Incidental Mutation 'R2098:Or2a20'
ID 230363
Institutional Source Beutler Lab
Gene Symbol Or2a20
Ensembl Gene ENSMUSG00000059411
Gene Name olfactory receptor family 2 subfamily A member 2
Synonyms Olfr434, GA_x6K02T2P3E9-4341246-4340281, MOR261-10
MMRRC Submission 040102-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.134) question?
Stock # R2098 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 43193849-43194814 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 43194437 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 197 (V197I)
Ref Sequence ENSEMBL: ENSMUSP00000149678 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076752] [ENSMUST00000216562]
AlphaFold Q8VF17
Predicted Effect probably benign
Transcript: ENSMUST00000076752
AA Change: V197I

PolyPhen 2 Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000076039
Gene: ENSMUSG00000059411
AA Change: V197I

DomainStartEndE-ValueType
Pfam:7tm_4 30 307 7.7e-62 PFAM
Pfam:7tm_1 40 289 2.1e-29 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000204448
SMART Domains Protein: ENSMUSP00000145171
Gene: ENSMUSG00000059411

DomainStartEndE-ValueType
Pfam:7tm_4 30 156 1.2e-26 PFAM
Pfam:7TM_GPCR_Srsx 34 156 3.5e-6 PFAM
Pfam:7tm_1 40 156 7.5e-22 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215485
Predicted Effect probably benign
Transcript: ENSMUST00000216562
AA Change: V197I

