Incidental Mutation 'R2098:Prl5a1'
ID 230390
Institutional Source Beutler Lab
Gene Symbol Prl5a1
Ensembl Gene ENSMUSG00000017064
Gene Name prolactin family 5, subfamily a, member 1
Synonyms 1600013P04Rik, D13Wsu14e, Prlpl, PLP-L
MMRRC Submission 040102-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.053) question?
Stock # R2098 (G1)
Quality Score 225
Status Not validated
Chromosome 13
Chromosomal Location 28326467-28335578 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 28329488 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 56 (S56P)
Ref Sequence ENSEMBL: ENSMUSP00000017208 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000017208]
AlphaFold Q9JII2
Predicted Effect probably damaging
Transcript: ENSMUST00000017208
AA Change: S56P

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000017208
Gene: ENSMUSG00000017064
AA Change: S56P

DomainStartEndE-ValueType
Pfam:Hormone_1 17 230 4.8e-50 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.7%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8a T C 11: 109,927,405 (GRCm39) E1316G probably damaging Het
Arhgap32 C A 9: 32,171,207 (GRCm39) T1329K probably damaging Het
Arhgef10l G C 4: 140,306,743 (GRCm39) L104V probably damaging Het
Bend3 T C 10: 43,386,500 (GRCm39) S298P probably damaging Het
Cacna1b C T 2: 24,540,558 (GRCm39) V1385M probably damaging Het
Camk2d G A 3: 126,574,091 (GRCm39) G166D probably damaging Het
Cd84 G A 1: 171,713,148 (GRCm39) C291Y probably benign Het
Cdhr2 A G 13: 54,863,457 (GRCm39) I113V probably benign Het
Cfap206 G A 4: 34,719,053 (GRCm39) Q318* probably null Het
Chd9 C T 8: 91,760,615 (GRCm39) P2120L probably benign Het
Cyth1 T A 11: 118,084,479 (GRCm39) I25F probably damaging Het
Dock2 A T 11: 34,216,279 (GRCm39) N1208K probably benign Het
Dock2 A G 11: 34,609,832 (GRCm39) S203P probably damaging Het
Ehbp1l1 G T 19: 5,758,686 (GRCm39) T1652K possibly damaging Het
Eps8l2 G A 7: 140,935,705 (GRCm39) probably null Het
Fam3d T C 14: 8,361,479 (GRCm38) I47V probably benign Het
Gm10250 A G 15: 5,150,296 (GRCm39) probably benign Het
Gm9772 T C 17: 22,225,618 (GRCm39) H94R probably benign Het
Hspg2 G A 4: 137,247,420 (GRCm39) G1184D probably damaging Het
Igfn1 T A 1: 135,906,043 (GRCm39) D255V probably damaging Het
Marf1 T C 16: 13,932,064 (GRCm39) H1651R probably benign Het
Mllt10 T C 2: 18,167,464 (GRCm39) V385A possibly damaging Het
Mmp1b G A 9: 7,386,984 (GRCm39) S76L probably benign Het
Mrps2 C A 2: 28,358,327 (GRCm39) T39K probably benign Het
Myo6 T C 9: 80,188,808 (GRCm39) Y715H probably damaging Het
Nsun7 A G 5: 66,441,055 (GRCm39) E392G probably damaging Het
Obscn C T 11: 58,960,817 (GRCm39) E3374K probably damaging Het
Or2a20 G A 6: 43,194,437 (GRCm39) V197I probably benign Het
Or4c11 A T 2: 88,695,215 (GRCm39) I89F probably benign Het
Or56a4 A G 7: 104,806,478 (GRCm39) V137A probably benign Het
Or5w13 A T 2: 87,524,073 (GRCm39) M51K probably benign Het
Pkd2 C T 5: 104,626,768 (GRCm39) P317S probably damaging Het
Psmd1 A G 1: 86,009,823 (GRCm39) probably null Het
Ptchd3 T C 11: 121,733,305 (GRCm39) C732R probably damaging Het
Rad51c A T 11: 87,293,589 (GRCm39) V71E probably benign Het
Scn11a A T 9: 119,621,560 (GRCm39) I619K possibly damaging Het
Sgpp1 T G 12: 75,763,284 (GRCm39) D299A probably damaging Het
Slc16a4 C A 3: 107,208,163 (GRCm39) Y224* probably null Het
Slc22a30 G A 19: 8,378,175 (GRCm39) S167L probably damaging Het
Slc6a5 T C 7: 49,595,315 (GRCm39) I559T probably damaging Het
Spire1 A G 18: 67,636,536 (GRCm39) F364L probably damaging Het
Srek1 G A 13: 103,881,363 (GRCm39) T421I unknown Het
St8sia4 T C 1: 95,581,253 (GRCm39) H163R probably damaging Het
Supt6 A G 11: 78,104,087 (GRCm39) probably null Het
Tas2r103 T C 6: 133,013,560 (GRCm39) T169A probably benign Het
Thrap3 A G 4: 126,073,823 (GRCm39) S308P probably damaging Het
V1rd19 C T 7: 23,703,160 (GRCm39) L209F probably damaging Het
Zfp267 T A 3: 36,220,289 (GRCm39) S771T probably benign Het
Other mutations in Prl5a1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01638:Prl5a1 APN 13 28,329,422 (GRCm39) missense possibly damaging 0.77
IGL01820:Prl5a1 APN 13 28,332,683 (GRCm39) missense probably benign 0.34
IGL02682:Prl5a1 APN 13 28,329,403 (GRCm39) missense probably benign 0.32
R0266:Prl5a1 UTSW 13 28,333,970 (GRCm39) missense possibly damaging 0.77
R1022:Prl5a1 UTSW 13 28,333,880 (GRCm39) missense probably damaging 0.97
R1024:Prl5a1 UTSW 13 28,333,880 (GRCm39) missense probably damaging 0.97
R5467:Prl5a1 UTSW 13 28,333,994 (GRCm39) missense possibly damaging 0.92
R6002:Prl5a1 UTSW 13 28,329,465 (GRCm39) missense probably benign 0.00
R6026:Prl5a1 UTSW 13 28,335,247 (GRCm39) missense probably benign 0.43
R6242:Prl5a1 UTSW 13 28,326,538 (GRCm39) nonsense probably null
R6616:Prl5a1 UTSW 13 28,333,839 (GRCm39) missense probably benign 0.00
R6733:Prl5a1 UTSW 13 28,333,919 (GRCm39) missense possibly damaging 0.81
R6979:Prl5a1 UTSW 13 28,335,189 (GRCm39) missense probably benign 0.32
R7692:Prl5a1 UTSW 13 28,333,997 (GRCm39) missense probably damaging 1.00
R9610:Prl5a1 UTSW 13 28,329,492 (GRCm39) missense possibly damaging 0.71
R9611:Prl5a1 UTSW 13 28,329,492 (GRCm39) missense possibly damaging 0.71
Predicted Primers PCR Primer
(F):5'- TAACAGAGGACACGGTGGCT -3'
(R):5'- GCTTTCTTGAGCCTATGAATGTGTA -3'

Sequencing Primer
(F):5'- GCTAGACAGGGTTTCACTATACAGC -3'
(R):5'- AGCCTATGAATGTGTATTGTTTGG -3'
Posted On 2014-09-18