Incidental Mutation 'R2084:Fcrl5'
ID 230181
Institutional Source Beutler Lab
Gene Symbol Fcrl5
Ensembl Gene ENSMUSG00000048031
Gene Name Fc receptor-like 5
Synonyms Fcrh3, BXMAS1-like protein 2, mBXMH2
MMRRC Submission 040089-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R2084 (G1)
Quality Score 225
Status Validated
Chromosome 3
Chromosomal Location 87343084-87407985 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 87351537 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 262 (F262L)
Ref Sequence ENSEMBL: ENSMUSP00000136046 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049926] [ENSMUST00000166297] [ENSMUST00000178261] [ENSMUST00000193229] [ENSMUST00000194102]
AlphaFold Q68SN8
Predicted Effect probably benign
Transcript: ENSMUST00000049926
AA Change: F262L

PolyPhen 2 Score 0.101 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000050151
Gene: ENSMUSG00000048031
AA Change: F262L

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
IG 40 113 2.08e-1 SMART
IGc2 128 188 6.16e-4 SMART
IG_like 213 296 4.41e1 SMART
IGc2 316 380 3.97e-7 SMART
IG_like 410 473 2.94e-1 SMART
transmembrane domain 495 517 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000166297
AA Change: F174L

PolyPhen 2 Score 0.069 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000131176
Gene: ENSMUSG00000048031
AA Change: F174L

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
IGc2 40 100 6.16e-4 SMART
IG_like 125 208 4.41e1 SMART
IGc2 228 292 3.97e-7 SMART
IG_like 322 385 2.94e-1 SMART
transmembrane domain 407 429 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000178261
AA Change: F262L

PolyPhen 2 Score 0.241 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000136046
Gene: ENSMUSG00000048031
AA Change: F262L

DomainStartEndE-ValueType
signal peptide 1 30 N/A INTRINSIC
IG 40 113 2.08e-1 SMART
IGc2 128 188 6.16e-4 SMART
IG_like 213 296 4.41e1 SMART
IGc2 316 380 3.97e-7 SMART
IG_like 410 473 2.94e-1 SMART
transmembrane domain 495 517 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000193229
AA Change: F174L

PolyPhen 2 Score 0.069 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000141311
Gene: ENSMUSG00000048031
AA Change: F174L

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
IGc2 40 100 6.16e-4 SMART
IG_like 125 208 4.41e1 SMART
IGc2 228 292 3.97e-7 SMART
IG_like 322 385 2.94e-1 SMART
transmembrane domain 407 429 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000194102
AA Change: F262L

PolyPhen 2 Score 0.101 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000142210
Gene: ENSMUSG00000048031
AA Change: F262L

