Incidental Mutation 'R2105:Agrn'
ID |
230857 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Agrn
|
Ensembl Gene |
ENSMUSG00000041936 |
Gene Name |
agrin |
Synonyms |
Agrin, NMF380, nmf380 |
MMRRC Submission |
040109-MU
|
Accession Numbers |
|
Essential gene? |
Possibly non essential
(E-score: 0.458)
|
Stock # |
R2105 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
4 |
Chromosomal Location |
156249747-156281945 bp(-) (GRCm39) |
Type of Mutation |
nonsense |
DNA Base Change (assembly) |
G to T
at 156261756 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Tyrosine to Stop codon
at position 511
(Y511*)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000137931
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000071248]
[ENSMUST00000105574]
[ENSMUST00000105575]
[ENSMUST00000180572]
|
AlphaFold |
A2ASQ1 |
Predicted Effect |
probably null
Transcript: ENSMUST00000071248
AA Change: Y404*
|
SMART Domains |
Protein: ENSMUSP00000071229 Gene: ENSMUSG00000041936 AA Change: Y404*
Domain | Start | End | E-Value | Type |
transmembrane domain
|
25 |
47 |
N/A |
INTRINSIC |
FOLN
|
66 |
91 |
8.25e-6 |
SMART |
KAZAL
|
91 |
137 |
1.22e-17 |
SMART |
FOLN
|
142 |
166 |
7.58e-5 |
SMART |
EGF_like
|
142 |
181 |
7.38e1 |
SMART |
KAZAL
|
166 |
212 |
1.51e-13 |
SMART |
KAZAL
|
241 |
284 |
1.8e-6 |
SMART |
KAZAL
|
310 |
356 |
1.55e-10 |
SMART |
FOLN
|
362 |
384 |
8.25e-6 |
SMART |
KAZAL
|
384 |
429 |
1.14e-17 |
SMART |
KAZAL
|
449 |
494 |
6.43e-17 |
SMART |
FOLN
|
496 |
519 |
2.94e-2 |
SMART |
KAZAL
|
507 |
559 |
8.96e-16 |
SMART |
low complexity region
|
565 |
572 |
N/A |
INTRINSIC |
KAZAL
|
599 |
645 |
1.12e-16 |
SMART |
EGF_Lam
|
688 |
739 |
3.29e-15 |
SMART |
EGF_Lam
|
742 |
786 |
6.7e-7 |
SMART |
FOLN
|
795 |
817 |
1.94e-2 |
SMART |
KAZAL
|
817 |
864 |
3.9e-16 |
SMART |
low complexity region
|
889 |
906 |
N/A |
INTRINSIC |
low complexity region
|
949 |
978 |
N/A |
INTRINSIC |
SEA
|
1014 |
1139 |
5.57e-35 |
SMART |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000105574
AA Change: Y404*
|
SMART Domains |
Protein: ENSMUSP00000101199 Gene: ENSMUSG00000041936 AA Change: Y404*
Domain | Start | End | E-Value | Type |
transmembrane domain
|
25 |
47 |
N/A |
INTRINSIC |
FOLN
|
66 |
91 |
8.25e-6 |
SMART |
KAZAL
|
91 |
137 |
1.22e-17 |
SMART |
FOLN
|
142 |
166 |
7.58e-5 |
SMART |
EGF_like
|
142 |
181 |
7.38e1 |
SMART |
KAZAL
|
166 |
212 |
1.51e-13 |
SMART |
KAZAL
|
241 |
284 |
1.8e-6 |
SMART |
KAZAL
|
310 |
356 |
1.55e-10 |
SMART |
FOLN
|
362 |
384 |
8.25e-6 |
SMART |
KAZAL
|
384 |
429 |
1.14e-17 |
SMART |
KAZAL
|
449 |
494 |
6.43e-17 |
SMART |
FOLN
|
496 |
519 |
2.94e-2 |
SMART |
KAZAL
|
507 |
559 |
8.96e-16 |
SMART |
low complexity region
|
565 |
572 |
N/A |
INTRINSIC |
KAZAL
|
599 |
645 |
1.12e-16 |
SMART |
EGF_Lam
|
688 |
739 |
3.29e-15 |
SMART |
EGF_Lam
|
742 |
786 |
6.7e-7 |
SMART |
FOLN
|
795 |
817 |
1.94e-2 |
SMART |
KAZAL
|
817 |
864 |
3.9e-16 |
SMART |
low complexity region
|
889 |
906 |
