Mutagenetix > Incidental Mutation

Incidental Mutation 'R2117:Setx'

231029

Institutional Source

Beutler Lab

Gene Symbol

Setx

Ensembl Gene

ENSMUSG00000043535

Gene Name

senataxin

Synonyms

A930037J23Rik, Als4

MMRRC Submission

040121-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R2117 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

29124181-29182471 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 29130301 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 100 (D100G)

Ref Sequence

ENSEMBL: ENSMUSP00000051492 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000061578] [ENSMUST00000129544]

AlphaFold

A2AKX3

Predicted Effect

probably benign
Transcript: ENSMUST00000061578
AA Change: D100G

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)

SMART Domains

Protein: ENSMUSP00000051492
Gene: ENSMUSG00000043535
AA Change: D100G

Domain	Start	End	E-Value	Type
low complexity region	864	876	N/A	INTRINSIC
low complexity region	1002	1020	N/A	INTRINSIC
low complexity region	1058	1079	N/A	INTRINSIC
low complexity region	1575	1594	N/A	INTRINSIC
Pfam:AAA_11	1909	2194	1.9e-68	PFAM
Pfam:AAA_19	1924	2015	2.9e-11	PFAM
Pfam:AAA_12	2201	2402	1.1e-54	PFAM
low complexity region	2499	2516	N/A	INTRINSIC
low complexity region	2576	2587	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000129544