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
IG 40 113 2.08e-1 SMART
IGc2 128 188 6.16e-4 SMART
IG_like 213 296 4.41e1 SMART
IGc2 316 380 3.97e-7 SMART
IG_like 410 473 2.94e-1 SMART
transmembrane domain 495 517 N/A INTRINSIC
Meta Mutation Damage Score 0.2054 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.3%
Validation Efficiency 100% (53/53)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the immunoglobulin receptor superfamily and the Fc-receptor like family. This gene and several other Fc receptor-like gene members are clustered on the long arm of chromosome 1. The encoded protein is a single-pass type I membrane protein and contains 8 immunoglobulin-like C2-type domains. This gene is implicated in B cell development and lymphomagenesis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankrd36 C T 11: 5,612,378 (GRCm39) Q1237* probably null Het
Aph1c T G 9: 66,726,579 (GRCm39) R258S probably damaging Het
Arfgap3 T A 15: 83,218,767 (GRCm39) N102I probably damaging Het
Astn1 T C 1: 158,299,978 (GRCm39) V106A probably damaging Het
BC005537 G T 13: 24,996,698 (GRCm39) probably null Het
Card10 G A 15: 78,677,171 (GRCm39) T412M possibly damaging Het
Cars1 T C 7: 143,140,919 (GRCm39) I126M probably benign Het
Cfap20dc T C 14: 8,558,171 (GRCm38) D138G probably damaging Het
Col11a1 C T 3: 113,951,791 (GRCm39) R1074C probably damaging Het
Cpped1 T C 16: 11,646,365 (GRCm39) D153G probably damaging Het
Cyp2j11 T A 4: 96,227,438 (GRCm39) I193F probably damaging Het
Dnm2 T C 9: 21,411,667 (GRCm39) probably null Het
Efemp1 A G 11: 28,865,763 (GRCm39) D288G probably damaging Het
Espl1 T C 15: 102,205,286 (GRCm39) probably null Het
Fcgbpl1 G A 7: 27,856,960 (GRCm39) V2103M probably damaging Het
Gh G A 11: 106,191,958 (GRCm39) P84L probably damaging Het
Gm10267 T C 18: 44,290,397 (GRCm39) R37G probably benign Het
Hmgxb3 C T 18: 61,288,095 (GRCm39) probably benign Het
Ifit2 T C 19: 34,550,750 (GRCm39) W97R probably damaging Het
Ift81 T G 5: 122,705,410 (GRCm39) K491Q probably benign Het
Ints8 A G 4: 11,230,377 (GRCm39) V488A probably benign Het
Krba1 T A 6: 48,391,502 (GRCm39) L797Q probably damaging Het
Krr1 T C 10: 111,812,690 (GRCm39) V100A probably damaging Het
Nav1 C T 1: 135,535,158 (GRCm39) probably benign Het
Nos1 C A 5: 118,081,310 (GRCm39) Q1205K probably damaging Het
Nup85 A T 11: 115,459,517 (GRCm39) D125V possibly damaging Het
Or5ak23 T C 2: 85,244,959 (GRCm39) E88G probably benign Het
Pclo T G 5: 14,732,162 (GRCm39) S3555A probably benign Het
Pdzrn3 T C 6: 101,131,256 (GRCm39) I473V probably benign Het
Polr1a A G 6: 71,927,793 (GRCm39) E848G possibly damaging Het
Pop1 T C 15: 34,508,744 (GRCm39) probably benign Het
Pramel23 T A 4: 143,425,920 (GRCm39) T8S probably damaging Het
Prpf3 C T 3: 95,756,301 (GRCm39) E117K probably benign Het
Psmg3 C T 5: 139,809,744 (GRCm39) V101M probably benign Het
Rexo1 G A 10: 80,397,100 (GRCm39) S52L probably benign Het
Ryk C T 9: 102,752,971 (GRCm39) T210M probably damaging Het
Sde2 A G 1: 180,690,198 (GRCm39) E306G probably damaging Het
Sec24c A G 14: 20,741,347 (GRCm39) Q658R probably benign Het
Sgsm1 G A 5: 113,433,266 (GRCm39) T183I probably damaging Het
Skint7 T A 4: 111,837,375 (GRCm39) V51E probably damaging Het
Slc6a5 T A 7: 49,598,002 (GRCm39) M622K probably benign Het
Slco1a5 T C 6: 142,180,437 (GRCm39) H655R probably benign Het
Slco1c1 T A 6: 141,505,578 (GRCm39) Y452* probably null Het
Spn T C 7: 126,736,210 (GRCm39) E99G probably benign Het
Ssc5d A G 7: 4,940,011 (GRCm39) I789V probably benign Het
Taok2 G A 7: 126,469,363 (GRCm39) T1155I probably benign Het
Tet2 T C 3: 133,193,528 (GRCm39) Q302R possibly damaging Het
Trmt1l A G 1: 151,316,605 (GRCm39) T189A probably damaging Het
Tubal3 T C 13: 3,978,192 (GRCm39) I36T possibly damaging Het