N/A |
INTRINSIC |
low complexity region
|
949 |
978 |
N/A |
INTRINSIC |
SEA
|
1014 |
1136 |
2.26e-35 |
SMART |
low complexity region
|
1142 |
1169 |
N/A |
INTRINSIC |
low complexity region
|
1183 |
1198 |
N/A |
INTRINSIC |
EGF
|
1214 |
1249 |
1.49e-4 |
SMART |
LamG
|
1274 |
1410 |
4e-45 |
SMART |
EGF
|
1434 |
1468 |
2.23e-3 |
SMART |
EGF
|
1473 |
1507 |
7.13e-2 |
SMART |
LamG
|
1542 |
1678 |
6.51e-36 |
SMART |
EGF
|
1699 |
1735 |
4.35e-6 |
SMART |
LamG
|
1771 |
1907 |
5.01e-37 |
SMART |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000105575
AA Change: Y404*
|
SMART Domains |
Protein: ENSMUSP00000101200 Gene: ENSMUSG00000041936 AA Change: Y404*
Domain | Start | End | E-Value | Type |
transmembrane domain
|
25 |
47 |
N/A |
INTRINSIC |
FOLN
|
66 |
91 |
8.25e-6 |
SMART |
KAZAL
|
91 |
137 |
1.22e-17 |
SMART |
FOLN
|
142 |
166 |
7.58e-5 |
SMART |
EGF_like
|
142 |
181 |
7.38e1 |
SMART |
KAZAL
|
166 |
212 |
1.51e-13 |
SMART |
KAZAL
|
241 |
284 |
1.8e-6 |
SMART |
KAZAL
|
310 |
356 |
1.55e-10 |
SMART |
FOLN
|
362 |
384 |
8.25e-6 |
SMART |
KAZAL
|
384 |
429 |
1.14e-17 |
SMART |
KAZAL
|
449 |
494 |
6.43e-17 |
SMART |
FOLN
|
496 |
519 |
2.94e-2 |
SMART |
KAZAL
|
507 |
559 |
8.96e-16 |
SMART |
low complexity region
|
565 |
572 |
N/A |
INTRINSIC |
KAZAL
|
599 |
645 |
1.12e-16 |
SMART |
EGF_Lam
|
688 |
739 |
3.29e-15 |
SMART |
EGF_Lam
|
742 |
786 |
6.7e-7 |
SMART |
FOLN
|
795 |
817 |
1.94e-2 |
SMART |
KAZAL
|
817 |
864 |
3.9e-16 |
SMART |
low complexity region
|
889 |
906 |
N/A |
INTRINSIC |
low complexity region
|
949 |
978 |
N/A |
INTRINSIC |
SEA
|
1014 |
1136 |
2.26e-35 |
SMART |
low complexity region
|
1142 |
1169 |
N/A |
INTRINSIC |
low complexity region
|
1183 |
1198 |
N/A |
INTRINSIC |
EGF
|
1214 |
1249 |
1.49e-4 |
SMART |
LamG
|
1274 |
1410 |
4e-45 |
SMART |
EGF
|
1434 |
1468 |
2.23e-3 |
SMART |
EGF
|
1473 |
1507 |
7.13e-2 |
SMART |
LamG
|
1542 |
1682 |
9.2e-36 |
SMART |
EGF
|
1703 |
1739 |
4.35e-6 |
SMART |
LamG
|
1794 |
1930 |
5.01e-37 |
SMART |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000144749
|
Predicted Effect |
probably null
Transcript: ENSMUST00000180572
AA Change: Y511*
|
SMART Domains |
Protein: ENSMUSP00000137931 Gene: ENSMUSG00000041936 AA Change: Y511*
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
31 |
N/A |
INTRINSIC |
Pfam:NtA
|
32 |
159 |
5.1e-91 |
PFAM |
FOLN
|
173 |
198 |
8.25e-6 |
SMART |
KAZAL
|
198 |
244 |
1.22e-17 |
SMART |
FOLN
|
249 |
273 |
7.58e-5 |
SMART |
EGF_like
|
249 |
288 |
7.38e1 |
SMART |
KAZAL
|
273 |
319 |
1.51e-13 |
SMART |
KAZAL
|
348 |
391 |
1.8e-6 |
SMART |
KAZAL
|
417 |
463 |
1.55e-10 |
SMART |
FOLN
|
469 |
491 |
8.25e-6 |
SMART |
KAZAL
|
491 |
536 |
1.14e-17 |
SMART |
KAZAL
|
556 |
601 |
6.43e-17 |
SMART |
FOLN
|
603 |
626 |
2.94e-2 |
SMART |
KAZAL
|
614 |
666 |
8.96e-16 |
SMART |
low complexity region
|
672 |
679 |
N/A |
INTRINSIC |
KAZAL
|
706 |
752 |
1.12e-16 |
SMART |
EGF_Lam
|
795 |
846 |
3.29e-15 |
SMART |
EGF_Lam
|
849 |