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000154910

Coding Region Coverage

1x: 99.1%
3x: 98.5%
10x: 97.2%
20x: 95.0%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein named for its homology to the Sen1p protein of fungi which has RNA helicase activity encoded by a domain at the C-terminal end of the protein. The protein encoded by this gene contains a DNA/RNA helicase domain at its C-terminal end which suggests that it may be involved in both DNA and RNA processing. Mutations in this gene have been associated with ataxia-ocular apraxia-2 (AOA2) and an autosomal dominant form of juvenile amyotrophic lateral sclerosis (ALS4). [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit male infertility due to arrested male meiosis and reduced female fertility. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 101 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrv1	A	T	13: 81,492,537 (GRCm38)	C3357S	probably benign	Het
Ago1	T	A	4: 126,463,857 (GRCm38)		probably null	Het
Akap10	A	T	11: 61,890,303 (GRCm38)	D562E	possibly damaging	Het
Akr1b7	G	A	6: 34,418,994 (GRCm38)	A144T	possibly damaging	Het
Ankle1	A	G	8: 71,407,918 (GRCm38)	T340A	probably benign	Het
Arf5	C	T	6: 28,424,784 (GRCm38)	Q71*	probably null	Het
Arl15	C	T	13: 113,967,660 (GRCm38)	S111F	probably damaging	Het
Asph	G	A	4: 9,517,671 (GRCm38)	Q468*	probably null	Het
Bcam	G	T	7: 19,758,427 (GRCm38)	A581E	possibly damaging	Het
Blvra	G	T	2: 127,086,069 (GRCm38)	E80*	probably null	Het
Casc1	C	T	6: 145,205,241 (GRCm38)		probably null	Het
Ccr6	T	C	17: 8,256,082 (GRCm38)	F40L	possibly damaging	Het
Cfap161	A	T	7: 83,775,976 (GRCm38)	N302K	possibly damaging	Het
Ckmt2	T	A	13: 91,855,845 (GRCm38)	I345F	probably benign	Het
Cpsf6	A	G	10: 117,366,120 (GRCm38)		probably benign	Het
Ctnna1	A	G	18: 35,152,625 (GRCm38)	N8S	possibly damaging	Het
Cyp2d11	A	G	15: 82,391,753 (GRCm38)	L209P	probably damaging	Het
Dab2	T	C	15: 6,435,615 (GRCm38)	V628A	probably damaging	Het
Dcstamp	C	T	15: 39,755,175 (GRCm38)	Q327*	probably null	Het
Defb38	A	T	8: 19,023,467 (GRCm38)	Y63*	probably null	Het
Dlg5	A	T	14: 24,177,758 (GRCm38)	L365*	probably null	Het
Dnmt3l	C	A	10: 78,063,296 (GRCm38)	L110I	probably damaging	Het
Exoc3l2	G	T	7: 19,494,982 (GRCm38)	L108F	possibly damaging	Het
Exoc4	T	A	6: 33,347,825 (GRCm38)	N351K	possibly damaging	Het
Fam83h	C	A	15: 76,004,733 (GRCm38)	E252*	probably null	Het
Fancm	A	G	12: 65,077,174 (GRCm38)	D202G	probably damaging	Het
Fat1	T	A	8: 45,037,463 (GRCm38)	V3804E	probably benign	Het
Fbxw28	T	C	9: 109,330,917 (GRCm38)	T190A	probably benign	Het
Fer1l4	T	C	2: 156,039,118 (GRCm38)	T843A	probably benign	Het
Fnip1	A	T	11: 54,500,624 (GRCm38)	H461L	probably damaging	Het
Gcn1l1	A	T	5: 115,598,825 (GRCm38)	M1276L	probably benign	Het
Gemin4	A	G	11: 76,211,001 (GRCm38)	V978A	possibly damaging	Het
Gm7247	A	T	14: 51,365,335 (GRCm38)	I43F	probably damaging	Het
Gm853	C	A	4: 130,215,363 (GRCm38)	V295L	possibly damaging	Het
Gm9978	C	T	10: 78,486,897 (GRCm38)		noncoding transcript	Het
Gpr4	T	C	7: 19,223,145 (GRCm38)	S331P	probably damaging	Het
Hspa1a	T	A	17: 34,970,479 (GRCm38)	N483Y	probably damaging	Het
Ift74	A	G	4: 94,627,259 (GRCm38)	T138A	probably benign	Het
Ints14	T	G	9: 64,979,795 (GRCm38)	L336R	probably damaging	Het
Irak1	G	T	X: 74,022,612 (GRCm38)	P197Q	possibly damaging	Het
Kif4	A	G	X: 100,665,717 (GRCm38)	S315G	probably benign	Het
L3mbtl1	T	A	2: 162,960,070 (GRCm38)		probably null	Het
Lamb3	A	G	1: 193,334,181 (GRCm38)	R657G	probably benign	Het
Lrp2	A	C	2: 69,483,385 (GRCm38)	V2334G	probably benign	Het
