Incidental Mutation 'R2126:Eif2ak4'
ID 229850
Institutional Source Beutler Lab
Gene Symbol Eif2ak4
Ensembl Gene ENSMUSG00000005102
Gene Name eukaryotic translation initiation factor 2 alpha kinase 4
Synonyms GCN2
MMRRC Submission 040129-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R2126 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 118219099-118305715 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 118252604 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Leucine at position 392 (H392L)
Ref Sequence ENSEMBL: ENSMUSP00000106501 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000005233] [ENSMUST00000102527] [ENSMUST00000110870] [ENSMUST00000110872] [ENSMUST00000110874] [ENSMUST00000110877]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000005233
AA Change: H392L

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000005233
Gene: ENSMUSG00000005102
AA Change: H392L

DomainStartEndE-ValueType
low complexity region 2 13 N/A INTRINSIC
RWD 25 137 3.42e-38 SMART
coiled coil region 146 205 N/A INTRINSIC
Pfam:Pkinase 323 538 4.6e-27 PFAM
Pfam:Pkinase_Tyr 326 535 5.5e-18 PFAM
Pfam:Pkinase 589 663 1.7e-11 PFAM
Pfam:Pkinase_Tyr 589 663 1.2e-5 PFAM
low complexity region 728 738 N/A INTRINSIC
Pfam:Pkinase 781 1000 2.6e-38 PFAM
Pfam:Pkinase_Tyr 786 998 1.8e-18 PFAM
Pfam:tRNA-synt_His 1054 1380 5.7e-18 PFAM
Pfam:HGTP_anticodon2 1392 1647 5.8e-17 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000102527
AA Change: H280L

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
SMART Domains Protein: ENSMUSP00000099586
Gene: ENSMUSG00000005102
AA Change: H280L

DomainStartEndE-ValueType
coiled coil region 34 93 N/A INTRINSIC
Pfam:Pkinase 211 426 1.6e-22 PFAM
Pfam:Pkinase_Tyr 215 423 6.8e-18 PFAM
Pfam:Pkinase_Tyr 477 551 1.2e-5 PFAM
Pfam:Pkinase 477 552 3.9e-11 PFAM
low complexity region 616 626 N/A INTRINSIC
Pfam:Pkinase 647 888 9.4e-42 PFAM
Pfam:Pkinase_Tyr 672 886 1.4e-19 PFAM
Pfam:tRNA-synt_His 941 1268 4.8e-19 PFAM
Pfam:HGTP_anticodon2 1280 1535 1e-16 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000110870
AA Change: H114L

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000106494
Gene: ENSMUSG00000005102
AA Change: H114L

DomainStartEndE-ValueType
Pfam:Pkinase 45 260 3.3e-22 PFAM
Pfam:Pkinase_Tyr 47 257 1.3e-17 PFAM
Pfam:Pkinase_Tyr 311 385 2.5e-5 PFAM
Pfam:Pkinase 311 386 8e-11 PFAM
low complexity region 450 460 N/A INTRINSIC
Pfam:Pkinase 481 722 1.9e-41 PFAM
Pfam:Pkinase_Tyr 506 720 2.8e-19 PFAM
Pfam:tRNA-synt_His 775 1102 8.7e-19 PFAM
Pfam:HGTP_anticodon2 1114 1369 1.9e-16 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000110872
AA Change: H271L

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000106496
Gene: ENSMUSG00000005102
AA Change: H271L

DomainStartEndE-ValueType
coiled coil region 25 84 N/A INTRINSIC
Pfam:Pkinase 202 417 3.8e-22 PFAM
Pfam:Pkinase_Tyr 206 414 1.6e-17 PFAM
Pfam:Pkinase_Tyr 468 542 2.8e-5 PFAM
Pfam:Pkinase 468 543 9.1e-11 PFAM
low complexity region 607 617 N/A INTRINSIC
Pfam:Pkinase 638 879 2.2e-41 PFAM
Pfam:Pkinase_Tyr 663 877 3.3e-19 PFAM
Pfam:tRNA-synt_His 932 1259 1.1e-18 PFAM
Pfam:HGTP_anticodon2 1271 1526 2.2e-16 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000110874
AA Change: H314L

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000106498
Gene: ENSMUSG00000005102
AA Change: H314L

