Incidental Mutation 'R2086:Greb1l'
ID 230047
Institutional Source Beutler Lab
Gene Symbol Greb1l
Ensembl Gene ENSMUSG00000042942
Gene Name growth regulation by estrogen in breast cancer-like
Synonyms AK220484, mKIAA4095
MMRRC Submission 040091-MU
Accession Numbers

Genbank: NM_001083628; MGI: 3576497

Essential gene? Essential (E-score: 1.000) question?
Stock # R2086 (G1)
Quality Score 162
Status Validated
Chromosome 18
Chromosomal Location 10325177-10562934 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 10523281 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 813 (V813A)
Ref Sequence ENSEMBL: ENSMUSP00000049003 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000048977] [ENSMUST00000172532] [ENSMUST00000172680]
AlphaFold B9EJV3
Predicted Effect probably damaging
Transcript: ENSMUST00000048977
AA Change: V813A

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000049003
Gene: ENSMUSG00000042942
AA Change: V813A

DomainStartEndE-ValueType
Pfam:GREB1 1 1172 N/A PFAM
Pfam:GREB1 1154 1913 N/A PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000172532
AA Change: V704A

PolyPhen 2 Score 0.511 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000134090
Gene: ENSMUSG00000042942
AA Change: V704A

DomainStartEndE-ValueType
low complexity region 83 100 N/A INTRINSIC
low complexity region 282 301 N/A INTRINSIC
low complexity region 606 617 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000172680
SMART Domains Protein: ENSMUSP00000134314
Gene: ENSMUSG00000042942

DomainStartEndE-ValueType
low complexity region 116 129 N/A INTRINSIC
Meta Mutation Damage Score 0.1987 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.3%
Validation Efficiency 99% (80/81)
Allele List at MGI

All alleles(5) : Targeted, other(2) Gene trapped(3)

