Incidental Mutation 'R2097:Pglyrp3'
ID 230305
Institutional Source Beutler Lab
Gene Symbol Pglyrp3
Ensembl Gene ENSMUSG00000042244
Gene Name peptidoglycan recognition protein 3
Synonyms LOC242100
MMRRC Submission 040101-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # R2097 (G1)
Quality Score 225
Status Validated
Chromosome 3
Chromosomal Location 92014583-92031582 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to A at 92028171 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Isoleucine at position 243 (F243I)
Ref Sequence ENSEMBL: ENSMUSP00000035737 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047660]
AlphaFold A1A547
Predicted Effect possibly damaging
Transcript: ENSMUST00000047660
AA Change: F243I

PolyPhen 2 Score 0.914 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000035737
Gene: ENSMUSG00000042244
AA Change: F243I

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
PGRP 28 169 2.64e-45 SMART
Ami_2 39 169 1.06e-2 SMART
PGRP 185 326 3.23e-72 SMART
Ami_2 195 332 1.75e-17 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000118636
Meta Mutation Damage Score 0.4007 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.2%
Validation Efficiency 100% (43/43)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. These proteins are part of the innate immune system and recognize peptidoglycan, a ubiquitous component of bacterial cell walls. This antimicrobial protein binds to murein peptidoglycans of Gram-positive bacteria. [provided by RefSeq, Oct 2014]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased susceptibility to DSS-induced colitis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5430419D17Rik A T 7: 131,181,964 R29* probably null Het
Actr8 T C 14: 29,987,228 V263A probably damaging Het
Apol6 T A 15: 77,047,133 probably null Het
Aqp3 C T 4: 41,098,004 V36M possibly damaging Het
Bace1 G T 9: 45,860,222 C478F probably benign Het
Bbof1 C A 12: 84,413,307 A116D probably damaging Het
Casq1 A T 1: 172,210,421 L381Q probably damaging Het
Ccdc138 T A 10: 58,561,937 L533* probably null Het
Cnga1 C T 5: 72,619,061 V20I possibly damaging Het
Cntn6 A G 6: 104,861,949 E988G probably damaging Het
Cts6 T A 13: 61,195,445 N321Y probably damaging Het
Dnmt1 A G 9: 20,909,788 S1269P probably benign Het
Dsg4 C A 18: 20,471,044 P856H probably damaging Het
Fndc3a C A 14: 72,574,351 probably null Het
Galc T C 12: 98,252,032 D187G probably benign Het
Gfm1 T C 3: 67,449,746 I384T probably damaging Het
Hacd2 A G 16: 35,048,720 I92V probably benign Het
Hmcn2 T A 2: 31,380,419 Y1223N probably damaging Het
Il20ra T C 10: 19,759,463 I484T probably damaging Het
Map7 G T 10: 20,246,616 V143F probably damaging Het
Mcm3ap T C 10: 76,512,489 L1893P probably damaging Het
Msh6 A G 17: 87,985,416 N533S probably benign Het
Nbea T C 3: 55,723,217 D2233G probably damaging Het
Nlrp6 A T 7: 140,923,204 T408S probably damaging Het
Notch3 A T 17: 32,122,754 L2008Q probably damaging Het
Olfr1051 A T 2: 86,276,039 Y149* probably null Het
Olfr603 T A 7: 103,383,633 D123V probably damaging Het
Pggt1b T C 18: 46,246,628 N296D probably benign Het
Phip T C 9: 82,915,339 H537R possibly damaging Het
Ptch1 T G 13: 63,524,959 E944A probably benign Het
Ptpdc1 T A 13: 48,592,659 probably null Het
Ptprq T C 10: 107,653,493 T924A probably benign Het
Pwp2 C A 10: 78,177,742 probably benign Het
Slc7a4 G T 16: 17,573,455 probably null Het
Tmem132b T A 5: 125,638,208 I327K probably damaging Het
Trim9 T C 12: 70,347,159 M4V probably damaging Het
Tspan13 T C 12: 36,021,830 S128G probably benign Het
Ttc25 T A 11: 100,563,582 F398I possibly damaging Het
Zbtb20 A G 16: 43,609,519 D131G probably null Het
Zeb2 A T 2: 44,997,156 C615S probably damaging Het
Zfp777 C T 6: 48,044,242 D149N probably benign Het
Zfp990 A G 4: 145,537,322 K297E possibly damaging Het
Other mutations in Pglyrp3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00335:Pglyrp3 APN 3 92022679 missense probably damaging 0.96
IGL00769:Pglyrp3 APN 3 92014622 utr 5 prime probably benign
IGL02491:Pglyrp3 APN 3 92014637 missense possibly damaging 0.77
IGL03279:Pglyrp3 APN 3 92026527 missense probably damaging 1.00
R0056:Pglyrp3 UTSW 3 92025804 splice site probably benign
R1128:Pglyrp3 UTSW 3 92028172 missense probably benign 0.22
R2140:Pglyrp3 UTSW 3 92026567 missense probably benign 0.00
R3697:Pglyrp3 UTSW 3 92028174 missense probably damaging 1.00
R4369:Pglyrp3 UTSW 3 92028079 missense probably damaging 1.00
R4430:Pglyrp3 UTSW 3 92031491 missense probably damaging 1.00
R4775:Pglyrp3 UTSW 3 92025730 missense possibly damaging 0.64
R6020:Pglyrp3 UTSW 3 92031534 missense probably damaging 1.00
R7352:Pglyrp3 UTSW 3 92014640 nonsense probably null
R7437:Pglyrp3 UTSW 3 92030678 missense probably benign 0.00
R8150:Pglyrp3 UTSW 3 92026483 missense probably benign 0.00
R8466:Pglyrp3 UTSW 3 92014634 missense probably benign 0.16
R8695:Pglyrp3 UTSW 3 92026455 missense probably null 1.00
R9413:Pglyrp3 UTSW 3 92022799 missense probably damaging 1.00
R9479:Pglyrp3 UTSW 3 92028003 missense probably benign 0.04
R9592:Pglyrp3 UTSW 3 92031552 missense probably benign 0.22
R9722:Pglyrp3 UTSW 3 92031388 missense possibly damaging 0.67
Z1176:Pglyrp3 UTSW 3 92028085 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACCCTCTGGCTGTACATTGC -3'
(R):5'- TGCCTGAGCAGTTAAATAGCCC -3'

Sequencing Primer
(F):5'- GGCTGTACATTGCTTTCATAACAGTC -3'
(R):5'- GTTAAATAGCCCAAGCAATAGCCTG -3'
Posted On 2014-09-18