Lrwd1	T	A	5: 136,130,478 (GRCm38)	Y431F	probably damaging	Het
Map3k21	A	T	8: 125,924,042 (GRCm38)	H261L	probably benign	Het
Meis1	G	T	11: 18,881,679 (GRCm38)	P453Q	probably damaging	Het
Mettl16	G	T	11: 74,802,929 (GRCm38)	M255I	probably benign	Het
Mllt10	A	G	2: 18,162,569 (GRCm38)	N435S	probably benign	Het
Mpp5	T	C	12: 78,809,922 (GRCm38)	F180L	possibly damaging	Het
Mta2	T	C	19: 8,943,516 (GRCm38)	I27T	probably damaging	Het
Nav2	A	G	7: 49,464,580 (GRCm38)	I771V	probably benign	Het
Nisch	A	T	14: 31,177,285 (GRCm38)		probably benign	Het
Npc1	G	A	18: 12,196,556 (GRCm38)	P990L	probably damaging	Het
Nrxn1	A	T	17: 90,704,277 (GRCm38)	I308K	probably damaging	Het
Olfr1378	A	T	11: 50,969,320 (GRCm38)	I101F	probably damaging	Het
Olfr1402	C	A	3: 97,410,449 (GRCm38)	C244F	probably damaging	Het
Olfr183	T	C	16: 59,000,420 (GRCm38)	L245P	possibly damaging	Het
Otogl	T	C	10: 107,858,918 (GRCm38)	D823G	probably benign	Het
P2rx7	A	G	5: 122,681,266 (GRCm38)	T584A	probably benign	Het
Pank1	T	A	19: 34,841,086 (GRCm38)	I18F	probably damaging	Het
Pgap3	A	G	11: 98,391,107 (GRCm38)	L126P	probably damaging	Het
Phka1	C	T	X: 102,610,201 (GRCm38)	R290H	probably damaging	Het
Pkd2	G	A	5: 104,483,176 (GRCm38)	E489K	probably damaging	Het
Prdm16	T	A	4: 154,347,925 (GRCm38)	S296C	probably null	Het
Prex2	T	A	1: 11,186,713 (GRCm38)	N1216K	probably damaging	Het
Prmt7	A	G	8: 106,227,298 (GRCm38)	T124A	probably damaging	Het
Ptpra	G	T	2: 130,539,735 (GRCm38)	R372L	probably damaging	Het
Ptpro	T	A	6: 137,443,594 (GRCm38)	V1007D	probably damaging	Het
Rap2b	G	T	3: 61,365,091 (GRCm38)	G12V	probably damaging	Het
Rapgef5	T	A	12: 117,714,064 (GRCm38)		probably null	Het
Rassf4	A	G	6: 116,645,127 (GRCm38)	F168S	possibly damaging	Het
Rtf1	T	A	2: 119,705,518 (GRCm38)	H184Q	probably benign	Het
Sacs	A	G	14: 61,213,771 (GRCm38)	K4422R	probably benign	Het
Sec11c	A	T	18: 65,800,649 (GRCm38)	T9S	probably benign	Het
Sema3d	C	T	5: 12,563,273 (GRCm38)	T439I	probably benign	Het
Sephs1	A	G	2: 4,899,540 (GRCm38)	N243S	probably benign	Het
Setd2	TTGGGA	T	9: 110,604,144 (GRCm38)		probably null	Het
Slc22a7	C	A	17: 46,433,972 (GRCm38)	V383L	possibly damaging	Het
Slc25a40	T	C	5: 8,430,417 (GRCm38)	C56R	probably damaging	Het
Stk38l	T	A	6: 146,768,846 (GRCm38)	L229I	probably damaging	Het
Sult2a5	T	C	7: 13,625,434 (GRCm38)	S112P	probably damaging	Het
Syt4	A	G	18: 31,440,467 (GRCm38)	Y332H	probably damaging	Het
Tcof1	T	C	18: 60,832,785 (GRCm38)	E415G	possibly damaging	Het
Tenm2	A	G	11: 36,024,854 (GRCm38)	L1951P	probably damaging	Het
Tlr9	A	G	9: 106,225,337 (GRCm38)	N609S	probably damaging	Het
Tmem120a	A	T	5: 135,736,123 (GRCm38)	S266T	possibly damaging	Het
Tmem132b	A	G	5: 125,622,551 (GRCm38)	E92G	probably damaging	Het
Tmem8	C	T	17: 26,117,884 (GRCm38)	L259F	possibly damaging	Het
Tnfrsf18	T	A	4: 156,028,516 (GRCm38)	V196E	probably damaging	Het
Trpc1	A	T	9: 95,717,584 (GRCm38)	L474H	probably damaging	Het
Trpm6	T	C	19: 18,829,952 (GRCm38)	V1020A	probably damaging	Het
Usp20	T	A	2: 31,016,305 (GRCm38)	C562S	probably damaging	Het
Usp47	T	A	7: 112,067,236 (GRCm38)		probably null	Het
Vgll1	A	C	X: 57,092,430 (GRCm38)	K53T	probably damaging	Het
Vmn1r26	T	C	6: 58,008,350 (GRCm38)	N285D	possibly damaging	Het
Zfp445	T	A	9: 122,853,437 (GRCm38)	K480*	probably null	Het
Zfp786	A	G	6: 47,826,997 (GRCm38)	V37A	probably damaging	Het
Zfp821	A	G	8: 109,721,219 (GRCm38)	E64G	probably damaging	Het
Zfp994	T	A	17: 22,200,981 (GRCm38)	D329V	probably damaging	Het
Zkscan8	T	C	13: 21,520,318 (GRCm38)	S484G	probably damaging	Het