Other mutations in this stock
Total: 80 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930533L02Rik T C 7: 125,318,595 (GRCm38) M53T unknown Het
Abcb11 T A 2: 69,259,476 (GRCm38) probably benign Het
Acap2 C G 16: 31,110,945 (GRCm38) A432P probably damaging Het
Adamtsl1 A G 4: 86,228,012 (GRCm38) R302G probably damaging Het
Ap2b1 T G 11: 83,351,118 (GRCm38) S608A possibly damaging Het
Atp13a3 T A 16: 30,352,298 (GRCm38) T310S possibly damaging Het
Atp6v1b1 T C 6: 83,757,852 (GRCm38) V382A probably benign Het
Atp6v1g1 T A 4: 63,550,067 (GRCm38) F102L probably benign Het
B430306N03Rik T A 17: 48,316,782 (GRCm38) V37D probably damaging Het
Cacna1d T C 14: 30,047,357 (GRCm38) Y1872C possibly damaging Het
Carf T A 1: 60,109,411 (GRCm38) Y54N probably damaging Het
Cct5 T C 15: 31,594,203 (GRCm38) E256G probably damaging Het
Cd5 A G 19: 10,723,256 (GRCm38) S295P probably benign Het
Cenpb T C 2: 131,178,597 (GRCm38) probably benign Het
Cntnap3 A G 13: 64,794,262 (GRCm38) M218T possibly damaging Het
Colec11 C T 12: 28,594,787 (GRCm38) R236H probably damaging Het
Crem T A 18: 3,288,098 (GRCm38) probably benign Het
Csnk2a1 A G 2: 152,254,281 (GRCm38) N58S probably benign Het
Cyp2a4 T G 7: 26,312,308 (GRCm38) M318R probably damaging Het
Dhrs1 T A 14: 55,743,659 (GRCm38) Q98L probably null Het
Dnah11 G T 12: 118,113,871 (GRCm38) Q1296K possibly damaging Het
Doxl2 A G 6: 48,977,602 (GRCm38) E558G probably damaging Het
Edc4 T A 8: 105,888,002 (GRCm38) D105E probably damaging Het
Eid2b C T 7: 28,277,773 (GRCm38) probably benign Het
Exoc1 A T 5: 76,532,846 (GRCm38) K28* probably null Het
Fam114a1 A G 5: 64,980,059 (GRCm38) D115G probably benign Het
Fam151a A T 4: 106,735,563 (GRCm38) probably null Het
Gc T C 5: 89,438,342 (GRCm38) Y313C probably damaging Het
Gdpd1 A G 11: 87,035,268 (GRCm38) Y284H probably benign Het
Gm21957 T A 7: 125,219,706 (GRCm38) noncoding transcript Het
Golm1 G A 13: 59,645,185 (GRCm38) Q169* probably null Het
Itih1 C T 14: 30,937,843 (GRCm38) A279T probably damaging Het
Kirrel C T 3: 87,089,151 (GRCm38) M380I probably null Het
Lama1 T C 17: 67,817,623 (GRCm38) C2893R probably damaging Het
Lama3 T A 18: 12,524,830 (GRCm38) N334K probably benign Het
Loxhd1 A G 18: 77,384,946 (GRCm38) D1053G probably damaging Het
Map3k20 A G 2: 72,398,385 (GRCm38) K316R probably benign Het
Mapre3 A C 5: 30,863,202 (GRCm38) probably null Het
Mfsd7a C T 5: 108,445,621 (GRCm38) R117H probably damaging Het
Mgam T A 6: 40,761,028 (GRCm38) probably null Het
Mical2 A C 7: 112,318,603 (GRCm38) H389P probably benign Het
Mtmr2 A G 9: 13,799,952 (GRCm38) D347G probably damaging Het
Nbeal2 G A 9: 110,634,071 (GRCm38) L1309F probably benign Het
Nid2 G A 14: 19,778,043 (GRCm38) G516S probably benign Het
Nodal A T 10: 61,423,298 (GRCm38) E171D possibly damaging Het
Notch2 T C 3: 98,102,367 (GRCm38) S537P probably damaging Het
Obox6 A G 7: 15,833,607 (GRCm38) L305S probably damaging Het
Obscn T C 11: 59,078,256 (GRCm38) D2715G probably damaging Het
Olfr154 A C 2: 85,663,746 (GRCm38) S229R probably benign Het
Olfr728 T A 14: 50,140,123 (GRCm38) N172I probably damaging Het
Pcca T C 14: 122,686,115 (GRCm38) S404P probably damaging Het
Pcdh10 T C 3: 45,380,471 (GRCm38) S407P probably damaging Het
Plekha5 C A 6: 140,570,318 (GRCm38) probably null Het
Ptdss1 A G 13: 66,953,555 (GRCm38) N72S probably benign Het
Ptprs T C 17: 56,454,984 (GRCm38) I43V probably null Het
Pygm G A 19: 6,391,481 (GRCm38) probably null Het
Rab7 C T 6: 88,012,318 (GRCm38) V57I probably benign Het
Rasl10a A G 11: 5,059,431 (GRCm38) probably null Het