DomainStartEndE-ValueType
Pfam:RWD 8 56 6.4e-8 PFAM
coiled coil region 68 127 N/A INTRINSIC
Pfam:Pkinase 245 460 1.1e-22 PFAM
Pfam:Pkinase_Tyr 247 457 4.2e-18 PFAM
Pfam:Pkinase_Tyr 511 585 7.8e-6 PFAM
Pfam:Pkinase 511 586 2.5e-11 PFAM
low complexity region 650 660 N/A INTRINSIC
Pfam:Pkinase 681 922 6.2e-42 PFAM
Pfam:Pkinase_Tyr 706 920 9.3e-20 PFAM
Pfam:tRNA-synt_His 975 1302 3.8e-19 PFAM
Pfam:HGTP_anticodon2 1314 1569 5.4e-17 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000110877
AA Change: H392L

PolyPhen 2 Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000106501
Gene: ENSMUSG00000005102
AA Change: H392L

DomainStartEndE-ValueType
low complexity region 2 13 N/A INTRINSIC
RWD 25 137 3.42e-38 SMART
coiled coil region 146 205 N/A INTRINSIC
Pfam:Pkinase 323 538 2.6e-23 PFAM
Pfam:Pkinase_Tyr 327 535 1.1e-18 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.8%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2. [provided by RefSeq, Mar 2014]
PHENOTYPE: Homozygotes for a null allele have altered feeding behavior, synaptic plasticity and dendritic cell function. Homozygotes for another null allele show enhanced muscle loss and morbidity after amino acid deprivation. Homozygotes for an ENU-induced allele show higher susceptibility to viral infection. [provided by MGI curators]
Allele List at MGI

All alleles(8) : Targeted(3) Gene trapped(4) Chemically induced(1)
 