Other mutations in Setx

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00688:Setx	APN	2	29,148,445 (GRCm38)	missense	possibly damaging	0.50
IGL00806:Setx	APN	2	29,127,026 (GRCm38)	missense	probably damaging	1.00
IGL01346:Setx	APN	2	29,144,809 (GRCm38)	missense	probably damaging	1.00
IGL01623:Setx	APN	2	29,163,009 (GRCm38)	missense	possibly damaging	0.70
IGL02351:Setx	APN	2	29,146,964 (GRCm38)	missense	probably benign	0.45
IGL02358:Setx	APN	2	29,146,964 (GRCm38)	missense	probably benign	0.45
IGL02378:Setx	APN	2	29,173,726 (GRCm38)	splice site	probably benign
IGL02388:Setx	APN	2	29,173,653 (GRCm38)	missense	probably damaging	1.00
IGL02408:Setx	APN	2	29,133,930 (GRCm38)	missense	probably damaging	1.00
IGL02425:Setx	APN	2	29,148,408 (GRCm38)	missense	probably benign	0.00
IGL03023:Setx	APN	2	29,145,902 (GRCm38)	missense	probably benign	0.02
IGL03351:Setx	APN	2	29,161,799 (GRCm38)	missense	probably benign	0.25
Addison	UTSW	2	29,158,905 (GRCm38)	missense	probably damaging	1.00
dallas	UTSW	2	29,154,061 (GRCm38)	frame shift	probably null
Denton	UTSW	2	29,145,060 (GRCm38)	missense	possibly damaging	0.81
doggie	UTSW	2	29,164,550 (GRCm38)	missense	probably damaging	1.00
Irving	UTSW	2	29,139,221 (GRCm38)	missense	probably damaging	0.99
G1Funyon:Setx	UTSW	2	29,145,690 (GRCm38)	missense	possibly damaging	0.69
IGL03014:Setx	UTSW	2	29,139,411 (GRCm38)	missense	probably damaging	1.00
PIT4403001:Setx	UTSW	2	29,133,955 (GRCm38)	missense	probably damaging	1.00
R0027:Setx	UTSW	2	29,139,221 (GRCm38)	missense	probably damaging	0.99
R0031:Setx	UTSW	2	29,176,929 (GRCm38)	missense	probably benign	0.02
R0070:Setx	UTSW	2	29,161,525 (GRCm38)	missense	probably benign	0.00
R0070:Setx	UTSW	2	29,161,525 (GRCm38)	missense	probably benign	0.00
R0092:Setx	UTSW	2	29,146,293 (GRCm38)	missense	probably benign	0.00
R0193:Setx	UTSW	2	29,179,673 (GRCm38)	missense	probably benign	0.21
R0281:Setx	UTSW	2	29,179,643 (GRCm38)	missense	probably benign	0.00
R0401:Setx	UTSW	2	29,166,289 (GRCm38)	nonsense	probably null
R0413:Setx	UTSW	2	29,139,278 (GRCm38)	missense	probably damaging	1.00
R0517:Setx	UTSW	2	29,157,133 (GRCm38)	missense	probably benign	0.00
R0536:Setx	UTSW	2	29,158,248 (GRCm38)	missense	possibly damaging	0.46
R0617:Setx	UTSW	2	29,146,807 (GRCm38)	missense	possibly damaging	0.86
R1183:Setx	UTSW	2	29,180,092 (GRCm38)	missense	probably benign
R1331:Setx	UTSW	2	29,179,686 (GRCm38)	missense	probably benign
R1465:Setx	UTSW	2	29,140,389 (GRCm38)	critical splice donor site	probably null
R1465:Setx	UTSW	2	29,140,389 (GRCm38)	critical splice donor site	probably null
R1467:Setx	UTSW	2	29,158,905 (GRCm38)	missense	probably damaging	1.00
R1467:Setx	UTSW	2	29,158,905 (GRCm38)	missense	probably damaging	1.00
R1482:Setx	UTSW	2	29,162,992 (GRCm38)	missense	probably damaging	0.99
R1599:Setx	UTSW	2	29,140,373 (GRCm38)	missense	probably benign	0.04
R1663:Setx	UTSW	2	29,126,905 (GRCm38)	missense	probably damaging	1.00
R1909:Setx	UTSW	2	29,163,009 (GRCm38)	missense	possibly damaging	0.70
R2207:Setx	UTSW	2	29,154,061 (GRCm38)	frame shift	probably null
R2221:Setx	UTSW	2	29,154,061 (GRCm38)	frame shift	probably null
R2223:Setx	UTSW	2	29,154,061 (GRCm38)	frame shift	probably null
R2223:Setx	UTSW	2	29,148,537 (GRCm38)	missense	possibly damaging	0.89
R2273:Setx	UTSW	2	29,154,061 (GRCm38)	frame shift	probably null