Rergl T C 6: 139,494,834 (GRCm38) T106A probably benign Het
Rnf17 T G 14: 56,483,380 (GRCm38) V1023G probably damaging Het
Rnf25 T A 1: 74,593,967 (GRCm38) R409W probably damaging Het
Rps6ka1 T C 4: 133,872,969 (GRCm38) M1V probably null Het
Rps6ka5 T C 12: 100,619,615 (GRCm38) T140A possibly damaging Het
Sbno2 T A 10: 80,057,856 (GRCm38) I1204F possibly damaging Het
Serpina16 A T 12: 103,675,262 (GRCm38) I68N probably damaging Het
Slc35a5 A G 16: 45,144,265 (GRCm38) S202P probably damaging Het
Slc35g3 G C 11: 69,760,946 (GRCm38) S93W probably damaging Het
Smc1b A G 15: 85,121,851 (GRCm38) probably benign Het
Spag1 T C 15: 36,227,141 (GRCm38) L648P probably damaging Het
Tagap1 T C 17: 6,956,703 (GRCm38) D198G probably benign Het
Tedc2 T C 17: 24,217,900 (GRCm38) E287G probably damaging Het
Tjp1 C A 7: 65,312,921 (GRCm38) R1089S probably damaging Het
Tnrc6a CTGTTTTGTTTTGTTTTGTTTTGTTTTGTTTTGTTTTGTT CTGTTTTGTTTTGTTTTGTTTTGTTTTGTTTTGTTTTGTTTTGTT 7: 123,162,446 (GRCm38) probably benign Het
Ttc38 T A 15: 85,838,727 (GRCm38) D125E probably benign Het
Uggt1 C T 1: 36,192,414 (GRCm38) R490Q probably null Het
Uroc1 T G 6: 90,344,114 (GRCm38) L224R probably damaging Het
Vmn1r228 A T 17: 20,777,193 (GRCm38) I21N possibly damaging Het
Vmn2r102 T G 17: 19,676,687 (GRCm38) L99V probably damaging Het
Vps13c C T 9: 67,950,289 (GRCm38) S2601F probably benign Het
Zfp462 T C 4: 55,010,830 (GRCm38) L932P probably damaging Het
Other mutations in Greb1l
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00485:Greb1l APN 18 10,555,962 (GRCm38) missense possibly damaging 0.90
IGL01554:Greb1l APN 18 10,522,144 (GRCm38) missense probably benign 0.01
IGL01563:Greb1l APN 18 10,469,399 (GRCm38) missense probably damaging 0.99
IGL01944:Greb1l APN 18 10,557,280 (GRCm38) missense possibly damaging 0.91
IGL02110:Greb1l APN 18 10,515,271 (GRCm38) missense probably damaging 1.00
IGL02249:Greb1l APN 18 10,532,961 (GRCm38) missense probably damaging 1.00
IGL02318:Greb1l APN 18 10,469,388 (GRCm38) missense possibly damaging 0.91
IGL02340:Greb1l APN 18 10,515,200 (GRCm38) missense probably damaging 0.99
IGL02516:Greb1l APN 18 10,537,064 (GRCm38) missense probably benign 0.31
IGL02566:Greb1l APN 18 10,503,299 (GRCm38) missense probably damaging 0.99
IGL02583:Greb1l APN 18 10,542,362 (GRCm38) missense probably damaging 1.00
IGL02838:Greb1l APN 18 10,560,430 (GRCm38) missense probably damaging 1.00
A4554:Greb1l UTSW 18 10,532,862 (GRCm38) missense possibly damaging 0.58
PIT4453001:Greb1l UTSW 18 10,533,032 (GRCm38) missense probably benign 0.08
PIT4453001:Greb1l UTSW 18 10,533,031 (GRCm38) missense probably damaging 0.98
R0099:Greb1l UTSW 18 10,509,158 (GRCm38) missense probably damaging 1.00
R0226:Greb1l UTSW 18 10,522,076 (GRCm38) intron probably benign
R0234:Greb1l UTSW 18 10,560,331 (GRCm38) missense probably damaging 1.00
R0234:Greb1l UTSW 18 10,560,331 (GRCm38) missense probably damaging 1.00
R0239:Greb1l UTSW 18 10,458,567 (GRCm38) splice site probably benign
R0316:Greb1l UTSW 18 10,547,420 (GRCm38) missense probably damaging 1.00
R0369:Greb1l UTSW 18 10,469,375 (GRCm38) missense possibly damaging 0.80
R0394:Greb1l UTSW 18 10,523,374 (GRCm38) missense probably damaging 0.99
R0478:Greb1l UTSW 18 10,509,281 (GRCm38) missense probably damaging 1.00
R0555:Greb1l UTSW 18 10,458,781 (GRCm38) splice site probably benign
R0671:Greb1l UTSW 18 10,474,303 (GRCm38) missense probably damaging 1.00
R1282:Greb1l UTSW 18 10,547,289 (GRCm38) missense probably benign 0.13
R1574:Greb1l UTSW 18 10,554,997 (GRCm38) missense possibly damaging 0.95
R1574:Greb1l UTSW 18 10,554,997 (GRCm38) missense possibly damaging 0.95