893 |
6.7e-7 |
SMART |
FOLN
|
902 |
924 |
1.94e-2 |
SMART |
KAZAL
|
924 |
971 |
3.9e-16 |
SMART |
low complexity region
|
996 |
1013 |
N/A |
INTRINSIC |
low complexity region
|
1056 |
1085 |
N/A |
INTRINSIC |
SEA
|
1121 |
1243 |
2.26e-35 |
SMART |
low complexity region
|
1249 |
1276 |
N/A |
INTRINSIC |
low complexity region
|
1290 |
1305 |
N/A |
INTRINSIC |
EGF
|
1321 |
1356 |
1.49e-4 |
SMART |
LamG
|
1381 |
1517 |
4e-45 |
SMART |
EGF
|
1541 |
1575 |
2.23e-3 |
SMART |
EGF
|
1580 |
1614 |
7.13e-2 |
SMART |
LamG
|
1649 |
1785 |
6.51e-36 |
SMART |
EGF
|
1806 |
1842 |
4.35e-6 |
SMART |
LamG
|
1878 |
2014 |
5.01e-37 |
SMART |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000181062
|
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.4%
- 20x: 95.5%
|
Validation Efficiency |
|
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes one of several proteins that are critical in the development of the neuromuscular junction (NMJ), as identified in mouse knock-out studies. The encoded protein contains several laminin G, Kazal type serine protease inhibitor, and epidermal growth factor domains. Additional post-translational modifications occur to add glycosaminoglycans and disulfide bonds. In one family with congenital myasthenic syndrome affecting limb-girdle muscles, a mutation in this gene was found. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015] PHENOTYPE: Nullizygous mice display embryonic failure of NMJ formation, inability to breathe or move and perinatal lethality. Homozygotes for an ENU-induced allele show poor hindlimb motor control, myopathy, muscle atrophy, spasms and fiber-type switching, NMJ disaggregation, camptodactyly and premature death. [provided by MGI curators]
|
Allele List at MGI |
All alleles(12) : Targeted, knock-out(4) Targeted, other(1) Gene trapped(7) |
Other mutations in this stock |
Total: 86 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
A2m |
C |
T |
6: 121,650,459 (GRCm39) |
P1189L |
probably benign |
Het |
Acbd4 |
G |
A |
11: 102,995,265 (GRCm39) |
D57N |
probably damaging |
Het |
Acot4 |
A |
T |
12: 84,085,516 (GRCm39) |
M78L |
probably damaging |
Het |
Ago1 |
A |
T |
4: 126,355,581 (GRCm39) |
M76K |
probably benign |
Het |
Arhgef15 |
A |
T |
11: 68,838,507 (GRCm39) |
|
probably null |
Het |
Atp1a3 |
A |
T |
7: 24,689,278 (GRCm39) |
M594K |
probably damaging |
Het |
Atp4a |
G |
A |
7: 30,419,793 (GRCm39) |
|
probably null |
Het |
Bckdk |
T |
A |
7: 127,506,489 (GRCm39) |
I272N |
probably damaging |
Het |
Bod1l |
A |
G |
5: 41,989,622 (GRCm39) |
V367A |
probably benign |
Het |
C1galt1c1 |
T |
C |
X: 37,720,145 (GRCm39) |
M284V |
possibly damaging |
Het |
Cenpk |
T |
A |
13: 104,366,105 (GRCm39) |
C4* |
probably null |
Het |
Cfap53 |
T |
C |
18: 74,416,294 (GRCm39) |
V9A |
possibly damaging |
Het |
Chil3 |
T |
C |
3: 106,067,794 (GRCm39) |
I124V |
possibly damaging |
Het |
Creld2 |
G |
A |
15: 88,704,834 (GRCm39) |
W103* |
probably null |