Vmn2r71 A T 7: 85,267,945 (GRCm39) Y133F probably benign Het
Vps11 G T 9: 44,264,558 (GRCm39) H673N probably benign Het
Zc3h12a C T 4: 125,013,802 (GRCm39) S354N probably benign Het
Zfp2 A G 11: 50,791,789 (GRCm39) S85P probably benign Het
Other mutations in Fcrl5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01743:Fcrl5 APN 3 87,351,598 (GRCm39) missense probably damaging 0.96
IGL01868:Fcrl5 APN 3 87,351,014 (GRCm39) missense possibly damaging 0.58
IGL01939:Fcrl5 APN 3 87,353,606 (GRCm39) missense probably damaging 0.99
IGL02817:Fcrl5 APN 3 87,343,220 (GRCm39) missense probably benign 0.35
IGL03106:Fcrl5 APN 3 87,343,190 (GRCm39) splice site probably null
R0381:Fcrl5 UTSW 3 87,353,767 (GRCm39) missense probably damaging 1.00
R0523:Fcrl5 UTSW 3 87,365,099 (GRCm39) missense possibly damaging 0.72
R0646:Fcrl5 UTSW 3 87,349,320 (GRCm39) missense probably benign 0.00
R1231:Fcrl5 UTSW 3 87,349,486 (GRCm39) missense probably benign 0.13
R1353:Fcrl5 UTSW 3 87,355,669 (GRCm39) missense probably damaging 1.00
R1711:Fcrl5 UTSW 3 87,364,721 (GRCm39) missense possibly damaging 0.61
R1714:Fcrl5 UTSW 3 87,353,713 (GRCm39) missense probably damaging 1.00
R1719:Fcrl5 UTSW 3 87,364,704 (GRCm39) missense probably damaging 0.98
R2358:Fcrl5 UTSW 3 87,353,726 (GRCm39) missense probably damaging 0.99
R2884:Fcrl5 UTSW 3 87,364,698 (GRCm39) missense probably damaging 1.00
R2885:Fcrl5 UTSW 3 87,364,698 (GRCm39) missense probably damaging 1.00
R3085:Fcrl5 UTSW 3 87,353,771 (GRCm39) missense probably damaging 1.00
R3153:Fcrl5 UTSW 3 87,350,987 (GRCm39) missense probably benign 0.09
R4288:Fcrl5 UTSW 3 87,349,531 (GRCm39) missense probably benign 0.09
R4289:Fcrl5 UTSW 3 87,349,531 (GRCm39) missense probably benign 0.09
R4614:Fcrl5 UTSW 3 87,355,733 (GRCm39) missense probably damaging 1.00
R4719:Fcrl5 UTSW 3 87,351,496 (GRCm39) missense probably damaging 1.00
R4788:Fcrl5 UTSW 3 87,364,495 (GRCm39) missense probably damaging 1.00
R4920:Fcrl5 UTSW 3 87,351,480 (GRCm39) missense probably damaging 1.00
R4972:Fcrl5 UTSW 3 87,361,957 (GRCm39) missense probably benign 0.00
R5373:Fcrl5 UTSW 3 87,353,698 (GRCm39) missense probably benign 0.01
R5374:Fcrl5 UTSW 3 87,353,698 (GRCm39) missense probably benign 0.01
R5963:Fcrl5 UTSW 3 87,351,480 (GRCm39) missense probably damaging 1.00
R5975:Fcrl5 UTSW 3 87,349,410 (GRCm39) missense probably benign 0.00
R6022:Fcrl5 UTSW 3 87,363,070 (GRCm39) missense probably benign 0.42
R6267:Fcrl5 UTSW 3 87,355,631 (GRCm39) missense probably damaging 1.00
R6372:Fcrl5 UTSW 3 87,351,501 (GRCm39) nonsense probably null
R6393:Fcrl5 UTSW 3 87,355,634 (GRCm39) missense probably damaging 1.00
R7088:Fcrl5 UTSW 3 87,365,141 (GRCm39) makesense probably null
R7175:Fcrl5 UTSW 3 87,353,645 (GRCm39) missense probably benign 0.37
R7210:Fcrl5 UTSW 3 87,353,719 (GRCm39) missense possibly damaging 0.85
R7217:Fcrl5 UTSW 3 87,351,081 (GRCm39) missense probably damaging 1.00
R7243:Fcrl5 UTSW 3 87,349,552 (GRCm39) missense probably benign
R7776:Fcrl5 UTSW 3 87,351,502 (GRCm39) missense possibly damaging 0.84
R7813:Fcrl5 UTSW 3 87,350,930 (GRCm39) missense probably benign 0.09
R8357:Fcrl5 UTSW 3 87,351,567 (GRCm39) missense probably damaging 0.99
R8457:Fcrl5 UTSW 3 87,351,567 (GRCm39) missense probably damaging 0.99
R9257:Fcrl5 UTSW 3 87,343,195 (GRCm39) missense probably benign 0.11
R9276:Fcrl5 UTSW 3 87,343,138 (GRCm39) start gained probably benign
R9748:Fcrl5 UTSW 3 87,364,469 (GRCm39) missense possibly damaging 0.93
X0054:Fcrl5 UTSW 3 87,353,606 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCTGCAGACTACTTAACTGCTCAG -3'
(R):5'- GCTAGTGACCCAAACTGGTG -3'

Sequencing Primer
(F):5'- CAGACTACTTAACTGCTCAGTGGATG -3'
(R):5'- GTGACCCAAACTGGTGAATGCTTC -3'
Posted On 2014-09-18