Other mutations in this stock
Total: 116 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadac A G 3: 59,947,066 (GRCm39) T255A possibly damaging Het
Acat3 C T 17: 13,146,294 (GRCm39) A230T probably benign Het
Acsl1 C A 8: 46,986,663 (GRCm39) P650Q probably benign Het
Adgrl3 T A 5: 81,660,383 (GRCm39) I316N probably damaging Het
Agrp G T 8: 106,293,467 (GRCm39) T106K probably damaging Het
AI429214 T A 8: 37,461,362 (GRCm39) V170E probably benign Het
Akap13 G A 7: 75,375,052 (GRCm39) G1895S possibly damaging Het
Alpk2 G A 18: 65,483,439 (GRCm39) Q190* probably null Het
Aox3 C A 1: 58,197,375 (GRCm39) Q574K probably benign Het
Apeh A G 9: 107,962,866 (GRCm39) Y702H probably damaging Het
Aqp11 A G 7: 97,386,692 (GRCm39) I151T probably benign Het
Arhgap28 A G 17: 68,176,010 (GRCm39) V363A possibly damaging Het
Arhgef18 A G 8: 3,501,939 (GRCm39) N699S probably damaging Het
Asnsd1 A G 1: 53,386,476 (GRCm39) S384P probably benign Het
Atl1 G T 12: 69,978,431 (GRCm39) probably null Het
Atp13a2 A T 4: 140,722,702 (GRCm39) D203V possibly damaging Het
Axdnd1 A T 1: 156,160,784 (GRCm39) N164K probably benign Het
Bnipl T A 3: 95,152,994 (GRCm39) I162F probably damaging Het
Cacna1d A T 14: 29,845,120 (GRCm39) L655I probably damaging Het
Canx T C 11: 50,195,185 (GRCm39) I294M probably damaging Het
Casz1 T C 4: 149,030,521 (GRCm39) F1180S probably damaging Het
Cav3 T C 6: 112,449,344 (GRCm39) Y121H probably benign Het
Cd4 A C 6: 124,847,499 (GRCm39) S222A probably benign Het
Cds1 T C 5: 101,960,416 (GRCm39) I289T probably benign Het
Cep112 T C 11: 108,399,084 (GRCm39) F328L probably damaging Het
Ces4a G A 8: 105,864,729 (GRCm39) G69S probably damaging Het
Cfap44 A T 16: 44,230,838 (GRCm39) D273V probably benign Het
Cfap91 T C 16: 38,162,124 (GRCm39) T6A probably benign Het
Clec7a C T 6: 129,447,918 (GRCm39) G49D probably benign Het
Col22a1 G A 15: 71,729,102 (GRCm39) Q599* probably null Het
Col6a5 T A 9: 105,822,799 (GRCm39) H186L unknown Het
Dclk2 C T 3: 86,712,946 (GRCm39) R503Q possibly damaging Het
Dnah12 A T 14: 26,445,613 (GRCm39) R725* probably null Het
Dnajc10 G A 2: 80,181,078 (GRCm39) probably null Het
Edem3 A T 1: 151,670,482 (GRCm39) H337L possibly damaging Het
Ercc6l2 G A 13: 63,996,585 (GRCm39) V365I probably damaging Het
Fan1 T C 7: 63,996,636 (GRCm39) E978G probably damaging Het
Fcrl6 C T 1: 172,426,815 (GRCm39) V44M probably benign Het
Gaa G A 11: 119,161,108 (GRCm39) W50* probably null Het
Gm10032 T C 14: 67,030,227 (GRCm39) noncoding transcript Het
Gm10985 CTCTAT CT 3: 53,752,670 (GRCm39) probably null Het
Gprc5b G T 7: 118,583,398 (GRCm39) P157Q probably damaging Het
Gsdmc3 G A 15: 63,730,383 (GRCm39) Q394* probably null Het
Gucd1 A G 10: 75,347,922 (GRCm39) S38P probably damaging Het
Higd1a A T 9: 121,679,313 (GRCm39) I58N probably damaging Het
Hmx3 G C 7: 131,146,278 (GRCm39) V329L possibly damaging Het
Hnrnpul2 A T 19: 8,801,802 (GRCm39) R337* probably null Het
Idua T A 5: 108,829,304 (GRCm39) H368Q possibly damaging Het
Ifih1 A G 2: 62,453,811 (GRCm39) V218A probably benign Het
Ip6k1 G A 9: 107,918,195 (GRCm39) E77K possibly damaging Het
Kif1b G A 4: 149,272,097 (GRCm39) S1568L possibly damaging Het
Klhl30 T A 1: 91,286,499 (GRCm39) probably null Het
Lasp1 T A 11: 97,726,960 (GRCm39) D227E probably benign Het
Lhx6 A G 2: 35,981,336 (GRCm39) I85T possibly damaging Het
Limch1 A G 5: 67,187,103 (GRCm39) D840G probably damaging Het
Loxl4 C G 19: 42,592,402 (GRCm39) E385D probably damaging Het
Lrrtm4 A T 6: 79,998,722 (GRCm39) I44F probably damaging Het
Ltbp2 T C 12: 84,832,483 (GRCm39) probably null Het