R1607:Greb1l UTSW 18 10,529,703 (GRCm38) missense possibly damaging 0.85
R1666:Greb1l UTSW 18 10,529,708 (GRCm38) critical splice donor site probably null
R1666:Greb1l UTSW 18 10,501,080 (GRCm38) critical splice donor site probably null
R1720:Greb1l UTSW 18 10,553,848 (GRCm38) missense probably benign 0.19
R1808:Greb1l UTSW 18 10,542,143 (GRCm38) missense probably benign
R1829:Greb1l UTSW 18 10,509,314 (GRCm38) missense probably damaging 1.00
R1897:Greb1l UTSW 18 10,498,992 (GRCm38) missense probably benign 0.00
R1967:Greb1l UTSW 18 10,501,049 (GRCm38) missense possibly damaging 0.91
R2025:Greb1l UTSW 18 10,515,221 (GRCm38) missense possibly damaging 0.71
R2125:Greb1l UTSW 18 10,511,422 (GRCm38) missense probably damaging 0.98
R2139:Greb1l UTSW 18 10,555,011 (GRCm38) missense probably damaging 1.00
R2255:Greb1l UTSW 18 10,554,857 (GRCm38) missense probably damaging 1.00
R2256:Greb1l UTSW 18 10,503,307 (GRCm38) missense possibly damaging 0.91
R2257:Greb1l UTSW 18 10,503,307 (GRCm38) missense possibly damaging 0.91
R2880:Greb1l UTSW 18 10,547,288 (GRCm38) missense possibly damaging 0.93
R3623:Greb1l UTSW 18 10,542,380 (GRCm38) missense probably damaging 0.99
R3778:Greb1l UTSW 18 10,469,444 (GRCm38) missense possibly damaging 0.60
R3975:Greb1l UTSW 18 10,522,247 (GRCm38) missense possibly damaging 0.71
R4038:Greb1l UTSW 18 10,515,209 (GRCm38) missense possibly damaging 0.93
R4062:Greb1l UTSW 18 10,522,150 (GRCm38) missense probably damaging 0.99
R4134:Greb1l UTSW 18 10,529,708 (GRCm38) critical splice donor site probably null
R4342:Greb1l UTSW 18 10,544,561 (GRCm38) missense probably benign 0.12
R4409:Greb1l UTSW 18 10,503,182 (GRCm38) missense possibly damaging 0.70
R4600:Greb1l UTSW 18 10,553,705 (GRCm38) missense probably damaging 1.00
R4618:Greb1l UTSW 18 10,498,965 (GRCm38) missense probably benign 0.00
R4683:Greb1l UTSW 18 10,529,563 (GRCm38) splice site probably null
R4686:Greb1l UTSW 18 10,522,112 (GRCm38) missense probably damaging 0.98
R4707:Greb1l UTSW 18 10,532,922 (GRCm38) missense probably benign 0.02
R4780:Greb1l UTSW 18 10,541,792 (GRCm38) missense probably benign 0.00
R4819:Greb1l UTSW 18 10,458,358 (GRCm38) missense probably damaging 1.00
R4925:Greb1l UTSW 18 10,547,447 (GRCm38) missense possibly damaging 0.79
R4960:Greb1l UTSW 18 10,547,306 (GRCm38) missense probably damaging 0.99
R5150:Greb1l UTSW 18 10,555,950 (GRCm38) frame shift probably null
R5154:Greb1l UTSW 18 10,458,312 (GRCm38) missense probably benign 0.02
R5269:Greb1l UTSW 18 10,511,409 (GRCm38) missense probably benign
R5290:Greb1l UTSW 18 10,542,427 (GRCm38) missense probably damaging 1.00
R5310:Greb1l UTSW 18 10,542,427 (GRCm38) missense probably damaging 1.00
R5328:Greb1l UTSW 18 10,553,720 (GRCm38) missense probably damaging 1.00
R5337:Greb1l UTSW 18 10,509,143 (GRCm38) missense probably damaging 1.00
R5393:Greb1l UTSW 18 10,458,312 (GRCm38) missense probably benign 0.02
R5402:Greb1l UTSW 18 10,537,169 (GRCm38) missense probably benign 0.26
R5718:Greb1l UTSW 18 10,542,427 (GRCm38) missense probably damaging 1.00
R5719:Greb1l UTSW 18 10,542,427 (GRCm38) missense probably damaging 1.00
R5720:Greb1l UTSW 18 10,542,427 (GRCm38) missense probably damaging 1.00
R5721:Greb1l UTSW 18 10,542,427 (GRCm38) missense probably damaging 1.00
R5902:Greb1l UTSW 18 10,538,302 (GRCm38) missense probably benign 0.00
R5993:Greb1l UTSW 18 10,544,455 (GRCm38) missense probably benign 0.10
R6035:Greb1l UTSW 18 10,501,025 (GRCm38) missense possibly damaging 0.91
R6035:Greb1l UTSW 18 10,501,025 (GRCm38) missense possibly damaging 0.91