Het |
Cyp2c67 |
T |
C |
19: 39,614,681 (GRCm39) |
Y282C |
probably benign |
Het |
D5Ertd579e |
C |
T |
5: 36,770,793 (GRCm39) |
A1201T |
probably benign |
Het |
Dock4 |
A |
G |
12: 40,742,988 (GRCm39) |
H381R |
probably benign |
Het |
Drc1 |
C |
T |
5: 30,513,785 (GRCm39) |
S447F |
probably benign |
Het |
Fam83g |
G |
T |
11: 61,594,284 (GRCm39) |
R606L |
probably benign |
Het |
Fmnl1 |
A |
C |
11: 103,085,518 (GRCm39) |
S688R |
probably benign |
Het |
Fryl |
C |
T |
5: 73,279,642 (GRCm39) |
V219I |
probably benign |
Het |
Golgb1 |
T |
A |
16: 36,735,026 (GRCm39) |
N1424K |
probably benign |
Het |
Gpr39 |
T |
C |
1: 125,605,621 (GRCm39) |
V183A |
possibly damaging |
Het |
H2-T22 |
A |
T |
17: 36,351,409 (GRCm39) |
Y274N |
probably benign |
Het |
Hif1a |
T |
A |
12: 73,984,519 (GRCm39) |
Y313N |
probably damaging |
Het |
Hip1r |
T |
A |
5: 124,138,267 (GRCm39) |
M787K |
probably damaging |
Het |
Hipk3 |
T |
C |
2: 104,269,737 (GRCm39) |
E484G |
probably damaging |
Het |
Hsh2d |
T |
A |
8: 72,954,490 (GRCm39) |
F291I |
probably benign |
Het |
Ino80 |
T |
C |
2: 119,262,410 (GRCm39) |
E692G |
probably null |
Het |
Itgam |
T |
A |
7: 127,680,884 (GRCm39) |
V271D |
probably damaging |
Het |
Kansl1 |
A |
C |
11: 104,226,385 (GRCm39) |
I924S |
probably damaging |
Het |
Kcnq2 |
A |
G |
2: 180,723,145 (GRCm39) |
C628R |
probably benign |
Het |
Krt78 |
A |
C |
15: 101,855,849 (GRCm39) |
V654G |
possibly damaging |
Het |
Lrit2 |
A |
G |
14: 36,793,913 (GRCm39) |
T326A |
probably damaging |
Het |
Ltk |
T |
C |
2: 119,582,569 (GRCm39) |
E710G |
probably damaging |
Het |
Lysmd1 |
T |
C |
3: 95,042,285 (GRCm39) |
L53S |
probably damaging |
Het |
Mc4r |
T |
C |
18: 66,992,669 (GRCm39) |
Y148C |
probably damaging |
Het |
Mfn2 |
G |
A |
4: 147,973,162 (GRCm39) |
Q172* |
probably null |
Het |
Mknk2 |
A |
G |
10: 80,504,435 (GRCm39) |
L242P |
possibly damaging |
Het |
Mrpl45 |
A |
T |
11: 97,216,573 (GRCm39) |
H167L |
probably benign |
Het |
Myc |
T |
C |
15: 61,859,951 (GRCm39) |
V208A |
probably damaging |
Het |
Myh7b |
A |
G |
2: 155,471,377 (GRCm39) |
E1175G |
probably benign |
Het |
Myo18a |
A |
T |
11: 77,741,060 (GRCm39) |
M1456L |
probably benign |
Het |
Myocd |
G |
A |
11: 65,109,484 (GRCm39) |
Q96* |
probably null |
Het |
Nckap5 |
T |
A |
1: 125,954,255 (GRCm39) |
I766F |
probably damaging |
Het |
Ndst1 |
T |
C |
18: 60,824,325 (GRCm39) |
E784G |
probably benign |
Het |
Nf1 |
A |
T |
11: 79,360,652 (GRCm39) |
R1443S |
possibly damaging |
Het |
Nhlrc3 |
A |
G |
3: 53,361,072 (GRCm39) |
W228R |
probably damaging |
Het |
Nup107 |
G |
A |
10: 117,609,225 (GRCm39) |
T378I |
probably damaging |
Het |
Or14c40 |
A |
T |
7: 86,313,591 (GRCm39) |
K240N |
probably damaging |
Het |
Or1o3 |
A |
T |
17: 37,573,964 (GRCm39) |
M197K |
probably benign |
Het |
Or52d13 |
T |
A |
7: 103,109,480 (GRCm39) |
|
probably null |
Het |
Or5m3b |
C |
T |
2: 85,871,674 (GRCm39) |
T5I |
probably damaging |
Het |
Or5w11 |
A |
G |