R2274:Setx	UTSW	2	29,154,061 (GRCm38)	frame shift	probably null
R2275:Setx	UTSW	2	29,154,061 (GRCm38)	frame shift	probably null
R2309:Setx	UTSW	2	29,158,904 (GRCm38)	missense	probably damaging	1.00
R2328:Setx	UTSW	2	29,154,061 (GRCm38)	frame shift	probably null
R2328:Setx	UTSW	2	29,154,060 (GRCm38)	frame shift	probably null
R2329:Setx	UTSW	2	29,154,061 (GRCm38)	frame shift	probably null
R2331:Setx	UTSW	2	29,154,061 (GRCm38)	frame shift	probably null
R2332:Setx	UTSW	2	29,154,061 (GRCm38)	frame shift	probably null
R2429:Setx	UTSW	2	29,179,898 (GRCm38)	missense	probably benign	0.00
R2438:Setx	UTSW	2	29,154,061 (GRCm38)	frame shift	probably null
R2439:Setx	UTSW	2	29,154,061 (GRCm38)	frame shift	probably null
R2496:Setx	UTSW	2	29,144,801 (GRCm38)	missense	probably benign	0.11
R2858:Setx	UTSW	2	29,154,061 (GRCm38)	frame shift	probably null
R2859:Setx	UTSW	2	29,154,061 (GRCm38)	frame shift	probably null
R2884:Setx	UTSW	2	29,148,625 (GRCm38)	missense	probably damaging	0.98
R2885:Setx	UTSW	2	29,148,625 (GRCm38)	missense	probably damaging	0.98
R2886:Setx	UTSW	2	29,148,625 (GRCm38)	missense	probably damaging	0.98
R2915:Setx	UTSW	2	29,172,324 (GRCm38)	missense	probably damaging	0.99
R2921:Setx	UTSW	2	29,154,061 (GRCm38)	frame shift	probably null
R2921:Setx	UTSW	2	29,154,060 (GRCm38)	small deletion	probably benign
R2923:Setx	UTSW	2	29,154,061 (GRCm38)	frame shift	probably null
R3426:Setx	UTSW	2	29,154,061 (GRCm38)	frame shift	probably null
R3609:Setx	UTSW	2	29,154,061 (GRCm38)	frame shift	probably null
R3610:Setx	UTSW	2	29,154,061 (GRCm38)	frame shift	probably null
R3731:Setx	UTSW	2	29,154,061 (GRCm38)	frame shift	probably null
R3813:Setx	UTSW	2	29,154,061 (GRCm38)	frame shift	probably null
R3835:Setx	UTSW	2	29,145,060 (GRCm38)	missense	possibly damaging	0.81
R3871:Setx	UTSW	2	29,145,741 (GRCm38)	missense	probably damaging	0.98
R4013:Setx	UTSW	2	29,154,061 (GRCm38)	frame shift	probably null
R4014:Setx	UTSW	2	29,154,061 (GRCm38)	frame shift	probably null
R4015:Setx	UTSW	2	29,154,061 (GRCm38)	frame shift	probably null
R4017:Setx	UTSW	2	29,154,061 (GRCm38)	frame shift	probably null
R4246:Setx	UTSW	2	29,154,061 (GRCm38)	frame shift	probably null
R4248:Setx	UTSW	2	29,154,061 (GRCm38)	frame shift	probably null
R4297:Setx	UTSW	2	29,154,061 (GRCm38)	frame shift	probably null
R4298:Setx	UTSW	2	29,154,061 (GRCm38)	frame shift	probably null
R4539:Setx	UTSW	2	29,179,748 (GRCm38)	missense	probably benign	0.14
R4590:Setx	UTSW	2	29,144,809 (GRCm38)	missense	probably damaging	1.00
R4632:Setx	UTSW	2	29,148,615 (GRCm38)	missense	probably benign	0.23
R4782:Setx	UTSW	2	29,144,046 (GRCm38)	missense	probably damaging	0.99
R4801:Setx	UTSW	2	29,146,373 (GRCm38)	missense	probably benign	0.14
R4802:Setx	UTSW	2	29,146,373 (GRCm38)	missense	probably benign	0.14
R4975:Setx	UTSW	2	29,164,550 (GRCm38)	missense	probably damaging	1.00
R5040:Setx	UTSW	2	29,139,338 (GRCm38)	missense	probably damaging	1.00
R5133:Setx	UTSW	2	29,180,081 (GRCm38)	missense	probably benign	0.02
R5208:Setx	UTSW	2	29,166,367 (GRCm38)	missense	possibly damaging	0.63
R5237:Setx	UTSW	2	29,146,983 (GRCm38)	missense	probably benign	0.00
R5248:Setx	UTSW	2	29,148,418 (GRCm38)	missense	probably benign	0.26
R5288:Setx	UTSW	2	29,134,033 (GRCm38)	critical splice donor site	probably null