PolyPhen 2 Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.7%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8a T C 11: 109,927,405 (GRCm39) E1316G probably damaging Het
Arhgap32 C A 9: 32,171,207 (GRCm39) T1329K probably damaging Het
Arhgef10l G C 4: 140,306,743 (GRCm39) L104V probably damaging Het
Bend3 T C 10: 43,386,500 (GRCm39) S298P probably damaging Het
Cacna1b C T 2: 24,540,558 (GRCm39) V1385M probably damaging Het
Camk2d G A 3: 126,574,091 (GRCm39) G166D probably damaging Het
Cd84 G A 1: 171,713,148 (GRCm39) C291Y probably benign Het
Cdhr2 A G 13: 54,863,457 (GRCm39) I113V probably benign Het
Cfap206 G A 4: 34,719,053 (GRCm39) Q318* probably null Het
Chd9 C T 8: 91,760,615 (GRCm39) P2120L probably benign Het
Cyth1 T A 11: 118,084,479 (GRCm39) I25F probably damaging Het
Dock2 A T 11: 34,216,279 (GRCm39) N1208K probably benign Het
Dock2 A G 11: 34,609,832 (GRCm39) S203P probably damaging Het
Ehbp1l1 G T 19: 5,758,686 (GRCm39) T1652K possibly damaging Het
Eps8l2 G A 7: 140,935,705 (GRCm39) probably null Het
Fam3d T C 14: 8,361,479 (GRCm38) I47V probably benign Het
Gm10250 A G 15: 5,150,296 (GRCm39) probably benign Het
Gm9772 T C 17: 22,225,618 (GRCm39) H94R probably benign Het
Hspg2 G A 4: 137,247,420 (GRCm39) G1184D probably damaging Het
Igfn1 T A 1: 135,906,043 (GRCm39) D255V probably damaging Het
Marf1 T C 16: 13,932,064 (GRCm39) H1651R probably benign Het
Mllt10 T C 2: 18,167,464 (GRCm39) V385A possibly damaging Het
Mmp1b G A 9: 7,386,984 (GRCm39) S76L probably benign Het
Mrps2 C A 2: 28,358,327 (GRCm39) T39K probably benign Het
Myo6 T C 9: 80,188,808 (GRCm39) Y715H probably damaging Het
Nsun7 A G 5: 66,441,055 (GRCm39) E392G probably damaging Het
Obscn C T 11: 58,960,817 (GRCm39) E3374K probably damaging Het
Or4c11 A T 2: 88,695,215 (GRCm39) I89F probably benign Het
Or56a4 A G 7: 104,806,478 (GRCm39) V137A probably benign Het
Or5w13 A T 2: 87,524,073 (GRCm39) M51K probably benign Het
Pkd2 C T 5: 104,626,768 (GRCm39) P317S probably damaging Het
Prl5a1 T C 13: 28,329,488 (GRCm39) S56P probably damaging Het
Psmd1 A G 1: 86,009,823 (GRCm39) probably null Het
Ptchd3 T C 11: 121,733,305 (GRCm39) C732R probably damaging Het
Rad51c A T 11: 87,293,589 (GRCm39) V71E probably benign Het
Scn11a A T 9: 119,621,560 (GRCm39) I619K possibly damaging Het
Sgpp1 T G 12: 75,763,284 (GRCm39) D299A probably damaging Het
Slc16a4 C A 3: 107,208,163 (GRCm39) Y224* probably null Het
Slc22a30 G A 19: 8,378,175 (GRCm39) S167L probably damaging Het
Slc6a5 T C 7: 49,595,315 (GRCm39) I559T probably damaging Het
Spire1 A G 18: 67,636,536 (GRCm39) F364L probably damaging Het
Srek1 G A 13: 103,881,363 (GRCm39) T421I unknown Het
St8sia4 T C 1: 95,581,253 (GRCm39) H163R probably damaging Het
Supt6 A G 11: 78,104,087 (GRCm39) probably null Het
Tas2r103 T C 6: 133,013,560 (GRCm39) T169A probably benign Het
Thrap3 A G 4: 126,073,823 (GRCm39) S308P probably damaging Het
V1rd19 C T 7: 23,703,160 (GRCm39) L209F probably damaging Het
Zfp267 T A 3: 36,220,289 (GRCm39) S771T probably benign Het
Other mutations in Or2a20
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00339:Or2a20 APN 6 43,194,782 (GRCm39) missense probably benign 0.00
R0347:Or2a20 UTSW 6 43,194,296 (GRCm39) missense probably benign
R1099:Or2a20 UTSW 6 43,194,558 (GRCm39) missense probably damaging 1.00
R1147:Or2a20 UTSW 6 43,194,146 (GRCm39) missense probably damaging 0.99
R1147:Or2a20 UTSW 6 43,194,146 (GRCm39) missense probably damaging 0.99
R1353:Or2a20 UTSW 6 43,194,624 (GRCm39) missense probably benign 0.41
R1570:Or2a20 UTSW 6 43,194,285 (GRCm39) missense probably benign
R1720:Or2a20 UTSW 6 43,194,494 (GRCm39) missense probably damaging 1.00
R4707:Or2a20 UTSW 6 43,193,883 (GRCm39) missense probably benign 0.27
R4942:Or2a20 UTSW 6 43,193,928 (GRCm39) missense probably damaging 1.00
R5008:Or2a20 UTSW 6 43,193,991 (GRCm39) missense probably damaging 0.98
R5084:Or2a20 UTSW 6 43,194,594 (GRCm39) missense probably damaging 1.00
R6472:Or2a20 UTSW 6 43,194,293 (GRCm39) missense probably benign
R7592:Or2a20 UTSW 6 43,194,179 (GRCm39) missense probably damaging 1.00
R7756:Or2a20 UTSW 6 43,193,950 (GRCm39) nonsense probably null
R7784:Or2a20 UTSW 6 43,194,322 (GRCm39) missense possibly damaging 0.82
R8056:Or2a20 UTSW 6 43,193,978 (GRCm39) missense probably damaging 0.99
R9093:Or2a20 UTSW 6 43,194,500 (GRCm39) missense probably benign
R9193:Or2a20 UTSW 6 43,194,086 (GRCm39) missense probably benign 0.45
R9745:Or2a20 UTSW 6 43,194,258 (GRCm39) nonsense probably null
R9749:Or2a20 UTSW 6 43,194,258 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- AGTGTGTACCATTCTGGCTG -3'
(R):5'- AAAGAACCTTCTGCTGCTCCTC -3'

Sequencing Primer
(F):5'- CTGCTGTTTCCTGGATATTTAGC -3'
(R):5'- TGTACATGACAATGGCACTGC -3'
Posted On 2014-09-18