Incidental Mutation 'R2085:Zfp874a'
ID 230286
Institutional Source Beutler Lab
Gene Symbol Zfp874a
Ensembl Gene ENSMUSG00000069206
Gene Name zinc finger protein 874a
Synonyms C330011K17Rik, Zfp874, Rslcan15
MMRRC Submission 040090-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.078) question?
Stock # R2085 (G1)
Quality Score 225
Status Not validated
Chromosome 13
Chromosomal Location 67588550-67599743 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 67590967 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Leucine at position 239 (H239L)
Ref Sequence ENSEMBL: ENSMUSP00000074735 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057241] [ENSMUST00000075255] [ENSMUST00000180580] [ENSMUST00000223682] [ENSMUST00000225479]
AlphaFold Q8BX23
Predicted Effect probably benign
Transcript: ENSMUST00000057241
SMART Domains Protein: ENSMUSP00000077307
Gene: ENSMUSG00000069206

DomainStartEndE-ValueType
KRAB 5 65 1.73e-27 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000075255
AA Change: H239L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000074735
Gene: ENSMUSG00000069206
AA Change: H239L

DomainStartEndE-ValueType
KRAB 5 65 1.73e-27 SMART
ZnF_C2H2 137 159 9.58e-3 SMART
ZnF_C2H2 165 187 5.99e-4 SMART
ZnF_C2H2 193 215 7.26e-3 SMART
ZnF_C2H2 221 243 2.4e-3 SMART
ZnF_C2H2 249 269 1.88e2 SMART
ZnF_C2H2 277 299 5.21e-4 SMART
ZnF_C2H2 305 327 2.12e-4 SMART
ZnF_C2H2 333 355 2.12e-4 SMART
ZnF_C2H2 361 383 8.47e-4 SMART
ZnF_C2H2 389 411 1.79e-2 SMART
ZnF_C2H2 417 438 2.86e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000180580
SMART Domains Protein: ENSMUSP00000137953
Gene: ENSMUSG00000069206