Lyg1 T C 1: 37,989,755 (GRCm39) Y44C probably damaging Het
Map1a A G 2: 121,129,122 (GRCm39) I129V probably damaging Het
Med27 C T 2: 29,414,442 (GRCm39) Q150* probably null Het
Ms4a5 A T 19: 11,256,732 (GRCm39) I55N probably damaging Het
Muc5ac T C 7: 141,364,479 (GRCm39) S2597P possibly damaging Het
Mxd1 A C 6: 86,628,422 (GRCm39) probably null Het
Myo3a A G 2: 22,468,186 (GRCm39) D480G probably benign Het
Neb T C 2: 52,200,650 (GRCm39) Y343C probably damaging Het
Niban1 A C 1: 151,571,886 (GRCm39) E277A probably damaging Het
Niban1 A G 1: 151,584,884 (GRCm39) I494V possibly damaging Het
Nrn1 A C 13: 36,914,180 (GRCm39) V34G probably damaging Het
Or4k52 A G 2: 111,610,841 (GRCm39) M59V probably damaging Het
Or4n5 A G 14: 50,132,524 (GRCm39) I245T probably benign Het
Or52b1 C T 7: 104,978,459 (GRCm39) W313* probably null Het
Or56a3 A G 7: 104,735,822 (GRCm39) T300A probably damaging Het
Or8b39 G T 9: 37,996,572 (GRCm39) V147L probably benign Het
Or8h9 T C 2: 86,789,442 (GRCm39) Y120C possibly damaging Het
Or8k40 A T 2: 86,584,796 (GRCm39) N95K probably benign Het
Pdia4 A T 6: 47,773,771 (GRCm39) V526E probably damaging Het
Pdia6 T C 12: 17,328,546 (GRCm39) V167A probably damaging Het
Pgk2 A G 17: 40,518,400 (GRCm39) F343L probably damaging Het
Piwil1 T C 5: 128,831,160 (GRCm39) V827A probably damaging Het
Plag1 A T 4: 3,904,169 (GRCm39) Y341N possibly damaging Het
Plch2 T C 4: 155,083,456 (GRCm39) E393G probably damaging Het
Ptprg T A 14: 12,154,355 (GRCm38) M692K probably benign Het
Rassf8 G A 6: 145,760,908 (GRCm39) R78H probably benign Het
Rif1 GCCACCA GCCA 2: 52,000,336 (GRCm39) probably benign Het
Rnf213 A G 11: 119,341,027 (GRCm39) Q3556R probably damaging Het
Rpa2 T C 4: 132,496,099 (GRCm39) probably null Het
Rpe T G 1: 66,755,139 (GRCm39) F174V possibly damaging Het
Sbf2 T C 7: 110,159,502 (GRCm39) D36G probably damaging Het
Scn2a T A 2: 65,582,423 (GRCm39) Y1590* probably null Het
Slc24a4 T C 12: 102,189,018 (GRCm39) V151A probably damaging Het
Slc30a8 A T 15: 52,159,330 (GRCm39) M17L probably benign Het
Slit3 T C 11: 35,579,506 (GRCm39) Y1228H probably damaging Het
Smad4 G A 18: 73,795,815 (GRCm39) T193M probably benign Het
Smtn T A 11: 3,480,045 (GRCm39) H392L probably benign Het
St8sia3 A G 18: 64,402,745 (GRCm39) D128G probably damaging Het
Sucla2 A T 14: 73,830,108 (GRCm39) M382L possibly damaging Het
Tbx5 A G 5: 119,974,988 (GRCm39) T4A probably benign Het
Tdrd5 T C 1: 156,104,143 (GRCm39) R528G probably damaging Het
Tex44 T C 1: 86,354,811 (GRCm39) L240P probably benign Het
Tns4 A T 11: 98,970,904 (GRCm39) probably null Het
Trappc10 A T 10: 78,039,758 (GRCm39) V731E possibly damaging Het
Ttf1 A G 2: 28,961,357 (GRCm39) K582E probably damaging Het
Ttf2 C A 3: 100,855,509 (GRCm39) Q895H possibly damaging Het
Ttll6 A G 11: 96,038,358 (GRCm39) E402G probably damaging Het
Ttn A T 2: 76,720,436 (GRCm39) probably null Het
Ugt8a T C 3: 125,669,195 (GRCm39) D303G probably damaging Het
Ulk1 G T 5: 110,940,302 (GRCm39) A373D probably benign Het
Vmn2r13 A G 5: 109,306,058 (GRCm39) S507P probably benign Het
Vmn2r19 T A 6: 123,293,033 (GRCm39) D358E possibly damaging Het
Vmn2r88 T C 14: 51,651,264 (GRCm39) S201P probably benign Het
Zfp36l2 A G 17: 84,494,403 (GRCm39) F78S probably damaging Het
Zfp454 A C 11: 50,764,822 (GRCm39) S203R probably benign Het
Zfp616 C A 11: 73,976,229 (GRCm39) Q833K probably benign Het
Znhit2 A G 19: 6,112,091 (GRCm39) T279A probably benign Het
Zswim3 T A 2: 164,661,913 (GRCm39) I131N probably benign Het
