Cul7	T	A	17: 46,653,835	V131E	possibly damaging	Het
Dab2	T	C	15: 6,429,827	S407P	probably benign	Het
Dnah17	C	T	11: 118,127,171	G166D	probably benign	Het
F13b	G	A	1: 139,503,847	V52I	probably benign	Het
Fam208b	C	A	13: 3,575,550	V1467L	probably benign	Het
Gjd4	T	C	18: 9,280,549	I176M	probably benign	Het
Gm13083	C	T	4: 143,615,796	P158S	probably damaging	Het
Gm4969	T	C	7: 19,107,020	H63R	possibly damaging	Het
Hoxc11	A	G	15: 102,955,001	Y159C	probably damaging	Het
Hydin	T	C	8: 110,300,010	I120T	possibly damaging	Het
Il20rb	A	G	9: 100,473,079	Y104H	probably damaging	Het
Krtap21-1	A	G	16: 89,403,542	C71R	unknown	Het
Lamc1	T	C	1: 153,262,607	D167G	probably benign	Het
Lin7c	C	A	2: 109,895,169	A73E	probably damaging	Het
Mms22l	C	A	4: 24,588,224	A952E	probably damaging	Het
Myh3	A	G	11: 67,082,909	N136S	probably benign	Het
Ndufb10	T	C	17: 24,724,244	T31A	probably benign	Het
Nlrp2	T	C	7: 5,308,770	Y37C	possibly damaging	Het
Olfr1384	T	C	11: 49,513,773	I45T	probably damaging	Het
Olfr314	T	C	11: 58,787,059	F275S	probably damaging	Het
Orc3	C	A	4: 34,607,130		probably null	Het
Pard3b	A	C	1: 62,211,633	M512L	probably damaging	Het
Pcdh10	A	G	3: 45,379,701	D150G	probably damaging	Het
Pcolce	A	T	5: 137,610,479		probably null	Het
Pdcl	A	C	2: 37,352,177	I187S	probably damaging	Het
Pkn1	T	C	8: 83,692,820	I51M	probably damaging	Het
Pla2g4e	T	A	2: 120,170,181	T692S	probably benign	Het
Plcb2	C	A	2: 118,718,541	V380F	probably damaging	Het
Pmpcb	A	T	5: 21,742,952	I218F	probably damaging	Het
Pms1	A	T	1: 53,195,037	Y773*	probably null	Het
Polr2e	C	T	10: 80,036,781	G184R	probably damaging	Het
Polr3a	T	C	14: 24,479,186	I369V	probably damaging	Het
Prpf4b	T	C	13: 34,884,031		probably benign	Het
Pzp	G	A	6: 128,523,976	Q140*	probably null	Het
Qrich2	T	A	11: 116,441,395	E2325V	probably damaging	Het
R3hdm2	T	G	10: 127,471,989	L373R	probably damaging	Het
Sema3d	A	T	5: 12,508,137	D212V	possibly damaging	Het
Sidt2	A	G	9: 45,939,267	I850T	probably damaging	Het
Slc22a29	C	T	19: 8,162,742	R433H	possibly damaging	Het
Slitrk6	A	T	14: 110,749,932	L781H	probably damaging	Het
Sox21	G	A	14: 118,235,942		probably benign	Het
Steap3	A	G	1: 120,227,649	*527R	probably null	Het
Svep1	T	C	4: 58,069,830	E2652G	possibly damaging	Het
Tecta	A	G	9: 42,375,011	V783A	probably benign	Het
Vmn1r173	T	A	7: 23,702,397	I19N	probably damaging	Het
Vwa5b1	T	A	4: 138,604,879	M276L	probably benign	Het
Yeats2	A	C	16: 20,221,677	*142C	probably null	Het
Zfp26	G	T	9: 20,437,870	T466K	probably benign	Het
Zfp426	T	C	9: 20,471,136	N171S	probably benign	Het