DomainStartEndE-ValueType
KRAB 5 65 1.73e-27 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000223682
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224239
Predicted Effect probably benign
Transcript: ENSMUST00000225479
Predicted Effect probably benign
Transcript: ENSMUST00000225778
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2810408A11Rik G T 11: 69,791,198 (GRCm39) T127K possibly damaging Het
A2m T G 6: 121,653,918 (GRCm39) I1417S probably damaging Het
Acad10 A G 5: 121,787,523 (GRCm39) I142T possibly damaging Het
Adprm T A 11: 66,932,678 (GRCm39) D77V probably damaging Het
Apob C T 12: 8,062,240 (GRCm39) T3574I probably damaging Het
Bahcc1 A G 11: 120,178,908 (GRCm39) K2489R probably damaging Het
Bub1b A G 2: 118,452,676 (GRCm39) E443G possibly damaging Het
Cd9 A T 6: 125,440,734 (GRCm39) probably null Het
Cgnl1 G A 9: 71,538,160 (GRCm39) T1194M probably damaging Het
Clec9a T C 6: 129,387,274 (GRCm39) V43A probably benign Het
Col11a1 C T 3: 113,951,791 (GRCm39) R1074C probably damaging Het
Dpep3 A G 8: 106,701,346 (GRCm39) V401A probably damaging Het
Duox2 G T 2: 122,111,448 (GRCm39) H1417N probably damaging Het
Efhb C T 17: 53,733,937 (GRCm39) probably null Het
F2r T C 13: 95,741,418 (GRCm39) N39S probably benign Het
Fcamr T C 1: 130,739,335 (GRCm39) F212L probably damaging Het
Galt G A 4: 41,758,162 (GRCm39) R309Q probably damaging Het
Gas2l2 C A 11: 83,318,209 (GRCm39) A167S probably benign Het
Hecw1 A T 13: 14,438,672 (GRCm39) F904I possibly damaging Het
Herc2 C A 7: 55,862,713 (GRCm39) H4127Q possibly damaging Het
Hipk1 T C 3: 103,657,670 (GRCm39) T805A probably benign Het
Hivep1 A G 13: 42,337,226 (GRCm39) E2435G probably benign Het
Hivep2 C A 10: 14,004,713 (GRCm39) T437K probably benign Het
Hivep2 C A 10: 14,015,273 (GRCm39) C1813* probably null Het
Hyal4 C T 6: 24,755,749 (GRCm39) probably benign Het
Inpp4b A G 8: 82,678,903 (GRCm39) Y311C probably damaging Het
Itih4 A G 14: 30,614,280 (GRCm39) Y410C possibly damaging Het
Lama2 A T 10: 27,080,837 (GRCm39) C995* probably null Het
Lingo4 C A 3: 94,309,552 (GRCm39) D163E probably damaging Het
Malt1 A G 18: 65,606,218 (GRCm39) D642G probably damaging Het
Mbd4 T A 6: 115,825,918 (GRCm39) M358L probably benign Het
Mbd5 T A 2: 49,169,323 (GRCm39) F1498Y possibly damaging Het
Me1 T C 9: 86,495,607 (GRCm39) Q280R probably damaging Het
Megf9 T C 4: 70,367,004 (GRCm39) H326R probably damaging Het
Nid2 G A 14: 19,828,111 (GRCm39) G516S probably benign Het
Or13p10 T C 4: 118,523,301 (GRCm39) S196P probably damaging Het
Or1e1 T C 11: 73,245,247 (GRCm39) S223P possibly damaging Het
Or4k1 T A 14: 50,377,580 (GRCm39) N172I probably damaging Het
Or5h18 C T 16: 58,848,232 (GRCm39) V13I probably benign Het
Or8b1c A G 9: 38,384,223 (GRCm39) Y60C probably damaging Het
Polr2j T C 5: 136,145,625 (GRCm39) F7L probably damaging Het
Ppp1r16a T A 15: 76,577,796 (GRCm39) D303E probably damaging Het
Prickle2 T C 6: 92,353,345 (GRCm39) E763G probably damaging Het
Rdh11 T C 12: 79,229,556 (GRCm39) Y239C possibly damaging Het
Sdhaf3 A G 6: 6,956,048 (GRCm39) R8G probably benign Het
Sgk2 T C 2: 162,854,890 (GRCm39) S305P probably damaging Het
Sptbn2 A G 19: 4,788,587 (GRCm39) S1189G probably benign Het
Stab2 A G 10: 86,790,023 (GRCm39) L581P probably damaging Het
Tifab T C 13: 56,324,110 (GRCm39) Q111R probably damaging Het
Ubr3 C T 2: 69,784,108 (GRCm39) R775C probably damaging Het
Usp17lb T A 7: 104,489,622 (GRCm39) Q434L possibly damaging Het
Wdr46 G T 17: 34,160,425 (GRCm39) E135* probably null Het
Zfp318 T A 17: 46,720,590 (GRCm39) probably null Het
Zscan29 A T 2: 121,000,427 (GRCm39) L60* probably null Het
Other mutations in Zfp874a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02490:Zfp874a APN 13 67,590,819 (GRCm39) nonsense probably null
R1052:Zfp874a UTSW 13 67,590,539 (GRCm39) missense possibly damaging 0.89
R1991:Zfp874a UTSW 13 67,590,623 (GRCm39) missense probably benign 0.03
R2103:Zfp874a UTSW 13 67,590,623 (GRCm39) missense probably benign 0.03
R5129:Zfp874a UTSW 13 67,591,100 (GRCm39) missense probably damaging 1.00
R5336:Zfp874a UTSW 13 67,590,799 (GRCm39) missense probably damaging 1.00
R5423:Zfp874a UTSW 13 67,590,473 (GRCm39) missense possibly damaging 0.75
R5713:Zfp874a UTSW 13 67,597,476 (GRCm39) missense probably benign 0.16
R5855:Zfp874a UTSW 13 67,590,812 (GRCm39) missense probably benign 0.03
R6496:Zfp874a UTSW 13 67,590,694 (GRCm39) missense possibly damaging 0.62
R7046:Zfp874a UTSW 13 67,590,418 (GRCm39) missense probably damaging 1.00
R7065:Zfp874a UTSW 13 67,590,401 (GRCm39) missense probably damaging 0.97
R7233:Zfp874a UTSW 13 67,590,776 (GRCm39) missense possibly damaging 0.83
R7271:Zfp874a UTSW 13 67,591,415 (GRCm39) missense probably benign 0.00
R7465:Zfp874a UTSW 13 67,590,376 (GRCm39) missense probably damaging 0.99
R7468:Zfp874a UTSW 13 67,573,723 (GRCm39) splice site probably null
R8108:Zfp874a UTSW 13 67,591,353 (GRCm39) nonsense probably null
R8109:Zfp874a UTSW 13 67,597,563 (GRCm39) missense possibly damaging 0.46
R8843:Zfp874a UTSW 13 67,590,764 (GRCm39) missense probably damaging 1.00
R8859:Zfp874a UTSW 13 67,590,647 (GRCm39) missense probably benign 0.17
R9137:Zfp874a UTSW 13 67,590,841 (GRCm39) missense probably damaging 1.00
R9673:Zfp874a UTSW 13 67,591,156 (GRCm39) missense probably benign 0.03
X0063:Zfp874a UTSW 13 67,591,106 (GRCm39) missense probably damaging 1.00
Z1177:Zfp874a UTSW 13 67,590,781 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTTGATGTCTTTTCAGGGATGTAAA -3'
(R):5'- ACTCTTAGTAGTCGCTCATCACT -3'

Sequencing Primer
(F):5'- CTTGTAGGGATACTCTCCAGAATGC -3'
(R):5'- GCAAAGGGTTTTTCCGTTCCTCAG -3'
Posted On 2014-09-18