2: 87,459,283 (GRCm39) |
T159A |
probably benign |
Het |
Or6b13 |
T |
A |
7: 139,782,656 (GRCm39) |
D9V |
probably benign |
Het |
Otop1 |
A |
G |
5: 38,457,801 (GRCm39) |
D520G |
probably benign |
Het |
Papln |
C |
T |
12: 83,827,010 (GRCm39) |
P712S |
probably benign |
Het |
Pcbd2 |
T |
A |
13: 55,880,846 (GRCm39) |
I34N |
probably damaging |
Het |
Pkd1l3 |
T |
A |
8: 110,374,205 (GRCm39) |
C29* |
probably null |
Het |
Pou5f1 |
G |
A |
17: 35,820,899 (GRCm39) |
V114M |
probably benign |
Het |
Pramel28 |
A |
T |
4: 143,692,390 (GRCm39) |
Y204N |
probably benign |
Het |
Prpf4b |
C |
A |
13: 35,068,214 (GRCm39) |
|
probably benign |
Het |
Prr23a1 |
C |
T |
9: 98,724,709 (GRCm39) |
P24S |
probably damaging |
Het |
Ptch1 |
T |
A |
13: 63,693,059 (GRCm39) |
M65L |
probably benign |
Het |
Rc3h2 |
A |
T |
2: 37,289,636 (GRCm39) |
I392K |
possibly damaging |
Het |
Reck |
G |
T |
4: 43,943,195 (GRCm39) |
D916Y |
probably damaging |
Het |
Rtf2 |
A |
G |
2: 172,287,285 (GRCm39) |
D68G |
probably damaging |
Het |
Ryr1 |
G |
T |
7: 28,789,575 (GRCm39) |
T1513K |
probably damaging |
Het |
Sacs |
A |
G |
14: 61,410,890 (GRCm39) |
D55G |
possibly damaging |
Het |
Scn9a |
A |
G |
2: 66,398,527 (GRCm39) |
S28P |
probably benign |
Het |
Scrn3 |
A |
G |
2: 73,160,196 (GRCm39) |
M280V |
probably damaging |
Het |
Snx29 |
C |
T |
16: 11,328,898 (GRCm39) |
T559I |
possibly damaging |
Het |
Spn |
C |
T |
7: 126,735,413 (GRCm39) |
E109K |
probably damaging |
Het |
Sra1 |
C |
T |
18: 36,808,121 (GRCm39) |
R369H |
probably benign |
Het |
Srsf11 |
C |
T |
3: 157,724,982 (GRCm39) |
A64T |
probably damaging |
Het |
Stk17b |
A |
G |
1: 53,815,764 (GRCm39) |
S12P |
probably benign |
Het |
Sult1d1 |
C |
A |
5: 87,707,661 (GRCm39) |
G153V |
probably damaging |
Het |
Sycp2 |
A |
T |
2: 177,991,931 (GRCm39) |
|
probably null |
Het |
Tgfb3 |
T |
C |
12: 86,116,543 (GRCm39) |
E165G |
possibly damaging |
Het |
Tns2 |
C |
A |
15: 102,015,941 (GRCm39) |
H160N |
probably benign |
Het |
Ubn1 |
T |
A |
16: 4,895,088 (GRCm39) |
C711* |
probably null |
Het |
Usp13 |
A |
T |
3: 32,956,135 (GRCm39) |
D469V |
probably damaging |
Het |
Vmn1r231 |
A |
T |
17: 21,110,380 (GRCm39) |
H178Q |
possibly damaging |
Het |
Vwa1 |
A |
G |
4: 155,857,250 (GRCm39) |
S183P |
probably damaging |
Het |
Xpo7 |
A |
G |
14: 70,928,431 (GRCm39) |
I424T |
probably benign |
Het |
Zfp109 |
A |
G |
7: 23,936,041 (GRCm39) |
|
probably null |
Het |
|
Other mutations in Agrn |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00479:Agrn
|
APN |
4 |
156,255,029 (GRCm39) |
splice site |
probably benign |
|
IGL00811:Agrn
|
APN |
4 |
156,253,231 (GRCm39) |
missense |
possibly damaging |
0.70 |
IGL01066:Agrn
|
APN |
4 |
156,261,800 (GRCm39) |
missense |
probably benign |
0.00 |
IGL01412:Agrn
|
APN |
4 |
156,255,491 (GRCm39) |
splice site |
probably benign |
|
IGL01414:Agrn
|
APN |
4 |
156,279,696 (GRCm39) |
splice site |
probably null |
|
IGL02075:Agrn
|
APN |
4 |