Other mutations in Taar2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00229:Taar2	APN	10	23941368	missense	possibly damaging	0.50
IGL00807:Taar2	APN	10	23940675	missense	probably benign	0.00
IGL01346:Taar2	APN	10	23941099	missense	probably damaging	1.00
IGL01433:Taar2	APN	10	23940759	missense	probably benign	0.02
IGL01782:Taar2	APN	10	23941144	missense	probably damaging	1.00
IGL03106:Taar2	APN	10	23941297	missense	probably damaging	0.99
IGL03372:Taar2	APN	10	23941171	missense	probably benign	0.03
R0046:Taar2	UTSW	10	23941495	missense	probably benign	0.00
R0046:Taar2	UTSW	10	23941495	missense	probably benign	0.00
R0090:Taar2	UTSW	10	23941495	missense	probably benign	0.00
R0101:Taar2	UTSW	10	23941495	missense	probably benign	0.00
R0101:Taar2	UTSW	10	23941495	missense	probably benign	0.00
R0103:Taar2	UTSW	10	23941495	missense	probably benign	0.00
R0189:Taar2	UTSW	10	23941495	missense	probably benign	0.00
R0190:Taar2	UTSW	10	23941495	missense	probably benign	0.00
R0226:Taar2	UTSW	10	23941063	missense	probably damaging	1.00
R0226:Taar2	UTSW	10	23941495	missense	probably benign	0.00
R0265:Taar2	UTSW	10	23941495	missense	probably benign	0.00
R0267:Taar2	UTSW	10	23941495	missense	probably benign	0.00
R0349:Taar2	UTSW	10	23941429	missense	possibly damaging	0.79
R0349:Taar2	UTSW	10	23941509	missense	probably benign	0.01
R0426:Taar2	UTSW	10	23941495	missense	probably benign	0.00
R0556:Taar2	UTSW	10	23940895	missense	probably damaging	1.00
R0698:Taar2	UTSW	10	23941495	missense	probably benign	0.00
R1191:Taar2	UTSW	10	23941029	missense	probably damaging	1.00
R2919:Taar2	UTSW	10	23941556	missense	probably benign	0.00
R4615:Taar2	UTSW	10	23941365	missense	probably benign	0.43
R4658:Taar2	UTSW	10	23941503	missense	probably benign	0.04
R4766:Taar2	UTSW	10	23940771	missense	probably damaging	0.98
R4872:Taar2	UTSW	10	23940693	missense	probably benign	0.02
R5205:Taar2	UTSW	10	23940976	missense	probably benign	0.42
R5271:Taar2	UTSW	10	23941032	missense	probably damaging	0.97
R5517:Taar2	UTSW	10	23940729	missense	possibly damaging	0.92
R6033:Taar2	UTSW	10	23940976	missense	probably benign
R6033:Taar2	UTSW	10	23940976	missense	probably benign
R6325:Taar2	UTSW	10	23940717	missense	probably benign	0.05
R6398:Taar2	UTSW	10	23941279	missense	probably benign	0.00
R6762:Taar2	UTSW	10	23941402	missense	probably damaging	0.98
R7121:Taar2	UTSW	10	23940827	missense	probably damaging	1.00
R7209:Taar2	UTSW	10	23940699	missense	possibly damaging	0.57
R7709:Taar2	UTSW	10	23940723	missense	probably benign	0.00
R8045:Taar2	UTSW	10	23941488	missense	probably damaging	1.00
Z1176:Taar2	UTSW	10	23941186	missense	possibly damaging	0.94

Predicted Primers

PCR Primer
(F):5'- GCTCGCGTAATTGACAACTTGCC -3'
(R):5'- TCAGTCTCCTAAGCCCCTTGAAGC -3'

Sequencing Primer
(F):5'- CAGCCAAAACTTTAGGGATAGTG -3'
(R):5'- GCAAATTCATTCTTTGAGTGCCAG -3'

Posted On

2013-04-16