Other mutations in Eif2ak4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00233:Eif2ak4 APN 2 118,294,536 (GRCm39) missense probably damaging 1.00
IGL00806:Eif2ak4 APN 2 118,271,647 (GRCm39) missense probably benign 0.08
IGL01343:Eif2ak4 APN 2 118,252,570 (GRCm39) missense probably benign 0.00
IGL01796:Eif2ak4 APN 2 118,276,785 (GRCm39) missense probably benign 0.10
IGL02263:Eif2ak4 APN 2 118,292,259 (GRCm39) missense probably benign 0.00
IGL02391:Eif2ak4 APN 2 118,251,272 (GRCm39) missense probably benign 0.19
IGL02516:Eif2ak4 APN 2 118,266,735 (GRCm39) missense probably damaging 1.00
IGL02603:Eif2ak4 APN 2 118,280,807 (GRCm39) missense probably damaging 1.00
IGL02731:Eif2ak4 APN 2 118,219,295 (GRCm39) missense probably benign
IGL02928:Eif2ak4 APN 2 118,303,168 (GRCm39) critical splice donor site probably null
IGL02947:Eif2ak4 APN 2 118,261,514 (GRCm39) missense probably benign 0.00
IGL03191:Eif2ak4 APN 2 118,252,693 (GRCm39) missense probably damaging 1.00
IGL03202:Eif2ak4 APN 2 118,231,101 (GRCm39) missense probably damaging 1.00
IGL03235:Eif2ak4 APN 2 118,273,621 (GRCm39) missense probably damaging 1.00
IGL03375:Eif2ak4 APN 2 118,252,799 (GRCm39) missense probably benign 0.08
absurdum UTSW 2 118,251,291 (GRCm39) nonsense probably null
Ad UTSW 2 118,266,722 (GRCm39) missense probably damaging 1.00
atchoum UTSW 2 118,231,134 (GRCm39) splice site probably benign
reductio UTSW 2 118,266,639 (GRCm39) splice site probably null
PIT4520001:Eif2ak4 UTSW 2 118,292,808 (GRCm39) missense probably damaging 1.00
R0023:Eif2ak4 UTSW 2 118,293,202 (GRCm39) missense probably damaging 1.00
R0358:Eif2ak4 UTSW 2 118,294,410 (GRCm39) splice site probably null
R0482:Eif2ak4 UTSW 2 118,292,828 (GRCm39) missense probably damaging 1.00
R0505:Eif2ak4 UTSW 2 118,261,517 (GRCm39) missense probably benign 0.01
R0523:Eif2ak4 UTSW 2 118,272,577 (GRCm39) critical splice donor site probably null
R0578:Eif2ak4 UTSW 2 118,305,472 (GRCm39) splice site probably benign
R0615:Eif2ak4 UTSW 2 118,266,666 (GRCm39) missense probably damaging 1.00
R1300:Eif2ak4 UTSW 2 118,294,464 (GRCm39) missense possibly damaging 0.79
R1531:Eif2ak4 UTSW 2 118,273,691 (GRCm39) missense probably damaging 1.00
R1777:Eif2ak4 UTSW 2 118,261,320 (GRCm39) missense probably damaging 0.98
R1866:Eif2ak4 UTSW 2 118,303,142 (GRCm39) missense probably damaging 1.00
R1932:Eif2ak4 UTSW 2 118,278,967 (GRCm39) missense probably damaging 1.00
R1977:Eif2ak4 UTSW 2 118,292,238 (GRCm39) nonsense probably null
R2011:Eif2ak4 UTSW 2 118,261,428 (GRCm39) missense probably damaging 1.00
R2046:Eif2ak4 UTSW 2 118,281,889 (GRCm39) splice site probably benign
R2122:Eif2ak4 UTSW 2 118,286,274 (GRCm39) missense probably damaging 1.00
R2125:Eif2ak4 UTSW 2 118,252,604 (GRCm39) missense probably benign 0.02
R2193:Eif2ak4 UTSW 2 118,252,747 (GRCm39) missense probably benign 0.12
R2259:Eif2ak4 UTSW 2 118,286,264 (GRCm39) missense probably damaging 0.97
R2513:Eif2ak4 UTSW 2 118,257,064 (GRCm39) missense probably damaging 1.00
R3798:Eif2ak4 UTSW 2 118,304,564 (GRCm39) missense probably damaging 1.00
R3898:Eif2ak4 UTSW 2 118,261,404 (GRCm39) missense probably damaging 1.00
R3900:Eif2ak4 UTSW 2 118,305,510 (GRCm39) missense probably damaging 1.00
R4375:Eif2ak4 UTSW 2 118,258,405 (GRCm39) missense probably damaging 1.00
R4423:Eif2ak4 UTSW 2 118,269,547 (GRCm39) missense probably benign 0.01
R4589:Eif2ak4 UTSW 2 118,247,819 (GRCm39) missense probably damaging 1.00
R4734:Eif2ak4 UTSW 2 118,252,568 (GRCm39) missense probably damaging 1.00
R5173:Eif2ak4 UTSW 2 118,238,841 (GRCm39) missense probably damaging 1.00