156,254,667 (GRCm39) |
missense |
probably benign |
0.40 |
IGL02609:Agrn
|
APN |
4 |
156,259,680 (GRCm39) |
splice site |
probably benign |
|
IGL02669:Agrn
|
APN |
4 |
156,259,018 (GRCm39) |
splice site |
probably benign |
|
IGL02671:Agrn
|
APN |
4 |
156,259,018 (GRCm39) |
splice site |
probably benign |
|
IGL02672:Agrn
|
APN |
4 |
156,259,018 (GRCm39) |
splice site |
probably benign |
|
IGL02674:Agrn
|
APN |
4 |
156,259,018 (GRCm39) |
splice site |
probably benign |
|
IGL02724:Agrn
|
APN |
4 |
156,257,264 (GRCm39) |
nonsense |
probably null |
|
IGL02804:Agrn
|
APN |
4 |
156,258,512 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02986:Agrn
|
APN |
4 |
156,263,311 (GRCm39) |
missense |
possibly damaging |
0.84 |
IGL03160:Agrn
|
APN |
4 |
156,254,820 (GRCm39) |
missense |
probably damaging |
0.98 |
BB004:Agrn
|
UTSW |
4 |
156,257,266 (GRCm39) |
missense |
probably damaging |
0.99 |
BB014:Agrn
|
UTSW |
4 |
156,257,266 (GRCm39) |
missense |
probably damaging |
0.99 |
F6893:Agrn
|
UTSW |
4 |
156,258,636 (GRCm39) |
missense |
probably benign |
|
R0092:Agrn
|
UTSW |
4 |
156,263,410 (GRCm39) |
missense |
probably damaging |
1.00 |
R0100:Agrn
|
UTSW |
4 |
156,259,415 (GRCm39) |
missense |
probably damaging |
1.00 |
R0100:Agrn
|
UTSW |
4 |
156,259,415 (GRCm39) |
missense |
probably damaging |
1.00 |
R0482:Agrn
|
UTSW |
4 |
156,258,012 (GRCm39) |
missense |
probably damaging |
0.98 |
R0531:Agrn
|
UTSW |
4 |
156,263,891 (GRCm39) |
missense |
probably benign |
0.38 |
R0536:Agrn
|
UTSW |
4 |
156,264,010 (GRCm39) |
missense |
probably benign |
0.01 |
R0690:Agrn
|
UTSW |
4 |
156,258,910 (GRCm39) |
missense |
probably damaging |
1.00 |
R0750:Agrn
|
UTSW |
4 |
156,251,394 (GRCm39) |
nonsense |
probably null |
|
R1079:Agrn
|
UTSW |
4 |
156,261,682 (GRCm39) |
missense |
probably damaging |
1.00 |
R1199:Agrn
|
UTSW |
4 |
156,256,756 (GRCm39) |
missense |
probably benign |
0.00 |
R1222:Agrn
|
UTSW |
4 |
156,261,842 (GRCm39) |
missense |
probably damaging |
0.99 |
R1534:Agrn
|
UTSW |
4 |
156,261,141 (GRCm39) |
missense |
probably damaging |
1.00 |
R1587:Agrn
|
UTSW |
4 |
156,263,897 (GRCm39) |
missense |
probably damaging |
0.99 |
R1625:Agrn
|
UTSW |
4 |
156,257,317 (GRCm39) |
missense |
probably damaging |
1.00 |
R1698:Agrn
|
UTSW |
4 |
156,251,015 (GRCm39) |
missense |
probably benign |
0.03 |
R1717:Agrn
|
UTSW |
4 |
156,250,976 (GRCm39) |
frame shift |
probably null |
|
R1718:Agrn
|
UTSW |
4 |
156,250,976 (GRCm39) |
frame shift |
probably null |
|
R1721:Agrn
|
UTSW |
4 |
156,259,630 (GRCm39) |
nonsense |
probably null |
|
R1765:Agrn
|
UTSW |
4 |
156,261,284 (GRCm39) |
nonsense |
probably null |
|
R1840:Agrn
|
UTSW |
4 |
156,251,872 (GRCm39) |
missense |
probably damaging |
1.00 |
R1865:Agrn
|
UTSW |
4 |
156,250,976 (GRCm39) |
frame shift |
probably null |
|
R2265:Agrn
|
UTSW |
4 |
156,263,675 (GRCm39) |
missense |
probably damaging |
0.99 |
R2266:Agrn
|
UTSW |
4 |
156,263,675 (GRCm39) |
missense |