R5385:Setx	UTSW	2	29,134,033 (GRCm38)	critical splice donor site	probably null
R5387:Setx	UTSW	2	29,147,594 (GRCm38)	missense	probably benign	0.00
R5407:Setx	UTSW	2	29,145,474 (GRCm38)	missense	probably benign	0.00
R5685:Setx	UTSW	2	29,171,280 (GRCm38)	missense	probably damaging	1.00
R6110:Setx	UTSW	2	29,140,290 (GRCm38)	missense	probably damaging	1.00
R6136:Setx	UTSW	2	29,148,027 (GRCm38)	missense	probably benign	0.01
R6310:Setx	UTSW	2	29,176,935 (GRCm38)	missense	possibly damaging	0.57
R6328:Setx	UTSW	2	29,174,462 (GRCm38)	intron	probably benign
R6358:Setx	UTSW	2	29,171,348 (GRCm38)	missense	possibly damaging	0.79
R6384:Setx	UTSW	2	29,173,558 (GRCm38)	missense	probably damaging	1.00
R6400:Setx	UTSW	2	29,130,274 (GRCm38)	missense	probably damaging	0.97
R6572:Setx	UTSW	2	29,173,694 (GRCm38)	missense	possibly damaging	0.63
R6662:Setx	UTSW	2	29,158,114 (GRCm38)	missense	probably damaging	0.97
R6898:Setx	UTSW	2	29,148,108 (GRCm38)	missense	probably benign	0.00
R7188:Setx	UTSW	2	29,148,172 (GRCm38)	missense	probably benign	0.02
R7332:Setx	UTSW	2	29,146,626 (GRCm38)	missense	probably benign	0.00
R7357:Setx	UTSW	2	29,130,301 (GRCm38)	missense	probably benign	0.01
R7556:Setx	UTSW	2	29,146,493 (GRCm38)	missense	possibly damaging	0.88
R7646:Setx	UTSW	2	29,177,549 (GRCm38)	missense	possibly damaging	0.94
R7802:Setx	UTSW	2	29,147,021 (GRCm38)	missense	probably benign	0.02
R7810:Setx	UTSW	2	29,148,651 (GRCm38)	missense	probably benign	0.43
R7831:Setx	UTSW	2	29,179,854 (GRCm38)	missense	possibly damaging	0.75
R7831:Setx	UTSW	2	29,157,108 (GRCm38)	missense	probably damaging	1.00
R7843:Setx	UTSW	2	29,173,569 (GRCm38)	missense	probably damaging	1.00
R7850:Setx	UTSW	2	29,147,418 (GRCm38)	missense	probably damaging	1.00
R7858:Setx	UTSW	2	29,161,550 (GRCm38)	missense	probably damaging	1.00
R8121:Setx	UTSW	2	29,145,034 (GRCm38)	missense	possibly damaging	0.93
R8284:Setx	UTSW	2	29,145,336 (GRCm38)	missense	possibly damaging	0.46
R8301:Setx	UTSW	2	29,145,690 (GRCm38)	missense	possibly damaging	0.69
R8752:Setx	UTSW	2	29,158,980 (GRCm38)	missense	probably damaging	0.97
R8785:Setx	UTSW	2	29,145,263 (GRCm38)	missense	probably damaging	1.00
R8871:Setx	UTSW	2	29,148,102 (GRCm38)	missense	probably benign	0.11
R8927:Setx	UTSW	2	29,126,959 (GRCm38)	missense	possibly damaging	0.59
R8928:Setx	UTSW	2	29,126,959 (GRCm38)	missense	possibly damaging	0.59
R9182:Setx	UTSW	2	29,171,287 (GRCm38)	missense	probably damaging	1.00
R9334:Setx	UTSW	2	29,154,020 (GRCm38)	nonsense	probably null
R9335:Setx	UTSW	2	29,145,951 (GRCm38)	missense	probably benign	0.00
R9491:Setx	UTSW	2	29,147,823 (GRCm38)	missense	probably benign	0.03
R9551:Setx	UTSW	2	29,130,232 (GRCm38)	missense	possibly damaging	0.80
R9627:Setx	UTSW	2	29,144,649 (GRCm38)	missense	probably damaging	1.00
R9688:Setx	UTSW	2	29,146,316 (GRCm38)	missense	probably damaging	1.00
R9689:Setx	UTSW	2	29,161,543 (GRCm38)	missense	probably damaging	1.00
R9747:Setx	UTSW	2	29,174,365 (GRCm38)	nonsense	probably null
R9780:Setx	UTSW	2	29,126,987 (GRCm38)	missense	possibly damaging	0.88
X0066:Setx	UTSW	2	29,147,879 (GRCm38)	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- TCCATAGGAAAGATTCACACATAGC -3'
(R):5'- TGCCATTAAGCTATACTCAGACTAG -3'

Sequencing Primer
(F):5'- TCACACATAGCGTATTTTGTTAGG -3'
(R):5'- TAGTAGGTGTCTTAACCACCAGGC -3'

Posted On

2014-09-18