R5367:Eif2ak4 UTSW 2 118,266,639 (GRCm39) splice site probably null
R5471:Eif2ak4 UTSW 2 118,304,613 (GRCm39) missense probably benign 0.02
R5528:Eif2ak4 UTSW 2 118,258,419 (GRCm39) missense probably damaging 1.00
R5634:Eif2ak4 UTSW 2 118,292,792 (GRCm39) missense probably damaging 1.00
R5726:Eif2ak4 UTSW 2 118,273,613 (GRCm39) missense probably damaging 1.00
R5756:Eif2ak4 UTSW 2 118,293,221 (GRCm39) missense possibly damaging 0.95
R5779:Eif2ak4 UTSW 2 118,243,444 (GRCm39) missense possibly damaging 0.85
R5807:Eif2ak4 UTSW 2 118,219,332 (GRCm39) missense probably benign
R6045:Eif2ak4 UTSW 2 118,219,296 (GRCm39) nonsense probably null
R6187:Eif2ak4 UTSW 2 118,287,638 (GRCm39) missense probably damaging 0.98
R6193:Eif2ak4 UTSW 2 118,231,081 (GRCm39) start gained probably benign
R6468:Eif2ak4 UTSW 2 118,266,722 (GRCm39) missense probably damaging 1.00
R6555:Eif2ak4 UTSW 2 118,258,350 (GRCm39) missense probably damaging 0.96
R6616:Eif2ak4 UTSW 2 118,285,326 (GRCm39) nonsense probably null
R6737:Eif2ak4 UTSW 2 118,292,749 (GRCm39) frame shift probably null
R6956:Eif2ak4 UTSW 2 118,252,748 (GRCm39) missense probably damaging 0.96
R7075:Eif2ak4 UTSW 2 118,251,291 (GRCm39) nonsense probably null
R7109:Eif2ak4 UTSW 2 118,235,532 (GRCm39) missense probably damaging 1.00
R7228:Eif2ak4 UTSW 2 118,287,638 (GRCm39) missense probably damaging 0.98
R7441:Eif2ak4 UTSW 2 118,302,377 (GRCm39) missense probably benign 0.01
R7555:Eif2ak4 UTSW 2 118,247,764 (GRCm39) missense possibly damaging 0.64
R7567:Eif2ak4 UTSW 2 118,280,795 (GRCm39) missense probably benign
R8004:Eif2ak4 UTSW 2 118,247,775 (GRCm39) missense possibly damaging 0.64
R8063:Eif2ak4 UTSW 2 118,241,382 (GRCm39) missense possibly damaging 0.94
R8092:Eif2ak4 UTSW 2 118,272,513 (GRCm39) missense probably damaging 1.00
R8195:Eif2ak4 UTSW 2 118,280,819 (GRCm39) missense possibly damaging 0.50
R8306:Eif2ak4 UTSW 2 118,287,656 (GRCm39) missense possibly damaging 0.68
R8470:Eif2ak4 UTSW 2 118,293,207 (GRCm39) missense probably damaging 0.98
R8671:Eif2ak4 UTSW 2 118,252,667 (GRCm39) missense possibly damaging 0.88
R8693:Eif2ak4 UTSW 2 118,262,718 (GRCm39) missense probably damaging 0.98
R8714:Eif2ak4 UTSW 2 118,292,765 (GRCm39) missense possibly damaging 0.89
R8744:Eif2ak4 UTSW 2 118,261,474 (GRCm39) nonsense probably null
R8813:Eif2ak4 UTSW 2 118,278,806 (GRCm39) missense probably damaging 1.00
R8917:Eif2ak4 UTSW 2 118,287,617 (GRCm39) missense probably damaging 1.00
R8924:Eif2ak4 UTSW 2 118,258,513 (GRCm39) missense probably damaging 1.00
R9177:Eif2ak4 UTSW 2 118,271,701 (GRCm39) critical splice donor site probably null
R9189:Eif2ak4 UTSW 2 118,258,393 (GRCm39) missense probably damaging 1.00
R9231:Eif2ak4 UTSW 2 118,271,662 (GRCm39) missense probably benign 0.00
R9268:Eif2ak4 UTSW 2 118,271,701 (GRCm39) critical splice donor site probably null
R9321:Eif2ak4 UTSW 2 118,292,798 (GRCm39) missense possibly damaging 0.93
R9512:Eif2ak4 UTSW 2 118,293,196 (GRCm39) missense probably damaging 1.00
R9569:Eif2ak4 UTSW 2 118,251,316 (GRCm39) missense probably benign 0.00
R9658:Eif2ak4 UTSW 2 118,269,511 (GRCm39) missense probably damaging 1.00
R9748:Eif2ak4 UTSW 2 118,247,730 (GRCm39) missense probably benign 0.01
R9757:Eif2ak4 UTSW 2 118,269,398 (GRCm39) missense probably benign 0.02
R9766:Eif2ak4 UTSW 2 118,261,313 (GRCm39) nonsense probably null
X0061:Eif2ak4 UTSW 2 118,298,657 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACTTTTGGAGTGAAACACCAGC -3'
(R):5'- TCCTTGCAAATGTCTGCCAG -3'

Sequencing Primer
(F):5'- TTGGAGTGAAACACCAGCTAATGTC -3'
(R):5'- CCAGACGCTTAGAGATGCTGTAGTC -3'
Posted On 2014-09-17