probably damaging |
0.99 |
R2269:Agrn
|
UTSW |
4 |
156,263,675 (GRCm39) |
missense |
probably damaging |
0.99 |
R2382:Agrn
|
UTSW |
4 |
156,260,973 (GRCm39) |
missense |
probably damaging |
0.97 |
R2497:Agrn
|
UTSW |
4 |
156,258,268 (GRCm39) |
missense |
probably benign |
0.28 |
R2509:Agrn
|
UTSW |
4 |
156,250,881 (GRCm39) |
splice site |
probably null |
|
R2510:Agrn
|
UTSW |
4 |
156,250,881 (GRCm39) |
splice site |
probably null |
|
R2511:Agrn
|
UTSW |
4 |
156,250,881 (GRCm39) |
splice site |
probably null |
|
R2994:Agrn
|
UTSW |
4 |
156,251,785 (GRCm39) |
missense |
possibly damaging |
0.79 |
R3824:Agrn
|
UTSW |
4 |
156,253,759 (GRCm39) |
missense |
probably damaging |
1.00 |
R4736:Agrn
|
UTSW |
4 |
156,256,858 (GRCm39) |
missense |
probably benign |
0.38 |
R4755:Agrn
|
UTSW |
4 |
156,257,979 (GRCm39) |
intron |
probably benign |
|
R4853:Agrn
|
UTSW |
4 |
156,270,007 (GRCm39) |
critical splice donor site |
probably null |
|
R4878:Agrn
|
UTSW |
4 |
156,255,302 (GRCm39) |
missense |
probably damaging |
1.00 |
R5117:Agrn
|
UTSW |
4 |
156,270,010 (GRCm39) |
missense |
probably benign |
0.30 |
R5228:Agrn
|
UTSW |
4 |
156,251,403 (GRCm39) |
missense |
probably damaging |
1.00 |
R5236:Agrn
|
UTSW |
4 |
156,263,315 (GRCm39) |
missense |
possibly damaging |
0.93 |
R5269:Agrn
|
UTSW |
4 |
156,253,447 (GRCm39) |
missense |
probably benign |
0.10 |
R5282:Agrn
|
UTSW |
4 |
156,257,492 (GRCm39) |
missense |
probably damaging |
1.00 |
R5449:Agrn
|
UTSW |
4 |
156,251,737 (GRCm39) |
critical splice donor site |
probably null |
|
R5560:Agrn
|
UTSW |
4 |
156,262,954 (GRCm39) |
missense |
probably damaging |
0.99 |
R5668:Agrn
|
UTSW |
4 |
156,251,770 (GRCm39) |
missense |
probably damaging |
0.97 |
R5725:Agrn
|
UTSW |
4 |
156,258,332 (GRCm39) |
missense |
probably benign |
0.25 |
R5967:Agrn
|
UTSW |
4 |
156,259,560 (GRCm39) |
missense |
probably damaging |
1.00 |
R6226:Agrn
|
UTSW |
4 |
156,258,066 (GRCm39) |
missense |
probably damaging |
0.96 |
R6338:Agrn
|
UTSW |
4 |
156,255,042 (GRCm39) |
missense |
probably benign |
0.17 |
R6351:Agrn
|
UTSW |
4 |
156,263,891 (GRCm39) |
missense |
probably benign |
0.00 |
R6437:Agrn
|
UTSW |
4 |
156,261,235 (GRCm39) |
missense |
probably damaging |
0.96 |
R6490:Agrn
|
UTSW |
4 |
156,251,819 (GRCm39) |
nonsense |
probably null |
|
R6909:Agrn
|
UTSW |
4 |
156,261,464 (GRCm39) |
missense |
possibly damaging |
0.90 |
R7110:Agrn
|
UTSW |
4 |
156,263,332 (GRCm39) |
missense |
possibly damaging |
0.88 |
R7123:Agrn
|
UTSW |
4 |
156,257,297 (GRCm39) |
missense |
probably benign |
|
R7163:Agrn
|
UTSW |
4 |
156,262,966 (GRCm39) |
missense |
probably damaging |
1.00 |
R7180:Agrn
|
UTSW |
4 |
156,256,296 (GRCm39) |
missense |
probably benign |
0.00 |
R7251:Agrn
|
UTSW |
4 |
156,259,063 (GRCm39) |
missense |
probably damaging |
1.00 |
R7289:Agrn
|
UTSW |
4 |
156,263,389 (GRCm39) |
missense |
probably damaging |
1.00 |
R7335:Agrn
|
UTSW |
4 |
156,260,989 (GRCm39) |
missense |
probably damaging |