R6045:Greb1l UTSW 18 10,547,068 (GRCm38) missense probably damaging 1.00
R6063:Greb1l UTSW 18 10,557,340 (GRCm38) missense probably damaging 1.00
R6297:Greb1l UTSW 18 10,469,494 (GRCm38) missense probably damaging 1.00
R6405:Greb1l UTSW 18 10,501,076 (GRCm38) missense probably benign 0.30
R6552:Greb1l UTSW 18 10,541,814 (GRCm38) missense probably benign 0.00
R6572:Greb1l UTSW 18 10,522,131 (GRCm38) missense probably benign 0.07
R6575:Greb1l UTSW 18 10,547,347 (GRCm38) missense possibly damaging 0.88
R6922:Greb1l UTSW 18 10,547,482 (GRCm38) missense possibly damaging 0.88
R6957:Greb1l UTSW 18 10,558,786 (GRCm38) missense probably benign 0.23
R6962:Greb1l UTSW 18 10,547,327 (GRCm38) missense probably damaging 1.00
R7012:Greb1l UTSW 18 10,529,707 (GRCm38) critical splice donor site probably null
R7179:Greb1l UTSW 18 10,544,576 (GRCm38) missense probably benign 0.00
R7251:Greb1l UTSW 18 10,515,319 (GRCm38) missense probably damaging 1.00
R7275:Greb1l UTSW 18 10,544,561 (GRCm38) missense probably benign 0.12
R7301:Greb1l UTSW 18 10,544,970 (GRCm38) missense probably damaging 1.00
R7307:Greb1l UTSW 18 10,538,142 (GRCm38) missense probably damaging 0.99
R7455:Greb1l UTSW 18 10,554,915 (GRCm38) missense probably damaging 1.00
R7832:Greb1l UTSW 18 10,542,056 (GRCm38) missense probably benign 0.38
R7934:Greb1l UTSW 18 10,474,371 (GRCm38) nonsense probably null
R8137:Greb1l UTSW 18 10,474,357 (GRCm38) missense possibly damaging 0.77
R8138:Greb1l UTSW 18 10,533,060 (GRCm38) missense probably benign 0.13
R8208:Greb1l UTSW 18 10,510,703 (GRCm38) missense probably damaging 1.00
R8227:Greb1l UTSW 18 10,515,371 (GRCm38) missense probably damaging 1.00
R8312:Greb1l UTSW 18 10,511,587 (GRCm38) intron probably benign
R8331:Greb1l UTSW 18 10,458,706 (GRCm38) missense possibly damaging 0.96
R8364:Greb1l UTSW 18 10,529,687 (GRCm38) missense possibly damaging 0.85
R8389:Greb1l UTSW 18 10,529,613 (GRCm38) missense probably benign 0.00
R8695:Greb1l UTSW 18 10,544,450 (GRCm38) missense probably benign 0.01
R8795:Greb1l UTSW 18 10,553,739 (GRCm38) missense probably damaging 0.98
R8836:Greb1l UTSW 18 10,509,257 (GRCm38) missense probably benign 0.30
R8862:Greb1l UTSW 18 10,555,042 (GRCm38) missense possibly damaging 0.90
R8872:Greb1l UTSW 18 10,529,684 (GRCm38) missense probably benign 0.18
R8874:Greb1l UTSW 18 10,544,896 (GRCm38) missense probably benign 0.01
R8886:Greb1l UTSW 18 10,553,843 (GRCm38) missense probably benign 0.21
R8921:Greb1l UTSW 18 10,541,825 (GRCm38) missense probably benign 0.01
R8997:Greb1l UTSW 18 10,510,747 (GRCm38) missense probably damaging 1.00
R9015:Greb1l UTSW 18 10,541,675 (GRCm38) missense probably benign 0.00
R9018:Greb1l UTSW 18 10,542,004 (GRCm38) missense possibly damaging 0.76
R9074:Greb1l UTSW 18 10,558,795 (GRCm38) missense probably damaging 1.00
R9074:Greb1l UTSW 18 10,532,797 (GRCm38) missense probably damaging 1.00
R9117:Greb1l UTSW 18 10,542,422 (GRCm38) missense probably benign 0.31
R9189:Greb1l UTSW 18 10,499,983 (GRCm38) missense probably benign
R9332:Greb1l UTSW 18 10,532,796 (GRCm38) missense possibly damaging 0.92
R9367:Greb1l UTSW 18 10,522,130 (GRCm38) missense probably benign 0.00
R9497:Greb1l UTSW 18 10,458,600 (GRCm38) missense probably benign 0.00
R9796:Greb1l UTSW 18 10,538,233 (GRCm38) missense possibly damaging 0.69
Z1176:Greb1l UTSW 18 10,515,305 (GRCm38) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACATTCTGACTGGATCTGTCCC -3'
(R):5'- TGCTGTGTTTTACCAGGCCATG -3'

Sequencing Primer
(F):5'- CCCTCTCAGATAAAATAAGTCTGGTG -3'
(R):5'- CATGGCCATGTTCAGTTCCTGG -3'
Posted On 2014-09-18