1.00 |
R7336:Agrn
|
UTSW |
4 |
156,259,371 (GRCm39) |
nonsense |
probably null |
|
R7406:Agrn
|
UTSW |
4 |
156,256,758 (GRCm39) |
missense |
possibly damaging |
0.93 |
R7460:Agrn
|
UTSW |
4 |
156,258,881 (GRCm39) |
missense |
probably damaging |
0.98 |
R7531:Agrn
|
UTSW |
4 |
156,254,261 (GRCm39) |
missense |
probably damaging |
1.00 |
R7585:Agrn
|
UTSW |
4 |
156,255,131 (GRCm39) |
missense |
probably benign |
0.08 |
R7646:Agrn
|
UTSW |
4 |
156,279,811 (GRCm39) |
missense |
probably damaging |
0.99 |
R7652:Agrn
|
UTSW |
4 |
156,253,675 (GRCm39) |
critical splice donor site |
probably null |
|
R7714:Agrn
|
UTSW |
4 |
156,279,854 (GRCm39) |
missense |
probably damaging |
1.00 |
R7751:Agrn
|
UTSW |
4 |
156,260,886 (GRCm39) |
missense |
probably damaging |
1.00 |
R7852:Agrn
|
UTSW |
4 |
156,253,514 (GRCm39) |
missense |
probably benign |
0.01 |
R7927:Agrn
|
UTSW |
4 |
156,257,266 (GRCm39) |
missense |
probably damaging |
0.99 |
R8039:Agrn
|
UTSW |
4 |
156,253,468 (GRCm39) |
missense |
probably benign |
0.12 |
R8056:Agrn
|
UTSW |
4 |
156,254,868 (GRCm39) |
missense |
probably benign |
|
R8061:Agrn
|
UTSW |
4 |
156,263,411 (GRCm39) |
missense |
probably damaging |
1.00 |
R8158:Agrn
|
UTSW |
4 |
156,258,346 (GRCm39) |
missense |
probably benign |
|
R8159:Agrn
|
UTSW |
4 |
156,256,825 (GRCm39) |
missense |
probably benign |
0.27 |
R8325:Agrn
|
UTSW |
4 |
156,258,119 (GRCm39) |
missense |
probably benign |
0.01 |
R8338:Agrn
|
UTSW |
4 |
156,253,018 (GRCm39) |
missense |
probably benign |
0.01 |
R8739:Agrn
|
UTSW |
4 |
156,257,045 (GRCm39) |
missense |
probably benign |
|
R8956:Agrn
|
UTSW |
4 |
156,250,995 (GRCm39) |
missense |
probably damaging |
0.99 |
R9094:Agrn
|
UTSW |
4 |
156,253,264 (GRCm39) |
missense |
probably benign |
0.01 |
R9112:Agrn
|
UTSW |
4 |
156,261,514 (GRCm39) |
missense |
probably damaging |
1.00 |
R9384:Agrn
|
UTSW |
4 |
156,257,106 (GRCm39) |
missense |
probably damaging |
1.00 |
R9472:Agrn
|
UTSW |
4 |
156,254,841 (GRCm39) |
missense |
|
|
R9619:Agrn
|
UTSW |
4 |
156,258,490 (GRCm39) |
missense |
probably benign |
0.00 |
R9629:Agrn
|
UTSW |
4 |
156,257,094 (GRCm39) |
nonsense |
probably null |
|
R9732:Agrn
|
UTSW |
4 |
156,258,446 (GRCm39) |
missense |
probably benign |
0.13 |
R9749:Agrn
|
UTSW |
4 |
156,258,114 (GRCm39) |
missense |
probably benign |
0.02 |
R9757:Agrn
|
UTSW |
4 |
156,261,235 (GRCm39) |
missense |
probably benign |
0.03 |
R9792:Agrn
|
UTSW |
4 |
156,261,129 (GRCm39) |
missense |
probably benign |
0.09 |
R9793:Agrn
|
UTSW |
4 |
156,261,129 (GRCm39) |
missense |
probably benign |
0.09 |
Z1177:Agrn
|
UTSW |
4 |
156,264,033 (GRCm39) |
missense |
possibly damaging |
0.95 |
Z1177:Agrn
|
UTSW |
4 |
156,256,001 (GRCm39) |
nonsense |
probably null |
|
|
Predicted Primers |
PCR Primer
(F):5'- TGACTCCACACACTCAGAGG -3'
(R):5'- TGTGGACCGAGTAGTACGTC -3'
Sequencing Primer
(F):5'- CTCAGAGGGGCACACACAG -3'
(R):5'- GACCGAGTAGTACGTCTTCTCTAG -3'
|
Posted On |
2014-09-18 |